Takayuki Ikezoe

Summary

Affiliation: Kochi University
Country: Japan

Publications

  1. ncbi request reprint [Pancreatic metastasis from lung cancer: report of an autopsy case]
    Tetsuya Kubota
    Third Department of Medicine, Kochi Medical School, Kochi 783 8505, Japan
    Nihon Kokyuki Gakkai Zasshi 41:917-21. 2003
  2. doi request reprint Thrombomodulin enhances the antifibrinolytic and antileukemic effects of all-trans retinoic acid in acute promyelocytic leukemia cells
    Takayuki Ikezoe
    Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Kochi, Japan
    Exp Hematol 40:457-65. 2012
  3. doi request reprint Recombinant human soluble thrombomodulin safely and effectively rescues acute promyelocytic leukemia patients from disseminated intravascular coagulation
    Takayuki Ikezoe
    Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Kochi, Japan
    Leuk Res 36:1398-402. 2012
  4. doi request reprint Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling
    Takayuki Ikezoe
    Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Kochi 783 8505, Japan
    Arterioscler Thromb Vasc Biol 32:2259-70. 2012
  5. ncbi request reprint A novel treatment strategy targeting Aurora kinases in acute myelogenous leukemia
    Takayuki Ikezoe
    Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Kochi 783 8505, Japan
    Mol Cancer Ther 6:1851-7. 2007
  6. doi request reprint Expression of p-JAK2 predicts clinical outcome and is a potential molecular target of acute myelogenous leukemia
    Takayuki Ikezoe
    Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan
    Int J Cancer 129:2512-21. 2011
  7. doi request reprint Inhibition of signal transducer and activator of transcription 5 by the inhibitor of janus kinases stimulates dormant human leukemia CD34+ /CD38- cells and sensitizes them to antileukemia agents
    Takayuki Ikezoe
    Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi 783 8505, Japan
    Int J Cancer 128:2317-25. 2011
  8. doi request reprint A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies
    T Ikezoe
    Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Kochi, Japan
    Leukemia 23:1564-76. 2009
  9. doi request reprint Analysis of Aurora B kinase in non-Hodgkin lymphoma
    Takayuki Ikezoe
    Department of Hematology and Respiratory Medicine, Kochi University, Japan
    Lab Invest 89:1364-73. 2009
  10. doi request reprint p53 is critical for the Aurora B kinase inhibitor-mediated apoptosis in acute myelogenous leukemia cells
    Takayuki Ikezoe
    Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi, 783 8505, Japan
    Int J Hematol 91:69-77. 2010

Collaborators

Detail Information

Publications67

  1. ncbi request reprint [Pancreatic metastasis from lung cancer: report of an autopsy case]
    Tetsuya Kubota
    Third Department of Medicine, Kochi Medical School, Kochi 783 8505, Japan
    Nihon Kokyuki Gakkai Zasshi 41:917-21. 2003
    ..To our knowledge, obstructive jaundice due to pancreatic metastasis from lung SCC, especially that preceding the advent of a clinical manifestation of primary lung cancer, has rarely been reported...
  2. doi request reprint Thrombomodulin enhances the antifibrinolytic and antileukemic effects of all-trans retinoic acid in acute promyelocytic leukemia cells
    Takayuki Ikezoe
    Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Kochi, Japan
    Exp Hematol 40:457-65. 2012
    ..Taken together, these results suggest that administration of rTM should be considered for treatment of individuals with disseminated intravascular coagulation associated with APL...
  3. doi request reprint Recombinant human soluble thrombomodulin safely and effectively rescues acute promyelocytic leukemia patients from disseminated intravascular coagulation
    Takayuki Ikezoe
    Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Kochi, Japan
    Leuk Res 36:1398-402. 2012
    ..019). These results suggest that administration of rTM should be considered for the treatment of individuals with DIC associated with APL...
  4. doi request reprint Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling
    Takayuki Ikezoe
    Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Kochi 783 8505, Japan
    Arterioscler Thromb Vasc Biol 32:2259-70. 2012
    ..These observations prompted us to explore whether rTM possessed cytoprotective effects on endothelial cells...
  5. ncbi request reprint A novel treatment strategy targeting Aurora kinases in acute myelogenous leukemia
    Takayuki Ikezoe
    Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Kochi 783 8505, Japan
    Mol Cancer Ther 6:1851-7. 2007
    ..Taken together, inhibition of Aurora kinases may be a promising treatment strategy for individuals with leukemia...
  6. doi request reprint Expression of p-JAK2 predicts clinical outcome and is a potential molecular target of acute myelogenous leukemia
    Takayuki Ikezoe
    Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan
    Int J Cancer 129:2512-21. 2011
    ..Taken together, JAK2 may be a promising molecular target for treatment of AML...
  7. doi request reprint Inhibition of signal transducer and activator of transcription 5 by the inhibitor of janus kinases stimulates dormant human leukemia CD34+ /CD38- cells and sensitizes them to antileukemia agents
    Takayuki Ikezoe
    Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi 783 8505, Japan
    Int J Cancer 128:2317-25. 2011
    ..Taken together, JAK2/STAT5 signaling may be a promising molecular target to eradicate CD34(+) /CD38(-) leukemia cells in individuals with AML...
  8. doi request reprint A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies
    T Ikezoe
    Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Kochi, Japan
    Leukemia 23:1564-76. 2009
    ..Taken together, targeting PLK1 may be a promising treatment strategy for individuals with leukemia...
  9. doi request reprint Analysis of Aurora B kinase in non-Hodgkin lymphoma
    Takayuki Ikezoe
    Department of Hematology and Respiratory Medicine, Kochi University, Japan
    Lab Invest 89:1364-73. 2009
    ..Further experiments found that VCR increased levels of the p-Aurora B through the activation of c-Jun N-terminal kinase, which was blocked in the presence of AZD1152-HQPA...
  10. doi request reprint p53 is critical for the Aurora B kinase inhibitor-mediated apoptosis in acute myelogenous leukemia cells
    Takayuki Ikezoe
    Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi, 783 8505, Japan
    Int J Hematol 91:69-77. 2010
    ..P73 may mediate the late onset of apoptosis to eliminate the polyploid cells caused by the inhibitor of Aurora B kinase...
  11. doi request reprint Inhibition of mammalian target of rapamycin signaling potentiates the effects of all-trans retinoic acid to induce growth arrest and differentiation of human acute myelogenous leukemia cells
    Chie Nishioka
    Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan
    Int J Cancer 125:1710-20. 2009
    ..Taken together, concomitant blockade of the RA and mTORC1 signaling may be a promising treatment strategy for individuals with AML...
  12. doi request reprint Inhibition of mTORC1 by RAD001 (everolimus) potentiates the effects of 1,25-dihydroxyvitamin D(3) to induce growth arrest and differentiation of AML cells in vitro and in vivo
    Jing Yang
    Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Japan
    Exp Hematol 38:666-76. 2010
    ..This study explored the drug interaction of 1,25(OH)(2)D(3) and rapamycin analog RAD001 (everolimus) in AML cells...
  13. ncbi request reprint AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo
    Jing Yang
    Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Kochi, Japan
    Blood 110:2034-40. 2007
    ..Taken together, AZD1152 is a promising new agent for treatment of individuals with leukemia. The combined administration of AZD1152 and conventional chemotherapeutic agent to patients with leukemia warrants further investigation...
  14. ncbi request reprint Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells
    Takayuki Ikezoe
    Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Kochi 783 8505, Japan
    Leuk Res 31:673-82. 2007
    ..Taken together, longitudinal inhibition of PI3K/Akt/mTOR signaling represents a promising treatment strategy for individuals with adult T-cell leukemia...
  15. doi request reprint Inhibition of MEK/ERK signaling induces apoptosis of acute myelogenous leukemia cells via inhibition of eukaryotic initiation factor 4E-binding protein 1 and down-regulation of Mcl-1
    Chie Nishioka
    Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Oko cho, Nankoku, Kochi, 783 8505, Japan
    Apoptosis 15:795-804. 2010
    ..Moreover, we found that blockade of mTORC1 by RAD001 synergistically enhanced the action of AZD6244 in leukemia cells...
  16. ncbi request reprint The antitumor effects of sunitinib (formerly SU11248) against a variety of human hematologic malignancies: enhancement of growth inhibition via inhibition of mammalian target of rapamycin signaling
    Takayuki Ikezoe
    Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Kochi 783 8505, Japan
    Mol Cancer Ther 5:2522-30. 2006
    ..Taken together, sunitinib may be useful for treatment of individuals with leukemias possessing activation mutation of tyrosine kinase, and the combination of sunitinib and RAD001 represents a promising novel treatment strategy...
  17. doi request reprint MS-275, a novel histone deacetylase inhibitor with selectivity against HDAC1, induces degradation of FLT3 via inhibition of chaperone function of heat shock protein 90 in AML cells
    Chie Nishioka
    Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi 783 8505, Japan
    Leuk Res 32:1382-92. 2008
    ..Taken together, MS-275 may be useful for treatment of individuals with leukemia possessing activating mutation of FLT3 gene...
  18. doi request reprint Blockade of MEK signaling potentiates 5-Aza-2'-deoxycytidine-induced apoptosis and upregulation of p21(waf1) in acute myelogenous leukemia cells
    Chie Nishioka
    Department of Hematology and Respiratory Medicine, Kochi University, Japan
    Int J Cancer 125:1168-76. 2009
    ..Furthermore, knock-down of p21(waf1) by the siRNA rescued NB4 cells from 5-AzadC-mediated growth inhibition. Taken together, combination of 5-AzadC and the MEK inhibitor may be useful for treatment of individuals with a subset of AML...
  19. ncbi request reprint Histone deacetylase inhibitors induce growth arrest and apoptosis of HTLV-1-infected T-cells via blockade of signaling by nuclear factor kappaB
    Chie Nishioka
    Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi 783 8505, Japan
    Leuk Res 32:287-96. 2008
    ..Based on these findings, we believe HDACIs can be useful for treating patients with ATL or other types of cancer in which NF-kappaB plays a role...
  20. ncbi request reprint Blockade of MEK/ERK signaling enhances sunitinib-induced growth inhibition and apoptosis of leukemia cells possessing activating mutations of the FLT3 gene
    Chie Nishioka
    Department of Hematology and Respiratory Medicine, Kochi University, Kochi 783 8505, Japan
    Leuk Res 32:865-72. 2008
    ..Taken together, concomitant blockade of FLT3 and MEK signaling represents a promising treatment strategy for individuals with leukemia who possess activating mutations of FLT3...
  21. ncbi request reprint Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways
    Takayuki Ikezoe
    Department of Hematology and Respiratory Medicine, KMS, Kochi Medical School, Nankoku, 783 8505 Kochi, Japan
    Mol Cancer Ther 4:578-86. 2005
    ..Taken together, oridonin might be useful as adjunctive therapy for individuals with lymphoid malignancies, including the lethal disease adult T-cell leukemia...
  22. ncbi request reprint Zanthoxyli Fructus induces growth arrest and apoptosis of LNCaP human prostate cancer cells in vitro and in vivo in association with blockade of the AKT and AR signal pathways
    Yang Yang
    Department of Hematology and Respiratory Medicine, Kochi University, Okohcho, Nankoku, Kochi 783 8505, Japan
    Oncol Rep 15:1581-90. 2006
    ..Taken together, Zanthoxyli Fructus might be useful as an adjunctive therapeutic agent for the treatment of individuals with a variety of cancer types...
  23. ncbi request reprint HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling
    Yang Yang
    Department of Hematology and Respiratory Medicine, Kochi University, Kochi Medical School, Nankoku, Japan
    Cancer Sci 96:425-33. 2005
    ....
  24. doi request reprint Inhibition of MEK signaling enhances the ability of cytarabine to induce growth arrest and apoptosis of acute myelogenous leukemia cells
    Chie Nishioka
    Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Japan
    Apoptosis 14:1108-20. 2009
    ..Taken together, concomitant administration of AraC and the inhibitor of MEK/ERK signaling may be useful for treatment of individuals with AML...
  25. pmc Ki11502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo
    Chie Nishioka
    Department of Hematology and Respiratory Medicine, Kochi University, Kochi, Japan
    Blood 111:5086-92. 2008
    ..Taken together, Ki11502 has profound antiproliferative effects on select subsets of leukemia including those possessing imatinib-resistant mutation...
  26. doi request reprint CD82 regulates STAT5/IL-10 and supports survival of acute myelogenous leukemia cells
    Chie Nishioka
    Department of Immunology, Kochi Medical School, Kochi University, Nankoku, Kochi, 783 8505, Japan Research Fellow of the Japanese Society for the Promotion of Science JSPS, Chiyoda ku, Tokyo, 102 8472, Japan
    Int J Cancer 134:55-64. 2014
    ..Taken together, our data suggest that the CD82/STAT5/IL-10 signaling pathway is involved in the survival of CD34(+)/CD38(-) AML cells and may thus be a promising therapeutic target for eradication of AML LSCs...
  27. ncbi request reprint Effect of SU11248 on gastrointestinal stromal tumor-T1 cells: enhancement of growth inhibition via inhibition of 3-kinase/Akt/mammalian target of rapamycin signaling
    Takayuki Ikezoe
    Department of Hematology and Respiratory Medicine, Graduate School of Kuroshio Science, Kochi University, Nankoku, Kochi 783 8505, Japan
    Cancer Sci 97:945-51. 2006
    ....
  28. ncbi request reprint HIV-1 protease inhibitor ritonavir potentiates the effect of 1,25-dihydroxyvitamin D3 to induce growth arrest and differentiation of human myeloid leukemia cells via down-regulation of CYP24
    Takayuki Ikezoe
    Department of Hematology and Respiratory Disease, KMS, Kochi University, Okohcho, Kochi 783 8505, Japan
    Leuk Res 30:1005-11. 2006
    ..Taken together, inhibition of CYP24 might open a new paradigm for therapy using Vitamin D compounds...
  29. doi request reprint Simultaneous inhibition of DNA methyltransferase and histone deacetylase induces p53-independent apoptosis via down-regulation of Mcl-1 in acute myelogenous leukemia cells
    Chie Nishioka
    Department of Immunology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan
    Leuk Res 35:932-9. 2011
    ..Combination of 5-AzadC and MS-275 may be a promising treatment strategy for individuals with leukemia in which TP53 is inactivated...
  30. doi request reprint AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells
    Jing Yang
    Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Kochi 783 8505, Japan
    Mol Cancer Ther 9:3386-95. 2010
    ..Taken together, Jak2 is an attractive molecular target for treatment of ATL. Concomitant blockade of Jak2 and Bcl-xL may be a promising treatment strategy for this lethal disease...
  31. ncbi request reprint Establishment of a novel small cell lung carcinoma cell line with specific recoverin expression from a patient with cancer-associated retinopathy
    Makoto Kobayashi
    Department of Haematology, Kochi Medical School, Kochi University, Nankoku, Kochi 783 8505, and Division of Pathology, Matsuyama Shimin Hospital, Ehime, Japan
    Lung Cancer 56:319-26. 2007
    ..The present study demonstrates that human recoverin is expressed in SCLC cells cultured from an anti-recoverin antibody-negative patient with CAR. KK0206 might be important for further research on SCLC related retinopathy...
  32. doi request reprint Long-term exposure of gastrointestinal stromal tumor cells to sunitinib induces epigenetic silencing of the PTEN gene
    Jing Yang
    Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan
    Int J Cancer 130:959-66. 2012
    ..Blockade of the PI3K/Akt signaling with the specific inhibitors could be useful in such a case...
  33. doi request reprint Thrombomodulin-induced differentiation of acute myelomonocytic leukemia cells via JNK signaling
    Jing Yang
    Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi 783 8505, Japan
    Leuk Res 36:625-33. 2012
    ..Further studies indicated that the epidermal growth factor-like domain of TM was critical for the anti-leukemia effects of TM and these effects were independent of protein C activation...
  34. pmc The combination of IκB kinase β inhibitor and everolimus modulates expression of interleukin-10 in human T-cell lymphotropic virus type-1-infected T cells
    Chie Nishioka
    Department of Immunology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan
    Immunology 138:216-27. 2013
    ....
  35. ncbi request reprint HIV-1 protease inhibitor induces growth arrest and apoptosis of human multiple myeloma cells via inactivation of signal transducer and activator of transcription 3 and extracellular signal-regulated kinase 1/2
    Takayuki Ikezoe
    Department of Internal Medicine, Kochi Medical School, Nankoku, Kochi, Japan
    Mol Cancer Ther 3:473-9. 2004
    ..Taken together, protease inhibitors might be useful for treatment of individuals with MM...
  36. doi request reprint CD34⁺/CD38⁻ acute myelogenous leukemia cells aberrantly express Aurora kinase A
    Jing Yang
    Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Kochi, Japan Department of Immunology, Kochi Medical School, Kochi University, Kochi, Japan
    Int J Cancer 133:2706-19. 2013
    ..These results suggest that AURKA is a promising molecular target to eliminate chemotherapy-resistant CD34(+) /CD38(-) AML cells...
  37. doi request reprint IL-1β inhibits self-renewal capacity of dormant CD34⁺/CD38⁻ acute myelogenous leukemia cells in vitro and in vivo
    Jing Yang
    Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan
    Int J Cancer 133:1967-81. 2013
    ..Taken together, our results indicate that the inhibition of STAT5 by IL-1β may be a promising treatment strategy to eradicate leukemia stem cells in AML...
  38. doi request reprint CD34⁺/CD38⁻ acute myelogenous leukemia cells aberrantly express CD82 which regulates adhesion and survival of leukemia stem cells
    Chie Nishioka
    Department of Immunology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan
    Int J Cancer 132:2006-19. 2013
    ..Taken together, aberrant expression of CD82 might play a role in adhesion of LSCs to bone marrow microenvironment and survival of LSCs. CD82 could be an attractive molecular target to eradicate LSCs...
  39. doi request reprint A novel treatment strategy targeting shugoshin 1 in hematological malignancies
    Jing Yang
    Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan
    Leuk Res 37:76-82. 2013
    ..Thus, SGOL1 might be a promising molecular target for treating individuals with AML...
  40. ncbi request reprint PC-SPES decreases proliferation and induces differentiation and apoptosis of human acute myeloid leukemia cells
    Takayuki Ikezoe
    Department of Medicine, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Int J Oncol 23:1203-11. 2003
    ..PC-SPES might be useful with ATRA for treatment of patients with acute promyelocytic leukemia (APL), and it could have a role in other types of cancers including MDS...
  41. ncbi request reprint Proteasome inhibitor PS-341 down-regulates prostate-specific antigen (PSA) and induces growth arrest and apoptosis of androgen-dependent human prostate cancer LNCaP cells
    Takayuki Ikezoe
    Department of Internal Medicine, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Cancer Sci 95:271-5. 2004
    ..The proteasome may be a molecular target for treatment of a variety of cancers including prostate cancer...
  42. ncbi request reprint Long-term survival of a patient with small cell lung cancer associated with cancer-associated retinopathy
    Makoto Kobayashi
    Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi 783 8505, Japan
    Lung Cancer 57:399-403. 2007
    ..The current literature review was conducted to evaluate the impact on overall survival according to anti-recoverin antibody status...
  43. pmc DHMEQ, a novel nuclear factor-kappaB inhibitor, induces selective depletion of alloreactive or phytohaemagglutinin-stimulated peripheral blood mononuclear cells, decreases production of T helper type 1 cytokines, and blocks maturation of dendritic cells
    Chie Nishioka
    Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Kochi, Japan
    Immunology 124:198-205. 2008
    ..Taken together, the results suggest that DHMEQ may be useful for treatment of inflammatory diseases, including graft-versus-host disease after allogenic haematopoietic stem cell transplantation...
  44. pmc Clinical significance of aberrant DNA methylation in childhood acute lymphoblastic leukemia
    Seisho Takeuchi
    Department of Medicine, Kochi Medical School, Oko cho, Nankoku, Kochi 783 8505, Japan
    Leuk Res 35:1345-9. 2011
    ..004 and p=0.03, respectively). These results suggest that methylation status is associated with clinicopathological features in childhood ALL...
  45. ncbi request reprint Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells
    Takayuki Ikezoe
    Department of Internal Medicine, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Int J Oncol 23:1187-93. 2003
    ..Oridonin may be a novel, adjunctive therapy for a large variety of malignancies and probably represents one of the major, active components of PC-SPES...
  46. doi request reprint Bcr-Abl activates AURKA and AURKB in chronic myeloid leukemia cells via AKT signaling
    Jing Yang
    Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Kochi, Japan Department of Immunology, Kochi Medical School, Kochi University, Kochi University, Nankoku, Kochi, Japan
    Int J Cancer 134:1183-94. 2014
    ..Taken together, Bcr-Abl induces expression of AURKA and AURKB at least in part via AKT. Inhibition of AURKA could be useful to overcome imatinib-resistance mediated by Bcr-Abl mutants. ..
  47. ncbi request reprint [A case of sarcoidosis following chemotherapy for follicular lymphoma]
    Mizu Sakai
    Department of Hematology and Respiratory Medicine, Kochi University
    Nihon Kokyuki Gakkai Zasshi 48:774-8. 2010
    ..Sarcoidosis was diagnosed, he was treated with corticosteroid eye drops, and his chest ground-glass opacities spontaneously resolved after 2 months. Here, we report a rare case of sarcoidosis with a review of the literature...
  48. ncbi request reprint PC-SPES: a potent inhibitor of nuclear factor-kappa B rescues mice from lipopolysaccharide-induced septic shock
    Takayuki Ikezoe
    Department of Internal Medicine, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Mol Pharmacol 64:1521-9. 2003
    ..Together, PC-SPES is a potent inhibitor of NF-kappaB and might be useful for the treatment of sepsis and inflammatory diseases...
  49. doi request reprint Over-expression of Mcl-1 impairs the ability of ATRA to induce growth arrest and differentiation in acute promyelocytic leukemia cells
    Jing Yang
    Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi, 783 8505, Japan
    Apoptosis 18:1403-15. 2013
    ..Taken together, inhibition of Mcl-1 might be useful to potentiate the action of ATRA in APL as well as non-APL AML cells...
  50. ncbi request reprint Aberrant methylation in promoter-associated CpG islands of multiple genes in acute lymphoblastic leukemia
    Yang Yang
    Department of Medicine, Kochi Medical School, Okoh cho, Nankoku, Kochi 783 8505, Japan
    Leuk Res 30:98-102. 2006
    ..01). The number of patients with methylation of multiple genes was higher in adult ALL than that in childhood ALL (p=0.006). Moreover, overall frequency of methylation was higher in adult ALL than that in childhood ALL (p=0.01)...
  51. doi request reprint Recombinant human soluble thrombomodulin is active against hemophagocytic lymphohistiocytosis associated with acquired immunodeficiency syndrome
    Sunggi Chi
    Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Kochi, 783 8505, Japan
    Int J Hematol 98:615-9. 2013
    ..Although further clinical reports and trials are needed, rTM appears to provide an additional therapeutic option in the management of HLH...
  52. ncbi request reprint Plumbism
    Tsuyako Saito
    Department of Medicine, Kochi Medical School, Kochi, Japan
    Br J Haematol 124:2. 2004
  53. ncbi request reprint Identification of a new GLC1A mutation in a sporadic, primary open-angle glaucoma in Japan
    Takayuki Ikezoe
    Department of Internal Medicine, Kochi Medical School, Okohcho, Nankoku, Kochi 783 8505, Japan
    Int J Mol Med 12:259-61. 2003
    ..No other mutations of the GLC1A gene were found in other types of glaucoma. These findings further emphasize the importance of GLC1A mutation in the development of POAG...
  54. ncbi request reprint Effect of ligands of nuclear hormone receptors on sodium/iodide symporter expression and activity in breast cancer cells
    Sakae Tanosaki
    Division of Hematology Oncology, Department of Medicine, Cedars Sinai Research Institute, University of California Los Angeles School of Medicine, Los Angeles, CA 90048, USA
    Breast Cancer Res Treat 79:335-45. 2003
    ....
  55. ncbi request reprint PC-SPES inhibits colon cancer growth in vitro and in vivo
    Sergio Huerta
    University of California Los Angeles UCLA Center for Human Nutrition, UCLA School of Medicine, 900 Veteran Avenue, 12 217 Warren Hall, Los Angeles, CA 90095, USA
    Cancer Res 62:5204-9. 2002
    ..This suggests that the components of this herbal mixture, either independently or in combination, acted in colon cancer, resulting in a drastic effect on tumor initiation and tumor progression...
  56. ncbi request reprint PC-SPES: Molecular mechanism to induce apoptosis and down-regulate expression of PSA in LNCaP human prostate cancer cells
    Takayuki Ikezoe
    Division of Hematology Oncology, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Int J Oncol 23:1461-70. 2003
    ..Also, PC-SPES activated the JNK/c-Jun/AP-1 signal pathway resulting in growth arrest and apoptosis of prostate cancer cells...
  57. ncbi request reprint Saw Palmetto induces growth arrest and apoptosis of androgen-dependent prostate cancer LNCaP cells via inactivation of STAT 3 and androgen receptor signaling
    Yang Yang
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, PR China
    Int J Oncol 31:593-600. 2007
    ..These results indicate that Saw Palmetto might be useful for the treatment of individuals with prostate cancer...
  58. ncbi request reprint RWJ-241947 (MCC-555), a unique peroxisome proliferator-activated receptor-gamma ligand with antitumor activity against human prostate cancer in vitro and in beige/nude/ X-linked immunodeficient mice and enhancement of apoptosis in myeloma cells induced by
    Takashi Kumagai
    Departments of Medicine and Pathology, Center of Health of Science, University of California at Los Angeles School of Medicine, Los Angeles, California 90048, USA
    Clin Cancer Res 10:1508-20. 2004
    ..We, therefore, investigated these effects in vitro and in vivo either alone or in combination with other compounds...
  59. ncbi request reprint PC-SPES down-regulates COX-2 via inhibition of NF-kappaB and C/EBPbeta in non-small cell lung cancer cells
    Takayuki Ikezoe
    Division of Hematology Oncology and Thoracic Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Int J Oncol 29:453-61. 2006
    ..PC-SPES might be useful in the adjuvant setting for the treatment of individuals with resected NSCLC as well as other types of cancer in which COX-2 is activated...
  60. ncbi request reprint ZD6474 induces growth arrest and apoptosis of GIST-T1 cells, which is enhanced by concomitant use of sunitinib
    Yang Yang
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100083, China
    Cancer Sci 97:1404-9. 2006
    ..The combination of ZD6474 and sunitinib should be investigated further...
  61. ncbi request reprint Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors
    Carl W Miller
    Division of Hematology Oncology, Department of Medicine, UCLA School of Medicine, Cedars Sinai Research Institute, 8700 Beverly Blvd, Davis 5019, Los Angeles, CA 90048, USA
    Genes Chromosomes Cancer 33:17-21. 2002
    ..The occurrence of CHK2 mutations in sporadic cancers emphasizes the importance of the stress pathway which includes TP53...
  62. ncbi request reprint HIV-1 protease inhibitor, ritonavir: a potent inhibitor of CYP3A4, enhanced the anticancer effects of docetaxel in androgen-independent prostate cancer cells in vitro and in vivo
    Takayuki Ikezoe
    Division of Hematology Oncology, Cedars Sinai Medical Center and UCLA School of Medicine, Los Angeles, California, USA
    Cancer Res 64:7426-31. 2004
    ..In summary, combination therapy of ritonavir and anticancer drugs holds promise for the treatment of individuals with advanced, drug resistant cancers...
  63. ncbi request reprint CCAAT/enhancer-binding protein delta: a molecular target of 1,25-dihydroxyvitamin D3 in androgen-responsive prostate cancer LNCaP cells
    Takayuki Ikezoe
    Division of Hematology Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, Los Angeles, California, USA
    Cancer Res 65:4762-8. 2005
    ..Taken together, forced expression of C/EBPdelta in cancer cells may be a promising therapeutic strategy...
  64. ncbi request reprint Insulin-like growth factor binding protein-3 antagonizes the effects of retinoids in myeloid leukemia cells
    Takayuki Ikezoe
    Division of Hematology Oncology, Cedars Sinai Medical Center, Pediatric Endocrinology, University of California at Los Angeles School of Medicine, USA
    Blood 104:237-42. 2004
    ..Taken together, these results indicate that IGFBP-3 has antiproliferative activity against myeloid leukemia cells; while it enhances signaling through RXR/RXR, it blunts signaling by activated RAR/RXR...
  65. ncbi request reprint [Cytopathological features of multiple myeloma]
    Tamotsu Takeuchi
    Department of Pathology, Kochi Medical School
    Nihon Rinsho 65:2250-5. 2007
    ..In the present review, we described the cytopathological features, which is useful for diagnosis and estimation of the patients' prognosis and discrimination from reactive non-tumorous plasma cells...
  66. ncbi request reprint C/EBP-beta, C/EBP-delta, PU.1, AML1 genes: mutational analysis in 381 samples of hematopoietic and solid malignancies
    Vijaya Vegesna
    Division of Hematology Oncology, Cedars Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Leuk Res 26:451-7. 2002
    ..The C/EBP-delta alteration in Raji was a missense mutation (A177G). These findings suggest that mutations of the C/EBP-beta, C/EBP-delta, PU.1, and AML1 rarely contribute to the development of hematopoietic or solid cancers...
  67. ncbi request reprint P53 codon 72 polymorphism is associated with disease progression in adult T-cell leukaemia/lymphoma
    Seisho Takeuchi
    Br J Haematol 131:552-3. 2005