M Hiroi

Summary

Affiliation: Kochi Medical School
Country: Japan

Publications

  1. ncbi Adenoid basal carcinoma of the uterine cervix: a case report with ultrastructural findings
    M Hiroi
    First Department of Pathology, Kochi Medical School, Kohasu, Okoh cho, Nankoku City, Kochi 783 8505, Japan
    Med Electron Microsc 33:241-5. 2000
  2. ncbi Fascin-positive dendritic cells and fibroblastic reticulum cells build a framework of T-cell areas in lymph nodes
    M Hiroi
    The First Department of Pathology, Kochi Medical School, Kohasu, Okoh cho, 783 8505, Nankoku City, Kochi, Japan
    Virchows Arch 444:158-63. 2004
  3. ncbi Distribution and role of CD34-positive stromal cells and myofibroblasts in human normal testicular stroma
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi, Japan
    Histol Histopathol 19:743-51. 2004
  4. ncbi Cytokeratin-positive subserosal myofibroblasts in gastroduodenal ulcer; another type of myofibroblasts
    L Guo
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi, Japan
    Histol Histopathol 21:697-704. 2006
  5. ncbi The complementary role of beta-catenin in diagnosing various subtypes of renal cell carcinomas and its up-regulation in conventional renal cell carcinomas with high nuclear grades
    L Guo
    First Department of Pathology, Kochi Medical School, Kochi, Japan
    Oncol Rep 8:521-6. 2001
  6. ncbi CD34 expression as a novel marker of transformed mesangial cells in biopsied glomerular diseases
    K Naruse
    First Department of Pathology, Kochi Medical School, Kochi 783 8505
    J Pathol 189:105-11. 1999
  7. ncbi Expression of CD9/motility-related protein 1 (MRP-1) in renal parenchymal neoplasms: consistent expression in papillary and chromophobe renal cell carcinomas
    N Kuroda
    First Department of Pathology, Kochi Medical School, Kochi, Japan
    Hum Pathol 32:1071-7. 2001
  8. ncbi The distribution pattern of myofibroblasts in the stroma of human bladder carcinoma depends on their invasiveness
    N Shimasaki
    Department of Urology, Program of Tumor Biology and Regulation, Kochi Medical School, Kochi University, Japan
    Histol Histopathol 21:349-53. 2006
  9. ncbi The distribution of myofibroblasts and CD34-positive stromal cells in normal renal pelvis and ureter and their cancers
    N Kuroda
    Department of Pathology and Laboratory Medicine, Kochi Red Cross Hospital, Kochi City, Kochi, Japan
    Histol Histopathol 21:1303-7. 2006
  10. ncbi The specific distribution of dendritic interstitial cells at the tumor border of major salivary gland pleomorphic adenomas
    H Nakayama
    First Department of Pathology, Kochi Medical School, Japan
    Mod Pathol 12:445-9. 1999

Detail Information

Publications43

  1. ncbi Adenoid basal carcinoma of the uterine cervix: a case report with ultrastructural findings
    M Hiroi
    First Department of Pathology, Kochi Medical School, Kohasu, Okoh cho, Nankoku City, Kochi 783 8505, Japan
    Med Electron Microsc 33:241-5. 2000
    ..Furthermore, both tumors are considered to originate in the reserve cells of the uterine cervix. Because their outcomes are different, they should be distinguished from each other...
  2. ncbi Fascin-positive dendritic cells and fibroblastic reticulum cells build a framework of T-cell areas in lymph nodes
    M Hiroi
    The First Department of Pathology, Kochi Medical School, Kohasu, Okoh cho, 783 8505, Nankoku City, Kochi, Japan
    Virchows Arch 444:158-63. 2004
    ..In active paracortical response, both FPCs and FRCs are also stimulated and might play a significant role in the maturation of the lymphocytes...
  3. ncbi Distribution and role of CD34-positive stromal cells and myofibroblasts in human normal testicular stroma
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi, Japan
    Histol Histopathol 19:743-51. 2004
    ..This distribution and cytological identification was also confirmed by an ultrastructural study of four cases. Finally, CD34-positive stromal cells and myofibroblasts are major components of human testicular stroma...
  4. ncbi Cytokeratin-positive subserosal myofibroblasts in gastroduodenal ulcer; another type of myofibroblasts
    L Guo
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi, Japan
    Histol Histopathol 21:697-704. 2006
    ..In contrast, in the surface layer of ulceration, stromal cells expressing only ASMA were observed. The cytokeratin-positive subserosal myofibroblastic cell in human gastroduodenal ulcer is a novel type of myofibroblast...
  5. ncbi The complementary role of beta-catenin in diagnosing various subtypes of renal cell carcinomas and its up-regulation in conventional renal cell carcinomas with high nuclear grades
    L Guo
    First Department of Pathology, Kochi Medical School, Kochi, Japan
    Oncol Rep 8:521-6. 2001
    ..In conventional RCCs with low nuclear grades, beta-catenin expression is generally down-regulated, while it appears to be preserved in those with high nuclear grades...
  6. ncbi CD34 expression as a novel marker of transformed mesangial cells in biopsied glomerular diseases
    K Naruse
    First Department of Pathology, Kochi Medical School, Kochi 783 8505
    J Pathol 189:105-11. 1999
    ..These studies indicate that CD34 is a useful marker of mesangial transformation and that immunohistochemical examination with the anti-CD34 antibody is useful for the diagnosis and stage determination of glomerular diseases...
  7. ncbi Expression of CD9/motility-related protein 1 (MRP-1) in renal parenchymal neoplasms: consistent expression in papillary and chromophobe renal cell carcinomas
    N Kuroda
    First Department of Pathology, Kochi Medical School, Kochi, Japan
    Hum Pathol 32:1071-7. 2001
    ..These results suggest that CD9 may be a beneficial marker in the differential diagnosis between papillary RCCs and collecting duct carcinomas and also between chromophobe and conventional RCCs...
  8. ncbi The distribution pattern of myofibroblasts in the stroma of human bladder carcinoma depends on their invasiveness
    N Shimasaki
    Department of Urology, Program of Tumor Biology and Regulation, Kochi Medical School, Kochi University, Japan
    Histol Histopathol 21:349-53. 2006
    ..Understanding the distribution pattern of myofibroblasts in the stroma of bladder carcinoma may provide available information about the presence of carcinoma invasion...
  9. ncbi The distribution of myofibroblasts and CD34-positive stromal cells in normal renal pelvis and ureter and their cancers
    N Kuroda
    Department of Pathology and Laboratory Medicine, Kochi Red Cross Hospital, Kochi City, Kochi, Japan
    Histol Histopathol 21:1303-7. 2006
    ..These findings suggest that the invasion of renal pelvic and ureteral cancers may cause the phenotypic change of stromal cells...
  10. ncbi The specific distribution of dendritic interstitial cells at the tumor border of major salivary gland pleomorphic adenomas
    H Nakayama
    First Department of Pathology, Kochi Medical School, Japan
    Mod Pathol 12:445-9. 1999
    ....
  11. ncbi Adult-onset herpes simplex virus hepatitis with diffuse myofibroblastic transformation of hepatic stellate cells (Ito cells) in non-necrotic areas
    M Toi
    First Department of Pathology, Kochi Medical School, Kochi, Japan
    Pathol Int 51:288-92. 2001
    ..These findings indicate that not only liver cells but also HSC can become necrotic in HSV hepatitis. In contrast, in non-necrotic areas, almost all of the HSC showed active transformation to myofibroblasts...
  12. ncbi Goblet cell carcinoid of the appendix: Investigation of the expression of beta-catenin and E-cadherin
    N Kuroda
    First Department of Pathology, Kochi Medical School, Kochi, Japan
    Pathol Int 51:283-7. 2001
    ..These findings suggest the possibility that, in some cases, the adherens junctions of goblet cell carcinoids are similar to those of typical carcinoids rather than to those of adenocarcinomas...
  13. ncbi Immunohistochemical identification of intracytoplasmic lumens by cytokeratin typing may differentiate renal oncocytomas from chromophobe renal cell carcinomas
    N Kuroda
    First Department of Pathology, Faculty of Medicine, Kochi University, Kochi, Japan
    Histol Histopathol 19:23-8. 2004
    ..Therefore, immunohistochemical identification of ICLs by cytokeratin typing may be useful for differentiating between renal oncocytomas and chromophobe RCCs and be more sensitive in this respect than colloidal iron staining...
  14. ncbi Well differentiated adult-type fibrosarcoma arising from the occipital subcutaneous tissue in a 17-year-old man: case report with immunohistochemical study
    H Nakayama
    First Department of Pathology, Kochi Medical School, Japan
    Jpn J Clin Oncol 28:511-6. 1998
    ....
  15. ncbi The role of myofibroblasts at the tumor border of invasive colorectal adenocarcinomas
    H Nakayama
    First Department of Pathology, Kochi Medical School, Japan
    Jpn J Clin Oncol 28:615-20. 1998
    ..In order to elucidate the significance of myofibroblasts in invasive growth of colorectal adenocarcinomas, we examined the number of myofibroblasts at the tumor border of colorectal adenocarcinomas...
  16. ncbi An immunohistochemical study of developing glomeruli in human fetal kidneys
    K Naruse
    First Department of Pathology and Department of Pediatrics, Kochi Medical School, Kochi, Japan
    Kidney Int 57:1836-46. 2000
    ..Our aim was to clarify the characteristics of fetal mesangial cells and glomerular capillary endothelial cells, as well as their changes during glomerulogenesis using immunohistochemistry...
  17. ncbi The distribution and role of myofibroblasts and CD34-positive stromal cells in normal pancreas and various pancreatic lesions
    N Kuroda
    Department of Pathology, Kochi Medical School, Kochi, Japan
    Histol Histopathol 19:59-67. 2004
    ..Myofibroblasts and CD34-positive stromal cells may play a role in regulating the tumor growth in the capsule of islet cell tumors of the pancreas...
  18. ncbi The participation of myofibroblasts in the capsular formation of human conventional and chromophobe renal cell carcinomas
    N Shimasaki
    Department of Urology, Program of Tumor Biology and Regulation, Kochi Medical School, Kochi University, Kochi 783 8505, Japan
    Histol Histopathol 20:67-73. 2005
    ..In situ hybridization detected type I collagen mRNA in myofibroblasts of the capsule. Myofibroblasts may participate in the capsular formation of conventional and chromophobe RCCs through the collagen production...
  19. ncbi Renal leiomyoma: an immunohistochemical, ultrastructural and comparative genomic hybridization study
    N Kuroda
    Department of Pathology and Laboratory Medicine, Kochi Red Cross Hospital, Kochi, Japan
    Histol Histopathol 22:883-8. 2007
    ..Finally, the immunohistochemical panel of smooth muscle markers and ultrastructural and genetic study may be useful in diagnosing renal leiomyoma...
  20. ncbi The appearance of myofibroblasts and the disappearance of CD34-positive stromal cells in the area adjacent to xanthogranulomatous foci of chronic cholecystitis
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University, Kochi 785 8505, Japan
    Histol Histopathol 20:127-33. 2005
    ..Under these conditions, CD34-positive stromal cells tended to disappear from the connective tissue layer, which exhibited an increase in myofibroblasts...
  21. ncbi The distribution of CD34-positive stromal cells and myofibroblasts in colorectal carcinoid tumors
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University, Kochi 783 8505, Japan
    Histol Histopathol 20:27-33. 2005
    ..Namely, CD34-positive stromal cells existed between neoplastic nests in large-sized carcinoid tumors. Myofibroblasts in the stroma of colorectal neoplasms may originate from CD34-positive stromal cells...
  22. ncbi The disappearance of CD34-positive and alpha-smooth muscle actin-positive stromal cells associated with human intra-uterine and tubal pregnancies
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University, Kochi, Japan
    Histol Histopathol 19:707-13. 2004
    ..ASMA-positive stromal cells at the fetal side associated with pregnancy may play a role in the production of villous extracellular matrix or regulation of blood flow...
  23. ncbi Consistent lack of CD34-positive stromal cells in the stroma of malignant breast lesions
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University, Kohasu, Oko cho, Nanokku City, Kochi 783 8505, Japan
    Histol Histopathol 20:707-12. 2005
    ....
  24. ncbi Mesangial myofibroblastic transformation in steroid-dependent minimal change nephrotic syndrome
    K Naruse
    First Department of Pathology, Kochi Medical School, Kohasu Okohcho, Nankoku 783 8505, Japan
    Med Electron Microsc 33:102-7. 2000
    ..Furthermore, the immunohistochemical examination of ASMA and vimentin may be useful to detect mesangial myofibroblastic transformation that is not demonstrated in conventional light microscopy and immunofluorescence study...
  25. ncbi Review of sarcomatoid renal cell carcinoma with focus on clinical and pathobiological aspects
    N Kuroda
    First Department of Pathology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Kochi, Japan
    Histol Histopathol 18:551-5. 2003
    ..Little is know about genetic alterations in sarcomatoid RCCs. Further studies are therefore needed to identify the key gene involved in sarcomatoid transformation of RCCs...
  26. ncbi Malignant phyllodes tumor of the breast with expression of osteonectin and vinculin
    N Kuroda
    First Department of Pathology, Kochi Medical School, Kochi, Japan
    Pathol Int 51:277-82. 2001
    ..Further studies will be necessary to elucidate the significance of vinculin and osteonectin expression in malignant phyllodes tumor...
  27. ncbi So-called neoplastic myoepithelial cells in chondroid syringomas/mixed tumors of the skin: their subtypes and immunohistochemical analysis
    H Nakayama
    First Department of Pathology, Kochi Medical School, Japan
    Pathol Int 48:245-53. 1998
    ..The findings also suggest that the polyhedral cells show differentiation toward basal cells of the sweat gland dermal ducts or myoepithelial cells...
  28. ncbi Review of renal oncocytoma with focus on clinical and pathobiological aspects
    N Kuroda
    First Department of Pathology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Kochi, Japan
    Histol Histopathol 18:935-42. 2003
    ..Therefore, further studies are needed to resolve these problems and also to elucidate the genetic mechanisms responsible for the occurrence of oncocytomas...
  29. ncbi Review of chromophobe renal cell carcinoma with focus on clinical and pathobiological aspects
    N Kuroda
    First Department of Pathology, Kochi Medical School, Kohasu, Oko cho, Nankoku, Kochi 783 8505, Japan
    Histol Histopathol 18:165-71. 2003
    ..Therefore, further studies are needed to elucidate the relationship between chromophobe RCCs and oncocytomas, to confirm whether chromophobe adenoma actually exists or not, and to identify the key gene that causes chromophobe RCCs...
  30. ncbi Review of papillary renal cell carcinoma with focus on clinical and pathobiological aspects
    N Kuroda
    First Department of Pathology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Kochi, Japan
    Histol Histopathol 18:487-94. 2003
    ..Since papillary RCCs seem to constitute clinically, histologically, and even genetically more heterogenous groups than previously thought, further investigations are needed to characterize the subtype of papillary RCC...
  31. pmc High molecular weight caldesmon positive stromal cells in the capsule of thyroid follicular tumours and tumour-like lesions
    H Nakayama
    First Department of Pathology, Kochi Medical School, Nankoku City, Kochi 783 8505, Japan
    J Clin Pathol 55:917-20. 2002
    ..To investigate the smooth muscle nature of the spindle stromal cells in the capsule of thyroid tumours and tumour-like lesions...
  32. ncbi Neuroepithelial and ependymal changes in HTX rats with congenital hydrocephalus: an ultrastructural and immunohistochemical study
    Y Nojima
    Department of Neurosurgery, Kochi Medical School, Japan
    Pathol Int 48:115-25. 1998
    ..These morphological changes suggested that preferential involvement of the lateral ventricular neuroepithelium might be closely associated with the pathogenesis of congenital hydrocephalus in HTX rats...
  33. ncbi Pulmonary adenocarcinoma with micropapillary component: an immunohistochemical study. Case report
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University, Kohasu, Oko cho, Nankoku City, Kochi, Japan
    APMIS 113:550-4. 2005
    ....
  34. ncbi Review of mucinous tubular and spindle-cell carcinoma of the kidney with a focus on clinical and pathobiological aspects
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University, Kochi 783 8505, Japan
    Histol Histopathol 20:221-4. 2005
    ..Some cases with MTSCC seem to show overlapping histology with low-grade collecting-duct carcinoma. Therefore, further investigation will be needed to elucidate pathobiological characteristics of MTSCC...
  35. ncbi Compound melanocytic nevus arising in a mature cystic teratoma of the ovary
    N Kuroda
    First Department of Pathology, Kochi Medical School, Nankoku City, Japan
    Pathol Int 51:902-4. 2001
    ..Despite the extreme rarity of such a lesion, pathologists should recognize the possibility of such lesions occurring in ovarian teratoma...
  36. ncbi Review of metanephric adenoma of the kidney with focus on clinical and pathobiological aspects
    N Kuroda
    First Department of Pathology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Kochi 783 8505, Japan
    Histol Histopathol 18:253-7. 2003
    ..Therefore, further studies on various aspects are needed to identify the gene responsible for the occurrence of metanephric tumors and, furthermore, to clarify the association among the three types of metanephric tumors...
  37. pmc CD34 positive stromal cells in gastric adenocarcinomas
    H Nakayama
    Department of Pathology, Kure National Hospital, Kure City, Hiroshima 737 0023, Japan
    J Clin Pathol 54:846-8. 2001
    ....
  38. ncbi Review of collecting duct carcinoma with focus on clinical and pathobiological aspects
    N Kuroda
    First Department of Pathology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Kochi 783 8505, Japan
    Histol Histopathol 17:1329-34. 2002
    ..1-32.2. Further studies are needed to elucidate the genetic characteristics of CDCs and to determine the relationship or difference between CDCs and medullary carcinomas...
  39. ncbi Detection of human herpesvirus 6 and JC virus in progressive multifocal leukoencephalopathy complicating follicular lymphoma
    M Daibata
    Department of Medicine, Kochi Medical School, Kochi, Japan
    Am J Hematol 67:200-5. 2001
    ..Although it remains to be clarified whether HHV-6 plays an important role as a co-agent with JCV in causing demyelination of the brain, our observation alerts physicians to the possible association of HHV-6 with the pathogenesis of PML...
  40. ncbi Midline malignant B-cell lymphoma with leukemic transformation
    J Hirota
    Department of Oral Surgery, Kochi Medical School, Japan
    Cancer 70:2958-62. 1992
    ..In the presentation of this case, the authors mention clinically important matters regarding midline lethal lymphoma and briefly discuss the pathophysiology and pathogenesis...
  41. ncbi Mouse oviduct-specific glycoprotein gene: genomic organization and structure of the 5'-flanking regulatory region
    K Takahashi
    Department of Immunology and Parasitology and Obstetrics and Gynecology, Yamagata University School of Medicine, Research Institute for the Functional Peptides, Yamagata City 990 9585, Japan
    Biol Reprod 62:217-26. 2000
    ..These findings should facilitate our understanding of the regulation of OGP gene expression, and they may be helpful for designing experiments to unravel the role of OGP in the process of mammalian fertilization...
  42. pmc Lack of vascular adventitial fibroblastic cells in tumour stroma of intestinal-type and solid-type gastric carcinomas
    H Nakayama
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Clin Pathol 57:183-5. 2004
    ..To investigate the roles of vascular adventitial fibroblastic cells in tumour stroma, the distribution of vascular adventitial fibroblastic cells was studied in gastric carcinomas...
  43. pmc Presence of vascular adventitial fibroblastic cells in diffuse-type gastric carcinomas
    H Nakayama
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Clin Pathol 57:970-2. 2004
    ....