Ken Fukuda

Summary

Affiliation: Kochi University
Country: Japan

Publications

  1. doi request reprint Alarmins from corneal epithelial cells upregulate CCL11 and VCAM-1 in corneal fibroblasts
    Ken Fukuda
    Department of Ophthalmology, Kochi Medical School, Nankoku City, Kochi, Japan
    Invest Ophthalmol Vis Sci 54:5817-23. 2013
  2. pmc Pseudomonas aeruginosa keratitis in mice: effects of topical bacteriophage KPP12 administration
    Ken Fukuda
    Department of Ophthalmology and Visual Science, Kochi Medical School, Kochi, Japan
    PLoS ONE 7:e47742. 2012
  3. doi request reprint Long-term follow-up after lamellar keratoplasty in a patient with bilateral idiopathic corneal keloid
    Ken Fukuda
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Cornea 30:1491-4. 2011
  4. doi request reprint The murine CCR3 receptor regulates both eosinophilia and hyperresponsiveness in IgE-mediated allergic conjunctivitis
    Ken Fukuda
    Department of Ophthalmology, Kochi Medical School, Oko cho, Kohasu, Nankoku City, Kochi 783 8505, Japan
    Br J Ophthalmol 96:1132-6. 2012
  5. doi request reprint Case report of restoration of the corneal epithelium in a patient with atopic keratoconjunctivitis resulting in amelioration of ocular allergic inflammation
    Ken Fukuda
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Allergol Int 59:309-12. 2010
  6. ncbi request reprint Roles of galectin-9 in the development of experimental allergic conjunctivitis in mice
    Atsuki Fukushima
    Department of Ophthalmology and Visual Science, Kochi Medical School, Nankoku, Japan fukushima kochi u ac jp
    Int Arch Allergy Immunol 146:36-43. 2008
  7. ncbi request reprint Roles of CD4+CD25+ T cells in the development of experimental murine allergic conjunctivitis
    Atsuki Fukushima
    Department of Ophthalmology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, 783 8505, Japan
    Graefes Arch Clin Exp Ophthalmol 245:705-14. 2007
  8. ncbi request reprint T-cell Ig and mucin domain-containing protein (Tim)-2 regulates murine allergic conjunctivitis during the effector phase
    Atsuki Fukushima
    Department of Ophthalmology and Visual Science, Kochi Medical School, Oko cho, Nanhoku city, Japan
    Immunol Lett 110:133-8. 2007
  9. ncbi request reprint B7-H3 regulates the development of experimental allergic conjunctivitis in mice
    Atsuki Fukushima
    Department of Ophthalmology and Visual Science, Kochi Medical School, Kohasu, Oko cho, Nankoku city 783 8505, Japan
    Immunol Lett 113:52-7. 2007
  10. doi request reprint Inhibition by tranilast of the cytokine-induced expression of chemokines and the adhesion molecule VCAM-1 in human corneal fibroblasts
    Tadafumi Adachi
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 51:3954-60. 2010

Collaborators

Detail Information

Publications45

  1. doi request reprint Alarmins from corneal epithelial cells upregulate CCL11 and VCAM-1 in corneal fibroblasts
    Ken Fukuda
    Department of Ophthalmology, Kochi Medical School, Nankoku City, Kochi, Japan
    Invest Ophthalmol Vis Sci 54:5817-23. 2013
    ....
  2. pmc Pseudomonas aeruginosa keratitis in mice: effects of topical bacteriophage KPP12 administration
    Ken Fukuda
    Department of Ophthalmology and Visual Science, Kochi Medical School, Kochi, Japan
    PLoS ONE 7:e47742. 2012
    ..These results indicate that bacteriophage eye-drops may be a novel adjunctive or alternative therapeutic agent for the treatment of infectious keratitis secondary to antibiotic-resistant bacteria...
  3. doi request reprint Long-term follow-up after lamellar keratoplasty in a patient with bilateral idiopathic corneal keloid
    Ken Fukuda
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Cornea 30:1491-4. 2011
    ..To report a case of bilateral idiopathic corneal keloid...
  4. doi request reprint The murine CCR3 receptor regulates both eosinophilia and hyperresponsiveness in IgE-mediated allergic conjunctivitis
    Ken Fukuda
    Department of Ophthalmology, Kochi Medical School, Oko cho, Kohasu, Nankoku City, Kochi 783 8505, Japan
    Br J Ophthalmol 96:1132-6. 2012
    ..We investigated the importance of CC chemokine receptor (CCR) 3 in a murine model of IgE-mediated allergic conjunctivitis using CCR3-deficient (CCR3(-/-)) mice...
  5. doi request reprint Case report of restoration of the corneal epithelium in a patient with atopic keratoconjunctivitis resulting in amelioration of ocular allergic inflammation
    Ken Fukuda
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Allergol Int 59:309-12. 2010
    ..In vitro studies have suggested that breakdown of corneal epithelial barrier function and subsequent activation of stromal fibroblasts may amplify ocular allergic inflammation...
  6. ncbi request reprint Roles of galectin-9 in the development of experimental allergic conjunctivitis in mice
    Atsuki Fukushima
    Department of Ophthalmology and Visual Science, Kochi Medical School, Nankoku, Japan fukushima kochi u ac jp
    Int Arch Allergy Immunol 146:36-43. 2008
    ..Here, we investigated whether administration of anti-galectin-9 antibodies (Abs) affects the development of murine experimental allergic conjunctivitis (EC), a Th2-mediated disease...
  7. ncbi request reprint Roles of CD4+CD25+ T cells in the development of experimental murine allergic conjunctivitis
    Atsuki Fukushima
    Department of Ophthalmology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, 783 8505, Japan
    Graefes Arch Clin Exp Ophthalmol 245:705-14. 2007
    ..We therefore investigated whether T reg cells play a role in the development of experimental AC (EC)...
  8. ncbi request reprint T-cell Ig and mucin domain-containing protein (Tim)-2 regulates murine allergic conjunctivitis during the effector phase
    Atsuki Fukushima
    Department of Ophthalmology and Visual Science, Kochi Medical School, Oko cho, Nanhoku city, Japan
    Immunol Lett 110:133-8. 2007
    ..Thus, Tim-2 negatively regulates the Th2 differentiation of Ag-primed T-cells and the development of EC during the effector phase...
  9. ncbi request reprint B7-H3 regulates the development of experimental allergic conjunctivitis in mice
    Atsuki Fukushima
    Department of Ophthalmology and Visual Science, Kochi Medical School, Kohasu, Oko cho, Nankoku city 783 8505, Japan
    Immunol Lett 113:52-7. 2007
    ..Thus, regulation of EC by blocking of B7-H3 was observed during the induction phase but not the effector phase. Moreover, this study provides a new notion that B7-H3 regulates not only Th1-mediated but also Th2-mediated immune reactions...
  10. doi request reprint Inhibition by tranilast of the cytokine-induced expression of chemokines and the adhesion molecule VCAM-1 in human corneal fibroblasts
    Tadafumi Adachi
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 51:3954-60. 2010
    ..The effects of the antiallergy drug tranilast on the expression of such molecules were examined in human corneal fibroblasts...
  11. ncbi request reprint Endogenous interleukin-10 produced by antigen-irrelevant cells promotes the development of experimental murine allergic conjunctivitis
    Atsuki Fukushima
    Department of Ophthalmology, Kochi Medical School, Oko cho, Nankoku City, Japan
    Int Arch Allergy Immunol 144:79-84. 2007
    ..These data indicate that IL-10 does not serve as an immunoregulatory cytokine in the development of EC. Instead, it appears that IL-10 produced by antigen-irrelevant cells acts in the effector phase to promote the development of EC...
  12. doi request reprint B and T lymphocyte attenuator regulates the development of antigen-induced experimental conjunctivitis
    Waka Ishida
    Department of Ophthalmology and Visual Science, Kochi Medical School, Kohasu, Oko cho, Nankoku Shi, Kochi 783 8505, Japan
    Graefes Arch Clin Exp Ophthalmol 250:289-95. 2012
    ..To investigate the roles that B and T lymphocyte attenuator (BTLA) and herpesvirus entry mediator (HVEM) play in the development of antigen-induced experimental conjunctivitis (EC)...
  13. ncbi request reprint Differential contributions of B7-1 and B7-2 to the development of murine experimental allergic conjunctivitis
    Tamaki Sumi
    Department of Ophthalmology, Kochi Medical School, Kohasu, Oko cho, Nankoku city 783 8505, Japan
    Immunol Lett 108:62-7. 2007
    ..Collectively, B7-1 and B7-2 differently contribute to the development of EC during the induction and effector phases...
  14. doi request reprint Treatment with FTY720 during the induction or effector phase suppresses the development of experimental allergic conjunctivitis in mice
    Tamaki Sumi
    Department of Ophthalmology and Visual Science, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Japan
    Cell Biol Int 33:534-41. 2009
    ..To investigate whether experimental allergic conjunctivitis (EC) can be suppressed by treatment with the immunomodulatory drug FTY720, which reduces the recruitment of effector T cells into inflammatory sites...
  15. doi request reprint Regulation of experimental autoimmune uveoretinitis by anti-delta-like ligand 4 monoclonal antibody
    Waka Ishida
    Department of Ophthalmology, Science Research Center, Kochi Medical School, Nankoku City, Japan
    Invest Ophthalmol Vis Sci 52:8224-30. 2011
    ..To investigate the involvement of δ-like ligand (Dll)4 in the development of experimental autoimmune uveoretinitis (EAU) in B10.RIII mice...
  16. doi request reprint Oral administration of Ag suppresses Ag-induced allergic conjunctivitis in mice: critical timing and dose of Ag
    Waka Ishida
    Department of Ophthalmology, Kochi Medical School, Nankoku, Japan
    Br J Ophthalmol 97:492-7. 2013
    ..To investigate the effect of Ag doses and administration time points on oral tolerance induction in experimental allergic conjunctivitis (EAC)...
  17. doi request reprint Rebamipide increases barrier function and attenuates TNFα-induced barrier disruption and cytokine expression in human corneal epithelial cells
    Hiroshi Tanaka
    Machida Hospital, Kochi City, Kochi, Japan
    Br J Ophthalmol 97:912-6. 2013
    ..The effects of rebamipide, a drug used for the treatment of dry eye, on barrier function and cytokine expression in a human corneal epithelial (HCE) cell line were examined...
  18. ncbi request reprint CD8+ T cells play disparate roles in the induction and the effector phases of murine experimental allergic conjunctivitis
    Atsuki Fukushima
    Department of Ophthalmology and Visual Science, Kochi Medical School, Japan
    Microbiol Immunol 50:719-28. 2006
    ..Thus, CD8+ T cells promote the development of EC during the induction phase, but suppress it during the effector phase...
  19. ncbi request reprint Analysis of the interaction between IFN-gamma and IFN-gammaR in the effector phase of experimental murine allergic conjunctivitis
    Atsuki Fukushima
    Department of Ophthalmology and Visual Science, Kochi Medical School, Japan
    Immunol Lett 107:119-24. 2006
    ..These observations indicate that Dbl-KO mice will be useful for investigating the role(s) IFN-gamma play in inflammatory diseases...
  20. ncbi request reprint Inhibition by triptolide of chemokine, proinflammatory cytokine, and adhesion molecule expression induced by lipopolysaccharide in corneal fibroblasts
    Ying Lu
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube City, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 47:3796-800. 2006
    ..The effects of triptolide on the expression of these proteins induced by lipopolysaccharide (LPS) in human corneal fibroblasts were examined in comparison with those of dexamethasone...
  21. ncbi request reprint Inhibition of eotaxin expression in human corneal fibroblasts by interferon-gamma
    Ken Fukuda
    Department of Ocular Pathophysiology, Yamaguchi University School of Medicine, Ube City, Yamaguchi, Japan
    Int Arch Allergy Immunol 129:138-44. 2002
    ..The regulation of eotaxin synthesis in these cells was investigated by examining the effect of interferon-gamma (IFN-gamma), a T helper cell 1-derived cytokine, on eotaxin expression in cultured human corneal fibroblasts...
  22. ncbi request reprint Antibodies to T-cell Ig and mucin domain-containing proteins (Tim)-1 and -3 suppress the induction and progression of murine allergic conjunctivitis
    Atsuki Fukushima
    Department of Ophthalmology and Visual Science, Kochi Medical School, Kohasu, Nankoku city 783 8505, Japan
    Biochem Biophys Res Commun 353:211-6. 2007
    ..Thus, treatment with anti-Tim-1 or anti-Tim-3 Ab can suppress both the induction and progression of EC, which could indicate potential preventive and/or therapeutic approaches for allergic diseases such as allergic conjunctivitis...
  23. ncbi request reprint Expression of functional ICAM-1 on cultured human keratocytes induced by tumor necrosis factor-alpha
    Naoki Kumagai
    Department of Biomolecular Recognition and Ophthalmology, Ube City, Yamaguchi, Japan
    Jpn J Ophthalmol 47:134-41. 2003
    ....
  24. ncbi request reprint Thymus-derived CD4+ CD25+ T cells suppress the development of murine allergic conjunctivitis
    Tamaki Sumi
    Department of Ophthalmology, Kochi Medical School, Nankoku City, Japan
    Int Arch Allergy Immunol 143:276-81. 2007
    ..Taken together, these results suggest that CD4+ CD25+ T cells regulate the development of EC...
  25. doi request reprint Inhibition by a selective IkappaB kinase-2 inhibitor of interleukin-1-induced collagen degradation by corneal fibroblasts in three-dimensional culture
    Yukiko Kondo
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube City, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 49:4850-7. 2008
    ..The authors investigated the effects of the IKK-2 inhibitor [5-(p-fluorophenyl)-2-ureido]thiophene-3-carboxamide (TPCA-1) on collagen degradation by corneal fibroblasts...
  26. ncbi request reprint Lipopolysaccharide-induced expression of intercellular adhesion molecule-1 and chemokines in cultured human corneal fibroblasts
    Naoki Kumagai
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube City, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 46:114-20. 2005
    ....
  27. ncbi request reprint Modulation of murine experimental allergic conjunctivitis by treatment with alpha-galactosylceramide
    Atsuki Fukushima
    Department of Ophthalmology and Visual Science, Kochi Medical School, Kohasu, Nankoku city 783 8505, Japan
    Immunol Lett 107:32-40. 2006
    ..These data suggest that NKT cells can play a downregulatory role in the development of EC and that alpha-GalCer may be useful for treating allergic conjunctivitis...
  28. doi request reprint Delayed disruption of barrier function in cultured human corneal epithelial cells induced by tumor necrosis factor-alpha in a manner dependent on NF-kappaB
    Kazuhiro Kimura
    Department of Ocular Pathophysiology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 49:565-71. 2008
    ..The authors examined the effects of tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine, on barrier function and the expression of TJ proteins in simian virus 40-transformed human corneal epithelial (HCE) cells...
  29. ncbi request reprint IL-4-induced cell proliferation and production of extracellular matrix proteins in human conjunctival fibroblasts
    Youichiro Fujitsu
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube City, Yamaguchi, Japan
    Exp Eye Res 76:107-14. 2003
    ..These effects of IL-4 might contribute to the formation of giant papillae in individuals with vernal keratoconjunctivitis...
  30. pmc Conjunctival macrophages act as antigen-presenting cells in the conjunctiva during the development of experimental allergic conjunctivitis
    Waka Ishida
    Department of Ophthalmology, Kochi Medical School, Nankoku City, Japan
    Mol Vis 16:1280-5. 2010
    ..However, the conjunctival APCs that take up Ag in AC have not been identified. We sought to clarify the phenotypes of conjunctival APCs that take up, process, and present Ag to T cells during the development of experimental AC...
  31. ncbi request reprint Inhibition of gap junction-mediated intercellular communication by TNF-alpha in cultured human corneal fibroblasts
    Ji Long Hao
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 46:1195-200. 2005
    ..The possible effect of tumor necrosis factor (TNF)-alpha, a proinflammatory cytokine, on gap junctional intercellular communication (GJIC) in cultured human corneal fibroblasts was examined...
  32. ncbi request reprint Differential expression of thymus- and activation-regulated chemokine (CCL17) and macrophage-derived chemokine (CCL22) by human fibroblasts from cornea, skin, and lung
    Ken Fukuda
    Department of Ocular Pathophysiology, Yamaguchi University School of Medicine, Ube City, Yamaguchi, Japan
    J Allergy Clin Immunol 111:520-6. 2003
    ..Resident fibroblasts are thought to contribute to inflammatory cell infiltration through chemokine production...
  33. doi request reprint Adjuvants determine the contribution of basophils to antigen sensitization in vivo
    Waka Ishida
    Department of Ophthalmology, Kochi Medical School, Kohasu, Oko cho, Nankoku city 783 8505, Japan
    Immunol Lett 136:49-54. 2011
    ..To investigate whether these two types of APCs are involved differentially in Ag-sensitization when distinct types of adjuvants are utilized...
  34. ncbi request reprint [Remodeling in ocular allergic diseases]
    Ken Fukuda
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube City, Japan
    Nihon Ganka Gakkai Zasshi 111:699-710. 2007
    ..Tissue remodeling thus represents a potential therapeutic target for treatment of VKC...
  35. ncbi request reprint Genetic polymorphisms in the promoter of the interferon gamma receptor 1 gene are associated with atopic cataracts
    Akira Matsuda
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 48:583-9. 2007
    ..This study was conducted to examine the genetic association between the atopy-related genes and patients with ocular complications (ocular AD)...
  36. doi request reprint Identification of keratocyte-like cells differentiated from circulating bone marrow-derived cells in the mouse cornea
    Yosuke Harada
    Department of Ophthalmology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Kochi, 783 8505, Japan
    Med Mol Morphol 46:233-8. 2013
    ..Our results suggest that BM-derived cells introduced intravenously are able to differentiate into resident cells of the corneal stroma. ..
  37. doi request reprint Dynamic changes of microRNAs in the eye during the development of experimental autoimmune uveoretinitis
    Waka Ishida
    Department of Ophthalmology, Science Research Center, Kochi Medical School, Nankoku, Japan
    Invest Ophthalmol Vis Sci 52:611-7. 2011
    ..Recent studies revealed that the production of cytokines such as IL-17 is controlled by microRNA (miRNA). Here the authors investigated the expression of miRNA in the eye during the development of EAU...
  38. ncbi request reprint Activation of corneal fibroblast-derived matrix metalloproteinase-2 by tryptase
    Kazutaka Yamamoto
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube City, Yamaguchi, Japan
    Curr Eye Res 31:313-7. 2006
    ..Although tryptase does not mediate the activation of purified MMP-2, we have now examined whether it might activate MMP-2 in the presence of cultured human corneal fibroblasts...
  39. ncbi request reprint Fibroblasts as local immune modulators in ocular allergic disease
    Ken Fukuda
    Department of Ocular Pathophysiology, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
    Allergol Int 55:121-9. 2006
    ..Fibroblasts and fibroblast-derived factors thus represent new and potentially important therapeutic targets for treatment of the giant papillae and corneal disorders associated with VKC...
  40. ncbi request reprint [Successful treatment of cystoid macular edema with etanercept in a patient with rheumatoid arthritis associated panuveitis]
    Ken Fukuda
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube City, Japan
    Nihon Ganka Gakkai Zasshi 112:51-7. 2008
    ..It also appears to be effective for treatment of macular edema secondary to uveitis...
  41. doi request reprint Synergistic induction of eotaxin and VCAM-1 expression in human corneal fibroblasts by staphylococcal peptidoglycan and either IL-4 or IL-13
    Ken Fukuda
    Department of Ophthalmology and Visual Science, Kochi Medical School, Japan
    Allergol Int 60:355-63. 2011
    ..To examine the role of interaction between Th2 cells and bacterial infection in tissue eosinophilia, we determined the effects of Th2 cytokines and peptidoglycan derived from the cell wall of S. aureus on corneal fibroblasts...
  42. ncbi request reprint Characterization of the interleukin-4 receptor complex in human corneal fibroblasts
    Ken Fukuda
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube City, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 43:183-8. 2002
    ..To characterize the interleukin (IL)-4 receptor (IL-4R) complex in human corneal fibroblasts...
  43. doi request reprint Development of automated conjunctival hyperemia analysis software
    Tamaki Sumi
    Department of Ophthalmology, Kochi Medical School, Nankoku, Japan Eye Care Division, Nidek Co, Ltd, Gamagori, Japan Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan and Department of Environmental Medicine, Kochi Medical School, Nankoku, Japan
    Cornea 32:S52-9. 2013
    ..We propose that this newly developed automated hyperemia analysis software will be an objective clinical tool for the evaluation of ocular hyperemia...
  44. doi request reprint Soluble tumor necrosis factor receptor 1 and tissue inhibitor of metalloproteinase-1 in hemolytic uremic syndrome with encephalopathy
    Masahiro Shiraishi
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    J Neuroimmunol 196:147-52. 2008
    ..Our preliminary study suggests that serum IL-6, sTNFR1 and TIMP-1 levels, particularly sTNFR1 and TIMP-1, are important for predicting neurological complications in patients with HUS...
  45. ncbi request reprint Ocular allergic inflammation: interaction between the cornea and conjunctiva
    Ken Fukuda
    From the Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube City, Yamaguchi, Japan and Department of Ophthalmology, Kochi Medical School, Nankoku City, Kochi, Japan
    Cornea 29:S62-7. 2010
    ....