Masaru Yoshida

Summary

Affiliation: Kobe University
Country: Japan

Publications

  1. pmc A novel serum metabolomics-based diagnostic approach for colorectal cancer
    Shin Nishiumi
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    PLoS ONE 7:e40459. 2012
  2. doi request reprint Diagnosis of gastroenterological diseases by metabolome analysis using gas chromatography-mass spectrometry
    Masaru Yoshida
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chu o ku, Kobe, Hyogo 650 0017, Japan
    J Gastroenterol 47:9-20. 2012
  3. pmc Evolution in an oncogenic bacterial species with extreme genome plasticity: Helicobacter pylori East Asian genomes
    Mikihiko Kawai
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Minato ku, Tokyo, 108 8639, Japan
    BMC Microbiol 11:104. 2011
  4. ncbi request reprint IgG transport across mucosal barriers by neonatal Fc receptor for IgG and mucosal immunity
    Masaru Yoshida
    Frontier Medical Science in Gastroenterology, ICMRT, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Springer Semin Immunopathol 28:397-403. 2006
  5. doi request reprint Autophagy in the intestinal epithelium regulates Citrobacter rodentium infection
    Jun Inoue
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chu o ku, Kobe, Hyogo 650 0017, Japan
    Arch Biochem Biophys 521:95-101. 2012
  6. pmc Antigen-Specific IgG ameliorates allergic airway inflammation via Fcγ receptor IIB on dendritic cells
    Yumiko Ishikawa
    Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Respir Res 12:42. 2011
  7. pmc Intestinal anti-inflammatory activity of lentinan: influence on IL-8 and TNFR1 expression in intestinal epithelial cells
    Yosuke Nishitani
    Team of Health Bioscience, Organization of Advanced Science and Technology, Kobe University, Kobe, Japan
    PLoS ONE 8:e62441. 2013
  8. doi request reprint Inhibitory effects of vitamin K₃ derivatives on DNA polymerase and inflammatory activity
    Aoganghua Aoganghua
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Chuo Ku, Kobe, Hyogo, Japan
    Int J Mol Med 28:937-45. 2011
  9. doi request reprint Helicobacter suis KB1 derived from pig gastric lymphoid follicles induces the formation of gastric lymphoid follicles in mice through the activation of B cells and CD4 positive cells
    Koji Yamamoto
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Microbes Infect 13:697-708. 2011
  10. doi request reprint The CagA protein of Helicobacter pylori suppresses the functions of dendritic cell in mice
    Hiroshi Tanaka
    Department of Internal Medicine, Kobe University, Chu o ku, Hyogo, Japan
    Arch Biochem Biophys 498:35-42. 2010

Detail Information

Publications70

  1. pmc A novel serum metabolomics-based diagnostic approach for colorectal cancer
    Shin Nishiumi
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    PLoS ONE 7:e40459. 2012
    ..To improve the quality of life of colorectal cancer patients, it is important to establish new screening methods for early diagnosis of colorectal cancer...
  2. doi request reprint Diagnosis of gastroenterological diseases by metabolome analysis using gas chromatography-mass spectrometry
    Masaru Yoshida
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chu o ku, Kobe, Hyogo 650 0017, Japan
    J Gastroenterol 47:9-20. 2012
    ..The development of metabolome analysis using mass spectrometry will aid the discovery of novel biomarkers, hopefully leading to the early detection of various diseases...
  3. pmc Evolution in an oncogenic bacterial species with extreme genome plasticity: Helicobacter pylori East Asian genomes
    Mikihiko Kawai
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Minato ku, Tokyo, 108 8639, Japan
    BMC Microbiol 11:104. 2011
    ..We used newly developed comparative methods to follow the evolution of East Asian H. pylori genomes using 20 complete genome sequences from Japanese, Korean, Amerind, European, and West African strains...
  4. ncbi request reprint IgG transport across mucosal barriers by neonatal Fc receptor for IgG and mucosal immunity
    Masaru Yoshida
    Frontier Medical Science in Gastroenterology, ICMRT, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Springer Semin Immunopathol 28:397-403. 2006
    ..FcRn, through its ability to secrete and absorb IgG, thus integrates luminal antigen encounters with systemic immune compartments and, as such, provides essential host defense and immunoregulatory functions at the mucosal surfaces...
  5. doi request reprint Autophagy in the intestinal epithelium regulates Citrobacter rodentium infection
    Jun Inoue
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chu o ku, Kobe, Hyogo 650 0017, Japan
    Arch Biochem Biophys 521:95-101. 2012
    ..These results demonstrate that autophagy in intestinal epithelial cells plays an important role in host defense against C. rodentium infection and the regulation of C. rodentium infectious colitis...
  6. pmc Antigen-Specific IgG ameliorates allergic airway inflammation via Fcγ receptor IIB on dendritic cells
    Yumiko Ishikawa
    Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Respir Res 12:42. 2011
    ..The purpose of this study is to clarify the role of inhibitory FcRs and antigen presenting cells (APCs) in pathogenesis of asthma and to evaluate antigen-transporting and presenting capacity by APCs in the tracheobronchial mucosa...
  7. pmc Intestinal anti-inflammatory activity of lentinan: influence on IL-8 and TNFR1 expression in intestinal epithelial cells
    Yosuke Nishitani
    Team of Health Bioscience, Organization of Advanced Science and Technology, Kobe University, Kobe, Japan
    PLoS ONE 8:e62441. 2013
    ..Lentinan may be effective for the treatment of gut inflammation including IBD...
  8. doi request reprint Inhibitory effects of vitamin K₃ derivatives on DNA polymerase and inflammatory activity
    Aoganghua Aoganghua
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Chuo Ku, Kobe, Hyogo, Japan
    Int J Mol Med 28:937-45. 2011
    ..In conclusion, this study has identified several vitamin K₃ derivatives, such as compound 1, that are promising anti-inflammatory candidates...
  9. doi request reprint Helicobacter suis KB1 derived from pig gastric lymphoid follicles induces the formation of gastric lymphoid follicles in mice through the activation of B cells and CD4 positive cells
    Koji Yamamoto
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Microbes Infect 13:697-708. 2011
    ..These results may lead to better understanding of the relationship between H. suis and gastric diseases, especially follicular gastritis; and furthermore, our findings emphasize the zoonotic aspects of animal-human infection by H. suis...
  10. doi request reprint The CagA protein of Helicobacter pylori suppresses the functions of dendritic cell in mice
    Hiroshi Tanaka
    Department of Internal Medicine, Kobe University, Chu o ku, Hyogo, Japan
    Arch Biochem Biophys 498:35-42. 2010
    ..These data suggest that CagA protein negatively regulates the functions of DC via CagA phosphorylation and that cagA-positive H. pylori strains suppress host immune responses resulting in their chronic colonization of the stomach...
  11. doi request reprint GCMS-based metabolomic study in mice with colitis induced by dextran sulfate sodium
    Yuuki Shiomi
    Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Kobe, Japan
    Inflamm Bowel Dis 17:2261-74. 2011
    ....
  12. ncbi request reprint Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-kappaB activation
    Masayuki Nishida
    Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Hyogo 650 0017, Japan
    Int J Mol Med 25:761-7. 2010
    ..Monoacetylcurcumin also inhibited the LPS-induced NF-kappaB activation in the liver. Collectively, monoacetylcurcumin is a potential chemopreventive agent for treating inflammatory responses more effectively than curcumin...
  13. doi request reprint Regulation of the metabolite profile by an APC gene mutation in colorectal cancer
    Tomoo Yoshie
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Cancer Sci 103:1010-21. 2012
    ..These findings suggest that APC mutation causes changes in energetic metabolite pathways and that these alterations might be involved in the development of colorectal cancer...
  14. doi request reprint Serum fatty acid profiling of colorectal cancer by gas chromatography/mass spectrometry
    Yasuyuki Kondo
    Division of Gastroenterology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chu o ku, Kobe, Hyogo, Japan
    Biomark Med 5:451-60. 2011
    ....
  15. doi request reprint A role of the aryl hydrocarbon receptor in attenuation of colitis
    Keisuke Furumatsu
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1, Chuo Ku, Kusunoki cho, Kobe, Hyogo 650 0017, Japan
    Dig Dis Sci 56:2532-44. 2011
    ..In addition, AhR activation is known to aid the maintenance of homeostasis in vivo. In this study, we investigated whether AhR is functionally associated with intestinal immunity...
  16. pmc Gamma interferon produced by antigen-specific CD4+ T cells regulates the mucosal immune responses to Citrobacter rodentium infection
    Hideyuki Shiomi
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
    Infect Immun 78:2653-66. 2010
    ..rodentium infection. These results show that the IFN-gamma produced by antigen-specific CD4(+) T cells plays an important role in the defense against C. rodentium...
  17. doi request reprint Metabolomic analysis to discover candidate therapeutic agents against acute pancreatitis
    Aya Sakai
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chu o ku, Kobe, Hyogo 650 0017, Japan
    Arch Biochem Biophys 522:107-20. 2012
    ..Our results suggest that GC/MS-based metabolomics is capable of accurately representing the status of acute pancreatitis, leading to the discovery of therapeutic agents for pancreatitis...
  18. doi request reprint IFN-γ plays an essential role in the pathogenesis of gastric lymphoid follicles formation caused by Helicobacter suis infection
    Takuya Mimura
    Department of Internal Medicine, Division of Gastroenterology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
    FEMS Immunol Med Microbiol 63:25-34. 2011
    ..suis infection, and it is suggested that CD4-positive T cells and DC aid in the expansion of gastric lymphoid follicles...
  19. doi request reprint Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer
    Atsuki Ikeda
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chu o ku, Kobe, Hyogo 650 0017, Japan
    Biomed Chromatogr 26:548-58. 2012
    ..Our approach revealed that some metabolites are more sensitive for detecting gastrointestinal cancer than conventional biomarkers. Our study supports the potential of metabolomics as an early diagnostic tool for cancer...
  20. doi request reprint Endoscopic submucosal dissection for gastric neoplasm in patients with co-morbidities categorized according to the ASA Physical Status Classification
    Mariko Man-I
    Department of Gastroenterology, Kobe University, Kobe, Japan
    Gastric Cancer 16:56-66. 2013
    ..We aimed to evaluate the safety and efficacy of gastric ESD with co-morbidities categorized according to ASA Physical Status Classification...
  21. doi request reprint Short-term reductions in non-protein respiratory quotient and prealbumin can be associated with the long-term deterioration of liver function after transcatheter arterial chemoembolization in patients with hepatocellular carcinoma
    Masaya Saito
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    J Gastroenterol 47:704-14. 2012
    ..We aimed to make an early predictive model of long-term liver dysfunction after TACE...
  22. ncbi request reprint Effects of quinone derivatives, such as 1,4-naphthoquinone, on DNA polymerase inhibition and anti-inflammatory action
    Kazuki Kobayashi
    Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Chuo Ku, Kobe, Hyogo 650 0017, Japan
    Med Chem 7:37-44. 2011
    ..These anti-inflammatory responses of NQ were more potent than those of BQ. In conclusion, this study has identified several quinone derivatives, such as NQ, that are promising anti-inflammatory candidates...
  23. doi request reprint Lipoxin A(4) reduces lipopolysaccharide-induced inflammation in macrophages and intestinal epithelial cells through inhibition of nuclear factor-kappaB activation
    Izumi Kure
    Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Kobe, Hyogo 650 0017, Japan
    J Pharmacol Exp Ther 332:541-8. 2010
    ..These results indicate that LXA4 exerts anti-inflammatory effects through inhibition of NF-kappaB activation, and, therefore, LXA4 may be useful as a therapeutic strategy against intestinal mucosa inflammation...
  24. ncbi request reprint Serum albumin and prothrombin time before entecavir treatment in chronic hepatitis B or cirrhosis are related to amelioration of liver function after treatment
    Masaya Saito
    aDepartment of Internal Medicine, Division of Gastroenterology bDepartment of Pathology, Center for Infectious Diseases cDepartment of Internal Medicine, Division of Metabolomics Research, Kobe University Graduate School of Medicine, Kobe, Japan
    Eur J Gastroenterol Hepatol 25:1369-76. 2013
    ..We aimed to develop a new pretherapeutic predictive model for the amelioration of liver function after treatment...
  25. ncbi request reprint Sphincter of Oddi manometry using guide-wire-type manometer is feasible for examination of sphincter of Oddi motility
    Saori Kakuyama
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    J Gastroenterol 48:1144-50. 2013
    ..This study examined the feasibility of SOM with a guide-wire-type manometer, which is commonly used to measure the arterial pressure for coronary angiography, for the assessment of SO motility...
  26. doi request reprint Linoleoyl ethanolamide reduces lipopolysaccharide-induced inflammation in macrophages and ameliorates 2,4-dinitrofluorobenzene-induced contact dermatitis in mice
    Tsukasa Ishida
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Eur J Pharmacol 699:6-13. 2013
    ..These results indicate that LE exerts anti-inflammatory effects by inhibiting NF-κB signaling, and LE is proposed to be a useful therapeutic agent against contact dermatitis...
  27. doi request reprint A high value of serum des-γ-carboxy prothrombin before hepatocellular carcinoma treatment can be associated with long-term liver dysfunction after treatment
    Masaya Saito
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Gastroenterol 47:1134-42. 2012
    ..The pre-TACE prediction of liver dysfunction after TACE would be helpful to avoid long-term liver dysfunction...
  28. doi request reprint Autophagy in the intestinal epithelium is not involved in the pathogenesis of intestinal tumors
    Shin Nishiumi
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe, Hyogo 650 0017, Japan
    Biochem Biophys Res Commun 421:768-72. 2012
    ..These results indicate that autophagy in the intestinal epithelium is not involved in the pathogenesis of intestinal tumors, and future research should focus on regulating autophagy as a form of cancer therapy...
  29. ncbi request reprint Surveillance after colorectal polypectomy; comparison between Japan and U.S
    Shinwa Tanaka
    Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, 7 5 1 Chu o ku, Kusunoki cho, Kobe, Hyogo 650 0017, Japan
    Kobe J Med Sci 56:E204-13. 2011
    ..Post-polypectomy colonoscopic surveillance is so far entrusted to each institute or each gastroenterologist at present...
  30. doi request reprint Helicobacter heilmannii can induce gastric lymphoid follicles in mice via a Peyer's patch-independent pathway
    Kentaro Nobutani
    Department of Internal Medicine, Division of Gastroenterology, Kobe University Graduate School of Medicine, Hyogo, Japan
    FEMS Immunol Med Microbiol 60:156-64. 2010
    ..These results suggest that PP are not essential for the formation and development of gastric lymphoid follicles induced by H. heilmannii infection, although they are involved in the speed of gastric lymphoid follicle formation...
  31. doi request reprint A randomized controlled trial of rebamipide plus rabeprazole for the healing of artificial ulcers after endoscopic submucosal dissection
    Shoko Fujiwara
    Department of Gastroenterology, Kobe University, School of Medicine, Kobe, Japan
    J Gastroenterol 46:595-602. 2011
    ..This study examined whether healing rates of the latter especially were improved by the addition of the non-PPI mucosal healing agent rebamipide after ESD...
  32. ncbi request reprint Endoluminal MR imaging of porcine gastric structure in vivo
    Hayato Yoshinaka
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Chuo ku, Kusunoki cho, Kobe, 650 0017, Japan
    J Gastroenterol 45:600-7. 2010
    ..The aim of this study was to define the detailed anatomy of the gastric wall structure in vivo using original endoluminal radiofrequency coils for safer endoscopic therapy...
  33. ncbi request reprint Effect of 18β-glycyrrhetinic acid and hydroxypropyl γcyclodextrin complex on indomethacin-induced small intestinal injury in mice
    Tsukasa Ishida
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Eur J Pharmacol 714:125-31. 2013
    ..These results suggest that the complex of 18β-glycyrrhetinic acid and hydroxypropyl γcyclodextrin has the potential therapeutic value for preventing the adverse effects of indomethacin-induced small intestinal injury. ..
  34. doi request reprint A novel serum metabolomics-based diagnostic approach to pancreatic cancer
    Takashi Kobayashi
    Division of Gastroenterology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chu o ku, Kobe, Hyogo 6500017, Japan
    Cancer Epidemiol Biomarkers Prev 22:571-9. 2013
    ..To improve the prognosis of patients with pancreatic cancer, more accurate serum diagnostic methods are required. We used serum metabolomics as a diagnostic method for pancreatic cancer...
  35. doi request reprint AP1B plays an important role in intestinal tumorigenesis with the truncating mutation of an APC gene
    Mitsuko Mimura
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
    Int J Cancer 130:1011-20. 2012
    ....
  36. doi request reprint Clinicopathological characteristics of abnormal micro-lesions at the oro-hypopharynx detected by a magnifying narrow band imaging system
    Shinwa Tanaka
    Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Kobe, Japan
    Dig Endosc 24:100-9. 2012
    ..The purpose of the present study was to clarify the clinicopathological characteristics of abnormal micro-lesions of the oro-hypopharynx detected by NBI-ME...
  37. pmc Resolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate sodium-induced colitis
    Tsukasa Ishida
    Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Kobe, Hyogo, Japan
    Inflamm Bowel Dis 16:87-95. 2010
    ..The aim of this study was to determine whether RvE1 regulates colonic inflammation when the innate immune response of macrophages plays a key role in pathogenesis and tissue damage...
  38. doi request reprint Autophagy in the intestinal epithelium reduces endotoxin-induced inflammatory responses by inhibiting NF-κB activation
    Yoshimi Fujishima
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Arch Biochem Biophys 506:223-35. 2011
    ..These results demonstrate that autophagy can attenuate endotoxin-induced inflammatory responses in intestinal epithelium resulting in the maintenance of intestinal homeostasis...
  39. doi request reprint Prescreening of a high-risk group for gastric cancer by serologically determined Helicobacter pylori infection and atrophic gastritis
    Shigeto Mizuno
    Department of Medical Pharmaceutics, Kobe Pharmaceutical University, 4 19 1 Motoyama kita, Higashinada ku, Kobe, Japan
    Dig Dis Sci 55:3132-7. 2010
    ....
  40. doi request reprint Predictors of malignant intraductal papillary mucinous neoplasm of the pancreas
    Takuya Mimura
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
    J Clin Gastroenterol 44:e224-9. 2010
    ..The predictors of malignant intraductal papillary mucinous neoplasm (IPMN) and invasive IPMN were investigated in this study to determine the optimal indicators of surgical resection for IPMN...
  41. doi request reprint Lifestyle factors associated with gastroesophageal reflux disease in the Japanese population
    Nobuyuki Matsuki
    Department of Gastroenterology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    J Gastroenterol 48:340-9. 2013
    ..We aimed to clarify the lifestyle factors associated with erosive esophagitis and non-erosive reflux disease (NERD) in a Japanese population...
  42. doi request reprint Association between adherence to evidence-based guidelines for the prescription of non-steroidal anti-inflammatory drugs and the incidence of gastric mucosal lesions in Japanese patients
    Hidetaka Tsumura
    Department of Gastroenterology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, Hyogo 650 0017, Japan
    J Gastroenterol 45:944-51. 2010
    ..This study investigated the association between the current adherence to the guidelines and the incidence of gastric mucosal lesions caused by NSAIDs...
  43. ncbi request reprint Portal venous tumor growth-type of hepatocellular carcinoma without liver parenchyma tumor nodules: a case report
    Masaya Saito
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Ann Hepatol 12:969-73. 2013
    ..We also reported new tumor profiles of the portal venous tumor growth- type of HCC. ..
  44. doi request reprint Inhibition of repair-related DNA polymerases by vitamin Ks, their related quinone derivatives and associated inflammatory activity (Review)
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Kobe, Hyogo 651 2180, Japan
    Int J Oncol 42:793-802. 2013
    ..The promising anti-inflammatory candidates based on the inhibition of DNA repair-related pols, such as pol λ, by VKs quinone derivatives, such as NQ, are discussed...
  45. doi request reprint Claudin-2 regulates colorectal inflammation via myosin light chain kinase-dependent signaling
    Masayuki Nishida
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Chu o ku, Kusunoki cho, Kobe, Hyogo, 650 0017, Japan
    Dig Dis Sci 58:1546-59. 2013
    ..Claudins have been demonstrated to be associated with inflammatory bowel disease (IBD), but the specific role of claudin-2 in colorectal inflammation remains undefined...
  46. pmc Reduction in non-protein respiratory quotient is related to overall survival after hepatocellular carcinoma treatment
    Masaya Saito
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    PLoS ONE 8:e55441. 2013
    ..We aimed to make a new and more accurate prognostic model taking into account the course of disease after TACE...
  47. ncbi request reprint Sonazoid-enhanced ultrasonography and Ga-EOB-DTPA-enhanced MRI of hepatic inflammatory pseudotumor: a case report
    Masaya Saito
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
    Intern Med 51:723-6. 2012
    ..We encountered a rare case of hepatic IPT, the differential diagnosis of which was difficult to distinguish from malignant tumor. Here, we report new US and MRI findings of hepatic IPT...
  48. pmc Role of Fc Receptors as a therapeutic target
    Atsuhiro Masuda
    Department of Gastroenterology, Kobe University School of Medicine, Kobe, Hyogo, Japan
    Inflamm Allergy Drug Targets 8:80-6. 2009
    ..These diverse functions highlight the potential effectiveness of targeting Fc receptors for therapeutic purposes. This review summarizes new information available in the therapeutic applications of this biology...
  49. ncbi request reprint Autoimmune-associated hemophagocytic syndrome originating from autoimmune hepatitis with a successful response to therapy
    Masaya Saito
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
    Intern Med 53:103-7. 2014
    ..This is the first report of AAHS originating from AIH. The patient was followed up for five years after treatment, and no disease recurrence was detected. ..
  50. pmc The transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner
    Kyosuke Nakata
    Division of Respiratory Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Biochem Biophys Res Commun 395:238-43. 2010
    ..These data show that the transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner...
  51. doi request reprint Activation of the aryl hydrocarbon receptor induces hepatic steatosis via the upregulation of fatty acid transport
    Yuki Kawano
    Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
    Arch Biochem Biophys 504:221-7. 2010
    ..Taking together, AHR activation induces hepatic microvesicular steatosis by increasing the expression level of FAT...
  52. ncbi request reprint Identification of biomarkers of stent restenosis with serum metabolomic profiling using gas chromatography/mass spectrometry
    Minoru Hasokawa
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Circ J 76:1864-73. 2012
    ..This study investigated the use of serum metabolomics in the identification of biomarkers of restenosis...
  53. doi request reprint A metabolomic approach to lung cancer
    Suya Hori
    Division of Respiratory Medicine, Kobe University Graduate School of Medicine, Japan
    Lung Cancer 74:284-92. 2011
    ..Our results demonstrate that changes in metabolite pattern are useful for assessing the clinical characteristics of lung cancer. Our results will hopefully lead to the establishment of novel diagnostic tools...
  54. ncbi request reprint Inhibitory effects of sulfobacin B on DNA polymerase and inflammation
    Jun Maeda
    Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Kobe, Hyogo 650 0017, Japan
    Int J Mol Med 26:751-8. 2010
    ..These results indicate that sulfobacin B is a potential chemotherapeutic agent for inflammation...
  55. doi request reprint Vitamin K3 attenuates cerulein-induced acute pancreatitis through inhibition of the autophagic pathway
    Ryo Chinzei
    Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, and Division of Diagnostic Pathology, Kobe University Hospital, Kobe, Japan
    Pancreas 40:84-94. 2011
    ..The aims of this study were to determine the inhibitory effects of vitamin K3 (VK3) against cerulein-induced acute pancreatitis in mice and to examine the mechanisms behind these effects...
  56. doi request reprint Diversity of the cagA gene of Helicobacter pylori strains from patients with gastroduodenal diseases in the Philippines
    Maria Celeste C Cortes
    Department of Gastroenterology, Kobe University Graduate School of Medicine, Kobe, Japan
    FEMS Immunol Med Microbiol 60:90-7. 2010
    ..pylori strains in the Philippines. Therefore, H. pylori-infected Filipinos can be considered to be at a low risk of developing gastric cancer...
  57. ncbi request reprint Metabolomics-based search for therapeutic agents for non-alcoholic steatohepatitis
    Yoshihiko Terashima
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chu o ku, Kobe, Hyogo 650 0017, Japan
    Arch Biochem Biophys 555:55-65. 2014
    ....
  58. ncbi request reprint Successful treatment using coil embolization of a symptomatic intrahepatic portosystemic venous shunt developing through a patent ductus venosus in a noncirrhotic adult
    Masaya Saito
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
    Intern Med 52:555-9. 2013
    ..Our case involved the adult-onset of a patent ductus venosus, which is extremely rare. This case is the first in which coil embolization was successfully achieved in a noncirrhotic elderly patient with a patent ductus venosus...
  59. doi request reprint 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs an insulin signaling pathway through the induction of tumor necrosis factor-alpha in adipocytes
    Shin Nishiumi
    Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Kobe, Hyogo 650 0017, Japan
    Toxicol Sci 115:482-91. 2010
    ....
  60. pmc Effects of intermediates between vitamins K(2) and K(3) on mammalian DNA polymerase inhibition and anti-inflammatory activity
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Int J Mol Sci 12:1115-32. 2011
    ..In conclusion, this study has identified VK(2) and VK(3) intermediates, such as MK-2, that are promising anti-inflammatory candidates...
  61. doi request reprint The new resources of treatment for early stage colorectal tumors: EMR with small incision and simplified endoscopic submucosal dissection
    Takashi Toyonaga
    Department of Endoscopy, Kobe University Hospital, Japan
    Dig Endosc 21:S31-7. 2009
    ..We treated 24/44/468 colorectal tumors, and examined the tumor size, resected specimen size, procedure time, en-bloc resection rate, complication rate...
  62. doi request reprint Lactococcus lactis subsp. cremoris FC alleviates symptoms of colitis induced by dextran sulfate sodium in mice
    Yosuke Nishitani
    Organization of Advanced Science and Technology, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe 657 8501, Japan
    Int Immunopharmacol 9:1444-51. 2009
    ..7 cells. Our findings indicate that administration of L. lactis subsp. cremoris FC improves negative effects of DSS-induced colitis in mice through the inhibition of inflammatory cell infiltration...
  63. pmc GC/MS-based metabolomic analysis of cerebrospinal fluid (CSF) from glioma patients
    Satoshi Nakamizo
    Department of Neurosurgery, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Neurooncol 113:65-74. 2013
    ..Our study suggests that the metabolomic analysis of CSF from glioma patients may be useful for predicting the glioma grade, metabolic state, and prognosis of gliomas...
  64. ncbi request reprint GC/MS-based profiling of amino acids and TCA cycle-related molecules in ulcerative colitis
    Makoto Ooi
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1, Chuo Ku, Kusunoki cho, Kobe, Hyogo, 650 0017, Japan
    Inflamm Res 60:831-40. 2011
    ....
  65. doi request reprint Pharmacokinetics of fucoxanthinol in human plasma after the oral administration of kombu extract
    Takashi Hashimoto
    Graduate School of Agricultural Science, Kobe University, 1 1 Rokkodai, Nada, Kobe, 657 8501 Hyogo, Japan
    Br J Nutr 107:1566-9. 2012
    ..By comparing the present results with those of a previous study using mice, we found that the bioavailability and metabolism of fucoxanthinol differ between human subjects and mice...
  66. doi request reprint Newly developed surface coil for endoluminal MRI, depiction of pig gastric wall layers and vascular architecture in ex vivo study
    Yoshinori Morita
    Department of Gastroenterology, Kobe University School of Medicine, Kobe, Hyogo, Japan
    J Gastroenterol 44:390-5. 2009
    ..The purpose of this study was to visualize the gastric wall layers and to depict the vascular architecture in vitro by using resected porcine stomachs studied with high-spatial resolution magnetic resonance (MR) imaging...
  67. doi request reprint Metabolomics analysis of umbilical cord blood clarifies changes in saccharides associated with delivery method
    Fusako Hashimoto
    Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan
    Early Hum Dev 89:315-20. 2013
    ..A metabolomic approach using umbilical cord blood from infants at birth has not been studied widely yet...
  68. pmc Fcgamma receptor regulation of Citrobacter rodentium infection
    Atsuhiro Masuda
    Department of Gastroenterology, Kobe University School of Medicine, 7 5 1, Chu o ku, Kusunoki cho, Kobe, Hyogo 650 0017, Japan
    Infect Immun 76:1728-37. 2008
    ..rodentium infection, indicating that the critical role played by IgG in this infection is not mediated by IgG alone but is dependent upon this class of receptors...
  69. pmc Diverse characteristics of the CagA gene of Helicobacter pylori strains collected from patients from southern vietnam with gastric cancer and peptic ulcer
    Bui Xuan Truong
    Department of Gastroenterology, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Microbiol 47:4021-8. 2009
    ..Finally, phylogenetic data support that there is a Japanese subtype in the Western CagA type...
  70. ncbi request reprint Differential localization of colitogenic Th1 and Th2 cells monospecific to a microflora-associated antigen in mice
    Masaru Yoshida
    Division of Clinical Bio regulatory Science, Graduate School of Medicine, Kyoto University, Japan
    Gastroenterology 123:1949-61. 2002
    ..We investigated whether the introduction of CD4 T cells specific to a microflora would initiate colitis and assessed the cytokine requirements for colitogenic CD4 T cells...