Research Topics
Genomes and Genes
| Kazuyoshi YonezawaSummaryAffiliation: Kobe University Country: Japan Publications
| Collaborators
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Detail Information
Publications
Raptor, a binding partner of target of rapamycinKazuyoshi Yonezawa
Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
Biochem Biophys Res Commun 313:437-41. 2004....- Identification of TOR-interacting proteinsKazuyoshi Yonezawa
Biosignal Research Center, Kobe University, Kobe 657-8501, Japan
Mol Interv 3:189-93. 2003 - Kinase activities associated with mTORK Yonezawa
Biosignal Research Center, Kobe University, 657 8501, Kobe, Japan
Curr Top Microbiol Immunol 279:271-82. 2004..The requirement of raptor for binding to and phosphorylation by mTOR of these potential substrates would clarify their physiological importance in the mTOR signaling pathway... - The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motifHiroki Nojima
Biosignal Research Center, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe 657 8501, Japan
J Biol Chem 278:15461-4. 2003.... - Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR functionNoriko Oshiro
Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
Genes Cells 9:359-66. 2004.... 
The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1Noriko Oshiro
Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
J Biol Chem 282:20329-39. 2007..Moreover, they indicate that the ability of raptor to bind endogenous substrates is limiting for the activity of mTORC1 in vivo and is therefore a potential locus of regulation...- Different roles for the TOS and RAIP motifs of the translational regulator protein 4E-BP1 in the association with raptor and phosphorylation by mTOR in the regulation of cell sizeSatoshi Eguchi
Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
Genes Cells 11:757-66. 2006.... - Identification of TBC7 having TBC domain as a novel binding protein to TSC1-TSC2 complexAkio Nakashima
Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
Biochem Biophys Res Commun 361:218-23. 2007..These results indicate TBC7 could take a part in the negative regulation of the tumor suppressor complex through facilitating the downregulation of TSC1... - Raptor, a binding partner of target of rapamycin (TOR), mediates TOR actionKenta Hara
Biosignal Research Center, Kobe University, 657 8501, Kobe, Japan
Cell 110:177-89. 2002..elegans raptor yields an array of phenotypes that closely resemble those produced by inactivation of Ce-TOR. Thus, raptor is an essential scaffold for the mTOR-catalyzed phosphorylation of 4EBP1 and mediates TOR action in vivo... - [Rapamycin]Kazuyoshi Yonezawa
Biosignal Research Center, Kobe University
Nippon Rinsho 63:718-22. 2005 - Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycinGoh Ohji
Biosignal Research Center, Kobe University, Kobe 657 8501
J Biochem 139:129-35. 2006.... - Studying fertilization in cell-free extracts: focusing on membrane/lipid raft functions and proteomicsKen-ichi Sato
Research Center for Environmental Genomics, Kobe University, Japan
Methods Mol Biol 322:395-411. 2006..e., whole egg proteome) of fertilization in a cell-free manner. As one of these proteomics approaches, we provide a protocol for molecular identification of Xenopus egg raft proteins using mass spectrometry and database mining... - Identification and comparative analysis of the large subunit mitochondrial ribosomal proteins of Neurospora crassaXiang Gan
Department of Biology, Faculty of Science, Kobe University, Kobe, Japan
FEMS Microbiol Lett 254:157-64. 2006..One of the N. crassa mitochondrial ribosomal proteins was found to be homologous to yeast Mhr1p that is involved in homologous DNA recombination and genome maintenance in yeast mitochondria... 
AMP-activated protein kinase phosphorylates glutamine : fructose-6-phosphate amidotransferase 1 at Ser243 to modulate its enzymatic activitySatoshi Eguchi
Biosignal Research Center, Kobe University, Japan
Genes Cells 14:179-89. 2009..These results indicate that the phosphorylation of GFAT1 at Ser243 by AMPK has an important role in the regulation of the GFAT1 enzymatic activity...- AMP-activated protein kinase phosphorylates Golgi-specific brefeldin A resistance factor 1 at Thr1337 to induce disassembly of Golgi apparatusTakafumi Miyamoto
Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
J Biol Chem 283:4430-8. 2008.... - Inhibition of amino acid-mTOR signaling by a leucine derivative induces G1 arrest in Jurkat cellsSujuti Hidayat
Biosignal Research Center, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan
Biochem Biophys Res Commun 301:417-23. 2003..These effects are similar to the inhibitory effects of rapamycin on amino acid-mTOR signaling pathway and suggest that N-acetylleucine amide acts as a rapamycin-like reagent to inhibit cell cycle progression in Jurkat cells... - The yeast Tor signaling pathway is involved in G2/M transition via polo-kinaseAkio Nakashima
Biosignal Research Center, Kobe University, Kobe, Japan
PLoS ONE 3:e2223. 2008..The C-terminal polo-box domain of Cdc5 has an inhibitory role in nuclear translocation. Taken together, our results indicate a novel function of Tor in the regulation of cell cycle and proliferation... - Molecular identification and characterization of Xenopus egg uroplakin III, an egg raft-associated transmembrane protein that is tyrosine-phosphorylated upon fertilizationKeiichi Sakakibara
Graduate School of Science and Technology, Kobe University, Nada, Japan
J Biol Chem 280:15029-37. 2005..Thus, xUPIII represents an egg raft-associated protein that is likely involved in sperm-egg interaction as well as subsequent Src-dependent intracellular events of egg activation in Xenopus... - mTOR integrates amino acid- and energy-sensing pathwaysChiharu Tokunaga
Biosignal Research Center, Kobe University, Kobe 657-8501, Japan
Biochem Biophys Res Commun 313:443-6. 2004..Further understanding of the role of mTOR in coordinating amino acid- and energy-sensing pathways would provide new insights into relationship between nutrients and cellular functions... - Phosphorylation and up-regulation of diacylglycerol kinase gamma via its interaction with protein kinase C gammaYasuto Yamaguchi
Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
J Biol Chem 281:31627-37. 2006.... - A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathwayNaoki Kimura
Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
Genes Cells 8:65-79. 2003..AMP-activated protein kinase (AMPK) modulates metabolism in response to energy demand by responding to changes in AMP... - Regulation of hypoxia-inducible factor 1 by glucose availability under hypoxic conditionsJing Zhou
Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, 650 0017, Japan
Kobe J Med Sci 53:283-96. 2007.... - Phylogeny of vertebrate Src tyrosine kinases revealed by the epitope region of mAb327Tetsushi Iwasaki
Research Center for Environmental Genomics, Kobe University, Nada, Kobe 657 8501
J Biochem 139:347-54. 2006.... - Tag-mediated isolation of yeast mitochondrial ribosome and mass spectrometric identification of its new componentsXiang Gan
Graduate School of Science and Technology, Department of Biology, Faculty of Science, and Biosignal Research Center, Kobe University, Japan
Eur J Biochem 269:5203-14. 2002.... - [mTOR complex as an integrating controller of cell growth]Ken-ichi Yoshino
Tanpakushitsu Kakusan Koso 48:1378-85. 2003 - Biochemical and morphologic evidence of the interaction of oligodendrocyte membrane rafts with actin filamentsKatsutoshi Taguchi
Division of Bioinformation, Department of Biosystems Science, Graduate School of Science and Technology, Kobe University, Nada-ku, Kobe, Japan
J Neurosci Res 81:218-25. 2005..These results indicate that raft microdomains participate in the formation of cell shape through interaction with microfilaments in oligodendrocytes... - Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitroT Takahashi
Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
Genes Cells 5:765-75. 2000..mTOR plays a critical role in controlling translational effectors such as p70 S6 kinase alpha (p70 alpha) and eukaryotic initiation factor 4E binding protein 1 (4EBP1)... - Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitroS Isotani
Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
J Biol Chem 274:34493-8. 1999.... - Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alphaT Minami
Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
Genes Cells 6:1003-15. 2001..This includes the critical phosphorylation sites, Thr252, Ser394 and Thr412 in p70alpha1, which correspond to Thr241, Ser383 and Thr401 in p70beta1, respectively. However, the regulatory mechanism for p70beta remains to be elucidated... - Alpha4 protein as a common regulator of type 2A-related serine/threonine protein phosphatasesM Nanahoshi
Biosignal Research Center, Kobe University, Japan
FEBS Lett 446:108-12. 1999..These results suggest that the alpha4 protein is a common regulator of the C subunit of serine/threonine phosphatase 2A and protein phosphatase 2A-related protein phosphatases... - Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendritesNobuyuki Takei
Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
J Neurosci 24:9760-9. 2004..Taken together, these data indicate that mTOR-dependent translation activation is essential for the upregulation of local protein synthesis in neuronal dendrites... - Rheb binds and regulates the mTOR kinaseXiaomeng Long
Diabetes Unit and Medical Services and Department of Molecular Biology, Massachusetts General Hospital, Boston, 02114, USA
Curr Biol 15:702-13. 2005..The Tuberous Sclerosis heterodimer (TSC1/TSC2) functions as a Rheb GTPase activator and inhibits TOR signaling in vivo... - Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat regionTerunao Takahara
Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
J Biol Chem 281:28605-14. 2006..In addition, Saccharomyces cerevisiae TOR proteins Tor1p and Tor2p also exist as homomultimers. These results suggest that TOR multimerization is a conserved mechanism for TOR functioning... - Characterization of ubiquilin 1, an mTOR-interacting proteinShilan Wu
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02135, USA
Biochim Biophys Acta 1542:41-56. 2002..Our data suggest that we have identified a novel mTOR interactor, ubiquilin 1. The biological significance of this, presumably membrane based, interaction, requires further study... - MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PRYoshihiko Kono
Department of Immunology, Kumamoto University School of Medicine, 2 2 1, Honjo, Kumamoto, 860 0811, Japan
Genes Cells 7:821-34. 2002..GANP, carrying DNA-primase and MCM3-binding domains, is up-regulated in germinal centre B cells. To understand the regulatory function of GANP upon MCM complex, we searched for GANP-associated molecules by yeast two-hybrid screening... - mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cellsMirei Murakami
Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Nara 630 0192, Japan
Mol Cell Biol 24:6710-8. 2004..These data show that mTOR controls both cell size and proliferation in early mouse embryos and embryonic stem cells... - Protein-tyrosine phosphatase alpha, RPTP alpha, is a Helicobacter pylori VacA receptorKinnosuke Yahiro
Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 8528523, Japan
J Biol Chem 278:19183-9. 2003..These data suggest that RPTP alpha acts as a receptor for VacA in G401 cells. Thus, two receptor tyrosine phosphatases, RPTP alpha and RPTP beta, serve as VacA receptors... - Involvement of general transcriptional coactivator PC4 in the transcription of medaka fish intestine-specific membrane guanylyl cyclase gene (OlGC6)Mina Nakauchi
Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo 060 0810
J Biochem 137:509-15. 2005..In CACO-2 cells, cotransfection of the OlGC6-luciferase fusion genes with an OlPC4 expression vector resulted in 1.5-fold stimulation of the OlGC6 promoter... - TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrientsYoshimi Honma
Faculty of Science, Shizuoka University, Shizuoka, Japan
EMBO J 25:3832-42. 2006..Thus, the Nog1 complex is a critical regulator of ribosome biogenesis mediated by TOR. This is the first description of a physiological regulation of nucleolus-to-nucleoplasm translocation of pre-ribosome complexes... - Glutamine is a key regulator for amino acid-controlled cell growth through the mTOR signaling pathway in rat intestinal epithelial cellsTohru Nakajo
Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Graduate School of Medicine and Dentistry, Okayama University, 2-5-1 Shikatacho, Okayama 700-8558, Japan
Biochem Biophys Res Commun 326:174-80. 2005....