Kazuyoshi Yonezawa

Summary

Affiliation: Kobe University
Country: Japan

Publications

  1. ncbi request reprint Identification of TOR-interacting proteins
    Kazuyoshi Yonezawa
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Mol Interv 3:189-93. 2003
  2. ncbi request reprint Raptor, a binding partner of target of rapamycin
    Kazuyoshi Yonezawa
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Biochem Biophys Res Commun 313:437-41. 2004
  3. ncbi request reprint Kinase activities associated with mTOR
    K Yonezawa
    Biosignal Research Center, Kobe University, 657 8501, Kobe, Japan
    Curr Top Microbiol Immunol 279:271-82. 2004
  4. ncbi request reprint The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
    Hiroki Nojima
    Biosignal Research Center, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe 657 8501, Japan
    J Biol Chem 278:15461-4. 2003
  5. ncbi request reprint Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function
    Noriko Oshiro
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Genes Cells 9:359-66. 2004
  6. pmc The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1
    Noriko Oshiro
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    J Biol Chem 282:20329-39. 2007
  7. ncbi request reprint Different roles for the TOS and RAIP motifs of the translational regulator protein 4E-BP1 in the association with raptor and phosphorylation by mTOR in the regulation of cell size
    Satoshi Eguchi
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Genes Cells 11:757-66. 2006
  8. ncbi request reprint Identification of TBC7 having TBC domain as a novel binding protein to TSC1-TSC2 complex
    Akio Nakashima
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Biochem Biophys Res Commun 361:218-23. 2007
  9. ncbi request reprint Studying fertilization in cell-free extracts: focusing on membrane/lipid raft functions and proteomics
    Ken ichi Sato
    Research Center for Environmental Genomics, Kobe University, Japan
    Methods Mol Biol 322:395-411. 2006
  10. pmc Association of CAD, a multifunctional protein involved in pyrimidine synthesis, with mLST8, a component of the mTOR complexes
    Akio Nakashima
    Biosignal Research Center, Kobe University, Kobe, 657 8501, Japan
    J Biomed Sci 20:24. 2013

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Identification of TOR-interacting proteins
    Kazuyoshi Yonezawa
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Mol Interv 3:189-93. 2003
  2. ncbi request reprint Raptor, a binding partner of target of rapamycin
    Kazuyoshi Yonezawa
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Biochem Biophys Res Commun 313:437-41. 2004
    ....
  3. ncbi request reprint Kinase activities associated with mTOR
    K Yonezawa
    Biosignal Research Center, Kobe University, 657 8501, Kobe, Japan
    Curr Top Microbiol Immunol 279:271-82. 2004
    ..The requirement of raptor for binding to and phosphorylation by mTOR of these potential substrates would clarify their physiological importance in the mTOR signaling pathway...
  4. ncbi request reprint The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
    Hiroki Nojima
    Biosignal Research Center, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe 657 8501, Japan
    J Biol Chem 278:15461-4. 2003
    ....
  5. ncbi request reprint Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function
    Noriko Oshiro
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Genes Cells 9:359-66. 2004
    ....
  6. pmc The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1
    Noriko Oshiro
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    J Biol Chem 282:20329-39. 2007
    ..Moreover, they indicate that the ability of raptor to bind endogenous substrates is limiting for the activity of mTORC1 in vivo and is therefore a potential locus of regulation...
  7. ncbi request reprint Different roles for the TOS and RAIP motifs of the translational regulator protein 4E-BP1 in the association with raptor and phosphorylation by mTOR in the regulation of cell size
    Satoshi Eguchi
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Genes Cells 11:757-66. 2006
    ....
  8. ncbi request reprint Identification of TBC7 having TBC domain as a novel binding protein to TSC1-TSC2 complex
    Akio Nakashima
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Biochem Biophys Res Commun 361:218-23. 2007
    ..These results indicate TBC7 could take a part in the negative regulation of the tumor suppressor complex through facilitating the downregulation of TSC1...
  9. ncbi request reprint Studying fertilization in cell-free extracts: focusing on membrane/lipid raft functions and proteomics
    Ken ichi Sato
    Research Center for Environmental Genomics, Kobe University, Japan
    Methods Mol Biol 322:395-411. 2006
    ..e., whole egg proteome) of fertilization in a cell-free manner. As one of these proteomics approaches, we provide a protocol for molecular identification of Xenopus egg raft proteins using mass spectrometry and database mining...
  10. pmc Association of CAD, a multifunctional protein involved in pyrimidine synthesis, with mLST8, a component of the mTOR complexes
    Akio Nakashima
    Biosignal Research Center, Kobe University, Kobe, 657 8501, Japan
    J Biomed Sci 20:24. 2013
    ....
  11. ncbi request reprint Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
    Kenta Hara
    Biosignal Research Center, Kobe University, 657 8501, Kobe, Japan
    Cell 110:177-89. 2002
    ..elegans raptor yields an array of phenotypes that closely resemble those produced by inactivation of Ce-TOR. Thus, raptor is an essential scaffold for the mTOR-catalyzed phosphorylation of 4EBP1 and mediates TOR action in vivo...
  12. ncbi request reprint [Rapamycin]
    Kazuyoshi Yonezawa
    Biosignal Research Center, Kobe University
    Nihon Rinsho 63:718-22. 2005
  13. doi request reprint A positive role of mammalian Tip41-like protein, TIPRL, in the amino-acid dependent mTORC1-signaling pathway through interaction with PP2A
    Akio Nakashima
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    FEBS Lett 587:2924-9. 2013
    ..Collectively, unlike yeast TIP41, TIPRL has a positive effect on mTORC1 signaling through the association with PP2Ac. ..
  14. doi request reprint AMP-activated protein kinase phosphorylates glutamine : fructose-6-phosphate amidotransferase 1 at Ser243 to modulate its enzymatic activity
    Satoshi Eguchi
    Biosignal Research Center, Kobe University, Japan
    Genes Cells 14:179-89. 2009
    ..These results indicate that the phosphorylation of GFAT1 at Ser243 by AMPK has an important role in the regulation of the GFAT1 enzymatic activity...
  15. ncbi request reprint Identification and comparative analysis of the large subunit mitochondrial ribosomal proteins of Neurospora crassa
    Xiang Gan
    Department of Biology, Faculty of Science, Kobe University, Kobe, Japan
    FEMS Microbiol Lett 254:157-64. 2006
    ..One of the N. crassa mitochondrial ribosomal proteins was found to be homologous to yeast Mhr1p that is involved in homologous DNA recombination and genome maintenance in yeast mitochondria...
  16. ncbi request reprint AMP-activated protein kinase phosphorylates Golgi-specific brefeldin A resistance factor 1 at Thr1337 to induce disassembly of Golgi apparatus
    Takafumi Miyamoto
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    J Biol Chem 283:4430-8. 2008
    ....
  17. ncbi request reprint Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin
    Goh Ohji
    Biosignal Research Center, Kobe University, Kobe 657 8501
    J Biochem 139:129-35. 2006
    ....
  18. ncbi request reprint Inhibition of amino acid-mTOR signaling by a leucine derivative induces G1 arrest in Jurkat cells
    Sujuti Hidayat
    Biosignal Research Center, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe 657 8501, Japan
    Biochem Biophys Res Commun 301:417-23. 2003
    ..These effects are similar to the inhibitory effects of rapamycin on amino acid-mTOR signaling pathway and suggest that N-acetylleucine amide acts as a rapamycin-like reagent to inhibit cell cycle progression in Jurkat cells...
  19. pmc The yeast Tor signaling pathway is involved in G2/M transition via polo-kinase
    Akio Nakashima
    Biosignal Research Center, Kobe University, Kobe, Japan
    PLoS ONE 3:e2223. 2008
    ..The C-terminal polo-box domain of Cdc5 has an inhibitory role in nuclear translocation. Taken together, our results indicate a novel function of Tor in the regulation of cell cycle and proliferation...
  20. ncbi request reprint mTOR integrates amino acid- and energy-sensing pathways
    Chiharu Tokunaga
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Biochem Biophys Res Commun 313:443-6. 2004
    ..Further understanding of the role of mTOR in coordinating amino acid- and energy-sensing pathways would provide new insights into relationship between nutrients and cellular functions...
  21. ncbi request reprint Molecular identification and characterization of Xenopus egg uroplakin III, an egg raft-associated transmembrane protein that is tyrosine-phosphorylated upon fertilization
    Keiichi Sakakibara
    Graduate School of Science and Technology, Kobe University, Nada, Japan
    J Biol Chem 280:15029-37. 2005
    ..Thus, xUPIII represents an egg raft-associated protein that is likely involved in sperm-egg interaction as well as subsequent Src-dependent intracellular events of egg activation in Xenopus...
  22. ncbi request reprint Phosphorylation and up-regulation of diacylglycerol kinase gamma via its interaction with protein kinase C gamma
    Yasuto Yamaguchi
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    J Biol Chem 281:31627-37. 2006
    ....
  23. ncbi request reprint A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway
    Naoki Kimura
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Genes Cells 8:65-79. 2003
    ..AMP-activated protein kinase (AMPK) modulates metabolism in response to energy demand by responding to changes in AMP...
  24. ncbi request reprint Tag-mediated isolation of yeast mitochondrial ribosome and mass spectrometric identification of its new components
    Xiang Gan
    Graduate School of Science and Technology, Department of Biology, Faculty of Science, and Biosignal Research Center, Kobe University, Japan
    Eur J Biochem 269:5203-14. 2002
    ....
  25. ncbi request reprint Regulation of hypoxia-inducible factor 1 by glucose availability under hypoxic conditions
    Jing Zhou
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, 650 0017, Japan
    Kobe J Med Sci 53:283-96. 2007
    ....
  26. ncbi request reprint [mTOR complex as an integrating controller of cell growth]
    Ken ichi Yoshino
    Tanpakushitsu Kakusan Koso 48:1378-85. 2003
  27. ncbi request reprint Phylogeny of vertebrate Src tyrosine kinases revealed by the epitope region of mAb327
    Tetsushi Iwasaki
    Research Center for Environmental Genomics, Kobe University, Nada, Kobe 657 8501
    J Biochem 139:347-54. 2006
    ....
  28. ncbi request reprint Biochemical and morphologic evidence of the interaction of oligodendrocyte membrane rafts with actin filaments
    Katsutoshi Taguchi
    Division of Bioinformation, Department of Biosystems Science, Graduate School of Science and Technology, Kobe University, Nada Ku, Kobe, Japan
    J Neurosci Res 81:218-25. 2005
    ..These results indicate that raft microdomains participate in the formation of cell shape through interaction with microfilaments in oligodendrocytes...
  29. ncbi request reprint Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro
    S Isotani
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    J Biol Chem 274:34493-8. 1999
    ....
  30. ncbi request reprint Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro
    T Takahashi
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Genes Cells 5:765-75. 2000
    ..mTOR plays a critical role in controlling translational effectors such as p70 S6 kinase alpha (p70 alpha) and eukaryotic initiation factor 4E binding protein 1 (4EBP1)...
  31. ncbi request reprint Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha
    T Minami
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Genes Cells 6:1003-15. 2001
    ..This includes the critical phosphorylation sites, Thr252, Ser394 and Thr412 in p70alpha1, which correspond to Thr241, Ser383 and Thr401 in p70beta1, respectively. However, the regulatory mechanism for p70beta remains to be elucidated...
  32. ncbi request reprint Alpha4 protein as a common regulator of type 2A-related serine/threonine protein phosphatases
    M Nanahoshi
    Biosignal Research Center, Kobe University, Japan
    FEBS Lett 446:108-12. 1999
    ..These results suggest that the alpha4 protein is a common regulator of the C subunit of serine/threonine phosphatase 2A and protein phosphatase 2A-related protein phosphatases...
  33. ncbi request reprint Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region
    Terunao Takahara
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 281:28605-14. 2006
    ..In addition, Saccharomyces cerevisiae TOR proteins Tor1p and Tor2p also exist as homomultimers. These results suggest that TOR multimerization is a conserved mechanism for TOR functioning...
  34. ncbi request reprint Rheb binds and regulates the mTOR kinase
    Xiaomeng Long
    Diabetes Unit and Medical Services and Department of Molecular Biology, Massachusetts General Hospital, Boston, 02114, USA
    Curr Biol 15:702-13. 2005
    ..The Tuberous Sclerosis heterodimer (TSC1/TSC2) functions as a Rheb GTPase activator and inhibits TOR signaling in vivo...
  35. pmc mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells
    Mirei Murakami
    Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Nara 630 0192, Japan
    Mol Cell Biol 24:6710-8. 2004
    ..These data show that mTOR controls both cell size and proliferation in early mouse embryos and embryonic stem cells...
  36. ncbi request reprint Characterization of ubiquilin 1, an mTOR-interacting protein
    Shilan Wu
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02135, USA
    Biochim Biophys Acta 1542:41-56. 2002
    ..Our data suggest that we have identified a novel mTOR interactor, ubiquilin 1. The biological significance of this, presumably membrane based, interaction, requires further study...
  37. ncbi request reprint MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR
    Yoshihiko Kono
    Department of Immunology, Kumamoto University School of Medicine, 2 2 1, Honjo, Kumamoto, 860 0811, Japan
    Genes Cells 7:821-34. 2002
    ..GANP, carrying DNA-primase and MCM3-binding domains, is up-regulated in germinal centre B cells. To understand the regulatory function of GANP upon MCM complex, we searched for GANP-associated molecules by yeast two-hybrid screening...
  38. ncbi request reprint Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites
    Nobuyuki Takei
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    J Neurosci 24:9760-9. 2004
    ..Taken together, these data indicate that mTOR-dependent translation activation is essential for the upregulation of local protein synthesis in neuronal dendrites...
  39. ncbi request reprint Involvement of general transcriptional coactivator PC4 in the transcription of medaka fish intestine-specific membrane guanylyl cyclase gene (OlGC6)
    Mina Nakauchi
    Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo 060 0810
    J Biochem 137:509-15. 2005
    ..In CACO-2 cells, cotransfection of the OlGC6-luciferase fusion genes with an OlPC4 expression vector resulted in 1.5-fold stimulation of the OlGC6 promoter...
  40. pmc TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients
    Yoshimi Honma
    Faculty of Science, Shizuoka University, Shizuoka, Japan
    EMBO J 25:3832-42. 2006
    ..Thus, the Nog1 complex is a critical regulator of ribosome biogenesis mediated by TOR. This is the first description of a physiological regulation of nucleolus-to-nucleoplasm translocation of pre-ribosome complexes...
  41. ncbi request reprint Protein-tyrosine phosphatase alpha, RPTP alpha, is a Helicobacter pylori VacA receptor
    Kinnosuke Yahiro
    Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 8528523, Japan
    J Biol Chem 278:19183-9. 2003
    ..These data suggest that RPTP alpha acts as a receptor for VacA in G401 cells. Thus, two receptor tyrosine phosphatases, RPTP alpha and RPTP beta, serve as VacA receptors...
  42. ncbi request reprint Glutamine is a key regulator for amino acid-controlled cell growth through the mTOR signaling pathway in rat intestinal epithelial cells
    Tohru Nakajo
    Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Biochem Biophys Res Commun 326:174-80. 2005
    ....