Hisafumi Yasuda

Summary

Affiliation: Kobe University
Country: Japan

Publications

  1. ncbi request reprint Immunological aspects of 'fulminant type 1 diabetes'
    Masao Nagata
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Diabetes Res Clin Pract 77:S99-103. 2007
  2. doi request reprint Development of fulminant Type 1 diabetes with thrombocytopenia after influenza vaccination: a case report
    H Yasuda
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Diabet Med 29:88-9. 2012
  3. doi request reprint NO-mediated cytotoxicity contributes to multiple low-dose streptozotocin-induced diabetes but not to NOD diabetes
    Hisafumi Yasuda
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Chuo Ku, Kobe, Japan
    Diabetes Res Clin Pract 83:200-7. 2009
  4. doi request reprint Administration of a determinant of preproinsulin can induce regulatory T cells and suppress anti-islet autoimmunity in NOD mice
    Takashi Arai
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Clin Immunol 136:74-82. 2010
  5. doi request reprint Intravenous administration of proinsulin 1 or 2-expressing fiber-mutant recombinant adenovirus vector protects against the development of diabetes in NOD mice
    Katsumi Yamada
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Ann N Y Acad Sci 1150:183-6. 2008
  6. ncbi request reprint Low-dose warfarin functions as an immunomodulator to prevent cyclophosphamide-induced NOD diabetes
    Midori Kurohara
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Japan
    Kobe J Med Sci 54:E1-13. 2008
  7. doi request reprint One amino acid difference is critical for suppression of the development of experimental autoimmune diabetes (EAD) with intravenous injection of insulinB:9-23 peptide
    Yasuyo Okumachi
    Department of Internal and Geriatric Medicine, Kobe University, Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe, Japan
    Biochem Biophys Res Commun 374:581-6. 2008
  8. doi request reprint Prevention of recurrent but not spontaneous autoimmune diabetes by transplanted NOD islets adenovirally transduced with immunomodulating molecules
    Muneaki Sakata
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Diabetes Res Clin Pract 80:352-9. 2008
  9. ncbi request reprint Detection of GAD65-reactive T-Cells in type 1 diabetes by immunoglobulin-free ELISPOT assays
    Reiko Kotani
    Division of Internal and Geriatric Medicine, Department of Development and Aging, Kobe University Graduate School of Medicine, Kobe, Japan
    Diabetes Care 25:1390-7. 2002
  10. doi request reprint Regulatory CD8+ T cells induced by exposure to all-trans retinoic acid and TGF-beta suppress autoimmune diabetes
    Minoru Kishi
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Biochem Biophys Res Commun 394:228-32. 2010

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Immunological aspects of 'fulminant type 1 diabetes'
    Masao Nagata
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Diabetes Res Clin Pract 77:S99-103. 2007
    ..These results implicated that once anti-islet immunity is optimally activated, subjects with partially resistant alleles could become overt diabetes...
  2. doi request reprint Development of fulminant Type 1 diabetes with thrombocytopenia after influenza vaccination: a case report
    H Yasuda
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Diabet Med 29:88-9. 2012
    ..Involvement of viral infections in the pathogenesis of fulminant T1D has been suggested, but the development of fulminant Type 1 diabetes after influenza vaccination has not been reported...
  3. doi request reprint NO-mediated cytotoxicity contributes to multiple low-dose streptozotocin-induced diabetes but not to NOD diabetes
    Hisafumi Yasuda
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Chuo Ku, Kobe, Japan
    Diabetes Res Clin Pract 83:200-7. 2009
    ..These findings suggest that NO-mediated cytotoxicity significantly contributes to MLDS-induced diabetes but not to NOD diabetes...
  4. doi request reprint Administration of a determinant of preproinsulin can induce regulatory T cells and suppress anti-islet autoimmunity in NOD mice
    Takashi Arai
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Clin Immunol 136:74-82. 2010
    ..L7-24 peptide, which has a high affinity for pockets of I-A(g7), induced regulatory T cells and showed therapeutic effects. This peptide may provide a new approach for developing antigen-specific immunotherapy for autoimmune diabetes...
  5. doi request reprint Intravenous administration of proinsulin 1 or 2-expressing fiber-mutant recombinant adenovirus vector protects against the development of diabetes in NOD mice
    Katsumi Yamada
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Ann N Y Acad Sci 1150:183-6. 2008
    ..Pins1-RGD and that of Ad.Pins2-RGD. Our study suggests that systemic administration of fiber-mutant adenovirus vectors, which induce transient expression of proinsulin, may be applicable to a gene therapy inducing tolerance to insulin...
  6. ncbi request reprint Low-dose warfarin functions as an immunomodulator to prevent cyclophosphamide-induced NOD diabetes
    Midori Kurohara
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Japan
    Kobe J Med Sci 54:E1-13. 2008
    ..In conclusion, low-dose warfarin is a potential immunomodulator which can prevent autoimmune diabetes...
  7. doi request reprint One amino acid difference is critical for suppression of the development of experimental autoimmune diabetes (EAD) with intravenous injection of insulinB:9-23 peptide
    Yasuyo Okumachi
    Department of Internal and Geriatric Medicine, Kobe University, Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe, Japan
    Biochem Biophys Res Commun 374:581-6. 2008
    ....
  8. doi request reprint Prevention of recurrent but not spontaneous autoimmune diabetes by transplanted NOD islets adenovirally transduced with immunomodulating molecules
    Muneaki Sakata
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Diabetes Res Clin Pract 80:352-9. 2008
    ....
  9. ncbi request reprint Detection of GAD65-reactive T-Cells in type 1 diabetes by immunoglobulin-free ELISPOT assays
    Reiko Kotani
    Division of Internal and Geriatric Medicine, Department of Development and Aging, Kobe University Graduate School of Medicine, Kobe, Japan
    Diabetes Care 25:1390-7. 2002
    ..To investigate the prevalence of beta-cell autoantigen-reactive peripheral T-cells in type 1 diabetes, we developed an immunoglobulin-free enzyme-linked immunospot (ELISPOT) assay and assessed its usefulness for diagnosing this disease...
  10. doi request reprint Regulatory CD8+ T cells induced by exposure to all-trans retinoic acid and TGF-beta suppress autoimmune diabetes
    Minoru Kishi
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Biochem Biophys Res Commun 394:228-32. 2010
    ..Here we show that exposure to ATRA and TGF-beta induces CD8(+)Foxp3(+) T cells ex vivo, which suppress diabetogenic T cells in vitro and in vivo...
  11. doi request reprint Autoreactive T cell response in CD25-negative fraction of peripheral blood mononuclear cells in established type 1 diabetes
    Hiroaki Moriyama
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Ann N Y Acad Sci 1150:278-81. 2008
    ..The phenomena were not observed for IL-4 spots. Our data suggest a possible role of Tregs maintaining dominant peripheral tolerance in T1D and application of further improved T cell assay detecting autoimmunity even in established T1D...
  12. ncbi request reprint Insulin as a T cell antigen in type 1 diabetes supported by the evidence from the insulin knockout NOD mice
    Hiroaki Moriyama
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Diabetes Res Clin Pract 77:S155-60. 2007
    ....
  13. doi request reprint Acceleration of autoimmune diabetes in Rheb-congenic NOD mice with β-cell-specific mTORC1 activation
    Hirotomo Sasaki
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Biochem Biophys Res Commun 408:306-11. 2011
    ..We conclude that not only enlargement but also regeneration of β-cells in addition to the prevention of β-cell destruction will be required for the ideal therapy of autoimmune T1D...
  14. doi request reprint Role of the mTOR complex 1 pathway in the in vivo maintenance of the intestinal mucosa by oral intake of amino acids
    Akira Nakamura
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Geriatr Gerontol Int 12:131-9. 2012
    ....
  15. pmc Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemia
    Suirin Hamada
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Diabetes 58:1321-32. 2009
    ..Our objective was to investigate the role of the mTORC1 pathway in the regulation of beta-cell mass in vivo...
  16. ncbi request reprint Modification of the Rb-binding domain of replication-competent adenoviral vector enhances cytotoxicity against human esophageal cancers via NF-kappaB activity
    Katsumi Yamada
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Hum Gene Ther 18:389-400. 2007
    ..These data demonstrate that the Rb-binding domain of E1A can regulate NF-kappaB activity and that modifications to this domain may lead to advances in gene therapies for the treatment of human cancers...
  17. doi request reprint Usefulness of 18F-fluorodeoxyglucose positron emission tomography for diagnosis of asymptomatic giant cell arteritis in a patient with Alzheimer's disease
    Saeko Kushida
    Division of Geriatric Medicine, Kobe University Hospital, Kobe, Japan
    Geriatr Gerontol Int 11:114-8. 2011
    ..Our experience suggests the usefulness of FDG-PET for the diagnosis of GCA, particularly in elderly patients without typical symptoms...
  18. ncbi request reprint Fas/Fas ligand interactions play an essential role in the initiation of murine autoimmune diabetes
    Maki Nakayama
    Department of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    Diabetes 51:1391-7. 2002
    ..These results suggest that Fas/FasL interactions contribute to CD4(+) T-cell-mediated beta-cell destruction and play an essential role in the initiation of autoimmune NOD diabetes...
  19. ncbi request reprint Bleeding from the small intestine and aortic regurgitation in Noonan syndrome
    Hiroshi Yoshino
    Department of General Internal Medicine, Kobe University Graduate School of Medicine, Japan
    Intern Med 50:2611-3. 2011
    ..By upper endoscopy with the single balloon we clearly revealed the angioectasia in the small intestine. This case documents the first association among NS, aortic regurgitation and angioectasia in the small intestine...
  20. ncbi request reprint Regulation of hypoxia-inducible factor 1 by glucose availability under hypoxic conditions
    Jing Zhou
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, 650 0017, Japan
    Kobe J Med Sci 53:283-96. 2007
    ....