Yoshihiko Yano

Summary

Affiliation: Kobe University
Country: Japan

Publications

  1. doi request reprint Mutations in non-structural 5A and rapid viral response to pegylated interferon-α-2b plus ribavirin therapy are associated with therapeutic efficacy in patients with genotype 1b chronic hepatitis C
    Yoshihiko Yano
    Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    Int J Mol Med 30:1048-52. 2012
  2. ncbi request reprint A case of undifferentiated carcinoma of the gallbladder with anomalous arrangement of the pancreaticobiliary ductal system
    Y Yano
    Department of Internal Medicine, Kakogawa Municipal Hospital, Hyogo, Japan
    Oncol Rep 8:1281-3. 2001
  3. ncbi request reprint Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-I beta/B10/gp130RB13-6) in human colon carcinoma
    Yoshihiko Yano
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Japan
    Int J Mol Med 12:763-6. 2003
  4. ncbi request reprint A case of well-differentiated hepatocellular carcinoma arising in primary biliary cirrhosis
    Yoshihiko Yano
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine
    Kobe J Med Sci 49:39-43. 2003
  5. ncbi request reprint Variations in the core promoter/pre-core region in HBV genotype C in Japanese and Northern Vietnamese patients
    Bui Xuan Truong
    Kobe University Graduate School of Medicine, Clinical Molecular Medicine, Kobe, Japan
    J Med Virol 79:1293-304. 2007
  6. ncbi request reprint Long-term follow-up of Japanese patients with chronic hepatitis B treated with interferon-alpha
    Bui Xuan Truong
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive, and Kidney Diseases, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Kobe 650 0017, Japan
    Int J Mol Med 16:279-84. 2005
  7. ncbi request reprint Hepatitis B and C virus infection among hemodialysis patients in yogyakarta, Indonesia: Prevalence and molecular evidence for nosocomial transmission
    Hanggoro Tri Rinonce
    Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    J Med Virol 85:1348-61. 2013
  8. ncbi request reprint Anti-tumor effect of pegylated interferon in the rat hepatocarcinogenesis model
    Akira Miki
    Division of Molecular Medicine and Medical Genetics, International Center of Medical Research and Treatment, Kobe University Graduate School of Medicine, Kusunoki cho, Kobe 650 0017, Japan
    Int J Oncol 32:603-8. 2008
  9. ncbi request reprint Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-1 (E-NPP1/PC-1) and -3 (E-NPP3/CD203c/PD-Ibeta/B10/gp130(RB13-6)) in inflammatory and neoplastic bile duct diseases
    Yoshihiko Yano
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive, and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    Cancer Lett 207:139-47. 2004
  10. ncbi request reprint Serum hepatitis B virus DNA levels differentiating inactive carriers from patients with chronic hepatitis B
    Yasushi Seo
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, International Center for Medical Research ICMR, Kobe University Graduate School of Medicine, Kobe, Japan
    Eur J Gastroenterol Hepatol 17:753-7. 2005

Collaborators

Detail Information

Publications51

  1. doi request reprint Mutations in non-structural 5A and rapid viral response to pegylated interferon-α-2b plus ribavirin therapy are associated with therapeutic efficacy in patients with genotype 1b chronic hepatitis C
    Yoshihiko Yano
    Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    Int J Mol Med 30:1048-52. 2012
    ..In conclusion, mutations in the NS5A region, particularly in patients with ≥6 aa mutations in IRRDR were strongly associated with a therapeutic response to pegylated IFN and ribavirin combination therapy...
  2. ncbi request reprint A case of undifferentiated carcinoma of the gallbladder with anomalous arrangement of the pancreaticobiliary ductal system
    Y Yano
    Department of Internal Medicine, Kakogawa Municipal Hospital, Hyogo, Japan
    Oncol Rep 8:1281-3. 2001
    ..The case is of interest because of two points of discrepancy: the primary cancer did not show deep invasion but demonstrated extensive lymph node metastases; the cancer was histologically malignant but prognosis was relatively good...
  3. ncbi request reprint Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-I beta/B10/gp130RB13-6) in human colon carcinoma
    Yoshihiko Yano
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Japan
    Int J Mol Med 12:763-6. 2003
    ..Our results suggested that E-NPP3 is associated with carcinogenesis of human colon cancer and that serum E-NPP3 might be a tumor marker of colon carcinoma...
  4. ncbi request reprint A case of well-differentiated hepatocellular carcinoma arising in primary biliary cirrhosis
    Yoshihiko Yano
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine
    Kobe J Med Sci 49:39-43. 2003
    ..It was interesting that such large well-differentiated hepatocellular carcinomas were generated in PBC...
  5. ncbi request reprint Variations in the core promoter/pre-core region in HBV genotype C in Japanese and Northern Vietnamese patients
    Bui Xuan Truong
    Kobe University Graduate School of Medicine, Clinical Molecular Medicine, Kobe, Japan
    J Med Virol 79:1293-304. 2007
    ..The subgenotypes and unique mutations of HBV genotype C in the Vietnamese and Japanese differed, and C/A1753 and C1858 variants might play a role in the pathogenesis of liver disease in Vietnamese patients...
  6. ncbi request reprint Long-term follow-up of Japanese patients with chronic hepatitis B treated with interferon-alpha
    Bui Xuan Truong
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive, and Kidney Diseases, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Kobe 650 0017, Japan
    Int J Mol Med 16:279-84. 2005
    ..The results of this long-term follow-up study showed that no benefit of IFN-alpha treatment was detectable during long-term follow-up in Japanese patients with chronic hepatitis B...
  7. ncbi request reprint Hepatitis B and C virus infection among hemodialysis patients in yogyakarta, Indonesia: Prevalence and molecular evidence for nosocomial transmission
    Hanggoro Tri Rinonce
    Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    J Med Virol 85:1348-61. 2013
    ..Implementation of strict infection-control programs is necessary in hemodialysis units in Indonesia...
  8. ncbi request reprint Anti-tumor effect of pegylated interferon in the rat hepatocarcinogenesis model
    Akira Miki
    Division of Molecular Medicine and Medical Genetics, International Center of Medical Research and Treatment, Kobe University Graduate School of Medicine, Kusunoki cho, Kobe 650 0017, Japan
    Int J Oncol 32:603-8. 2008
    ..The inhibitory effect of the PEG-IFN and IFN on hepatocarcinogenesis was almost the same, and this might be induced by the Fas-related apoptosis in the surrounding tissues...
  9. ncbi request reprint Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-1 (E-NPP1/PC-1) and -3 (E-NPP3/CD203c/PD-Ibeta/B10/gp130(RB13-6)) in inflammatory and neoplastic bile duct diseases
    Yoshihiko Yano
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive, and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    Cancer Lett 207:139-47. 2004
    ..These results suggest that E-NPP3 is involved in the infiltration of neoplastic BDC and is possible to be a tumor marker...
  10. ncbi request reprint Serum hepatitis B virus DNA levels differentiating inactive carriers from patients with chronic hepatitis B
    Yasushi Seo
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, International Center for Medical Research ICMR, Kobe University Graduate School of Medicine, Kobe, Japan
    Eur J Gastroenterol Hepatol 17:753-7. 2005
    ....
  11. ncbi request reprint Response to interferon-alpha in chronic hepatitis B with and without precore mutant strain detected by mutation site-specific assay
    Yasushi Seo
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Gastroenterol 38:460-4. 2004
    ..We investigated whether the presence of precore mutant (stop codon mutation at codon 28) affects the response to interferon-alpha in patients with chronic hepatitis B...
  12. ncbi request reprint Serum albumin and prothrombin time before entecavir treatment in chronic hepatitis B or cirrhosis are related to amelioration of liver function after treatment
    Masaya Saito
    aDepartment of Internal Medicine, Division of Gastroenterology bDepartment of Pathology, Center for Infectious Diseases cDepartment of Internal Medicine, Division of Metabolomics Research, Kobe University Graduate School of Medicine, Kobe, Japan
    Eur J Gastroenterol Hepatol 25:1369-76. 2013
    ..We aimed to develop a new pretherapeutic predictive model for the amelioration of liver function after treatment...
  13. pmc Sequence heterogeneity in NS5A of hepatitis C virus genotypes 2a and 2b and clinical outcome of pegylated-interferon/ribavirin therapy
    Ahmed El-Shamy
    Division of Microbiology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    PLoS ONE 7:e30513. 2012
    ..No significant correlation was observed between core protein polymorphism and PEG-IFN/RBV treatment outcome in HCV-2a or HCV-2b infection...
  14. doi request reprint GB virus C infection in Indonesian HIV-positive patients
    Nungki Anggorowati
    Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    Microbiol Immunol 57:298-308. 2013
    ..001 for both genotypes), indicating a shared transmission route with HCV. In conclusion, the prevalence of GBV-C among HIV-positive patients in Indonesia is high, and three genotypes were detected, namely genotype 2a, 3 and 6...
  15. doi request reprint Clinical and virological characteristics of hepatitis B or C virus co-infection with HIV in Indonesian patients
    Nungki Anggorowati
    Center for Infectious Diseases, Graduate School of Medicine, Kobe University, Kobe, Japan
    J Med Virol 84:857-65. 2012
    ..23-32.89) were independently associated with HCV co-infection. HCV co-infection was common among Indonesian patients infected with HIV, particularly among injecting drug users, and was a risk factor for disease progression of HIV...
  16. ncbi request reprint Molecular epidemiological study of hepatitis B virus infection in two different ethnic populations from the Solomon Islands
    Takako Utsumi
    Department of International and Environmental Medical Sciences, Kobe University Graduate School of Medicine, Kobe, Japan
    J Med Virol 79:229-35. 2007
    ..HBeAg appears to clear from the serum in young adulthood in HBV/D infection, which may be influenced by genotype-dependent features in relation to viral mutations...
  17. ncbi request reprint Early response to interferon alpha treatment and long-term clinical outcome in Japanese patients with chronic HBV genotype C infection
    Yasushi Seo
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan yseo med kobe u ac jp
    Int J Mol Med 13:75-9. 2004
    ..Early responsiveness to IFN alpha therapy in Japanese patients with chronic active HBV genotype C infection improves the long-term clinical outcome...
  18. doi request reprint Characteristics of hepatitis viruses among Egyptian children with acute hepatitis
    Ahmed Youssef
    Center for Infectious Diseases CID, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Int J Oncol 42:1459-65. 2013
    ..In conclusion, hepatitis viral infection, including acute-on-chronic infection with HCV and HBV, is common in Egyptian children hospitalised with acute hepatitis...
  19. doi request reprint A high value of serum des-γ-carboxy prothrombin before hepatocellular carcinoma treatment can be associated with long-term liver dysfunction after treatment
    Masaya Saito
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Gastroenterol 47:1134-42. 2012
    ..The pre-TACE prediction of liver dysfunction after TACE would be helpful to avoid long-term liver dysfunction...
  20. ncbi request reprint IFN-alpha prevents the growth of pre-neoplastic lesions and inhibits the development of hepatocellular carcinoma in the rat
    Miyuki Nakaji
    Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chu ku Kobe 650 0017, Japan
    Carcinogenesis 25:389-97. 2004
    ....
  21. ncbi request reprint Apoptotic pathway related to oval cell proliferation
    Yoshihiko Yano
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Gastroenterol Hepatol 19:866-72. 2004
    ..The mechanism behind how oval cells take their place among packed silent hepatocytes, however, is not well understood. We hypothesized that apoptosis involves a decrease in hepatocytes surrounding oval cells...
  22. ncbi request reprint Genotype and variations in core promoter and pre-core regions are related to progression of disease in HBV-infected patients from Northern Vietnam
    Bui Xuan Truong
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 751 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Int J Mol Med 19:293-9. 2007
    ..In Northern Vietnamese, HBV genotypes B and C were prevalent. Genotype C and mutations in the core promoter region were associated with progressive, severe liver diseases...
  23. ncbi request reprint Evaluation of the therapeutic effect using MD-CT immediately after RFA for HCC
    Toshiaki Ninomiya
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive, and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    Hepatogastroenterology 53:558-60. 2006
    ..The aim of this study is to evaluate whether we can assess the therapeutic effect of RFA immediately after RFA...
  24. doi request reprint Outcome of double-filtration plasmapheresis plus interferon treatment in nonresponders to pegylated interferon plus ribavirin combination therapy
    Kayo Sugimoto
    Department of Pharmacy, Kobe Asahi Hospital, Kobe, Japan
    Dig Dis 31:434-9. 2013
    ..Additionally, we investigated factors predictive of sustained virological response (SVR), including host and viral genetic factors, to DFPP plus IFN/RBV therapy...
  25. ncbi request reprint Different apoptotic regulation of TRAIL-caspase pathway in HBV- and HCV-related hepatocellular carcinoma
    Yoshihiko Yano
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe Asahi Hospital, Kobe, Japan
    Int J Mol Med 11:499-504. 2003
    ..HBV-related HCC demonstrated significantly suppressed caspase-3 activity, signifying apoptosis. Both TRAIL-R1 and -R2 showed coefficient correlation with caspase-3 activity, and were strongly associated with apoptosis in human HCC...
  26. doi request reprint Short-term reductions in non-protein respiratory quotient and prealbumin can be associated with the long-term deterioration of liver function after transcatheter arterial chemoembolization in patients with hepatocellular carcinoma
    Masaya Saito
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    J Gastroenterol 47:704-14. 2012
    ..We aimed to make an early predictive model of long-term liver dysfunction after TACE...
  27. ncbi request reprint Molecular epidemiological study of hepatitis viruses in Ismailia, Egypt
    Ahmed Youssef
    Division of Molecular Medicine and Medical Genetics, International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Kobe, Japan
    Intervirology 52:123-31. 2009
    ..Among 54 cases negative for HBsAg and HCV-Ab, HBV-DNA was detected in 35 cases (65%). Our results revealed that HBV and HCV, including occult HBV infection, are widespread and related to liver diseases in Ismailia province, Egypt...
  28. ncbi request reprint Expression of thioredoxin and thioredoxin-binding protein-2 in the liver of patients with chronic hepatitis C as a predictor of response to interferon therapy
    Kenichi Hamano
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Japan
    Int J Mol Med 17:989-95. 2006
    ..05). TRX and TBP-2 mRNA levels in the liver before IFN therapy may predict the outcome of IFN therapy in patients with chronic serotype 1 HCV infection...
  29. ncbi request reprint Mutational diversity of NS5A and NS3 during triple therapy (telaprevir, pegylated-interferon-α 2b and ribavirin) for genotype 1b chronic hepatitis C: The Kobe Hepatitis Therapeutic Group
    Fugui Bai
    Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo 650 0017, Japan
    Int J Mol Med 33:1652-6. 2014
    ..Half of the patients who did not achieve SVR12 had mutations conferring resistance to telaprevir. However, pre-existing mutations in NS3 did not affect the efficacy of triple therapy...
  30. ncbi request reprint Portal venous tumor growth-type of hepatocellular carcinoma without liver parenchyma tumor nodules: a case report
    Masaya Saito
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Ann Hepatol 12:969-73. 2013
    ..We also reported new tumor profiles of the portal venous tumor growth- type of HCC. ..
  31. ncbi request reprint Histological grading and staging in chronic hepatitis: its practical correlation
    Miyuki Nakaji
    Division of Surgical Pathology, Kobe University Graduate School of Medicine, Kobe, Japan
    Pathol Int 52:683-90. 2002
    ..To know the distribution of inflammation using the modified HAI scoring system may be helpful and convenient in evaluating patients with chronic inflammatory liver disease...
  32. pmc Reduction in non-protein respiratory quotient is related to overall survival after hepatocellular carcinoma treatment
    Masaya Saito
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    PLoS ONE 8:e55441. 2013
    ..We aimed to make a new and more accurate prognostic model taking into account the course of disease after TACE...
  33. doi request reprint Perfusion measurement of the whole upper abdomen of patients with and without liver diseases: initial experience with 320-detector row CT
    Tomonori Kanda
    Department of Radiology, Kobe University Graduate School of Medicine, 7 5 2 Kusunokicho, Chuoku, Kobe 650 0017, Japan k
    Eur J Radiol 81:2470-5. 2012
    ..To report initial experience of upper abdominal perfusion measurement with 320-detector row CT (CTP) for assessment of liver diseases and therapeutic effects...
  34. ncbi request reprint Sonazoid-enhanced ultrasonography and Ga-EOB-DTPA-enhanced MRI of hepatic inflammatory pseudotumor: a case report
    Masaya Saito
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
    Intern Med 51:723-6. 2012
    ..We encountered a rare case of hepatic IPT, the differential diagnosis of which was difficult to distinguish from malignant tumor. Here, we report new US and MRI findings of hepatic IPT...
  35. ncbi request reprint Japanese case of hepatitis B virus genotypes C/D hybrid
    Yoshihiko Yano
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, International Center of Medical Research and Treatment ICMRT, Kobe University Graduate School of Medicine, Kobe, Japan
    Hepatol Res 37:1095-9. 2007
    ..8% of the complete genome sequence. It was unclear whether or not this strain was transmitted from China, but the recombinant strains and intergenotypes of HBV have already existed in Japan...
  36. ncbi request reprint Autoimmune-associated hemophagocytic syndrome originating from autoimmune hepatitis with a successful response to therapy
    Masaya Saito
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
    Intern Med 53:103-7. 2014
    ..This is the first report of AAHS originating from AIH. The patient was followed up for five years after treatment, and no disease recurrence was detected. ..
  37. ncbi request reprint Successful treatment using coil embolization of a symptomatic intrahepatic portosystemic venous shunt developing through a patent ductus venosus in a noncirrhotic adult
    Masaya Saito
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
    Intern Med 52:555-9. 2013
    ..Our case involved the adult-onset of a patent ductus venosus, which is extremely rare. This case is the first in which coil embolization was successfully achieved in a noncirrhotic elderly patient with a patent ductus venosus...
  38. ncbi request reprint The cytological characteristics of small cell change of dysplasia in small hepatic nodules
    Okki Chang
    Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    Oncol Rep 23:1229-32. 2010
    ..SCD was frequently found in HGDN and W-HCC. The present study showed that detailed cytological findings of SCD are useful for differentiating HGDN from LGDN, and HGDN from W-HCC...
  39. ncbi request reprint Hepatitis B virus DNA in anti-HBe-positive asymptomatic carriers
    Yasushi Seo
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    Intervirology 46:43-9. 2003
    ..We examined the level of hepatitis B virus (HBV) DNA and the mutations in the precore, core and polymerase regions of HBV in sera from anti-HBe-positive asymptomatic carriers (ASC)...
  40. doi request reprint Factors of response to pegylated interferon/ribavirin combination therapy and mechanism of viral clearance
    Kayo Sugimoto
    Department of Pharmacy, Kobe Asahi Hospital, Kobe, Japan
    Dig Dis 31:421-5. 2013
    ....
  41. doi request reprint A case of Budd-Chiari syndrome: Gd-EOB-DTPA-enhanced MR findings
    Kazuhiro Kitajima
    Clinical PET Center, Institute of Biomedical Research and Innovation, Kobe, Japan
    Magn Reson Imaging 29:579-83. 2011
    ..Reduced uptake of Gd-EOB-DTPA by hepatocytes in the region of congestion or edema may account for this difference, which should be recognized in image interpretations...
  42. doi request reprint Mutations within enhancer II and BCP regions of hepatitis B virus in relation to advanced liver diseases in patients infected with subgenotype B3 in Indonesia
    Didik Setyo Heriyanto
    Center for Infectious Diseases, Graduate School of Medicine, Kobe University, Kobe, Japan
    J Med Virol 84:44-51. 2012
    ..The presence of C1638T and T1753V mutations may serve as predictive markers for the progression of liver diseases in Indonesia and other countries, where subgenotype B3 infection is prevalent...
  43. doi request reprint Activation of the aryl hydrocarbon receptor induces hepatic steatosis via the upregulation of fatty acid transport
    Yuki Kawano
    Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
    Arch Biochem Biophys 504:221-7. 2010
    ..Taking together, AHR activation induces hepatic microvesicular steatosis by increasing the expression level of FAT...
  44. pmc Serologic and molecular characteristics of hepatitis B virus among school children in East Java, Indonesia
    Takako Utsumi
    Indonesia Japan Collaborative Research Center for Emerging and Re emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University, Surabaya, Indonesia
    Am J Trop Med Hyg 83:189-93. 2010
    ..A single amino substitution (T126I) in the S region was frequently found. HBV infection remains endemic, and the prevalence of anti-HBs remains insufficient among children in East Java, Indonesia...
  45. ncbi request reprint Pancreatic arteriovenous malformation combined with portal thrombosis
    Ikuyo Takemoto
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe, Japan
    Intern Med 46:233-6. 2007
    ..Autopsy was performed and the thrombus and malformation were pathologically confirmed. This case indicates that PVT can be associated with PAVM...
  46. ncbi request reprint Multiple hypervascular liver nodules in a heavy drinker of alcohol
    Soo Ryang Kim
    Department of Gastroenterology, Kobe Asahi Hospital, Kobe, Japan
    J Gastroenterol Hepatol 20:795-9. 2005
    ..Further studies may provide insights into the pathogenesis of nodule formation and hypervascularity in heavy drinkers of alcohol...
  47. pmc The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity
    Jun Nakae
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Disease, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 116:2473-83. 2006
    ..In conclusion, the LXXLL motif of FoxO1 may have an important role for its transcriptional activity and Sirt1 binding and should be a target site for regulation of gene expression of FoxO1 target genes and glucose metabolism in vivo...
  48. doi request reprint Nonalcoholic fatty liver disease in adult hypopituitary patients with GH deficiency and the impact of GH replacement therapy
    Hitoshi Nishizawa
    Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Eur J Endocrinol 167:67-74. 2012
    ..Liver dysfunction in adult hypopituitary patients with GH deficiency (GHD) has been reported and an increased prevalence of nonalcoholic fatty liver disease (NAFLD) has been suggested...
  49. ncbi request reprint Development of multicentric hepatocellular carcinoma after completion of interferon therapy
    Soo Ryang Kim
    Department of Gastroenterology, Kobe Asahi Hospital, 3 5 25 Bouoji cho, Nagata ku, Kobe 653 0801, Japan
    J Gastroenterol 37:663-8. 2002
    ..Further studies may provide insights into the possible role of HCV in hepatocarcinogenesis in patients demonstrating HCV eradication by IFN treatment...
  50. ncbi request reprint Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2
    Masanobu Chinami
    Department of Nutrition, Kyushu Women s University, Jiyugaoka 1 1, Kitakyushushi 807 8586, Japan
    J Biol Chem 280:17235-42. 2005
    ..We show that this interaction not only facilitates access of KAP to Thr160 and accelerates KAP kinetics, but also forces exclusion of cyclin A from the KAP.cdk2 complex...