Yoshimi Takai

Summary

Affiliation: Kobe University
Country: Japan

Publications

  1. doi request reprint The immunoglobulin-like cell adhesion molecule nectin and its associated protein afadin
    Yoshimi Takai
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Annu Rev Cell Dev Biol 24:309-42. 2008
  2. pmc Role of nectin in formation of E-cadherin-based adherens junctions in keratinocytes: analysis with the N-cadherin dominant negative mutant
    Yoshinari Tanaka
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    Mol Biol Cell 14:1597-609. 2003
  3. pmc Regulation of Dendritic Filopodial Interactions by ZO-1 and Implications for Dendrite Morphogenesis
    Ryouhei Komaki
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    PLoS ONE 8:e76201. 2013
  4. pmc Genetic deletion of afadin causes hydrocephalus by destruction of adherens junctions in radial glial and ependymal cells in the midbrain
    Hideaki Yamamoto
    Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    PLoS ONE 8:e80356. 2013
  5. pmc Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter release
    Toshiaki Sakisaka
    Division of Membrane Dynamics, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Cell Biol 183:323-37. 2008
  6. doi request reprint Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation
    Yoshimi Takai
    Department of Biochemistry and Molecular Biology, Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    Nat Rev Mol Cell Biol 9:603-15. 2008
  7. ncbi request reprint Role of afadin in vascular endothelial growth factor- and sphingosine 1-phosphate-induced angiogenesis
    Hideto Tawa
    Division of Signal Transduction, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Circ Res 106:1731-42. 2010
  8. ncbi request reprint Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities
    Terunobu Fukuda
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Development 141:399-409. 2014
  9. pmc Regulation by afadin of cyclical activation and inactivation of Rap1, Rac1, and RhoA small G proteins at leading edges of moving NIH3T3 cells
    Muneaki Miyata
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    J Biol Chem 284:24595-609. 2009
  10. doi request reprint Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet-derived growth factor
    Muneaki Miyata
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Cell Sci 122:4319-29. 2009

Collaborators

Detail Information

Publications100

  1. doi request reprint The immunoglobulin-like cell adhesion molecule nectin and its associated protein afadin
    Yoshimi Takai
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Annu Rev Cell Dev Biol 24:309-42. 2008
    ..Additionally, nectins regulate many other cellular activities (such as movement, proliferation, survival, differentiation, polarization, and the entry of viruses) in cooperation with other CAMs and cell surface membrane receptors...
  2. pmc Role of nectin in formation of E-cadherin-based adherens junctions in keratinocytes: analysis with the N-cadherin dominant negative mutant
    Yoshinari Tanaka
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    Mol Biol Cell 14:1597-609. 2003
    ..Thus, nectin plays a role in the formation of E-cadherin-based AJs in keratinocytes...
  3. pmc Regulation of Dendritic Filopodial Interactions by ZO-1 and Implications for Dendrite Morphogenesis
    Ryouhei Komaki
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    PLoS ONE 8:e76201. 2013
    ..These results indicate that ZO-1 regulates dendritic filopodial dynamics, which is implicated in dendrite morphogenesis cooperatively with the nectin and cadherin systems in cultured neurons. ..
  4. pmc Genetic deletion of afadin causes hydrocephalus by destruction of adherens junctions in radial glial and ependymal cells in the midbrain
    Hideaki Yamamoto
    Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
    PLoS ONE 8:e80356. 2013
    ....
  5. pmc Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter release
    Toshiaki Sakisaka
    Division of Membrane Dynamics, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Cell Biol 183:323-37. 2008
    ..Thus, tomosyn inhibits neurotransmitter release by catalyzing oligomerization of the SNARE complex through the N-terminal WD-40 repeat domain in addition to the inhibitory activity of the C-terminal VLD...
  6. doi request reprint Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation
    Yoshimi Takai
    Department of Biochemistry and Molecular Biology, Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    Nat Rev Mol Cell Biol 9:603-15. 2008
    ....
  7. ncbi request reprint Role of afadin in vascular endothelial growth factor- and sphingosine 1-phosphate-induced angiogenesis
    Hideto Tawa
    Division of Signal Transduction, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Circ Res 106:1731-42. 2010
    ..It is not known whether afadin, an adherens junction protein that connects immunoglobulin-like adhesion molecule nectins to the actin cytoskeleton and binds activated Rap1, plays a role in angiogenesis...
  8. ncbi request reprint Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities
    Terunobu Fukuda
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Development 141:399-409. 2014
    ..These results indicate that, owing to the loss of Nectin-3, hair cells contact each other inappropriately and form abnormal junctions, ultimately resulting in abnormal hair bundle orientation and morphology. ..
  9. pmc Regulation by afadin of cyclical activation and inactivation of Rap1, Rac1, and RhoA small G proteins at leading edges of moving NIH3T3 cells
    Muneaki Miyata
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    J Biol Chem 284:24595-609. 2009
    ..These results indicate that afadin regulates the cyclical activation and inactivation of Rap1, Rac1, and RhoA through SPA-1 and ARAP1...
  10. doi request reprint Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet-derived growth factor
    Muneaki Miyata
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Cell Sci 122:4319-29. 2009
    ..These results indicate that afadin has a novel role in PDGF-induced directional cell movement, presumably in cooperation with active Rap1 and SHP-2...
  11. pmc Binding between the junctional proteins afadin and PLEKHA7 and implication in the formation of adherens junction in epithelial cells
    Souichi Kurita
    From the Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650 0017, Japan
    J Biol Chem 288:29356-68. 2013
    ..These results indicate that PLEKHA7 plays a cooperative role with nectin and afadin in the proper formation of AJ in epithelial cells. ..
  12. doi request reprint Sequential activation of Rap1 and Rac1 small G proteins by PDGF locally at leading edges of NIH3T3 cells
    Motonori Takahashi
    Department of Biochemistry and Molecular Biology, Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Genes Cells 13:549-69. 2008
    ..This process is pivotal for the PDGF-induced formation of leading edge structures and cell movement...
  13. pmc Reduction of the ST6 β-galactosamide α-2,6-sialyltransferase 1 (ST6GAL1)-catalyzed sialylation of nectin-like molecule 2/cell adhesion molecule 1 and enhancement of ErbB2/ErbB3 signaling by microRNA-199a
    Akihiro Minami
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, Hyogo 650 0017, Japan
    J Biol Chem 288:11845-53. 2013
    ....
  14. doi request reprint Nectin-like molecule-5 regulates intimal thickening after carotid artery ligation in mice
    Fumie Kureha
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Arterioscler Thromb Vasc Biol 33:1206-11. 2013
    ..It is unknown whether nectin-like molecule (Necl)-5, which is overexpressed in cancer cells, is involved in intimal thickening...
  15. pmc Interaction of nectin-like molecule 2 with integrin alpha6beta4 and inhibition of disassembly of integrin alpha6beta4 from hemidesmosomes
    Kiyohito Mizutani
    Division of Molecular and Cellular Biology, Department of Biochemistry, and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650 0017, Hyogo, Japan
    J Biol Chem 286:36667-76. 2011
    ..These results indicate that tumor-suppressive functions of Necl-2 are mediated by the stabilization of the hemidesmosome structure in addition to the inhibition of the ErbB3/ErbB2 signaling...
  16. doi request reprint Necl-5/PVR enhances PDGF-induced attraction of growing microtubules to the plasma membrane of the leading edge of moving NIH3T3 cells
    Akihiro Minami
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine Faculty of Medicine, Kobe, Hyogo, Japan
    Genes Cells 15:1123-35. 2010
    ..Thus, Necl-5 plays a role in the attraction of growing MTs to the plasma membrane of the leading edge of moving cells...
  17. pmc Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 protein
    Yuri Fukumoto
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650 0017, Japan
    J Biol Chem 286:43537-48. 2011
    ..These results indicate that ADIP plays an essential role in PDGF-induced cell movement by interacting with afadin and Vav2 and regulating the activation of Rac...
  18. doi request reprint Necl-5/poliovirus receptor interacts with VEGFR2 and regulates VEGF-induced angiogenesis
    Mitsuo Kinugasa
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Circ Res 110:716-26. 2012
    ..However, how the interaction between VEGFR2 and integrin α(V)β(3) is regulated is not clear...
  19. doi request reprint Directional cell migration regulation by small G proteins, nectin-like molecule-5, and afadin
    Yoshiyuki Rikitake
    Department of Biochemistry and Molecular Biology, Kobe University, Graduate School of Medicine, Kobe, Japan
    Int Rev Cell Mol Biol 287:97-143. 2011
    ....
  20. doi request reprint Nectins establish a checkerboard-like cellular pattern in the auditory epithelium
    Hideru Togashi
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Science 333:1144-7. 2011
    ..When cells expressing either nectin-1 or -3 were cocultured, they arranged themselves into a mosaic pattern. Thus, nectin-1 and -3 promote the formation of the checkerboard-like pattern of the auditory epithelia...
  21. doi request reprint Involvement of the γ-secretase-mediated EphA4 signaling pathway in synaptic pathogenesis of Alzheimer's disease
    Chiyuki Matsui
    KAN Research Institute, Kobe, Japan
    Brain Pathol 22:776-87. 2012
    ..These results suggest that attenuation of the EICD-mediated Rac signaling pathway is involved in the synaptic pathogenesis of AD...
  22. pmc Osteoblast-like differentiation of cultured human coronary artery smooth muscle cells by bone morphogenetic protein endothelial cell precursor-derived regulator (BMPER)
    Seimi Satomi-Kobayashi
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Kobe 650 0017, Japan
    J Biol Chem 287:30336-45. 2012
    ..These findings indicate that BMPER is a novel regulator of the osteoblast-like differentiation of HCASMCs...
  23. doi request reprint Interaction of integrin alpha(6)beta(4) with ErbB3 and implication in heregulin-induced ErbB3/ErbB2-mediated DNA synthesis
    Satoshi Kawano
    Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Hyogo, Japan
    Genes Cells 15:995-1001. 2010
    ..Here we show that integrin alpha(6)beta(4) interacts with ErbB3 but not with ErbB1, ErbB2 or ErbB4, and enhances the heregulin-induced, ErbB3/ErbB2 heterodimer-mediated DNA synthesis, but not cell motility, in A549 cells...
  24. pmc Cooperative role of nectin-nectin and nectin-afadin interactions in formation of nectin-based cell-cell adhesion
    Souichi Kurita
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650 0017, Japan
    J Biol Chem 286:36297-303. 2011
    ..Thus, the Necl-5-nectin, nectin-nectin, and nectin-afadin interactions cooperatively increase the clustering of the nectin-afadin complex at the cell-cell contact sites, promoting the formation of the nectin-based cell-cell adhesion...
  25. pmc Cell adhesion molecules nectins and associating proteins: Implications for physiology and pathology
    Hisakazu Ogita
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Hyogo, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 86:621-9. 2010
    ..Thus, nectins and Necls are crucial for physiology and pathology of multicellular organisms.(Communicated by Shigetada NAKANISHI, M.J.A.)...
  26. doi request reprint Immunoglobulin superfamily receptors and adherens junctions
    Yohei Shimono
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 650 0017, Kobe, Japan
    Subcell Biochem 60:137-70. 2012
    ..Furthermore, the Ig-CAMs are implicated in many human diseases including viral infections, ectodermal dysplasia, cancers, and Alzheimer's disease...
  27. doi request reprint Periderm cells covering palatal shelves have tight junctions and their desquamation reduces the polarity of palatal shelf epithelial cells in palatogenesis
    Midori Yoshida
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Genes Cells 17:455-72. 2012
    ..These results indicate that periderm cells covering growing palatal shelves have bona fide TJs and their desquamation reduces the polarity of palatal shelf epithelial cells in palatogenesis...
  28. ncbi request reprint miR-214 and hypoxia down-regulate Necl-2/CADM1 and enhance ErbB2/ErbB3 signaling
    Kenji Momose
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Genes Cells 18:195-202. 2013
    ..These results indicate that miR-214 and hypoxia are novel regulators that down-regulate Necl-2 and enhance ErbB2/ErbB3 signaling...
  29. pmc Silencing of ErbB3/ErbB2 signaling by immunoglobulin-like Necl-2
    Satoshi Kawano
    Division of Molecular and Cellular Biology, Department of Biochemistry, Kobe University Graduate School of Medicine, Kobe 650 0017, Hyogo, Japan
    J Biol Chem 284:23793-805. 2009
    ..These inhibitory effects of Necl-2 were mediated by the protein-tyrosine phosphatase PTPN13 which interacted with the cytoplasmic tail of Necl-2. We describe here this novel mechanism for silencing of the ErbB3/ErbB2 signaling by Necl-2...
  30. doi request reprint Afadin/AF-6 and canoe: roles in cell adhesion and beyond
    Kenji Mandai
    Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
    Prog Mol Biol Transl Sci 116:433-54. 2013
    ..Moreover, canoe regulates asymmetric cell division of Drosophila neuroblasts. Thus, afadin/AF-6 and canoe are pivotal regulatory elements in many fundamental signaling cascades in cells...
  31. doi request reprint The role of nectins in different types of cell-cell adhesion
    Yoshiyuki Rikitake
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Cell Sci 125:3713-22. 2012
    ..We summarize recent progress in our understanding of the biology of nectins and discuss their roles in heterotypic cell-cell adhesions, whose formation cannot be solely explained by the action of cadherins...
  32. doi request reprint Roles of Necl-5/poliovirus receptor and Rho-associated kinase (ROCK) in the regulation of transformation of integrin alpha(V)beta(3)-based focal complexes into focal adhesions
    Yuichi Nagamatsu
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    J Biol Chem 283:14532-41. 2008
    ....
  33. doi request reprint Absence of primary cilia in cell cycle-arrested human breast cancer cells
    Kentaro Nobutani
    Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 1 5 6 Minatojima minamimachi, Chuo Ku, Kobe, 650 0047, Japan Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Genes Cells 19:141-52. 2014
    ..These results indicate that the absence of primary cilia does not necessarily represent the proliferating phases of normal epithelial cells and cancer cells...
  34. pmc Cell adhesion molecules in the central nervous system
    Hideru Togashi
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Chuo Ku, Kobe, Japan
    Cell Adh Migr 3:29-35. 2009
    ..In this review, we describe the distribution and function of cell adhesion molecules at synapses and at contacts between synapses and astrocytes...
  35. pmc Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons
    Daisaku Toyoshima
    Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan CREST, Japan Science and Technology Agency, Kobe, Hyogo, Japan
    PLoS ONE 9:e89763. 2014
    ....
  36. doi request reprint Nectin and junctional adhesion molecule are critical cell adhesion molecules for the apico-basal alignment of adherens and tight junctions in epithelial cells
    Tomohiro Yamada
    KAN Research Institute, Inc, 6 7 3 Minatojima minamimachi, Chuo Ku, Kobe, 650 0047, Japan
    Genes Cells 18:985-98. 2013
    ..We describe the cooperative roles of these CAMs and CPMs in the apico-basal alignment of TJs and AJs in epithelial cells. ..
  37. pmc Dual regulation of RA-RhoGAP activity by phosphatidic acid and Rap1 during neurite outgrowth
    Takao Kurooka
    Division of Membrane Dynamics, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Biol Chem 286:6832-43. 2011
    ..These results indicate that PA and Rap1 cooperatively regulate RA-RhoGAP activity for promoting neurite outgrowth...
  38. doi request reprint Interaction of Necl-4/CADM4 with ErbB3 and integrin α6 β4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly
    Hirokazu Sugiyama
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Genes Cells 18:519-28. 2013
    ..These results indicate that Necl-4 serves as a tumor suppressor by inhibiting the ErbB2/ErbB3 signaling and hemidesmosome disassembly...
  39. doi request reprint Interaction and localization of Necl-5 and PDGF receptor beta at the leading edges of moving NIH3T3 cells: Implications for directional cell movement
    Hisayuki Amano
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Genes Cells 13:269-84. 2008
    ..These results indicate a key role of Necl-5 in directional cell movement by physically and functionally interacting with both integrin alpha(v)beta(3) and PDGF receptor...
  40. doi request reprint Hyaluronan-CD44 pathway regulates orientation of mitotic spindle in normal epithelial cells
    Takeshi Fujiwara
    KAN Research Institute, Inc, 6 7 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Hyogo, Japan
    Genes Cells 13:759-70. 2008
    ..We also found that microtubule dynamics is required for HMW HA-CD44 mediated regulation of mitotic spindle orientation. Our findings thus provide a novel mechanism for the regulation of mitotic spindle orientation...
  41. ncbi request reprint Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma
    Reiko Nakai
    Division of Thoracic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    Cancer Sci 101:1326-30. 2010
    ..These results indicate that Necl-5 plays a role in mediating tumor cell invasion and that the overexpression of Necl-5 in cancer cells has clinical significance for prognostic evaluation of patients with primary pulmonary adenocarcinoma...
  42. pmc Synaptic activity prompts gamma-secretase-mediated cleavage of EphA4 and dendritic spine formation
    Eiji Inoue
    KAN Research Institute, Kobe, Japan
    J Cell Biol 185:551-64. 2009
    ..These findings reveal a function for EphA4-mediated intracellular signaling in the morphogenesis of dendritic spines and suggest that the processing of EphA4 by gamma-secretase affects the pathogenesis of Alzheimer's disease...
  43. ncbi request reprint The roles of nectins in cell adhesions: cooperation with other cell adhesion molecules and growth factor receptors
    Toshiaki Sakisaka
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Osaka 565 0871, Japan
    Curr Opin Cell Biol 19:593-602. 2007
    ..Furthermore, nectin interacts in trans with nectin-like molecule-5 (Necl-5) and regulate cell movement and proliferation. We describe cooperative roles of nectins with other CAMs and growth factor receptors...
  44. doi request reprint Cross-talk among integrin, cadherin, and growth factor receptor: roles of nectin and nectin-like molecule
    Hisakazu Ogita
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Osaka 565 0871, Japan
    Int Rev Cytol 265:1-54. 2008
    ....
  45. ncbi request reprint Nectins and nectin-like molecules: roles in cell adhesion, polarization, movement, and proliferation
    Hisakazu Ogita
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Osaka, Japan
    IUBMB Life 58:334-43. 2006
    ..Thus, both nectin and Necl family members play important roles in fundamental cellular functions, including cell adhesion, polarization, movement, and proliferation...
  46. pmc Inhibition of cell movement and proliferation by cell-cell contact-induced interaction of Necl-5 with nectin-3
    Tsutomu Fujito
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Osaka, Japan
    J Cell Biol 171:165-73. 2005
    ..These results indicate that the down-regulation of Necl-5 induced by its interaction with nectin-3 upon cell-cell contacts may be at least one mechanism underlying contact inhibition of cell movement and proliferation...
  47. ncbi request reprint Common signaling pathway is used by the trans-interaction of Necl-5/Tage4/PVR/CD155 and nectin, and of nectin and nectin during the formation of cell-cell adhesion
    Tatsuhiro Sato
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine, Faculty of Medicine, Suita 565 0871, Japan
    Cancer Sci 96:578-89. 2005
    ..These results indicate that the trans-interactions of Necl-5 and nectin-3 and of nectin and nectin induce the activation of Cdc42 and Rac through the common signaling molecules c-Src, Rap1, FRG, and Vav2...
  48. ncbi request reprint Tage4/Nectin-like molecule-5 heterophilically trans-interacts with cell adhesion molecule Nectin-3 and enhances cell migration
    Wataru Ikeda
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    J Biol Chem 278:28167-72. 2003
    ..Thus, Tage4 heterophilically trans-interacts with nectin-3 and regulates cell migration. Tage4 is tentatively re-named here nectin-like molecule-5 (necl-5) on the basis of its function and domain structure similar to those of nectins...
  49. ncbi request reprint Nectins and nectin-like molecules: roles in cell adhesion, migration, and polarization
    Yoshimi Takai
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    Cancer Sci 94:655-67. 2003
    ..In this article, the roles and modes of action of nectins and necls in cell adhesion, migration, and polarization are reviewed...
  50. ncbi request reprint Nectin-like molecule-5/Tage4 enhances cell migration in an integrin-dependent, Nectin-3-independent manner
    Wataru Ikeda
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Osaka, Japan
    J Biol Chem 279:18015-25. 2004
    ..We furthermore show here that enhanced motility and metastasis of V12Ras-NIH3T3 cells are at least partly the result of up-regulated Necl-5...
  51. ncbi request reprint Involvement of heterophilic trans-interaction of Necl-5/Tage4/PVR/CD155 with nectin-3 in formation of nectin- and cadherin-based adherens junctions
    Tatsuhiro Sato
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    Genes Cells 9:791-9. 2004
    ..These results indicate that Necl-5 plays roles not only in cell motility and proliferation but also in cell-cell adhesion in cooperation with nectin-3...
  52. ncbi request reprint Biology and pathology of nectins and nectin-like molecules
    Toshiaki Sakisaka
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Osaka 565 0871, Japan
    Curr Opin Cell Biol 16:513-21. 2004
    ..On the other hand, nectins and Necls serve as viral receptors and are associated with human diseases (including cancer) when mutated or upregulated...
  53. ncbi request reprint Roles of nectins in cell adhesion, migration and polarization
    Hiroyuki Nakanishi
    Department of Molecular Pharmacology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860 8556, Japan
    Biol Chem 385:885-92. 2004
    ..Through these activities, nectins regulate a variety of cellular functions, including adhesion, migration, and polarization. Here we describe these activities and functions of nectins...
  54. doi request reprint Novel role of nectin: implication in the co-localization of JAM-A and claudin-1 at the same cell-cell adhesion membrane domain
    Kaori Kuramitsu
    Department of Molecular Biology and Biochemistry, Osaka Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Osaka, Japan
    Genes Cells 13:797-805. 2008
    ..Nectin-3 required afadin, a nectin- and F-actin-binding protein, for this ability. In conclusion, nectin plays a novel role in the co-localization of JAM and claudin at the same CAMD...
  55. doi request reprint Structural and functional associations of apical junctions with cytoskeleton
    Jun Miyoshi
    Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Biochim Biophys Acta 1778:670-91. 2008
    ..Here we describe how subcellular protein interactions are coordinated to induce changes in actin organization and dynamics, in response to the status of apical junctions...
  56. pmc Alternative entry receptors for herpes simplex virus and their roles in disease
    Joann M Taylor
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Cell Host Microbe 2:19-28. 2007
    ..This study illustrates the value of mutant mice for understanding receptor contributions to disease caused by a human virus...
  57. pmc Nectin: an adhesion molecule involved in formation of synapses
    Akira Mizoguchi
    Department of Anatomy and Neurobiology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Cell Biol 156:555-65. 2002
    ..These results indicate an important role of the nectin-afadin system in the formation of synapses...
  58. ncbi request reprint Involvement of nectin in the localization of IQGAP1 at the cell-cell adhesion sites through the actin cytoskeleton in Madin-Darby canine kidney cells
    Tatsuo Katata
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Japan
    Oncogene 22:2097-109. 2003
    ..These results indicate that nectin is involved in the localization of IQGAP1 at AJs through the actin cytoskeleton...
  59. ncbi request reprint Cdc42 and Rac small G proteins activated by trans-interactions of nectins are involved in activation of c-Jun N-terminal kinase, but not in association of nectins and cadherin to form adherens junctions, in fibroblasts
    Tomoyuki Honda
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Osaka University, Suita 565 0871, Japan
    Genes Cells 8:481-91. 2003
    ..We studied the roles of Cdc42 and Rac activated in this way in L fibroblasts stably expressing both nectin-1 and E-cadherin (nectin-1-EL cells)...
  60. ncbi request reprint Regulation by nectin of the velocity of the formation of adherens junctions and tight junctions
    Tomoyuki Honda
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Osaka University, 565 0871, Suita, Japan
    Biochem Biophys Res Commun 306:104-9. 2003
    ..These results indicate that nectins regulate the velocity of the formation of the E-cadherin-based AJs and the subsequent formation of the claudin-based TJs...
  61. ncbi request reprint Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells
    Tatsushi Shingai
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Osaka, Japan
    J Biol Chem 278:35421-7. 2003
    ..These results indicate the unique localization of Necl-2 and its possible involvement in localization of a transmembrane protein(s) through Pals2...
  62. ncbi request reprint Involvement of nectin-activated Cdc42 small G protein in organization of adherens and tight junctions in Madin-Darby canine kidney cells
    Atsunori Fukuhara
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    J Biol Chem 278:51885-93. 2003
    ..These results indicate that the Cdc42 activated by the trans-interactions of nectins is involved in the organization of AJs and TJs in different mechanisms in MDCK cells...
  63. ncbi request reprint Roles of the intercellular adhesion molecule nectin in intracellular signaling
    Kazuya Shimizu
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871
    J Biochem 134:631-6. 2003
    ..We describe here the roles of nectin in intracellular signaling...
  64. pmc A novel role of nectins in inhibition of the E-cadherin-induced activation of Rac and formation of cell-cell adherens junctions
    Takashi Hoshino
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    Mol Biol Cell 15:1077-88. 2004
    ..These results indicate a novel role of nectins in regulation of the E-cadherin-induced activation of Rac and formation of cell-cell AJs...
  65. ncbi request reprint Nectin-dependent localization of synaptic scaffolding molecule (S-SCAM) at the puncta adherentia junctions formed between the mossy fibre terminals and the dendrites of pyramidal cells in the CA3 area of the mouse hippocampus
    Akio Yamada
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    Genes Cells 8:985-94. 2003
    ..S-SCAM has been suggested to be a component of PSDs, but its precise localization at the synapses remains unknown...
  66. ncbi request reprint Evidence that tubulobulbar complexes in the seminiferous epithelium are involved with internalization of adhesion junctions
    Julian A Guttman
    Department of Anatomy and Cell Biology, Faculty of Medicine, The University of British Columbia, 313 2177 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 1Z3
    Biol Reprod 71:548-59. 2004
    ..Our results are consistent with the conclusion that tubulobulbar complexes are involved with the disassembly of ectoplasmic specializations and with the internalization of intercellular membrane adhesion domains during sperm release...
  67. ncbi request reprint [Role of the nectin-afadin system in organization of tight and adherens junctions in epithelial cells]
    Tatsuo Katata
    Tanpakushitsu Kakusan Koso 48:105-12. 2003
  68. ncbi request reprint Role of each immunoglobulin-like loop of nectin for its cell-cell adhesion activity
    Masato Yasumi
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Osaka, Japan
    Biochem Biophys Res Commun 302:61-6. 2003
    ....
  69. ncbi request reprint Restoration of E-cadherin-based cell-cell adhesion by overexpression of nectin in HSC-39 cells, a human signet ring cell gastric cancer cell line
    Ying Feng Peng
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    Oncogene 21:4108-19. 2002
    ..These results suggest that an unidentified mechanism, by which nectin and E-cadherin form the actin cytoskeleton-associated adherens junctions to form strong cell-cell adhesion, is impaired in HSC-39 cells...
  70. ncbi request reprint Role of the second immunoglobulin-like loop of nectin in cell-cell adhesion
    Yumiko Momose
    Department of Molecular Biology and Biochemistry, Faculty of Medicine, Osaka University Graduate School of Medicine, Suita 565 0871, Japan
    Biochem Biophys Res Commun 293:45-9. 2002
    ..We show here that the second Ig-like loop is essential for the cis-dimer formation of nectin on the same cell, and that the cis-dimer formation is essential for the trans-dimer formation...
  71. ncbi request reprint Nectin couples cell-cell adhesion and the actin scaffold at heterotypic testicular junctions
    Kumi Ozaki-Kuroda
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, 2 2 Yamada oka, Japan
    Curr Biol 12:1145-50. 2002
    ..These results indicate that the nectin-afadin system plays essential roles in coupling cell-cell adhesion and the cortical actin scaffold at SspJs and in subsequent sperm morphogenesis...
  72. ncbi request reprint Role of nectin in organization of tight junctions in epithelial cells
    Atsunori Fukuhara
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    Genes Cells 7:1059-72. 2002
    ..We show here that nectin is also involved in the formation of TJs...
  73. ncbi request reprint Trans-interactions of nectins induce formation of filopodia and Lamellipodia through the respective activation of Cdc42 and Rac small G proteins
    Tomomi Kawakatsu
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    J Biol Chem 277:50749-55. 2002
    ..These effects of nectins require their cytoplasmic tail but not their association with afadin. We propose here the functional relationship between nectins and the small G proteins in the organization of AJs...
  74. ncbi request reprint Involvement of nectin in the localization of junctional adhesion molecule at tight junctions
    Atsunori Fukuhara
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    Oncogene 21:7642-55. 2002
    ..These results suggest that nectin has a role in the localization of JAM at TJs in the process of the formation of the junctional complex in epithelial cells...
  75. ncbi request reprint Ectodomain shedding of nectin-1alpha by SF/HGF and TPA in MDCK cells
    Yoshinari Tanaka
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Japan
    Biochem Biophys Res Commun 299:472-8. 2002
    ....
  76. ncbi request reprint Nectin and afadin: novel organizers of intercellular junctions
    Yoshimi Takai
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    J Cell Sci 116:17-27. 2003
    ..The adhesion system is furthermore involved in the formation of synapses in neurons and the organization of heterotypic junctions between Sertoli cells and spermatids in the testis...
  77. ncbi request reprint Antagonistic and agonistic effects of an extracellular fragment of nectin on formation of E-cadherin-based cell-cell adhesion
    Tomoyuki Honda
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    Genes Cells 8:51-63. 2003
    ..To obtain evidence for this role of nectin, we attempted to develop an antagonist and/or agonist of nectin...
  78. ncbi request reprint Expression patterns of nectins and afadin during epithelial remodeling in the mouse embryo
    Noriko Okabe
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Osaka, Japan
    Dev Dyn 230:174-86. 2004
    ..These results suggest that nectins and afadin are involved in dynamic epithelial remodeling during mouse development...
  79. ncbi request reprint Involvement of LMO7 in the association of two cell-cell adhesion molecules, nectin and E-cadherin, through afadin and alpha-actinin in epithelial cells
    Takako Ooshio
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, 2 2 Yamada Oka Suita, Osaka 565 0871, USA
    J Biol Chem 279:31365-73. 2004
    ..These results indicate that LMO7 is an afadin- and alpha-actinin-binding protein that connects the nectin-afadin and E-cadherin-catenin systems through alpha-actinin...
  80. ncbi request reprint Regulation of the assembly and adhesion activity of E-cadherin by nectin and afadin for the formation of adherens junctions in Madin-Darby canine kidney cells
    Tatsuhiro Sato
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Osaka 565 0871, Japan
    J Biol Chem 281:5288-99. 2006
    ..Thus, nectin regulates the assembly and cell-cell adhesion activity of E-cadherin through afadin, nectin signaling, and p120(ctn) for the formation of AJs in Madin-Darby canine kidney cells...
  81. ncbi request reprint Involvement of the Ras-Ras-activated Rab5 guanine nucleotide exchange factor RIN2-Rab5 pathway in the hepatocyte growth factor-induced endocytosis of E-cadherin
    Toshihiro Kimura
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Osaka, Japan
    J Biol Chem 281:10598-609. 2006
    ..These results indicate that RIN2 connects Ras to Rab5 in the HGF-induced endocytosis of E-cadherin...
  82. ncbi request reprint Interaction of integrin alpha(v)beta3 with nectin. Implication in cross-talk between cell-matrix and cell-cell junctions
    Yasuhisa Sakamoto
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Osaka 565 0871, Japan
    J Biol Chem 281:19631-44. 2006
    ..Thus, integrin alpha(v)beta3 and nectin play pivotal roles in the cross-talk between cell-matrix and cell-cell junctions and the formation of cadherin-based AJs...
  83. ncbi request reprint [Role of nectins and nectin-like molecules in cell adhesion--a lesson on cell biology from the late Dr. Shoichiro Tsukita]
    Yoshimi Takai
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, 2 2 Yamada oka, Suita 565 0871, Japan
    Seikagaku 78:631-46. 2006
  84. ncbi request reprint Involvement of up-regulated Necl-5/Tage4/PVR/CD155 in the loss of contact inhibition in transformed NIH3T3 cells
    Yukiko Minami
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Osaka, Japan
    Biochem Biophys Res Commun 352:856-60. 2007
    ..In addition, expression of the gene encoding nectin-3 is markedly reduced in transformed cells. Thus, up-regulation of Necl-5 following transformation contributes to the loss of contact inhibition in transformed cells...
  85. ncbi request reprint Role of multiple bonds between the single cell adhesion molecules, nectin and cadherin, revealed by high sensitive force measurements
    Yoshikazu Tsukasaki
    Department of Nanobiology, Graduate School of Frontier Biosciences, Osaka University, 1 3, Yamadaoka, Suita, Osaka 565 0871, Japan
    J Mol Biol 367:996-1006. 2007
    ....
  86. ncbi request reprint Regulation of platelet-derived growth factor-induced Ras signaling by poliovirus receptor Necl-5 and negative growth regulator Sprouty2
    Mihoko Kajita
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Osaka 565 0871, Japan
    Genes Cells 12:345-57. 2007
    ..Thus, Necl-5 and Sprouty2 cooperatively regulate PDGF-induced Ras signaling. The roles of Necl-5 and Sprouty2 in contact inhibition for cell proliferation are also discussed...
  87. ncbi request reprint Necl-5/poliovirus receptor interacts in cis with integrin alphaVbeta3 and regulates its clustering and focal complex formation
    Yukiko Minami
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Osaka, Japan
    J Biol Chem 282:18481-96. 2007
    ..Thus, Necl-5 has a critical role in integrin alphavbeta3 clustering and focal complex formation...
  88. ncbi request reprint Nectin and nectin-like molecules: biology and pathology
    Jun Miyoshi
    Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Am J Nephrol 27:590-604. 2007
    ..Here we summarize our knowledge of nectins and Necls and discuss cell adhesion biology in the kidney...
  89. ncbi request reprint Migrating postmitotic neural precursor cells in the ventricular zone extend apical processes and form adherens junctions near the ventricle in the developing spinal cord
    Yasuko Minaki
    KAN Research Institute Inc Science Center Build 3, Kyoto Research Park, 93 Chudoji Awata cho, Shimogyo ku, Kyoto 600 8815, Japan
    Neurosci Res 52:250-62. 2005
    ....
  90. ncbi request reprint Recruitment of E-cadherin associated with alpha- and beta-catenins and p120ctn to the nectin-based cell-cell adhesion sites by the action of 12-O-tetradecanoylphorbol-13-acetate in MDCK cells
    Ryoko Okamoto
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    Genes Cells 10:435-45. 2005
    ....
  91. ncbi request reprint Requirement of the actin cytoskeleton for the association of nectins with other cell adhesion molecules at adherens and tight junctions in MDCK cells
    Akio Yamada
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    Genes Cells 9:843-55. 2004
    ..These results indicate that the actin cytoskeleton is required for the association of the nectin-afadin unit with other CAMs and PMPs at AJs and TJs...
  92. ncbi request reprint Vav2 as a Rac-GDP/GTP exchange factor responsible for the nectin-induced, c-Src- and Cdc42-mediated activation of Rac
    Tomomi Kawakatsu
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Osaka 565 0871, Japan
    J Biol Chem 280:4940-7. 2005
    ..Cdc42 activated through c-Src then enhanced the GEF activity of tyrosine-phosphorylated Vav2 on Rac1. These results indicate that Vav2 is a GEF responsible for the nectin-induced, c-Src-, and Cdc42-mediated activation of Rac...
  93. ncbi request reprint Involvement of the c-Src-Crk-C3G-Rap1 signaling in the nectin-induced activation of Cdc42 and formation of adherens junctions
    Taihei Fukuyama
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Biol Chem 280:815-25. 2005
    ..These results indicate that Rap1 is activated by nectins through the c-Src-Crk-C3G signaling and involved in the nectin-induced, c-Src- and FRG-mediated activation of Cdc42 and formation of AJs...
  94. ncbi request reprint Separation force measurements reveal different types of modulation of E-cadherin-based adhesion by nectin-1 and -3
    Clara Martinez-Rico
    UMR 144 CNRS Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    J Biol Chem 280:4753-60. 2005
    ....
  95. ncbi request reprint Roles and modes of action of nectins in cell-cell adhesion
    Kenji Irie
    Department of Molecular Biology and Biochemistry, Faculty of Medicine, Osaka University Graduate School of Medicine, Suita 565 0871, Japan
    Semin Cell Dev Biol 15:643-56. 2004
    ..We describe here the roles and modes of action of nectins as CAMs...
  96. ncbi request reprint Involvement of the annexin II-S100A10 complex in the formation of E-cadherin-based adherens junctions in Madin-Darby canine kidney cells
    Akio Yamada
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    J Biol Chem 280:6016-27. 2005
    ..Knockdown of annexin II by RNA interference also inhibited the re-concentration of E-cadherin. These results indicate that the annexin II-S100A10 complex is involved in the formation of the E-cadherin-based AJs in MDCK cells...
  97. ncbi request reprint Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development
    Maiko Inagaki
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    Development 132:1525-37. 2005
    ....
  98. ncbi request reprint [Small G proteins--their roles and functions on cell-cell junction]
    Taihei Fukuyama
    Nihon Ronen Igakkai Zasshi 42:9-14. 2005
  99. ncbi request reprint Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes
    Shigeki Kakunaga
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Osaka, Japan
    J Cell Sci 118:1267-77. 2005
    ....
  100. ncbi request reprint Involvement of nectin in inactivation of integrin alpha(v)beta(3) after the establishment of cell-cell adhesion
    Yasuhisa Sakamoto
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Osaka 565 0871, Japan
    J Biol Chem 283:496-505. 2008
    ..Therefore, the trans-interaction of nectin essentially functions in the inactivation of integrin at AJs through the PTPmu-induced inactivation of PIPKIgamma...