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Genomes and Genes | Reiko SugiuraSummaryAffiliation: Kobe University Country: Japan Publications
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Publications
Feedback regulation of MAPK signalling by an RNA-binding proteinReiko Sugiura
Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
Nature 424:961-5. 2003..Our findings--the post-transcriptional mRNA stabilization of a MAPK phosphatase mediated by an RNA-binding protein--provide an additional regulatory mechanism for fine-tuning of MAPK signalling pathways...- Upregulation of mRNA in MAPK signaling: transcriptional activation or mRNA stabilization?Reiko Sugiura
Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe, Japan
Cell Cycle 3:286-8. 2004..Our discovery highlights a potential role and an emerging view of RNA-binding protein as a regulator of cell signaling and as a future target of drug discovery... - The role of the regulatory subunit of fission yeast calcineurin for in vivo activity and its relevance to FK506 sensitivitySusie O Sio
Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Graduate School of Medicine, Kobe University, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
J Biol Chem 280:12231-8. 2005..These results suggest that Cnb1 is essential for the activation of calcineurin and that the activated calcineurin is the pharmacological target of the FKBP12-FK506 complex in vivo... 
Real-time monitoring of calcineurin activity in living cells: evidence for two distinct Ca2+-dependent pathways in fission yeastLu Deng
Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
Mol Biol Cell 17:4790-800. 2006....- Transient receptor potential (TRP) and Cch1-Yam8 channels play key roles in the regulation of cytoplasmic Ca2+ in fission yeastYan Ma
Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
PLoS ONE 6:e22421. 2011..These results suggest that Pmk1 MAPK and calcineurin positively and negatively regulate the Cch1-Yam8 complex, respectively, via modulating the balance between phosphorylation and dyphosphorylation state... - Genetic and functional interaction between Ryh1 and Ypt3: two Rab GTPases that function in S. pombe secretory pathwayYi He
Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
Genes Cells 11:207-21. 2006..These results suggest that Ryh1 is involved in the secretory pathway and may have a potential overlapping function with Ypt3 in addition to its role in recycling... 
Isolation of a fission yeast mutant that is sensitive to valproic acid and defective in the gene encoding Ric1, a putative component of Ypt/Rab-specific GEF for Ryh1 GTPaseYan Ma
Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
Mol Genet Genomics 284:161-71. 2010..In conclusion, Ric1 is a putative component of GEF for Ryh1 and might be regulated by Vps15. Further studies are needed to reveal the mechanism underlying the regulation...- Loss of Apm1, the micro1 subunit of the clathrin-associated adaptor-protein-1 complex, causes distinct phenotypes and synthetic lethality with calcineurin deletion in fission yeastAyako Kita
Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
Mol Biol Cell 15:2920-31. 2004.... - Cation diffusion facilitator Cis4 is implicated in Golgi membrane trafficking via regulating zinc homeostasis in fission yeastYue Fang
Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
Mol Biol Cell 19:1295-303. 2008..These results suggest that Cis4 forms a heteromeric functional complex with Zrg17 and that Cis4 is implicated in Golgi membrane trafficking through the regulation of zinc homeostasis in fission yeast... - Zinc finger protein Prz1 regulates Ca2+ but not Cl- homeostasis in fission yeast. Identification of distinct branches of calcineurin signaling pathway in fission yeastSonoko Hirayama
Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
J Biol Chem 278:18078-84. 2003..Our results suggest that calcineurin activates at least two distinct signaling branches, i.e. the Prz1-dependent transcriptional regulation and an unknown mechanism, which functions antagonistically with the Pmk1 MAPK pathway... - Deletion mutants of AP-1 adaptin subunits display distinct phenotypes in fission yeastYan Ma
Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
Genes Cells 14:1015-28. 2009..Altogether, results suggest that the four subunits are all essential for the heterotetrameric complex formation and for the AP-1 function in exit transport from endosomes... - Rho2 is a target of the farnesyltransferase Cpp1 and acts upstream of Pmk1 mitogen-activated protein kinase signaling in fission yeastYan Ma
Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
Mol Biol Cell 17:5028-37. 2006..Together, our results demonstrate that Cpp1 is a key component of the Pck2-Pmk1 signaling through the spatial control of the small GTPase Rho2... - Studies on the roles of clathrin-mediated membrane trafficking and zinc transporter Cis4 in the transport of GPI-anchored proteins in fission yeastWurentuya Jaiseng
Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
PLoS ONE 7:e41946. 2012.... - Phosphatidylinositol-4-phosphate 5-kinase regulates fission yeast cell integrity through a phospholipase C-mediated protein kinase C-independent pathwayLu Deng
Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
J Biol Chem 280:27561-8. 2005..These findings suggest that Its3 PIP5K regulates cell integrity through a Plc1-mediated PKC-independent pathway, in addition to the Rho/PKC pathway... - Genetic evidence for phospholipid-mediated regulation of the Rab GDP-dissociation inhibitor in fission yeastYan Ma
Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Hyogo, Japan
Genetics 174:1259-71. 2006..Together, our findings suggest that Spo20 modulates Gdi1 function via regulation of phospholipid metabolism of the membranes... - Valproic acid affects membrane trafficking and cell-wall integrity in fission yeastMakoto Miyatake
Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe, Hyogo 650 0017, Japan
Genetics 175:1695-705. 2007..Altogether, our results suggest that VPA affects membrane trafficking, which leads to the enhanced sensitivity to cell-wall damage in fission yeast... - Pleiotropic phenotypes caused by an opal nonsense mutation in an essential gene encoding HMG-CoA reductase in fission yeastYue Fang
Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
Genes Cells 14:759-71. 2009..These data suggest that the pleiotropic phenotypes reflect the integrated effects of the reduced availability of ergosterol and various intermediates of the mevalonate pathway... - MAP kinase kinase kinase (MAPKKK)-dependent and -independent activation of Sty1 stress MAPK in fission yeastXin Zhou
Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kusunoki cho 6 5 1, Chuo Ku, Kobe 650 0017, Japan
J Biol Chem 285:32818-23. 2010..On the other hand, knockout of tyrosine phosphatase gene pyp1(+) abolished the Atf1 response to cadmium and LG, but not to osmotic stress, suggesting that Pyp1 is a sensor for cadmium and LG... - Role of the Rab GTP-binding protein Ypt3 in the fission yeast exocytic pathway and its connection to calcineurin functionHong Cheng
Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Japan
Mol Biol Cell 13:2963-76. 2002..These results suggest that Ypt3 is required at multiple steps of the exocytic pathway and its mutation affects diverse cellular processes and that calcineurin is functionally connected to these cellular processes... - Wobble inosine tRNA modification is essential to cell cycle progression in G(1)/S and G(2)/M transitions in fission yeastSatoshi Tsutsumi
Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Graduate School of Medicine, Kobe University, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
J Biol Chem 282:33459-65. 2007..These results suggest that the wobble inosine tRNA modification is essential for cell cycle progression in the G(1)/S and G(2)/M transitions in fission yeast... - Six new amino acid-auxotrophic markers for targeted gene integration and disruption in fission yeastYan Ma
Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650 0017, Japan
Curr Genet 52:97-105. 2007..17c (named cys2 (+)). The cys2 mutation required cysteine rather than methionine. These new tools, specifically, new selectable markers, will be useful in further genetic and biological studies in fission yeast... - Genetic screening for regulators of Prz1, a transcriptional factor acting downstream of calcineurin in fission yeastAtsushi Koike
Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kusunoki cho 6 5 1, Chuo Ku, Kobe 650 0017, Japan
J Biol Chem 287:19294-303. 2012..In summary, our data suggest that Rad24 and Rad25 negatively regulate Prz1 and that Pka1, Msn5, Pac1, Tfs1, and Ape2 also regulate Prz1... - Pmr1, a P-type ATPase, and Pdt1, an Nramp homologue, cooperatively regulate cell morphogenesis in fission yeast: the importance of Mn2+ homeostasisTakuya Maeda
Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
Genes Cells 9:71-82. 2004..These results suggest that Pmr1 and Pdt1 cooperatively regulate cell morphogenesis through the control of Mn2+ homeostasis, and that calcineurin functions as a Mn2+ sensor as well as a Mn2+ homeostasis regulator... - Calcineurin is implicated in the regulation of the septation initiation network in fission yeastYabin Lu
Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
Genes Cells 7:1009-19. 2002..In fission yeast, calcineurin has been implicated in cytokinesis because calcineurin-deleted cells form multiple septa and cell separation is impeded. However, this mechanism remains unclear... - Isolation of a fission yeast mutant cell affected in MAP kinase signaling and sterol biosynthesisKiwamu Imagawa
Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
Kobe J Med Sci 55:E30-5. 2009.... - Lub1 participates in ubiquitin homeostasis and stress response via maintenance of cellular ubiquitin contents in fission yeastYasunari Ogiso
Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
Mol Cell Biol 24:2324-31. 2004..Our results indicated that Lub1 is responsible for ubiquitin homeostasis at the protein level through a negative regulation of ubiquitin degradation... - Genetic interaction between calcineurin and type 2 myosin and their involvement in the regulation of cytokinesis and chloride ion homeostasis in fission yeastMasaaki Fujita
Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
Genetics 161:971-81. 2002..These results indicate that calcineurin is involved in the regulation of cytokinesis and that chloride ion homeostasis is mediated by type 2 myosin... - Calcineurin phosphatase in signal transduction: lessons from fission yeastReiko Sugiura
Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan
Genes Cells 7:619-27. 2002..These findings highlight the potential of fission yeast genetic studies to elucidate conserved elements of signal transduction cascades... - Studies on fungal Pumilio gene family through mining multiple genome-scale data setsYutaka Matsushima
Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
Kobe J Med Sci 53:163-9. 2007..Evolution and function of these genes can be expected from the analysis based on the molecular phylogenies... - [Yeast as a model system for drug discovery]Hisato Shuntoh
Nippon Yakurigaku Zasshi 125:213-8. 2005 - [Functional analysis of calcineurin-mediated signalling pathway using fission yeast as a model system]Reiko Sugiura
Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe City 650-0017, Japan
Nippon Yakurigaku Zasshi 119:155-61. 2002..Possible roles of these gene products in cellular functions in relation to calcineurin are discussed... - Comparison of toxicity and toxicokinetics/pharmacokinetics of an alpha 1L-adrenoceptor agonist in rats and rhesus monkeysTakehisa Matsumaru
Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Hyogo, Japan
J Pharmacol Sci 97:273-83. 2005.... - Atf1 is a target of the mitogen-activated protein kinase Pmk1 and regulates cell integrity in fission yeastHirofumi Takada
Laboratory of Molecular Pharmacogenomics, School of Pharmaceutical Sciences, Kinki University, Higashi Osaka, 577 8502, Japan
Mol Biol Cell 18:4794-802. 2007..Together, our results suggest that PP2C is involved in a negative feedback loop of the Pmk1 signaling, and results also demonstrate that Atf1 is a key component of the cell integrity signaling downstream of Pmk1 MAPK... - Essential roles of class E Vps proteins for sorting into multivesicular bodies in Schizosaccharomyces pombeTomoko Iwaki
Department of Life Sciences, Faculty of Agriculture, Kagawa University, Kagawa 761 0795, Japan
Microbiology 153:2753-64. 2007..Phenotypic analyses suggested that Sst2p is a class E Vps protein. Taken together, these results suggest that sorting into multivesicular bodies is dependent on class E Vps proteins, including Sst2p, in Sch. pombe... - [Cell regulation through calcineurin signalling]Reiko Sugiura
Kinki University School of Pharmaceutical Sciences, Laboratory of Molecular Pharmacogenomics, 3-4-1 Koawake, Higashi-Osaka 577-8502, Japan
Seikagaku 77:1291-8. 2005