Yoshihiro Nishimura

Summary

Affiliation: Kobe University
Country: Japan

Publications

  1. ncbi request reprint Bronchial hyperresponsiveness and exhaled nitric oxide in patients with cardiac disease
    Y Nishimura
    First Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    Respiration 68:41-5. 2001
  2. ncbi request reprint Effect of continuous positive airway pressure on soluble CD40 ligand in patients with obstructive sleep apnea syndrome
    Kazuyuki Kobayashi
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Chest 129:632-7. 2006
  3. ncbi request reprint Inhalation of urokinase-type plasminogen activator reduces airway remodeling in a murine asthma model
    Emi Kuramoto
    Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
    Am J Physiol Lung Cell Mol Physiol 296:L337-46. 2009
  4. doi request reprint Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model
    Teruaki Nishiuma
    Division of Respiratory Medicine, Deptartment of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Am J Physiol Lung Cell Mol Physiol 294:L1085-93. 2008
  5. doi request reprint Non-small cell carcinoma: comparison of postoperative intra- and extrathoracic recurrence assessment capability of qualitatively and/or quantitatively assessed FDG-PET/CT and standard radiological examinations
    Yumiko Onishi
    Department of Radiology, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Hyogo, Japan
    Eur J Radiol 79:473-9. 2011
  6. pmc Antigen-Specific IgG ameliorates allergic airway inflammation via Fcγ receptor IIB on dendritic cells
    Yumiko Ishikawa
    Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Respir Res 12:42. 2011
  7. doi request reprint Comparison of capability of dynamic O₂-enhanced MRI and quantitative thin-section MDCT to assess COPD in smokers
    Yoshiharu Ohno
    Department of Radiology, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe, Hyogo 650 0017, Japan
    Eur J Radiol 81:1068-75. 2012
  8. doi request reprint Rad9 is upregulated and plays protective roles in an acute lung injury model
    Masatsugu Yamamoto
    Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunokicho, Chuo Ku, Kobe, Hyogo 650 0017, Japan
    Biochem Biophys Res Commun 376:590-4. 2008
  9. ncbi request reprint Thin-section multiplanar reformats from multidetector-row CT data: utility for assessment of regional tumor extent in non-small cell lung cancer
    Takanori Higashino
    Department of Radiology, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe, Hyogo 650 0017, Japan
    Eur J Radiol 56:48-55. 2005
  10. doi request reprint Dynamic MRI, dynamic multidetector-row computed tomography (MDCT), and coregistered 2-[fluorine-18]-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET)/CT: comparative study of capability for management of pulmonary nodules
    Yoshiharu Ohno
    Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan
    J Magn Reson Imaging 27:1284-95. 2008

Detail Information

Publications73

  1. ncbi request reprint Bronchial hyperresponsiveness and exhaled nitric oxide in patients with cardiac disease
    Y Nishimura
    First Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    Respiration 68:41-5. 2001
    ..In various cardiac diseases, bronchial hyperresponsiveness is observed, as is bronchial asthma. However, there have been few studies on the relationship between exhaled NO and bronchial responsiveness in cardiac diseases...
  2. ncbi request reprint Effect of continuous positive airway pressure on soluble CD40 ligand in patients with obstructive sleep apnea syndrome
    Kazuyuki Kobayashi
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Chest 129:632-7. 2006
    ..The present study examines whether CD40 ligation contributes to outcomes in patients with OSAS...
  3. ncbi request reprint Inhalation of urokinase-type plasminogen activator reduces airway remodeling in a murine asthma model
    Emi Kuramoto
    Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
    Am J Physiol Lung Cell Mol Physiol 296:L337-46. 2009
    ..The administration of uPA 1 wk after the last OVA inhalation also significantly reduced lung hydroxyproline content and AHR. These results show that enhancing uPA/plasmin activity lessens the airway remodeling in a murine asthma model...
  4. doi request reprint Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model
    Teruaki Nishiuma
    Division of Respiratory Medicine, Deptartment of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Am J Physiol Lung Cell Mol Physiol 294:L1085-93. 2008
    ..These data suggest that the inhibition of SPHK affected acute eosinophilic inflammation induced in antigen-challenged mouse model and that targeting SPHK may provide a novel therapeutic tool to treat bronchial asthma...
  5. doi request reprint Non-small cell carcinoma: comparison of postoperative intra- and extrathoracic recurrence assessment capability of qualitatively and/or quantitatively assessed FDG-PET/CT and standard radiological examinations
    Yumiko Onishi
    Department of Radiology, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Hyogo, Japan
    Eur J Radiol 79:473-9. 2011
    ....
  6. pmc Antigen-Specific IgG ameliorates allergic airway inflammation via Fcγ receptor IIB on dendritic cells
    Yumiko Ishikawa
    Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Respir Res 12:42. 2011
    ..The purpose of this study is to clarify the role of inhibitory FcRs and antigen presenting cells (APCs) in pathogenesis of asthma and to evaluate antigen-transporting and presenting capacity by APCs in the tracheobronchial mucosa...
  7. doi request reprint Comparison of capability of dynamic O₂-enhanced MRI and quantitative thin-section MDCT to assess COPD in smokers
    Yoshiharu Ohno
    Department of Radiology, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe, Hyogo 650 0017, Japan
    Eur J Radiol 81:1068-75. 2012
    ..The purpose of this study was to directly and prospectively compare the capability of dynamic O(2)-enhanced MRI and quantitatively assessed thin-section MDCT to assess smokers' COPD in a large prospective cohort...
  8. doi request reprint Rad9 is upregulated and plays protective roles in an acute lung injury model
    Masatsugu Yamamoto
    Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunokicho, Chuo Ku, Kobe, Hyogo 650 0017, Japan
    Biochem Biophys Res Commun 376:590-4. 2008
    ..In conclusion, Rad9 is a signal in the earlier stage of epithelial cell cycle regulation and plays protective roles in alveolar epithelial cells in the pathogenesis of acute lung injury...
  9. ncbi request reprint Thin-section multiplanar reformats from multidetector-row CT data: utility for assessment of regional tumor extent in non-small cell lung cancer
    Takanori Higashino
    Department of Radiology, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe, Hyogo 650 0017, Japan
    Eur J Radiol 56:48-55. 2005
    ..To determine the clinical utility of thin-section multiplanar reformats (MPRs) from multidetector-row CT (MDCT) data sets for assessing the extent of regional tumors in non-small cell lung cancer (NSCLC) patients...
  10. doi request reprint Dynamic MRI, dynamic multidetector-row computed tomography (MDCT), and coregistered 2-[fluorine-18]-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET)/CT: comparative study of capability for management of pulmonary nodules
    Yoshiharu Ohno
    Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan
    J Magn Reson Imaging 27:1284-95. 2008
    ..To compare the nodule management capabilities of dynamic MRI, dynamic multidetector-row computed tomography (MDCT) and coregistered positron emission tomography (PET)/CT...
  11. ncbi request reprint Neutrophil elastase inhibitor (sivelestat) attenuates subsequent ventilator-induced lung injury in mice
    Akihiro Sakashita
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, Japan
    Eur J Pharmacol 571:62-71. 2007
    ..These data suggested that sivelestat could protect against ventilator-induced lung injury by suppressing apoptotic responses through mechanical stress-induced cell signaling in addition to inhibiting neutrophil chemotaxis...
  12. ncbi request reprint The effect of overexpression of endothelial nitric oxide synthase on eosinophilic lung inflammation in a murine model
    Kazuyuki Kobayashi
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Int Immunopharmacol 6:1040-52. 2006
    ....
  13. doi request reprint Sphingosine kinase 1 regulates mucin production via ERK phosphorylation
    Yuko Kono
    The Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Pulm Pharmacol Ther 23:36-42. 2010
    ..These results suggest that SphK1 is involved in MUC5AC production induced by IL-13 upstream of ERK1/2 phosphorylation, and independent of STAT6 phosphorylation...
  14. ncbi request reprint Whole-body MR imaging vs. FDG-PET: comparison of accuracy of M-stage diagnosis for lung cancer patients
    Yoshiharu Ohno
    Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan
    J Magn Reson Imaging 26:498-509. 2007
    ..To conduct a prospective comparison of the accuracy of whole-body MR imaging and positron emission tomography (PET) with fluorine-18 deoxyglucose (FDG) (FDG-PET) to assess the M-stage in lung cancer patients...
  15. ncbi request reprint Coregistered ventilation and perfusion SPECT using krypton-81m and Tc-99m-labeled macroaggregated albumin with multislice CT utility for prediction of postoperative lung function in non-small cell lung cancer patients
    Yoshiharu Ohno
    Department of Radiology, Kobe University Graduate School of Medicine, Kobe, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Acad Radiol 14:830-8. 2007
    ....
  16. ncbi request reprint Metastases in mediastinal and hilar lymph nodes in patients with non-small cell lung cancer: quantitative and qualitative assessment with STIR turbo spin-echo MR imaging
    Yoshiharu Ohno
    Department of Radiology, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Radiology 231:872-9. 2004
    ..To evaluate short inversion time inversion-recovery (STIR) turbo spin-echo (TSE) magnetic resonance (MR) imaging for detection of metastases in lymph nodes by using quantitative and qualitative analyses...
  17. doi request reprint N stage disease in patients with non-small cell lung cancer: efficacy of quantitative and qualitative assessment with STIR turbo spin-echo imaging, diffusion-weighted MR imaging, and fluorodeoxyglucose PET/CT
    Yoshiharu Ohno
    Department of Radiology, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Radiology 261:605-15. 2011
    ....
  18. doi request reprint Targeted inactivation of endothelial lipase attenuates lung allergic inflammation through raising plasma HDL level and inhibiting eosinophil infiltration
    Hiroshi Otera
    Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Am J Physiol Lung Cell Mol Physiol 296:L594-602. 2009
    ..Thus EL is a novel modulator of the progression of allergic asthma...
  19. ncbi request reprint Synergistic effects of pemetrexed and amrubicin in non-small cell lung cancer cell lines: Potential for combination therapy
    Yukihisa Hatakeyama
    Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Cancer Lett 343:74-9. 2014
    ..In vivo, AMR/PEM treatment also showed synergistic antitumor activity both in A549-bearing and H520-bearing mice. PEM and AMR work synergistically to inhibit the proliferation of several different lung cancer cell lines...
  20. ncbi request reprint Overexpression of nitric oxide synthase by the endothelium attenuates bleomycin-induced lung fibrosis and impairs MMP-9/TIMP-1 balance
    Sho Yoshimura
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Respirology 11:546-56. 2006
    ..Nitric oxide (NO) produced by endothelial NO synthase (eNOS) is thought to effect an anti-inflammatory response, but its mechanism is still unknown...
  21. doi request reprint Reduced-dose chest CT with 3D automatic exposure control vs. standard chest CT: quantitative assessment of emphysematous changes in smokers' lung parenchyma
    Hisanobu Koyama
    Department of Radiology, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe, Hyogo, Japan
    Eur J Radiol 81:1330-4. 2012
    ..To determine the capability of reduced-dose chest CT with three-dimensional (3D) automatic exposure control (AEC) on quantitative assessment of emphysematous change in smoker' lung parenchyma, compared to standard chest CT...
  22. doi request reprint Differentiation of malignant and benign pulmonary nodules with quantitative first-pass 320-detector row perfusion CT versus FDG PET/CT
    Yoshiharu Ohno
    Department of Radiology, Division of Thoracic Surgery, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe, Hyogo 650 0017, Japan
    Radiology 258:599-609. 2011
    ....
  23. doi request reprint Quantitative and qualitative assessment of non-contrast-enhanced pulmonary MR imaging for management of pulmonary nodules in 161 subjects
    Hisanobu Koyama
    Department of Radiology, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe, 650 0017 Kobe, Japan
    Eur Radiol 18:2120-31. 2008
    ..05). The diagnostic capability of STIR was significantly higher than those of other MR sequences (p<0.05). Non-CE MR imaging was found to be as useful as MDCT for management of pulmonary nodules...
  24. ncbi request reprint An open-label, prospective clinical study to evaluate the efficacy of prophylactic antibiotics after diagnostic bronchoscopy
    Masatsugu Yamamoto
    Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Kobe J Med Sci 58:E110-8. 2012
    ....
  25. doi request reprint Quantitative bronchial luminal volumetric assessment of pulmonary function loss by thin-section MDCT in pulmonary emphysema patients
    Hisanobu Koyama
    Department of Radiology, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe, Hyogo 650 0017, Japan
    Eur J Radiol 81:384-8. 2012
    ..To determine the capability of quantitative bronchial luminal volume to assess pulmonary function loss and disease severity in pulmonary emphysema patients...
  26. ncbi request reprint Airway remodeling of murine chronic antigen exposure model
    Takaaki Tsuchiya
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Chuo Ku, Kobe, Japan
    J Asthma 40:935-44. 2003
    ..A murine chronic OVA exposure model in C57BL/6 mice revealed subepithelial layer thickening consisting of collagen fibers and increased lymphocytes until 7 weeks. C57BL/6 mice are useful to elucidate the mechanism of airway remodeling...
  27. ncbi request reprint Oxygen-enhanced MR imaging: correlation with postsurgical lung function in patients with lung cancer
    Yoshiharu Ohno
    Department of Radiology, Division of Cardiovascular, Thoracic, and Pediatric Surgery, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe, Hyogo 650 0017, Japan
    Radiology 236:704-11. 2005
    ....
  28. doi request reprint A metabolomic approach to lung cancer
    Suya Hori
    Division of Respiratory Medicine, Kobe University Graduate School of Medicine, Japan
    Lung Cancer 74:284-92. 2011
    ..Our results demonstrate that changes in metabolite pattern are useful for assessing the clinical characteristics of lung cancer. Our results will hopefully lead to the establishment of novel diagnostic tools...
  29. doi request reprint Oxygen-enhanced magnetic resonance imaging versus computed tomography: multicenter study for clinical stage classification of smoking-related chronic obstructive pulmonary disease
    Yoshiharu Ohno
    Department of Radiology, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe, Hyogo, 650 0017, Japan
    Am J Respir Crit Care Med 177:1095-102. 2008
    ..Oxygen-enhanced magnetic resonance imaging (MRI) has been proposed as a useful tool for assessing regional morphological and functional changes in chronic obstructive pulmonary disease (COPD)...
  30. ncbi request reprint Effective chemotherapy based on a chemosensitivity test for malignant pleural mesothelioma
    Yoshimasa Maniwa
    Divisions of Thoracic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    Ann Thorac Cardiovasc Surg 14:319-21. 2008
    ..Here we report a case of MPM in which the chemotherapy based on the chemosensitivity test was very effective on palliation with stable disease for a long time...
  31. ncbi request reprint Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta1
    Yuko Kono
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Am J Respir Cell Mol Biol 37:395-404. 2007
    ..These data suggested that SPHK1 activation by TGF-beta1 leads to Rho-associated myofibroblasts differentiation mediated by transactivated S1P receptors in the lung fibrogenic process...
  32. doi request reprint State-of-the-art radiological techniques improve the assessment of postoperative lung function in patients with non-small cell lung cancer
    Yoshiharu Ohno
    Department of Radiology, Kobe University Graduate School of Medicine, Chuo Ku, Kobe, Hyogo, Japan
    Eur J Radiol 77:97-104. 2011
    ..e. qualitative CT) and traditional nuclear medicine methods such as planar imaging and SPECT...
  33. pmc The transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner
    Kyosuke Nakata
    Division of Respiratory Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Biochem Biophys Res Commun 395:238-43. 2010
    ..These data show that the transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner...
  34. ncbi request reprint Diffuse periairway thickening in patients with Mikulicz disease
    Akihiro Sakashita
    Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, Japan
    J Thorac Imaging 23:213-5. 2008
    ..In this case, we presented a rare condition of coexistent Mikulicz disease with tracheobroncial wall thickening caused by lymphoproliferation without lesions in small airways or lung...
  35. ncbi request reprint Diffusion-weighted MR imaging vs. multi-detector row CT: Direct comparison of capability for assessment of management needs for anterior mediastinal solitary tumors
    Shinichiro Seki
    Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan Electronic address
    Eur J Radiol 83:835-42. 2014
    ..To evaluate and compare the capability of diffusion-weighted MR imaging (DWI) and CT for assessment of management needs for anterior mediastinal solitary tumors...
  36. ncbi request reprint Usefulness of the oximetry test for the diagnosis of sleep apnea syndrome in Japan
    Takayuki Takeda
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Am J Med Sci 331:304-8. 2006
    ..This criterion may be useful not only in clinical practice but also in medical checkups for asymptomatic patients, and also suggests that obese patients with sleep disturbance should undergo PSGs, irrespective of the DSI score...
  37. ncbi request reprint Long-term outcome after multidisciplinary approach for leptomeningeal carcinomatosis in a non-small cell lung cancer patient with poor performance status
    Tatsuya Nagano
    Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
    Intern Med 50:3019-22. 2011
    ..6 months after the initiation of erlotinib therapy. This multidisciplinary approach may be particularly useful in terms of increasing survival and improving quality of life...
  38. doi request reprint MT1-MMP plays an important role in an invasive activity of malignant pleural mesothelioma cell
    Takefumi Doi
    Division of Thoracic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    Exp Mol Pathol 90:91-6. 2011
    ....
  39. ncbi request reprint Cough sensitivity in pure cough variant asthma elicited using continuous capsaicin inhalation
    Takeo Nakajima
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
    Allergol Int 55:149-55. 2006
    ..Further studies of cough receptor sensitivity are necessary to fully characterize cough variant asthma...
  40. ncbi request reprint Characteristics of patients with chronic cough who developed classic asthma during the course of cough variant asthma: a longitudinal study
    Takeo Nakajima
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Respiration 72:606-11. 2005
    ..Some patients develop asthmatic symptoms such as wheezing and dyspnea during the course of cough variant asthma (CVA), which are considered precursors of classical asthma...
  41. ncbi request reprint [Pulmonary thromboembolism associated with familial protein C deficiency type I]
    Sho Yoshimura
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, Japan, 650 0017
    Nihon Kokyuki Gakkai Zasshi 41:451-6. 2003
    ..We could not get the conclusive proof of pulmonary thromboembolism, but we considered that the presence of familial protein C deficiency may cause exacerbation of pulmonary hypertension...
  42. ncbi request reprint Ventilator-induced lung injury is reduced in transgenic mice that overexpress endothelial nitric oxide synthase
    Kaori Takenaka
    Division of Cardiovascular and Respiratory Medicine, Kobe Univ Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Am J Physiol Lung Cell Mol Physiol 290:L1078-86. 2006
    ..In conclusion, chronic eNOS overexpression may protect the lung from VILI by inhibiting the production of inflammatory chemokines and cytokines that are associated with neutrophil infiltration into the air space...
  43. ncbi request reprint His239Arg SNP of HRAD9 is associated with lung adenocarcinoma
    Yoshimasa Maniwa
    Division of Cardiovascular, Thoracic, and Pediatric Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    Cancer 106:1117-22. 2006
    ..Those experiments, however, did not examine whether the hRad9 gene was mutated in those cells. The sequence of the HRAD9 gene in NSCLC cells was investigated...
  44. ncbi request reprint Adenoviral transfer of rho family proteins to lung cancer cells ameliorates cell proliferation and motility and increases apoptotic change
    Temiko Shimada
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Kobe J Med Sci 53:125-34. 2007
    ..Although the effect of gene therapy is cell-dependent, these data suggest that adenoviral gene transfer with Rho family small GTPases is one good approach to lung cancer therapy...
  45. ncbi request reprint [Survey findings about elucidating the actual condition of asthma treatment in emergency settings. ∼Activity report of "zero asthma death committee in Hyogo"∼]
    Suya Hori
    Division of Respiratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Arerugi 63:52-60. 2014
    ..To elucidate the actual condition of asthma treatment in emergency settings...
  46. ncbi request reprint A large abdominal wall mass as an initial manifestation of malignant mesothelioma
    Takayuki Takeda
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Am J Med Sci 333:218-20. 2007
    ..To the best of our knowledge, this is the first description of malignant mesothelioma presenting via initial invasion of the abdominal wall without changes in the thoracic space...
  47. ncbi request reprint A case of acute exacerbation of idiopathic pulmonary fibrosis after proton beam therapy for non-small cell lung cancer
    Tatsuya Nagano
    Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunokicho, Chuo Ku, Kobe, Hyogo, Japan
    Jpn J Clin Oncol 42:965-9. 2012
    ....
  48. ncbi request reprint Continuous positive nasal airway pressure decreases levels of serum amyloid A and improves autonomic function in obstructive sleep apnea syndrome
    Emi Kuramoto
    Department of Internal Medicine, Akashi Medical Center, Akashi, Japan
    Int J Cardiol 135:338-45. 2009
    ....
  49. doi request reprint Rebiopsy of non-small cell lung cancer patients with acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitor: Comparison between T790M mutation-positive and mutation-negative populations
    Akito Hata
    Division of Integrated Oncology, Institute of Biomedical Research and Innovation, Kobe, Japan
    Cancer 119:4325-32. 2013
    ..However, rebiopsy to confirm T790M status can be challenging due to limited tissue availability and procedural feasibility, and little is known regarding the differences among patients with or without T790M mutation...
  50. ncbi request reprint Semipermeable membrane dressings can be used with the nicotine transdermal system and do not interfere with nicotine absorption
    Nobuko Hazeki
    Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Hospital, Japan
    Intern Med 52:2743-8. 2013
    ..We studied the effects of semipermeable membrane dressings (SMD) used under nicotine patches (NP) on nicotine absorption, as assessed according to the urinary cotinine levels, and skin symptoms...
  51. ncbi request reprint A case of hard metal lung disease resembling a hypersensitive pneumonia in radiological images
    Keiko Okuno
    Department of Internal Medicine, Kasai Municipal Hospital, Kasai, Japan
    Intern Med 49:1185-9. 2010
    ....
  52. doi request reprint Visualized changes in respiratory resistance and reactance along a time axis in smokers: a cross-sectional study
    Haruko Shinke
    Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, Hyogo, Japan
    Respir Investig 51:166-74. 2013
    ..The objective of this study was to investigate any changes in the respiratory impedance of smokers with normal FEV1/FVC...
  53. ncbi request reprint Sphingosine 1-phosphate induces alpha-smooth muscle actin expression in lung fibroblasts via Rho-kinase
    Yoshiko Urata
    Division of Cardiovascular and Respiratory Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Kobe J Med Sci 51:17-27. 2005
    ..These processes were inhibited by Y-27632, but not by pertussis toxin. These results suggest that S1P induces a phenotypic change of lung fibroblasts via Rho-kinase that may lead to airway remodeling...
  54. pmc Slug increases sensitivity to tubulin-binding agents via the downregulation of βIII and βIVa-tubulin in lung cancer cells
    Daisuke Tamura
    Department of Genome Biology, Kinki University Faculty of Medicine Osaka, Japan Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine Kobe, Japan
    Cancer Med 2:144-54. 2013
    ....
  55. ncbi request reprint Lung carcinosarcoma with liposarcoma element: autopsy case
    Riko Kitazawa
    Division of Molecular Pathology, Kobe University Graduate School of Medicine, Kobe University Hospital, Japan
    Pathol Int 56:449-52. 2006
    ..This is the first documented case of primary lung carcinosarcoma with a liposarcoma element...
  56. ncbi request reprint [A case of malignant lymphoma associated with diffuse pulmonary involvement successfully treated with rituximab]
    Toshiya Kataoka
    Department of Internal Medicine, Akashi Medical Center, 743 33, Yagi Ohkubo cho, Akashi, Hyogo 674 0067, Japan
    Nihon Kokyuki Gakkai Zasshi 41:899-904. 2003
    ..One month later, the patient was in almost complete remission without adverse events. It is suggested that rituximab may be effective for refractory NHL with pulmonary involvement...
  57. ncbi request reprint Modulation of airway responsiveness by anionic and cationic polyelectrolyte substances
    Tomoyuki Yahata
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Eur J Pharmacol 434:71-9. 2002
    ..These findings indicated that the "cationic-anionic interaction" plays an important role in airway responsiveness...
  58. ncbi request reprint High-grade neuroendocrine carcinoma of the lung presenting an unusual spread mimicking pleural mesothelioma associated with dermatomyositis
    Yukiko Murakami
    Department of General Therapeutics, Kobe University Graduate School of Medicine, Kobe, Japan
    Am J Med Sci 327:227-30. 2004
    ..We report a case in which a high-grade neuroendocrine carcinoma, associated with dermatomyositis, presented an unusual pattern of progression, mimicking malignant pleural mesothelioma on diagnostic imaging...
  59. ncbi request reprint Imbalance of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 is associated with pulmonary emphysema in Klotho mice
    Yasuhiro Funada
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Kobe J Med Sci 50:59-67. 2004
    ..These findings suggest that imbalance of MMP-9 and TIMP-1 is associated with the development of pulmonary emphysema in Klotho mice...
  60. ncbi request reprint The effect of long-term treatment with sulindac on the progression of diabetic retinopathy
    Yukiko Hattori
    Department of Internal Medicine, Asama General Hospital, Saku, Japan
    Curr Med Res Opin 23:1913-7. 2007
    ..To evaluate the effects of long-term treatment with sulindac on the progression of diabetic retinopathy (DR)...
  61. ncbi request reprint Dynamic perfusion MRI versus perfusion scintigraphy: prediction of postoperative lung function in patients with lung cancer
    Yoshiharu Ohno
    Department of Radiology, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    AJR Am J Roentgenol 182:73-8. 2004
    ..To determine the capability of MRI as an alternative to scintigraphy, we evaluated correlations and the limits of agreement between predicted FEV(1,MRI) and postoperative FEV(1) and between predicted FEV(1,PS) and postoperative FEV(1)...
  62. ncbi request reprint EGFR mRNA is upregulated, but somatic mutations of the gene are hardly found in renal cell carcinoma in Japanese patients
    Toshiyuki Sakaeda
    Department of Hospital Pharmacy, School of Medicine, Kobe University, 7 5 2 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Pharm Res 22:1757-61. 2005
    ..In this work, the frequency of mutations was investigated in renal cell carcinoma (RCC) samples obtained from Japanese subjects to examine the potential of gefitinib as a therapeutic agent for RCC...
  63. ncbi request reprint Differential expression of S100A2 and S100A4 in lung adenocarcinomas: clinicopathological significance, relationship to p53 and identification of their target genes
    Daisuke Matsubara
    Department of Human Pathology, School of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer Sci 96:844-57. 2005
    ..Thus, the present study demonstrates involvement of S100A2 and S100A4 in the progression of lung adenocarcinomas and an inverse association between S100A4 and p53 expression, and provides a list of targets regulated by S100A2 and S100A4...
  64. ncbi request reprint Adenoviral transduction of MRP-1/CD9 and KAI1/CD82 inhibits lymph node metastasis in orthotopic lung cancer model
    Takayuki Takeda
    Department V of Oncology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, 2 4 20 Ohgimachi, Kita ku, Osaka 530 8480, Japan
    Cancer Res 67:1744-9. 2007
    ..This strategy may therefore be clinically applicable as a prophylactic treatment to suppress the occurrence of lymph node metastasis...
  65. doi request reprint Interstitial lung disease in Japanese patients with lung cancer: a cohort and nested case-control study
    Shoji Kudoh
    Nippon Medical School, Tokyo, Japan
    Am J Respir Crit Care Med 177:1348-57. 2008
    ..Interstitial lung disease (ILD) occurs in Japanese patients with non-small cell lung cancer (NSCLC) receiving gefitinib...
  66. ncbi request reprint Immunohistochemical study of Skp2 and Jab1, two key molecules in the degradation of P27, in lung adenocarcinoma
    Akiteru Goto
    Department of Human Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Pathol Int 54:675-81. 2004
    ..Thus, Skp2 and Jab1 regulate P27 degradation, and might contribute to the development and progression of lung AD through P27-mediated and -unmediated mechanisms...
  67. ncbi request reprint Bronchial hyperresponsiveness in patients with squamous cell lung cancer
    Ryuji Inoue
    Department of Respiratory Medicine, Hyogo Medical Center for Adults, Akashi, Japan
    Respirology 7:339-44. 2002
    ..The aim of this study was to examine the relationship between bronchial hyperresponsiveness, both in vivo and in vitro, and the type of lung cancer (squamous cell or adenocarcinoma)...
  68. ncbi request reprint [New approach to nuclear cardiology]
    Yoshihiro Nishimura
    Nihon Hoshasen Gijutsu Gakkai Zasshi 63:697-704. 2007
  69. ncbi request reprint [Measurement of left ventricular chamber and myocardial volume in hypertrophic cardiomyopathy patients by ECG-gated myocardial perfusion SPECT: application of a newly developed edge-detection algorithm]
    Yoshihiro Nishimura
    Department of Radiology, National Cardiovascular Center Department of Medical Engineering, Division of Allied Health Sciences, Osaka University Medical School
    Nihon Hoshasen Gijutsu Gakkai Zasshi 58:1586-91. 2002
    ..Our method gave more accurate measurements LVV and LMV whereas the QGS method underestimated LMV. Compared with QGS LVV and LMV, our method yielded better results in the phantom study...
  70. ncbi request reprint Multiple endocrine neoplasia type 1 with unusual concomitance of various neoplastic disorders
    Yoshihiro Nishimura
    Department of Aging Medicine and Geriatrics, Shinshu University Graduate School of Medicine, Matsumoto, Japan
    Endocr J 51:75-81. 2004
    ..Careful periodic screening of endocrine and other disorders for her siblings and children as well as for the patient is warranted...
  71. ncbi request reprint Does the lobectomy plus lymph node dissection still remain a standard surgical procedure for patients with cT1N0M0 adenocarcinoma of the lung?
    Arifumi Iwamaru
    Department of Surgery, National Seiran sou Hospital, Toukai, Ibaraki, Japan
    Jpn J Thorac Cardiovasc Surg 52:330-4. 2004
    ..The following topics need to be answered: 1) Should all patients undergo lobectomy plus lymph node dissection? and 2) Is there poor-prognostic subgroup that may need adjuvant therapy?..
  72. ncbi request reprint Pulmonary metastases from uterine malignancies: results of surgical resection in 133 patients
    Masaki Anraku
    Division of Thoracic Surgery, Tochigi Cancer Center, Utsunomiya, Japan
    J Thorac Cardiovasc Surg 127:1107-12. 2004
    ..The long-term results of the surgical treatment for patients with pulmonary metastases from uterine malignancies were clarified...
  73. ncbi request reprint Superimposed display of coronary artery on gated myocardial perfusion scintigraphy
    Yoshihiro Nishimura
    Department of Radiology, National Cardiovascular Center, Suita, Osaka, Japan
    J Nucl Med 45:1444-9. 2004
    ..The aim of this study was to develop a simple means of superimposing the images obtained from coronary angiography and gated myocardial perfusion SPECT...