Jun Nakae

Summary

Affiliation: Kobe University
Country: Japan

Publications

  1. ncbi request reprint Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditure
    Jun Nakae
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Diabetes 57:563-76. 2008
  2. ncbi request reprint The FoxO transcription factors and metabolic regulation
    Jun Nakae
    21st Century COE Program for Signal Transduction Disease, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    FEBS Lett 582:54-67. 2008
  3. pmc The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity
    Jun Nakae
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Disease, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 116:2473-83. 2006
  4. pmc PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure
    Yongheng Cao
    Division of Molecular Medicine and Medical Genetics, International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
    PLoS ONE 6:e18324. 2011
  5. doi request reprint PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake
    Kristy Iskandar
    International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
    Am J Physiol Endocrinol Metab 298:E787-98. 2010
  6. pmc Novel repressor regulates insulin sensitivity through interaction with Foxo1
    Jun Nakae
    Frontier Medicine on Metabolic Syndrome, Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    EMBO J 31:2275-95. 2012
  7. doi request reprint Muscle-specific overexpression of heparin-binding epidermal growth factor-like growth factor increases peripheral glucose disposal and insulin sensitivity
    Yasuhide Fukatsu
    Department of Clinical Molecular Medicine, Division of Diabetes, Kobe University Graduate School of Medicine, Kobe, Japan
    Endocrinology 150:2683-91. 2009
  8. ncbi request reprint Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway
    Yongheng Cao
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Disease, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Biol Chem 281:40242-51. 2006
  9. pmc Transgenic rescue of insulin receptor-deficient mice
    Haruka Okamoto
    Department of Medicine, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Clin Invest 114:214-23. 2004
  10. ncbi request reprint Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity
    Atsushi Tsuchida
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 279:30817-22. 2004

Collaborators

  • Masato Kasuga
  • Wataru Ogawa
  • Hiroshi Itoh
  • Masanori Nakata
  • Yoshihiko Yano
  • Streamson Chua
  • Hitoshi Okamura
  • Yasuhiko Minokoshi
  • Okio Hino
  • Gregory S Barsh
  • Karen C Arden
  • Tadahiro Kitamura
  • Atsuhiro Ichihara
  • D Accili
  • T Kadowaki
  • Morris F White
  • C Kahn
  • Yongheng Cao
  • Kristy Iskandar
  • Tetsuo Noda
  • Eisuke Takano
  • Toshihiko Yada
  • Yoshitake Hayashi
  • Yasuhide Fukatsu
  • Shouhong Xuan
  • Yoshiaki Kido
  • Haruka Okamoto
  • Atsushi Tsuchida
  • Jennifer Altomonte
  • Marta L Hribal
  • Argiris Efstratiadis
  • Shiki Okamoto
  • Hiroshi Hosoda
  • Kazunori Nakajima
  • Kenji Kangawa
  • Yukio Hirata
  • Miyo Oki
  • Changliang Zhang
  • Masahiro Matsuo
  • Mashito Sakai
  • Tetsuya Noguchi
  • Toyo Yoshioka
  • Tohru Fushiki
  • Kazutoshi Tobimatsu
  • Ryuji Hiramatsu
  • Tetsuya Hosooka
  • Kazuo Inoue
  • Takaya Abe
  • Kohei Kaku
  • Yasushi Matsuki
  • Tetsuro Shibakusa
  • Ko Kotani
  • Takeshi Ogura
  • Kenjiro Inagaki
  • Naoki Mochizuki
  • Norihide Yokoi
  • Masafumi Onodera
  • Toshiyuki Kobayashi
  • Yuji Kamioka
  • Ioannis Dragatsis
  • Kazuyuki Tobe
  • Masaki Kobayashi
  • Byung Chul Park
  • Philippe Froguel
  • Ryozo Nagai
  • Kazuo Hara
  • Yasuo Terauchi
  • Sato Takekawa
  • Ryo Suzuki
  • Toshimasa Yamauchi
  • Toshiyuki Maki
  • Junji Kamon
  • Kohjiro Ueki
  • Yusuke Hada
  • Naoto Kubota
  • Yusuke Ito
  • Swan N Thung
  • Sonal Harbaran
  • Jenny Suriawinata
  • Marcia Meseck
  • Hengjiang Dong
  • Anja Richter
  • John R Shutter
  • Katerina Politi
  • Pedro L Herrera
  • Peter E Fisher
  • Marta Letizia Hribal
  • Manrico Morroni
  • Saverio Cinti

Detail Information

Publications18

  1. ncbi request reprint Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditure
    Jun Nakae
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Diabetes 57:563-76. 2008
    ..Forkhead box-containing protein O subfamily (FoxO) 1 mediates insulin action at the transcriptional level. However, physiological roles of FoxO1 in adipose tissue remain unclear...
  2. ncbi request reprint The FoxO transcription factors and metabolic regulation
    Jun Nakae
    21st Century COE Program for Signal Transduction Disease, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    FEBS Lett 582:54-67. 2008
    ..The understanding of molecular mechanism how FoxOs affect glucose or lipid metabolism will shed light on the novel therapy of type 2 diabetes and the metabolic syndrome...
  3. pmc The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity
    Jun Nakae
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Disease, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 116:2473-83. 2006
    ..In conclusion, the LXXLL motif of FoxO1 may have an important role for its transcriptional activity and Sirt1 binding and should be a target site for regulation of gene expression of FoxO1 target genes and glucose metabolism in vivo...
  4. pmc PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure
    Yongheng Cao
    Division of Molecular Medicine and Medical Genetics, International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
    PLoS ONE 6:e18324. 2011
    ..These results suggested that PDK1 and Foxo1 signaling pathways play important roles in the control of energy homeostasis through AGRP-independent mechanisms...
  5. doi request reprint PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake
    Kristy Iskandar
    International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
    Am J Physiol Endocrinol Metab 298:E787-98. 2010
    ..These data suggest a requirement for PDK-1 and FoxO1 in transcriptional regulation of Pomc and food intake...
  6. pmc Novel repressor regulates insulin sensitivity through interaction with Foxo1
    Jun Nakae
    Frontier Medicine on Metabolic Syndrome, Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    EMBO J 31:2275-95. 2012
    ..Taken together, these data suggest that FCoR is a novel repressor that regulates insulin sensitivity and energy metabolism in adipose tissue by acting to fine-tune Foxo1 activity...
  7. doi request reprint Muscle-specific overexpression of heparin-binding epidermal growth factor-like growth factor increases peripheral glucose disposal and insulin sensitivity
    Yasuhide Fukatsu
    Department of Clinical Molecular Medicine, Division of Diabetes, Kobe University Graduate School of Medicine, Kobe, Japan
    Endocrinology 150:2683-91. 2009
    ..Our results suggest that HB-EGF produced by contracting muscle acts as an insulin sensitizer that facilitates peripheral glucose disposal...
  8. ncbi request reprint Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway
    Yongheng Cao
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Disease, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Biol Chem 281:40242-51. 2006
    ..These data suggest a novel mechanism by which FoxO1 regulates the insulin signaling pathway through negative regulation of TSC2 function...
  9. pmc Transgenic rescue of insulin receptor-deficient mice
    Haruka Okamoto
    Department of Medicine, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Clin Invest 114:214-23. 2004
    ..These data indicate, surprisingly, that insulin receptor signaling in noncanonical insulin target tissues is sufficient to maintain fuel homeostasis and prevent diabetes...
  10. ncbi request reprint Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity
    Atsushi Tsuchida
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 279:30817-22. 2004
    ....
  11. pmc Mosaic analysis of insulin receptor function
    Tadahiro Kitamura
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    J Clin Invest 113:209-19. 2004
    ..These findings indicate that insulin regulates growth independently of metabolism and that the number of insulin receptors is an important determinant of the specificity of insulin action...
  12. ncbi request reprint The forkhead transcription factor Foxo1 regulates adipocyte differentiation
    Jun Nakae
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Dev Cell 4:119-29. 2003
    ..We propose that Foxo1 plays an important role in the integration of hormone-activated signaling pathways with the complex transcriptional cascade that promotes adipocyte differentiation...
  13. pmc The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
    Tadahiro Kitamura
    Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    J Clin Invest 110:1839-47. 2002
    ..We propose that insulin/IGFs regulate beta cell proliferation by relieving Foxo1 inhibition of Pdx1 expression in a subset of cells embedded within pancreatic ducts...
  14. ncbi request reprint Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
    Jun Nakae
    Naomi Berrie Diabetes Center, Berrie Research Pavilion, 1150 St Nicholas Avenue, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Nat Genet 32:245-53. 2002
    ..This has been corrected in the full-text online version of the article. The name will appear correctly in the print version...
  15. pmc Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors
    Marta L Hribal
    Russ Berrie Research Pavilion, Rm 238, 1150 St Nicholas Avenue, New York, NY 10032, USA
    J Cell Biol 162:535-41. 2003
    ..Inhibition of Foxo expression by siRNA resulted in more efficient differentiation, associated with increased myosin expression. These observations indicate that Foxo proteins are key effectors of Akt-dependent myogenesis...
  16. ncbi request reprint Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice
    Jennifer Altomonte
    Carl C Icahn Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Am J Physiol Endocrinol Metab 285:E718-28. 2003
    ..These results demonstrated that functional inhibition of Foxo1, caused by hepatic expression of its mutant, is associated with reduced hepatic gluconeogenic activity and improved fasting glycemia in diabetic mice...
  17. pmc Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor
    Shouhong Xuan
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Clin Invest 110:1011-9. 2002
    ..These observations reveal a requirement of IGF1R-mediated signaling for insulin secretion...
  18. ncbi request reprint Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance
    Yoshiaki Kido
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 277:36740-7. 2002
    ..We conclude that Igf1r and Insr are required for embryonic development of the exocrine but not of the endocrine pancreas and that defects of Igf1r do not alter glucose homeostasis as long as the insulin receptor system remains intact...