Research Topics
Species | Shuji KitagawaSummaryAffiliation: Kobe Pharmaceutical University Country: Japan Publications
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Detail Information
Publications
Effects of dietary chemopreventive phytochemicals on P-glycoprotein functionTomohiro Nabekura
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
Biochem Biophys Res Commun 327:866-70. 2005..These results suggest that dietary phytochemicals, such as capsaicin, curcumin, [6]-gingerol, and resveratrol, have inhibitory effects on P-glycoprotein and potencies to cause drug-food interactions...- Efficient topical delivery of chlorogenic acid by an oil-in-water microemulsion to protect skin against UV-induced damageShuji Kitagawa
Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Higashinada ku, Kobe, Japan
Chem Pharm Bull (Tokyo) 59:793-6. 2011..These findings indicate the potential use of hydrophilic chlorogenic acid with o/w-type microemulsion as a vehicle to protect skin against UV-induced oxidative damage... - Enhanced skin delivery of genistein and other two isoflavones by microemulsion and prevention against UV irradiation-induced erythema formationShuji Kitagawa
Kobe Pharmaceutical University, Kobe 658 8558, Japan
Chem Pharm Bull (Tokyo) 58:398-401. 2010..These findings indicate the potential use of w/o-type microemulsion for the delivery of genistein to protect skin against UV-induced oxidative damage... 
Enhanced skin delivery of quercetin by microemulsionShuji Kitagawa
Kobe Pharmaceutical University, Kobe, Japan
J Pharm Pharmacol 61:855-60. 2009..The aim of this study was to determine the usefulness of a microemulsion for that purpose...- Inhibition of P-glycoprotein function by tannic acid and pentagalloylglucoseShuji Kitagawa
Kobe Pharmaceutical University, Motoyamakita machi 4 19 1, Kobe 658 8558, Japan
J Pharm Pharmacol 59:965-9. 2007..The findings also suggested that the presence of a large number of galloyl groups in polyphenols strengthens the interaction with regulatory regions in P-gp... - Physicochemical properties of tamoxifen hemicitrate sesquihydrateTakashi Kojima
Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Higashinada, Kobe 658 8558, Japan
Int J Pharm 352:146-51. 2008.... - Distribution of polyphenols and a surfactant component in skin during Aerosol OT microemulsion-enhanced intradermal deliveryReiko Yutani
Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Kobe 658 8558, Japan
Chem Pharm Bull (Tokyo) 60:989-94. 2012.... - Physicochemical characterization of tamoxifen citrate pseudopolymorphs, methanolate and ethanolateTakashi Kojima
Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Higashi Nada, Kobe, Japan
Chem Pharm Bull (Tokyo) 55:407-11. 2007.... - Inhibitory effects of ginsenosides and their hydrolyzed metabolites on daunorubicin transport in KB-C2 cellsShuji Kitagawa
Kobe Pharmaceutical University, Kobe, Japan
Biol Pharm Bull 30:1979-81. 2007..Analysis of verapamil-stimulated ATPase activity in membrane vesicles expressing human P-gp suggested that the increased daunorubicin accumulation by M4 was at least partly due to ATPase inhibition of P-gp... - Effect of pharmaceutical excipients on the stability of trichlormethiazide tablets under humid conditionsReiko Teraoka
Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Motoyama Kitamachi, Higashi Nada, Japan
Chem Pharm Bull (Tokyo) 57:1343-7. 2009..It was found that the TCM content decreased significantly in a binary mixture of TCM/HPC 1 : 1... - Effects of phosphatidylethanolamine N-methyltransferase on phospholipid composition, microvillus formation and bile salt resistance in LLC-PK1 cellsShin ya Morita
Department of Pharmacy, Shiga University of Medical Science Hospital, Otsu City, Shiga, Japan
FEBS J 278:4768-81. 2011..Because most bile salts exist as conjugated forms in the bile canaliculi, PEMT may be important in the protection of hepatocytes from bile salts and in cholestatic liver injury... - Presence of apolipoprotein C-III attenuates apolipoprotein E-mediated cellular uptake of cholesterol-containing lipid particles by HepG2 cellsShin ya Morita
Kobe Pharmaceutical University, Higashinada ku, Kobe, Japan
Lipids 46:323-32. 2011..Furthermore, cholesterol may affect these functions of apoC-III and apoE involved in the clearance of lipoprotein remnants... - Functional analysis of two isoforms of phosphatidylethanolamine N-methyltransferaseShin ya Morita
Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
Biochem J 432:387-98. 2010..Based upon these findings, we propose a model in which the enzymatic activity and substrate specificity are regulated by the glycosylated N-terminal region of PEMT-L localized in the ER lumen... - Effect of spectroscopic properties on photostability of tamoxifen citrate polymorphsTakashi Kojima
Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Higashi Nada, Kobe 658 8558, Japan
Int J Pharm 336:346-51. 2007..The results obtained suggested that the photodegradation followed by surface color change of form A crystal was caused by the selective absorption of photoenergy of UVA light irradiated by a xenon lamp... 
Enzymatic measurement of phosphatidic acid in cultured cellsShin ya Morita
Laboratory of Pharmaceutical Technology, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
J Lipid Res 50:1945-52. 2009..This novel method for PA quantification is simple, rapid, specific, sensitive, and high-throughput and will help to study the biological functions of PA and its related enzymes...- Inhibition of P-glycoprotein function by tea catechins in KB-C2 cellsShuji Kitagawa
Niigata University of Pharmacy and Applied Life Sciences, Kamishin ei cho 5 13 2, 950 2081, Japan
J Pharm Pharmacol 56:1001-5. 2004.... - Effects of alkyl gallates on P-glycoprotein functionShuji Kitagawa
Laboratory of Pharmaceutics, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan
Biochem Pharmacol 70:1262-6. 2005..The cytotoxicity of daunorubicin was recovered in the presence of alkyl gallates possibly due to their inhibition of P-gp function... - Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cellsShuji Kitagawa
Niigata University of Pharmacy and Applied Life Sciences, Japan
Biol Pharm Bull 28:2274-8. 2005..These results suggested that hydrophobicity as well as planar structure is important for the inhibitory effects of flavonoids on P-gp-mediated transport... - Effects of plant sterols on human multidrug transporters ABCB1 and ABCC1Tomohiro Nabekura
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Higashi jima, Akiha ku, Niigata 956 8603, Japan
Biochem Biophys Res Commun 369:363-8. 2008..These results suggest that guggulsterone, a natural dietary hypolipidemic agent have dual inhibitory effects on P-gp and MRP1 and the potencies to cause food-drug interactions... - Effect of triterpenoids isolated from the floral spikes of Betula platyphylla var. japonica on P-glycoprotein functionMichiko Sekiya
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
Planta Med 73:1558-62. 2007..In addition, compounds 13 and 20 showed a weak inhibitory activity of P-gp ATPase. These results suggested that MDR reversing effects of compounds 13 and 20 are partly involved in inhibition of P-gp ATPase... - Triterpenoids from the floral spikes of Betula platyphylla var. japonica and their reversing activity against multidrug-resistant cancer cellsYoshiki Kashiwada
Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1 78, Tokushima 770 8505, Japan
J Nat Prod 70:623-7. 2007..Compound 10 reversed the cytotoxicity of colchicine against KB-C2 cells at 8.1 microM and showed comparable potency to 5 microM verapamil...