Seigo Iwakawa

Summary

Affiliation: Kobe Pharmaceutical University
Country: Japan

Publications

  1. ncbi request reprint Effect of oxyethylene moiety in polyoxyethylene sorbitan esters on the pharmacokinetics of menatetrenone incorporated in O/W lipid emulsions prepared with polyoxyethylene sorbitan esters and soybean oil in rats
    Kumiko Ueda
    Department of Pharmaceutics, Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    J Pharm Pharmacol 54:1357-63. 2002
  2. ncbi request reprint [Cooperation of medical and pharmaceutical sciences between private and national universities to educate professionals in the fields of drug development and rational pharmacotherapy]
    Seigo Iwakawa
    Kobe Pharmaceutical University, Motoyama kita 4 19 1, Higashinada ku, Kobe 658 8558, Japan
    Yakugaku Zasshi 132:3-5. 2012
  3. ncbi request reprint Effect of glimepiride and glibenclamide on S-warfarin 7-hydroxylation by human liver microsomes, recombinant human CYP2C9.1 and CYP2C9.3
    Seigo Iwakawa
    Department of Pharmaceutics, Kobe Pharmaceutical University, Kobe, Japan
    Biol Pharm Bull 29:1983-5. 2006
  4. ncbi request reprint Prolonged circulation of menatetrenone by emulsions with hydrogenated castor oils in rats
    Kumiko Ueda
    Department of Pharmaceutics, Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Higashinada, Kobe 658 8558, Japan
    J Control Release 95:93-100. 2004
  5. ncbi request reprint Effect of acyl chains of phosphatidylcholines on the pharmacokinetics of menatetrenone incorporated in O/W lipid emulsions prepared with phosphatidylcholines and soybean oil in rats
    Kumiko Ueda
    Department of Pharmaceutics, Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    J Pharm Pharmacol 56:855-9. 2004
  6. ncbi request reprint Effect of particle size on the pharmacokinetics of menatetrenone incorporated in O/W lipid emulsions prepared with hydrogenated castor oils and soybean oil in rats
    Kumiko Ueda
    Department of Pharmaceutics, Kobe Pharmaceutical University, Japan
    J Drug Target 11:241-6. 2003
  7. ncbi request reprint Effect of oxyethylene moieties in hydrogenated castor oil on the pharmacokinetics of menatetrenone incorporated in O/W lipid emulsions prepared with hydrogenated castor oil and soybean oil in rats
    Kumiko Ueda
    Department of Pharmaceutics, Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    J Drug Target 11:37-43. 2003
  8. ncbi request reprint Effect of oxyethylene numbers on the pharmacokinetics of menatetrenone incorporated in oil-in-water lipid emulsions prepared with polyoxyethylene-polyoxypropylene block copolymers and soybean oil in rats
    Kumiko Ueda
    Department of Pharmaceutics, Kobe Pharmaceutical University, Japan
    Biol Pharm Bull 31:2283-7. 2008
  9. doi request reprint Effect of oil-in-water lipid emulsions prepared with fish oil or soybean oil on the growth of MCF-7 cells and HepG2 cells
    Kumiko Ueda
    Department of Pharmaceutics, Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    J Pharm Pharmacol 60:1069-75. 2008
  10. ncbi request reprint Effect of ethanol on S-warfarin and diclofenac metabolism by recombinant human CYP2C9.1
    Akitoshi Tatsumi
    Educational Center for Clinical Pharmacy, Kobe Pharmaceutical University, Japan
    Biol Pharm Bull 32:517-9. 2009

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Effect of oxyethylene moiety in polyoxyethylene sorbitan esters on the pharmacokinetics of menatetrenone incorporated in O/W lipid emulsions prepared with polyoxyethylene sorbitan esters and soybean oil in rats
    Kumiko Ueda
    Department of Pharmaceutics, Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    J Pharm Pharmacol 54:1357-63. 2002
    ....
  2. ncbi request reprint [Cooperation of medical and pharmaceutical sciences between private and national universities to educate professionals in the fields of drug development and rational pharmacotherapy]
    Seigo Iwakawa
    Kobe Pharmaceutical University, Motoyama kita 4 19 1, Higashinada ku, Kobe 658 8558, Japan
    Yakugaku Zasshi 132:3-5. 2012
    ..This systematic cooperation will contribute to the promotion of a new curriculum for inter-professional education in the health-science fields...
  3. ncbi request reprint Effect of glimepiride and glibenclamide on S-warfarin 7-hydroxylation by human liver microsomes, recombinant human CYP2C9.1 and CYP2C9.3
    Seigo Iwakawa
    Department of Pharmaceutics, Kobe Pharmaceutical University, Kobe, Japan
    Biol Pharm Bull 29:1983-5. 2006
    ..The apparent K(i) value of glimepiride was lower than that of glibenclamide. These results may provide valuable information for optimizing the anticoagulant activity of warfarin when glimepiride is co-administered to patients...
  4. ncbi request reprint Prolonged circulation of menatetrenone by emulsions with hydrogenated castor oils in rats
    Kumiko Ueda
    Department of Pharmaceutics, Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Higashinada, Kobe 658 8558, Japan
    J Control Release 95:93-100. 2004
    ..These findings suggest that the minimum number of oxyethylene units within HCOs for the prolonged plasma circulation of menatetrenone was 20 for MO/HCOs, similarly to SO/HCOs...
  5. ncbi request reprint Effect of acyl chains of phosphatidylcholines on the pharmacokinetics of menatetrenone incorporated in O/W lipid emulsions prepared with phosphatidylcholines and soybean oil in rats
    Kumiko Ueda
    Department of Pharmaceutics, Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    J Pharm Pharmacol 56:855-9. 2004
    ..The menatetrenone uptake by the lungs as SO/DPPC was also higher than that as SO/EYP. These findings suggest that SO/DPPC is a good candidate drug carrier for the prolonged plasma circulation of lipophilic drugs...
  6. ncbi request reprint Effect of particle size on the pharmacokinetics of menatetrenone incorporated in O/W lipid emulsions prepared with hydrogenated castor oils and soybean oil in rats
    Kumiko Ueda
    Department of Pharmaceutics, Kobe Pharmaceutical University, Japan
    J Drug Target 11:241-6. 2003
    ..These findings indicated that the particle sizes did not affect the minimum oxyethylene units within HCOs for the prolonged plasma circulation of menatetrenone as SO/HCOs, which was 20...
  7. ncbi request reprint Effect of oxyethylene moieties in hydrogenated castor oil on the pharmacokinetics of menatetrenone incorporated in O/W lipid emulsions prepared with hydrogenated castor oil and soybean oil in rats
    Kumiko Ueda
    Department of Pharmaceutics, Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    J Drug Target 11:37-43. 2003
    ..These findings clearly demonstrate that 20 oxyethylene units in HCOs is the minimum requirement for the prolongation of the plasma circulation time of menatetrenone incorporated in SO/HCOs...
  8. ncbi request reprint Effect of oxyethylene numbers on the pharmacokinetics of menatetrenone incorporated in oil-in-water lipid emulsions prepared with polyoxyethylene-polyoxypropylene block copolymers and soybean oil in rats
    Kumiko Ueda
    Department of Pharmaceutics, Kobe Pharmaceutical University, Japan
    Biol Pharm Bull 31:2283-7. 2008
    ..These findings suggested that larger numbers of oxyethylene units of Pluronics with 60 oxypropylene units were required for the longer plasma circulation of SO/Pluronics due to evasion of the RES...
  9. doi request reprint Effect of oil-in-water lipid emulsions prepared with fish oil or soybean oil on the growth of MCF-7 cells and HepG2 cells
    Kumiko Ueda
    Department of Pharmaceutics, Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    J Pharm Pharmacol 60:1069-75. 2008
    ....
  10. ncbi request reprint Effect of ethanol on S-warfarin and diclofenac metabolism by recombinant human CYP2C9.1
    Akitoshi Tatsumi
    Educational Center for Clinical Pharmacy, Kobe Pharmaceutical University, Japan
    Biol Pharm Bull 32:517-9. 2009
    ..1 was competitively inhibited by ethanol. S-Warfarin metabolism by CYP2C9.1 was more sensitive to ethanol than diclofenac metabolism. These results suggest that ethanol inhibits the metabolism by CYP2C9.1 in a substrate-dependent manner...
  11. ncbi request reprint Effect of ethanol on the binding of warfarin enantiomers to human serum albumin
    Akitoshi Tatsumi
    Department of Pharmaceutics, Kobe Pharmaceutical University, Japan
    Biol Pharm Bull 30:826-9. 2007
    ..In various commercial albumin preparations, unbound fractions of both the S- and R-enantiomer were increased by ethanol. The different effects of ethanol among fatty acid-free HSA and commercial albumin preparations were observed...
  12. ncbi request reprint Effect of 2-methoxyestradiol, buthionine sulfoximine and hydrogen peroxide on the viability of renal carcinoma cell lines (ACHN and ACVB)
    Yuka Hirai
    Department of Pharmaceutics, Kobe Pharmaceutical University, Kobe, Japan
    Biol Pharm Bull 29:1064-7. 2006
    ..The intracellular levels of reactive oxygen species (ROS) with a combination with 2-ME and H2O2 in ACHN and ACVB pretreated with BSO were markedly increased, which may have contributed to the potential antiproliferative action...
  13. ncbi request reprint Antiproliferative activity of Rhinacanthus nasutus (L.) Kurz extracts and the active moiety, Rhinacanthin C
    Akinobu Gotoh
    Department of Clinical Genetics and International Center for Medical Research, School of Medicine, Kobe University, Japan
    Biol Pharm Bull 27:1070-4. 2004
    ..nasutus was due to constituents other than rhinacanthin C, and 4) both of the R. nasutus extracts showed in vivo antiproliferative activity after oral administration once daily for 14 d...