M Ichihashi

Summary

Affiliation: Kobe University
Country: Japan

Publications

  1. ncbi request reprint Preventive effect of antioxidant on ultraviolet-induced skin cancer in mice
    M Ichihashi
    Department of Dermatology, Kobe University School of Medicine, 7 5 1 Kusunoki cho Chuo ku, Kobe, Japan
    J Dermatol Sci 23:S45-50. 2000
  2. ncbi request reprint The depigmenting effect of alpha-tocopheryl ferulate on human melanoma cells
    Y Funasaka
    Department of Dermatology, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Br J Dermatol 141:20-9. 1999
  3. ncbi request reprint Expression of proopiomelanocortin, corticotropin-releasing hormone (CRH), and CRH receptor in melanoma cells, nevus cells, and normal human melanocytes
    Y Funasaka
    Department of Dermatology, Kobe University School of Medicine, Japan
    J Investig Dermatol Symp Proc 4:105-9. 1999
  4. ncbi request reprint UV-induced skin damage
    M Ichihashi
    Division of Dermatology, Graduate School of Medicine, Translational Medicine, School of Medicine, Kobe University, Kobe, Japan
    Toxicology 189:21-39. 2003
  5. ncbi request reprint Modulation of melanocyte-stimulating hormone receptor expression on normal human melanocytes: evidence for a regulatory role of ultraviolet B, interleukin-1alpha, interleukin-1beta, endothelin-1 and tumour necrosis factor-alpha
    Y Funasaka
    Department of Dermatology, Kobe University School of Medicine, 5 1 Kusunoki cho 7 chome, Chuo Ku, Kobe 650, Japan
    Br J Dermatol 139:216-24. 1998
  6. ncbi request reprint gp100 mRNA is more sensitive than tyrosinase mRNA for RT-PCR amplification to detect circulating melanoma cells in peripheral blood of melanoma patients
    K Tsukamoto
    Department of Dermatology, Yamanashi Medical University, 1110 Shimokato, Tamaho, Nakakoma, Yamanashi, Japan
    J Dermatol Sci 23:126-31. 2000
  7. ncbi request reprint The effect of ultraviolet B induced adult T cell leukemia-derived factor/thioredoxin (ADF/TRX) on survival and growth of human melanocytes
    Y Funasaka
    Department of Dermatology, Kobe University School of Medicine, Japan
    Pigment Cell Res 10:68-73. 1997
  8. ncbi request reprint Regulation of melanogenesis through phosphatidylinositol 3-kinase-Akt pathway in human G361 melanoma cells
    M Oka
    Department of Dermatology, Kobe University School of Medicine, Japan
    J Invest Dermatol 115:699-703. 2000
  9. ncbi request reprint Low-dose ultraviolet B radiation synergizes with TNF-alpha to induce apoptosis of keratinocytes
    K Tsuru
    Department of Dermatology, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    J Dermatol Sci 26:209-16. 2001
  10. ncbi request reprint Tissue factor expression and serum level in patients with melanoma does not correlate with disease progression
    T Kageshita
    Department of Dermatology, Kumamoto University School of Medicine, Japan
    Pigment Cell Res 14:195-200. 2001

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Preventive effect of antioxidant on ultraviolet-induced skin cancer in mice
    M Ichihashi
    Department of Dermatology, Kobe University School of Medicine, 7 5 1 Kusunoki cho Chuo ku, Kobe, Japan
    J Dermatol Sci 23:S45-50. 2000
    ....
  2. ncbi request reprint The depigmenting effect of alpha-tocopheryl ferulate on human melanoma cells
    Y Funasaka
    Department of Dermatology, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Br J Dermatol 141:20-9. 1999
    ..These results suggest that alpha-TF is a candidate for an efficient whitening agent which suppresses melanogenesis and inhibits biological reactions induced by reactive oxygen species...
  3. ncbi request reprint Expression of proopiomelanocortin, corticotropin-releasing hormone (CRH), and CRH receptor in melanoma cells, nevus cells, and normal human melanocytes
    Y Funasaka
    Department of Dermatology, Kobe University School of Medicine, Japan
    J Investig Dermatol Symp Proc 4:105-9. 1999
    ..These results indicate that tumor progression accentuates CRH, CRH-R, and POMC expression by melanoma cells...
  4. ncbi request reprint UV-induced skin damage
    M Ichihashi
    Division of Dermatology, Graduate School of Medicine, Translational Medicine, School of Medicine, Kobe University, Kobe, Japan
    Toxicology 189:21-39. 2003
    ..Finally, possible prevention of UV-induced skin cancer by feeding or topical use of antioxidants, such as polyphenols, vitamin C, and vitamin E, is discussed...
  5. ncbi request reprint Modulation of melanocyte-stimulating hormone receptor expression on normal human melanocytes: evidence for a regulatory role of ultraviolet B, interleukin-1alpha, interleukin-1beta, endothelin-1 and tumour necrosis factor-alpha
    Y Funasaka
    Department of Dermatology, Kobe University School of Medicine, 5 1 Kusunoki cho 7 chome, Chuo Ku, Kobe 650, Japan
    Br J Dermatol 139:216-24. 1998
    ..Such a regulatory system would enable normal human melanocytes to respond to MSH more efficiently and induce an increase of melanization of the skin through the MSH/MSH-R system after UVB radiation...
  6. ncbi request reprint gp100 mRNA is more sensitive than tyrosinase mRNA for RT-PCR amplification to detect circulating melanoma cells in peripheral blood of melanoma patients
    K Tsukamoto
    Department of Dermatology, Yamanashi Medical University, 1110 Shimokato, Tamaho, Nakakoma, Yamanashi, Japan
    J Dermatol Sci 23:126-31. 2000
    ..4%), in one of six stage III patients (16. 7%) and in seven of 18 stage IV patients (38.9%). Thus gp100 mRNA is a more sensitive marker for detecting circulating melanoma cells compared with tyrosinase mRNA...
  7. ncbi request reprint The effect of ultraviolet B induced adult T cell leukemia-derived factor/thioredoxin (ADF/TRX) on survival and growth of human melanocytes
    Y Funasaka
    Department of Dermatology, Kobe University School of Medicine, Japan
    Pigment Cell Res 10:68-73. 1997
    ..Further, it may work as one of the stimulatory factors for UVB-induced melanogenesis by upregulating MSH-R binding activity in combination with the enhanced DNA synthesis by alpha-MSH...
  8. ncbi request reprint Regulation of melanogenesis through phosphatidylinositol 3-kinase-Akt pathway in human G361 melanoma cells
    M Oka
    Department of Dermatology, Kobe University School of Medicine, Japan
    J Invest Dermatol 115:699-703. 2000
    ..These results indicate that phosphatidylinositol 3-kinase regulates melanogenesis by modulating the expression of tyrosinase, and that activation of Akt is sufficient for suppression of melanin production in G361 melanoma cells...
  9. ncbi request reprint Low-dose ultraviolet B radiation synergizes with TNF-alpha to induce apoptosis of keratinocytes
    K Tsuru
    Department of Dermatology, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    J Dermatol Sci 26:209-16. 2001
    ....
  10. ncbi request reprint Tissue factor expression and serum level in patients with melanoma does not correlate with disease progression
    T Kageshita
    Department of Dermatology, Kumamoto University School of Medicine, Japan
    Pigment Cell Res 14:195-200. 2001
    ..These results suggest that TF was ubiquitously expressed in melanocytic cells and its expression was not correlated with disease progression and/or metastatic potency of melanoma cells...
  11. ncbi request reprint Effect of dopa-loading on glutathione metabolising enzymes and tyrosinase in relation to 5-S-cysteinyl-dopa genesis in cultured B-16 melanoma cells
    A K Chakraborty
    Department of Dermatology, Kobe University School of Medicine, Japan
    J Dermatol Sci 2:329-35. 1991
    ..The relative quantities of GSH at the sites of DOPA quinone formation and the levels of its metabolising enzymes can influence the type of product formed.(ABSTRACT TRUNCATED AT 250 WORDS)..
  12. ncbi request reprint Involvement of EGF receptor activation in the induction of cyclooxygenase-2 in HaCaT keratinocytes after UVB
    M Ashida
    Division of Dermatology, Clinical Molecular Medicine, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Exp Dermatol 12:445-52. 2003
    ..These data indicate that oxidative stress in association with activation of EGFR, ERK, p38 MAP kinase, and PI3-kinase plays crucial roles in the UVB induction of expression of COX-2...
  13. ncbi request reprint Elimination of CD4(+) T cells enhances anti-tumor effect of locally secreted interleukin-12 on B16 mouse melanoma and induces vitiligo-like coat color alteration
    H Nagai
    Department of Dermatology, Kobe University School of Medicine, Kobe, Japan
    J Invest Dermatol 115:1059-64. 2000
    ..This mouse model not only demonstrates the depletion of CD4(+) T cells as a useful strategy for cancer gene therapy with interleukin-12 but also provides a model for human melanoma-associated vitiligo.J Invest Dermatol 115:1059-1064 2000..
  14. ncbi request reprint Differential down-regulation of protein kinase C subspecies in normal human melanocytes: possible involvement of the zeta subspecies in growth regulation
    M Oka
    Department of Dermatology, Kobe University School of Medicine, Japan
    J Invest Dermatol 105:567-71. 1995
    ....
  15. ncbi request reprint The effect of thioredoxin on the expression of proopiomelanocortin-derived peptides, the melanocortin 1 receptor and cell survival of normal human keratinocytes
    Y Funasaka
    Department of Dermatology, Kobe University School of Medicine, Japan
    J Investig Dermatol Symp Proc 6:32-7. 2001
    ..Taken together, the results suggest that keratinocyte-derived TRX regulates the expression of stress inducible neuropeptides and their receptor, and is critically involved in the survival of keratinocytes...
  16. ncbi request reprint Widespread expression of parathyroid hormone-related peptide in melanocytic cells
    T Kageshita
    Department of Dermatology, Kumamoto University School of Medicine, 1 1 Honjo, Kumamoto 860 0811, Japan
    Br J Dermatol 148:533-8. 2003
    ..Parathyroid hormone-related peptide (PTH-rP) was associated with the syndrome of hypercalcaemia of malignancy. An increased serum level of PTH-rP could occur in patients with advanced melanoma...
  17. ncbi request reprint Depigmenting effect of alpha-tocopheryl ferulate on normal human melanocytes
    Y Funasaka
    Department of Dermatology, Kobe University School of Medicine, Japan
    Pigment Cell Res 13:170-4. 2000
    ..In this paper, the role of alpha-T and alpha-TF in inhibiting biological reactions induced by reactive oxygen species (ROS) is also discussed...
  18. ncbi request reprint Molecular genetic analysis of HLA class II alleles in Japanese patients with melanoma
    T Kageshita
    Department of Dermatology, Kumamoto University School of Medicine, Japan
    Tissue Antigens 49:466-70. 1997
    ..In addition, there was no correlation between these antigens and clinical parameters. These results indicate that HLA class II alleles may not contribute to a strong susceptibility to melanoma in the Japanese...
  19. ncbi request reprint Secreted type of modified interleukin-18 gene transduced into mouse renal cell carcinoma cells induces systemic tumor immunity
    S Hara
    Department of Urology, Kobe University School of Medicine, Kobe, Japan
    J Urol 165:2039-43. 2001
    ..CONCLUSIONS: Immune gene therapy using modified IL-18 cDNA appears to be effective and IL-18 secreting cancer cells may be a candidate for tumor vaccine therapy...
  20. ncbi request reprint Aspirin enhances the induction of type I allergic symptoms when combined with food and exercise in patients with food-dependent exercise-induced anaphylaxis
    S Harada
    Department of Dermatology, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    Br J Dermatol 145:336-9. 2001
    ..This is the first report of a synergistic effect of aspirin in inducing urticaria/anaphylaxis, which was confirmed using challenge tests in patients with FDEIA...
  21. ncbi request reprint Localized heat urticaria in a patient is associated with a wealing response to heated autologous serum
    A Fukunaga
    Division of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Br J Dermatol 147:994-7. 2002
    ..These findings indicate that certain materials in her serum that are activated by heat are responsible for the development of her anaphylactic and urticarial reactions and that these reactions may be mediated by histamine...
  22. ncbi request reprint Aberrant expression of MSG1 transcriptional activator in human malignant melanoma in vivo
    N U Ahmed
    Department of Dermatology, Kobe University School of Medicine, Japan
    Pigment Cell Res 14:140-3. 2001
    ..Alternatively, the aberrant expression of MSG1 in melanoma cells might be due to the abnormal environment, including aberrant cytokine or growth factor expression, associated with melanoma formation...
  23. ncbi request reprint Partial improvement of Olmsted syndrome with etretinate
    M Ueda
    Department of Dermatology, School of Medicine, Kobe University, Japan
    Pediatr Dermatol 10:376-81. 1993
    ..Because of periosteal thickening of the tibia, presumably caused by etretinate, therapy was terminated one year after it began...
  24. ncbi request reprint Protean manifestations of human papillomavirus type 60 infection on the extremities
    M Ashida
    Department of Dermatology, School of Medicine, Kobe University, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Br J Dermatol 146:885-90. 2002
    ..However, there is no information on the role of HPV-60 in the development of cutaneous lesions on other anatomical sites...
  25. ncbi request reprint Mercury-induced nummular dermatitis
    A Adachi
    Department of Dermatology, Hyogo Prefectural Kakogawa Hospital, Kakogawa, Japan
    J Am Acad Dermatol 43:383-5. 2000
    ..Hypersensitivity to haptens such as metals is possibly involved in, at least in some patients, the pathogenesis of nummular dermatitis...
  26. ncbi request reprint The efficacy of glycolic acid for treating wrinkles: analysis using newly developed facial imaging systems equipped with fluorescent illumination
    Y Funasaka
    Department of Dermatology, Kobe University School of Medicine, 650 0017, Kobe, Japan
    J Dermatol Sci 27:S53-9. 2001
    ..This quantitative analysis clearly shows the efficacy and limitation of GA treatment of wrinkles, and might help to disclose the precise mechanisms of GA effects on the skin structure and function...
  27. ncbi request reprint Heterozygous HPS1 mutations in a case of Hermansky-Pudlak syndrome with giant melanosomes
    T Horikawa
    Department of Dermatology, Kobe University School of Medicine, 7 5 1 Kusunokicho, Chuoku, Kobe 650 0017, Japan
    Br J Dermatol 143:635-40. 2000
    ..Our finding of mutations in the HPS1 gene in relation to abnormalities in melanosome morphology and melanin production shed light on the role and function of the HPS1 gene product in the synthesis of melanosomes and melanin pigment...
  28. ncbi request reprint Accelerated disappearance of melanocytes in bcl-2-deficient mice
    K Yamamura
    Department of Dermatology, Kobe University School of Medicine, Japan
    Cancer Res 56:3546-50. 1996
    ..These observations suggest that the expression of bcl-2 might be essential for melanocyte maintenance after the second hair cycle...
  29. doi request reprint A Zn(II)-glycine complex suppresses UVB-induced melanin production by stimulating metallothionein expression
    Y Ochiai
    Cosmos Technical Center Co, Ltd, 3 24 3 Hasune, Itabashi ku, Tokyo 174 0046, Japan
    Int J Cosmet Sci 30:105-12. 2008
    ..Thus, Zn(II)(Gly)(2) is a good candidate as a new skin-lightening active...