Kenta Hara

Summary

Affiliation: Kobe University
Country: Japan

Publications

  1. ncbi request reprint Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
    Kenta Hara
    Biosignal Research Center, Kobe University, 657 8501, Kobe, Japan
    Cell 110:177-89. 2002
  2. ncbi request reprint A case of an elderly patient with slowly progressive type 1 diabetes who developed severe nonocclusive mesenteric ischemia without predisposing events
    Kenta Hara
    Department of General Internal Medicine, Kobe University Hospital, Japan
    Intern Med 51:1065-8. 2012
  3. ncbi request reprint The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
    Hiroki Nojima
    Biosignal Research Center, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe 657 8501, Japan
    J Biol Chem 278:15461-4. 2003
  4. ncbi request reprint Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function
    Noriko Oshiro
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Genes Cells 9:359-66. 2004
  5. doi request reprint Administration of a determinant of preproinsulin can induce regulatory T cells and suppress anti-islet autoimmunity in NOD mice
    Takashi Arai
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Clin Immunol 136:74-82. 2010
  6. doi request reprint Intravenous administration of proinsulin 1 or 2-expressing fiber-mutant recombinant adenovirus vector protects against the development of diabetes in NOD mice
    Katsumi Yamada
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Ann N Y Acad Sci 1150:183-6. 2008
  7. pmc The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1
    Noriko Oshiro
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    J Biol Chem 282:20329-39. 2007
  8. pmc Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemia
    Suirin Hamada
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Diabetes 58:1321-32. 2009
  9. doi request reprint Acceleration of autoimmune diabetes in Rheb-congenic NOD mice with β-cell-specific mTORC1 activation
    Hirotomo Sasaki
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Biochem Biophys Res Commun 408:306-11. 2011
  10. doi request reprint Autoreactive T cell response in CD25-negative fraction of peripheral blood mononuclear cells in established type 1 diabetes
    Hiroaki Moriyama
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Ann N Y Acad Sci 1150:278-81. 2008

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
    Kenta Hara
    Biosignal Research Center, Kobe University, 657 8501, Kobe, Japan
    Cell 110:177-89. 2002
    ..elegans raptor yields an array of phenotypes that closely resemble those produced by inactivation of Ce-TOR. Thus, raptor is an essential scaffold for the mTOR-catalyzed phosphorylation of 4EBP1 and mediates TOR action in vivo...
  2. ncbi request reprint A case of an elderly patient with slowly progressive type 1 diabetes who developed severe nonocclusive mesenteric ischemia without predisposing events
    Kenta Hara
    Department of General Internal Medicine, Kobe University Hospital, Japan
    Intern Med 51:1065-8. 2012
    ..Prolonged generation of reactive oxygen species in SPIDDM, together with the decline in adaptive response to oxidative stress with aging, might be an exacerbating factor for ischemic injury in the elderly...
  3. ncbi request reprint The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
    Hiroki Nojima
    Biosignal Research Center, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe 657 8501, Japan
    J Biol Chem 278:15461-4. 2003
    ....
  4. ncbi request reprint Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function
    Noriko Oshiro
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Genes Cells 9:359-66. 2004
    ....
  5. doi request reprint Administration of a determinant of preproinsulin can induce regulatory T cells and suppress anti-islet autoimmunity in NOD mice
    Takashi Arai
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Clin Immunol 136:74-82. 2010
    ..L7-24 peptide, which has a high affinity for pockets of I-A(g7), induced regulatory T cells and showed therapeutic effects. This peptide may provide a new approach for developing antigen-specific immunotherapy for autoimmune diabetes...
  6. doi request reprint Intravenous administration of proinsulin 1 or 2-expressing fiber-mutant recombinant adenovirus vector protects against the development of diabetes in NOD mice
    Katsumi Yamada
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Ann N Y Acad Sci 1150:183-6. 2008
    ..Pins1-RGD and that of Ad.Pins2-RGD. Our study suggests that systemic administration of fiber-mutant adenovirus vectors, which induce transient expression of proinsulin, may be applicable to a gene therapy inducing tolerance to insulin...
  7. pmc The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1
    Noriko Oshiro
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    J Biol Chem 282:20329-39. 2007
    ..Moreover, they indicate that the ability of raptor to bind endogenous substrates is limiting for the activity of mTORC1 in vivo and is therefore a potential locus of regulation...
  8. pmc Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemia
    Suirin Hamada
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Diabetes 58:1321-32. 2009
    ..Our objective was to investigate the role of the mTORC1 pathway in the regulation of beta-cell mass in vivo...
  9. doi request reprint Acceleration of autoimmune diabetes in Rheb-congenic NOD mice with β-cell-specific mTORC1 activation
    Hirotomo Sasaki
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Biochem Biophys Res Commun 408:306-11. 2011
    ..We conclude that not only enlargement but also regeneration of β-cells in addition to the prevention of β-cell destruction will be required for the ideal therapy of autoimmune T1D...
  10. doi request reprint Autoreactive T cell response in CD25-negative fraction of peripheral blood mononuclear cells in established type 1 diabetes
    Hiroaki Moriyama
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Ann N Y Acad Sci 1150:278-81. 2008
    ..The phenomena were not observed for IL-4 spots. Our data suggest a possible role of Tregs maintaining dominant peripheral tolerance in T1D and application of further improved T cell assay detecting autoimmunity even in established T1D...
  11. doi request reprint Role of the mTOR complex 1 pathway in the in vivo maintenance of the intestinal mucosa by oral intake of amino acids
    Akira Nakamura
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Geriatr Gerontol Int 12:131-9. 2012
    ....
  12. ncbi request reprint Inhibition of amino acid-mTOR signaling by a leucine derivative induces G1 arrest in Jurkat cells
    Sujuti Hidayat
    Biosignal Research Center, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe 657 8501, Japan
    Biochem Biophys Res Commun 301:417-23. 2003
    ..These effects are similar to the inhibitory effects of rapamycin on amino acid-mTOR signaling pathway and suggest that N-acetylleucine amide acts as a rapamycin-like reagent to inhibit cell cycle progression in Jurkat cells...
  13. doi request reprint Usefulness of 18F-fluorodeoxyglucose positron emission tomography for diagnosis of asymptomatic giant cell arteritis in a patient with Alzheimer's disease
    Saeko Kushida
    Division of Geriatric Medicine, Kobe University Hospital, Kobe, Japan
    Geriatr Gerontol Int 11:114-8. 2011
    ..Our experience suggests the usefulness of FDG-PET for the diagnosis of GCA, particularly in elderly patients without typical symptoms...
  14. ncbi request reprint Bleeding from the small intestine and aortic regurgitation in Noonan syndrome
    Hiroshi Yoshino
    Department of General Internal Medicine, Kobe University Graduate School of Medicine, Japan
    Intern Med 50:2611-3. 2011
    ..By upper endoscopy with the single balloon we clearly revealed the angioectasia in the small intestine. This case documents the first association among NS, aortic regurgitation and angioectasia in the small intestine...
  15. ncbi request reprint Regulation of hypoxia-inducible factor 1 by glucose availability under hypoxic conditions
    Jing Zhou
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, 650 0017, Japan
    Kobe J Med Sci 53:283-96. 2007
    ....
  16. ncbi request reprint A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway
    Naoki Kimura
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Genes Cells 8:65-79. 2003
    ..AMP-activated protein kinase (AMPK) modulates metabolism in response to energy demand by responding to changes in AMP...
  17. doi request reprint One amino acid difference is critical for suppression of the development of experimental autoimmune diabetes (EAD) with intravenous injection of insulinB:9-23 peptide
    Yasuyo Okumachi
    Department of Internal and Geriatric Medicine, Kobe University, Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe, Japan
    Biochem Biophys Res Commun 374:581-6. 2008
    ....
  18. ncbi request reprint [mTOR complex as an integrating controller of cell growth]
    Ken ichi Yoshino
    Tanpakushitsu Kakusan Koso 48:1378-85. 2003
  19. ncbi request reprint Immunological aspects of 'fulminant type 1 diabetes'
    Masao Nagata
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Diabetes Res Clin Pract 77:S99-103. 2007
    ..These results implicated that once anti-islet immunity is optimally activated, subjects with partially resistant alleles could become overt diabetes...
  20. ncbi request reprint Insulin as a T cell antigen in type 1 diabetes supported by the evidence from the insulin knockout NOD mice
    Hiroaki Moriyama
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Diabetes Res Clin Pract 77:S155-60. 2007
    ....
  21. ncbi request reprint Characterization of ubiquilin 1, an mTOR-interacting protein
    Shilan Wu
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02135, USA
    Biochim Biophys Acta 1542:41-56. 2002
    ..Our data suggest that we have identified a novel mTOR interactor, ubiquilin 1. The biological significance of this, presumably membrane based, interaction, requires further study...
  22. ncbi request reprint Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region
    Terunao Takahara
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 281:28605-14. 2006
    ..In addition, Saccharomyces cerevisiae TOR proteins Tor1p and Tor2p also exist as homomultimers. These results suggest that TOR multimerization is a conserved mechanism for TOR functioning...
  23. pmc mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells
    Mirei Murakami
    Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Nara 630 0192, Japan
    Mol Cell Biol 24:6710-8. 2004
    ..These data show that mTOR controls both cell size and proliferation in early mouse embryos and embryonic stem cells...
  24. doi request reprint Prevention of recurrent but not spontaneous autoimmune diabetes by transplanted NOD islets adenovirally transduced with immunomodulating molecules
    Muneaki Sakata
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Diabetes Res Clin Pract 80:352-9. 2008
    ....
  25. ncbi request reprint Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites
    Nobuyuki Takei
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    J Neurosci 24:9760-9. 2004
    ..Taken together, these data indicate that mTOR-dependent translation activation is essential for the upregulation of local protein synthesis in neuronal dendrites...
  26. ncbi request reprint Modification of the Rb-binding domain of replication-competent adenoviral vector enhances cytotoxicity against human esophageal cancers via NF-kappaB activity
    Katsumi Yamada
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Hum Gene Ther 18:389-400. 2007
    ..These data demonstrate that the Rb-binding domain of E1A can regulate NF-kappaB activity and that modifications to this domain may lead to advances in gene therapies for the treatment of human cancers...