M Enomoto

Summary

Affiliation: Kobe University
Country: Japan

Publications

  1. doi request reprint The Watanabe heritable hyperlipidemic (WHHL) rabbit, its characteristics and history of development: a tribute to the late Dr. Yoshio Watanabe
    Masashi Shiomi
    Institute for Experimental Animals, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Atherosclerosis 207:1-7. 2009
  2. pmc Roles of the WHHL rabbit in translational research on hypercholesterolemia and cardiovascular diseases
    Tsutomu Kobayashi
    Institute for Experimental Animals, Kobe University Graduate School of Medicine, Chuo Ku, Kobe, Japan
    J Biomed Biotechnol 2011:406473. 2011
  3. ncbi request reprint Contribution of the WHHL rabbit, an animal model of familial hypercholesterolemia, to elucidation of the anti-atherosclerotic effects of statins
    Masashi Shiomi
    Institute for Experimental Animals, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan Division of Comparative Pathophysiology, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan Electronic address
    Atherosclerosis 231:39-47. 2013
  4. doi request reprint Myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits with mesenteric fat accumulation are a novel animal model for metabolic syndrome
    Masashi Shiomi
    Institute for Experimental Animals, Kobe University Graduate School of Medicine, Kobe, Japan
    Pathobiology 79:329-38. 2012
  5. doi request reprint Unstable coronary plaques and cardiac events in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits: questions and quandaries
    Masashi Shiomi
    Institute for Experimental Animals, Kobe University School of Medicine, Kobe, Hyogo, Japan
    Curr Opin Lipidol 19:631-6. 2008
  6. pmc Lapaquistat acetate, a squalene synthase inhibitor, changes macrophage/lipid-rich coronary plaques of hypercholesterolaemic rabbits into fibrous lesions
    M Shiomi
    Institute for Experimental Animals, Kobe University School of Medicine, Kobe, Japan
    Br J Pharmacol 154:949-57. 2008
  7. doi request reprint Invasion of atheromatous plaques into tunica media causes coronary outward remodeling in WHHLMI rabbits
    Masashi Shiomi
    Institute for Experimental Animals, Kobe University School of Medicine, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Atherosclerosis 198:287-93. 2008
  8. pmc Effect of cerivastatin sodium, a new inhibitor of HMG-CoA reductase, on plasma lipid levels, progression of atherosclerosis, and the lesional composition in the plaques of WHHL rabbits
    M Shiomi
    Institute for Experimental Animals, Kobe University School of Medicine, Japan
    Br J Pharmacol 126:961-8. 1999
  9. ncbi request reprint Atheroma stabilizing effects of simvastatin due to depression of macrophages or lipid accumulation in the atheromatous plaques of coronary plaque-prone WHHL rabbits
    Masashi Shiomi
    Institute for Experimental Animals, Kobe University School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Atherosclerosis 178:287-94. 2005
  10. ncbi request reprint Correlation of vulnerable coronary plaques to sudden cardiac events. Lessons from a myocardial infarction-prone animal model (the WHHLMI rabbit)
    Masashi Shiomi
    Institute for Experimental Animals, Kobe University School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe, Hyogo 650 0017, Japan
    J Atheroscler Thromb 11:184-9. 2004

Collaborators

Detail Information

Publications17

  1. doi request reprint The Watanabe heritable hyperlipidemic (WHHL) rabbit, its characteristics and history of development: a tribute to the late Dr. Yoshio Watanabe
    Masashi Shiomi
    Institute for Experimental Animals, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Atherosclerosis 207:1-7. 2009
    ..In studies with WHHL rabbits, plaque-stabilizing effects of statins were proved. In this review, we admire his achievements and describe the history of studies using WHHL rabbits...
  2. pmc Roles of the WHHL rabbit in translational research on hypercholesterolemia and cardiovascular diseases
    Tsutomu Kobayashi
    Institute for Experimental Animals, Kobe University Graduate School of Medicine, Chuo Ku, Kobe, Japan
    J Biomed Biotechnol 2011:406473. 2011
    ....
  3. ncbi request reprint Contribution of the WHHL rabbit, an animal model of familial hypercholesterolemia, to elucidation of the anti-atherosclerotic effects of statins
    Masashi Shiomi
    Institute for Experimental Animals, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan Division of Comparative Pathophysiology, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan Electronic address
    Atherosclerosis 231:39-47. 2013
    ..Although statins remain the standard treatment for cardiovascular disease, new therapeutics are eagerly awaited. WHHL rabbits will continue to contribute to the development of therapeutics...
  4. doi request reprint Myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits with mesenteric fat accumulation are a novel animal model for metabolic syndrome
    Masashi Shiomi
    Institute for Experimental Animals, Kobe University Graduate School of Medicine, Kobe, Japan
    Pathobiology 79:329-38. 2012
    ....
  5. doi request reprint Unstable coronary plaques and cardiac events in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits: questions and quandaries
    Masashi Shiomi
    Institute for Experimental Animals, Kobe University School of Medicine, Kobe, Hyogo, Japan
    Curr Opin Lipidol 19:631-6. 2008
    ....
  6. pmc Lapaquistat acetate, a squalene synthase inhibitor, changes macrophage/lipid-rich coronary plaques of hypercholesterolaemic rabbits into fibrous lesions
    M Shiomi
    Institute for Experimental Animals, Kobe University School of Medicine, Kobe, Japan
    Br J Pharmacol 154:949-57. 2008
    ..We have here treated WHHLMI rabbits, a model for coronary atherosclerosis and myocardial infarction, with a novel squalene synthase inhibitor, lapaquistat acetate (TAK-475)...
  7. doi request reprint Invasion of atheromatous plaques into tunica media causes coronary outward remodeling in WHHLMI rabbits
    Masashi Shiomi
    Institute for Experimental Animals, Kobe University School of Medicine, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Atherosclerosis 198:287-93. 2008
    ..Proliferation of smooth muscle cells was observed at the attenuated tunica media and adjacent adventitia. The present results suggest that invasion of atheromatous plaques into the tunica media causes coronary outward remodeling...
  8. pmc Effect of cerivastatin sodium, a new inhibitor of HMG-CoA reductase, on plasma lipid levels, progression of atherosclerosis, and the lesional composition in the plaques of WHHL rabbits
    M Shiomi
    Institute for Experimental Animals, Kobe University School of Medicine, Japan
    Br J Pharmacol 126:961-8. 1999
    ..4. These results indicate that cerivastatin contributed to the plaque stabilization and delayed progression of early atherosclerosis in young WHHL rabbits, in addition to the potent hypolipidemic effects...
  9. ncbi request reprint Atheroma stabilizing effects of simvastatin due to depression of macrophages or lipid accumulation in the atheromatous plaques of coronary plaque-prone WHHL rabbits
    Masashi Shiomi
    Institute for Experimental Animals, Kobe University School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Atherosclerosis 178:287-94. 2005
    ..In conclusion, our results suggest that simvastatin did not depress the fibromuscular components in atheromatous plaques and the plaque-stabilizing effects were due to the reduction of macrophages/lipid deposits...
  10. ncbi request reprint Correlation of vulnerable coronary plaques to sudden cardiac events. Lessons from a myocardial infarction-prone animal model (the WHHLMI rabbit)
    Masashi Shiomi
    Institute for Experimental Animals, Kobe University School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe, Hyogo 650 0017, Japan
    J Atheroscler Thromb 11:184-9. 2004
    ....
  11. ncbi request reprint Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbit)
    Masashi Shiomi
    Institute for Experimental Animals, Kobe University School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Arterioscler Thromb Vasc Biol 23:1239-44. 2003
    ..In this study, we attempted to obtain a rabbit strain with spontaneous myocardial infarction by selective breeding of coronary atherosclerosis-prone Watanabe heritable hyperlipidemic (WHHL) rabbits, designated as WHHLMI rabbits...
  12. ncbi request reprint Stability of atheromatous plaque affected by lesional composition: study of WHHL rabbits treated with statins
    M Shiomi
    Institute for Experimental Animals, Kobe University School of Medicine, Japan
    Ann N Y Acad Sci 947:419-23. 2001
    ..Our results suggest that reduction in M(phi)s in the fibromuscular cap is related to plaque stabilization and that reduction in SMCs in the fibromuscular cap is related to plaque destabilization...
  13. ncbi request reprint MTP inhibitor decreases plasma cholesterol levels in LDL receptor-deficient WHHL rabbits by lowering the VLDL secretion
    M Shiomi
    Institute for Experimental Animals, Kobe University School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, 650 0017, Kobe, Japan
    Eur J Pharmacol 431:127-31. 2001
    ..In conclusion, an inhibition of VLDL secretion led to a decrease of plasma LDL in WHHL rabbits, and MTP inhibitors should have hypolipidemic effects against homozygous familial hypercholesterolemia...
  14. ncbi request reprint Fibromuscular cap composition is important for the stability of established atherosclerotic plaques in mature WHHL rabbits treated with statins
    M Shiomi
    Institute for Experimental Animals, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Atherosclerosis 157:75-84. 2001
    ..Our results suggest that the stability of atheromatous plaques was improved due to a decrease of the lipid components and vulnerability index of the fibromuscular cap by pravastatin...
  15. ncbi request reprint Statins alter smooth muscle cell accumulation and collagen content in established atheroma of watanabe heritable hyperlipidemic rabbits
    Y Fukumoto
    Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 103:993-9. 2001
    ..CONCLUSIONS: This study showed that statins can reduce MMP expression in atheroma and that cell-permeant statins can decrease SMC number and collagen gene expression in vivo...
  16. ncbi request reprint Serum level of advanced glycation end-products (AGEs) is an independent determinant of plasminogen activator inhibitor-1 (PAI-1) in nondiabetic general population
    S Yamagishi
    Department of Medicine, Division of Cardiovascular Medicine, Kurume University School of Medicine, Kurume, Japan
    Horm Metab Res 39:845-8. 2007
    ..The AGE-associated thrombogenic abnormality may be involved in atherogenesis in nondiabetic subjects...
  17. pmc A haplotype of the human CXCR1 gene protective against rapid disease progression in HIV-1+ patients
    A Vasilescu
    Centre National de Genotypage, 91057 Evry, France
    Proc Natl Acad Sci U S A 104:3354-9. 2007
    ..0003). These results provide strong evidence of a protective role of the CXCR1-Ha allele on disease progression in AIDS, probably acting through modulation of CD4 and CXCR4 expression...