N Emoto

Summary

Affiliation: Kobe University
Country: Japan

Publications

  1. ncbi request reprint Obesity-induced upregulation of myocardial endothelin-1 expression is mediated by leptin
    Suko Adiarto
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Biochem Biophys Res Commun 353:623-7. 2007
  2. pmc Real-time monitoring of circadian clock oscillations in primary cultures of mammalian cells using Tol2 transposon-mediated gene transfer strategy
    Kazuhiro Yagita
    Department of Neuroscience and Cell Biology, Osaka University Graduate School of Medicine, Yamadaoka 2 2, Suita, Osaka, 565 0871 Japan
    BMC Biotechnol 10:3. 2010
  3. ncbi request reprint Dual ECE/NEP inhibition on cardiac and neurohumoral function during the transition from hypertrophy to heart failure in rats
    Noriaki Emoto
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki, Chuo, Kobe, 650 0017, Japan
    Hypertension 45:1145-52. 2005
  4. ncbi request reprint Constitutive lysosomal targeting and degradation of bovine endothelin-converting enzyme-1a mediated by novel signals in its alternatively spliced cytoplasmic tail
    N Emoto
    Division of Genetics, International Center for Medical Research, Kobe University School of Medicine, Kobe, 6500017 Japan
    J Biol Chem 274:1509-18. 1999
  5. ncbi request reprint Alternative splicing regulates the endoplasmic reticulum localization or secretion of soluble secreted endopeptidase
    S B Raharjo
    Division of Molecular Medicine, International Center for Medical Research, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki, Chuo, Kobe 6500017, Japan
    J Biol Chem 276:25612-20. 2001
  6. ncbi request reprint Molecular identification and characterization of novel membrane-bound metalloprotease, the soluble secreted form of which hydrolyzes a variety of vasoactive peptides
    K Ikeda
    Division of Genetics, International Center for Medical Research, Kobe University School of Medicine, 7 5 1 Kusunoki, Chuo, Kobe 6500017, Japan
    J Biol Chem 274:32469-77. 1999
  7. ncbi request reprint Angiotensin II induces circadian gene expression of clock genes in cultured vascular smooth muscle cells
    H Nonaka
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Circulation 104:1746-8. 2001
  8. ncbi request reprint [Physiological and pathophysiological roles of the endothelin converting enzymes]
    Noriaki Emoto
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
    Nihon Rinsho 62:636-9. 2004
  9. ncbi request reprint Decreased mAKAP, ryanodine receptor, and SERCA2a gene expression in mdx hearts
    Mohammad Saifur Rohman
    Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki, Chuo, Kobe 6500017, Japan
    Biochem Biophys Res Commun 310:228-35. 2003
  10. doi request reprint Attenuation of Doxorubicin-induced cardiomyopathy by endothelin-converting enzyme-1 ablation through prevention of mitochondrial biogenesis impairment
    Kazuya Miyagawa
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki, Chuo, 650 0017 Kobe, Japan
    Hypertension 55:738-46. 2010

Collaborators

  • M Matsuo
  • K Ikeda
  • Yoshiyuki Rikitake
  • T Yamada
  • M Yokoyama
  • J Xie
  • R Sato
  • Hitoshi Okamura
  • A Y Jeng
  • Yasuhiro Takeshima
  • Toshio Hayashi
  • Tomoya Yamashita
  • Atsuhiro Ichihara
  • Ken ichi Hirata
  • Kazuhiro Yagita
  • Bambang Widyantoro
  • Suko Adiarto
  • Hidemi Nonaka
  • Kazuya Miyagawa
  • Kazuhiko Nakayama
  • Dyah W Anggrahini
  • Naoko Iwasa
  • Masashi Yanagisawa
  • Hiroyuki Fukuya
  • H Nonaka
  • Takashi Suzuki
  • Keiko Yagi
  • Yaz Y Kisanuki
  • Yoko Masuda
  • Naoto Sasaki
  • S B Raharjo
  • Takao Mohri
  • Koichi Misawa
  • Daiji Isaka
  • Mohammad Saifur Rohman
  • Shoko Ikeda
  • Raviraj Kulathila
  • Iori Yamanaka
  • Koichi Kawakami
  • Shoichi Shimada
  • Takeshi Todo
  • Takahide Nomura
  • Tomofumi Takaya
  • Akiko Fukatsu
  • Masakazu Shinohara
  • Rio Shiraki
  • Kazuhisa Ikemoto
  • Masafumi Takeda
  • Seinosuke Kawashima
  • Sunu Budhi Raharjo
  • Hitoshi Shimano
  • Yuko Hirano
  • Jun Inoue
  • Taro Horiba
  • Naoto Arimura
  • Makoto Shimizu
  • Haryanto Alimsardjono
  • Kirk Clark
  • Paula Savage
  • Benjamin R Bowen
  • M S Rohman
  • K Yagita
  • H Fukuya
  • T Tsujino
  • Y Watari

Detail Information

Publications26

  1. ncbi request reprint Obesity-induced upregulation of myocardial endothelin-1 expression is mediated by leptin
    Suko Adiarto
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Biochem Biophys Res Commun 353:623-7. 2007
    ..In contrast, in leptin-deficient obese (ob/ob) mice, both serum and myocardial ET-1 levels were not higher than in wild type mice. These findings suggest that upregulation of myocardial ET-1 by obesity is mediated by leptin...
  2. pmc Real-time monitoring of circadian clock oscillations in primary cultures of mammalian cells using Tol2 transposon-mediated gene transfer strategy
    Kazuhiro Yagita
    Department of Neuroscience and Cell Biology, Osaka University Graduate School of Medicine, Yamadaoka 2 2, Suita, Osaka, 565 0871 Japan
    BMC Biotechnol 10:3. 2010
    ..Thus, it is important to understand the correlation between circadian oscillator and physiological functions in peripheral tissues. However, it is still difficult to investigate the molecular oscillator in primary culture cells...
  3. ncbi request reprint Dual ECE/NEP inhibition on cardiac and neurohumoral function during the transition from hypertrophy to heart failure in rats
    Noriaki Emoto
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki, Chuo, Kobe, 650 0017, Japan
    Hypertension 45:1145-52. 2005
    ..The beneficial effects of CGS 26303 are likely caused in part by the greater reduction of plasma ET-1. Dual ECE/NEP inhibitor may provide a new strategy for the treatment of human heart failure...
  4. ncbi request reprint Constitutive lysosomal targeting and degradation of bovine endothelin-converting enzyme-1a mediated by novel signals in its alternatively spliced cytoplasmic tail
    N Emoto
    Division of Genetics, International Center for Medical Research, Kobe University School of Medicine, Kobe, 6500017 Japan
    J Biol Chem 274:1509-18. 1999
    ....
  5. ncbi request reprint Alternative splicing regulates the endoplasmic reticulum localization or secretion of soluble secreted endopeptidase
    S B Raharjo
    Division of Molecular Medicine, International Center for Medical Research, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki, Chuo, Kobe 6500017, Japan
    J Biol Chem 276:25612-20. 2001
    ..Our results suggest that the unique subcellular localization and secretion of SEP proteins provide a novel model of protein trafficking within the secretory pathway...
  6. ncbi request reprint Molecular identification and characterization of novel membrane-bound metalloprotease, the soluble secreted form of which hydrolyzes a variety of vasoactive peptides
    K Ikeda
    Division of Genetics, International Center for Medical Research, Kobe University School of Medicine, 7 5 1 Kusunoki, Chuo, Kobe 6500017, Japan
    J Biol Chem 274:32469-77. 1999
    ..These findings suggest that SEP is a novel metalloprotease that possesses a broad substrate specificity and that it may be involved in the metabolism of biologically active peptides intracellulary as well as extracellularly...
  7. ncbi request reprint Angiotensin II induces circadian gene expression of clock genes in cultured vascular smooth muscle cells
    H Nonaka
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Circulation 104:1746-8. 2001
    ..Our in vitro system will provide a useful tool to further analyze the physiological significance of the peripheral clock in cardiovascular function...
  8. ncbi request reprint [Physiological and pathophysiological roles of the endothelin converting enzymes]
    Noriaki Emoto
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
    Nihon Rinsho 62:636-9. 2004
  9. ncbi request reprint Decreased mAKAP, ryanodine receptor, and SERCA2a gene expression in mdx hearts
    Mohammad Saifur Rohman
    Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki, Chuo, Kobe 6500017, Japan
    Biochem Biophys Res Commun 310:228-35. 2003
    ..Therefore, dystrophin deficiency may cause an impairment of SR Ca(2+) homeostasis and E-C coupling in mdx hearts, in part, by decreased gene expression of molecules involved in SR Ca(2+) handling...
  10. doi request reprint Attenuation of Doxorubicin-induced cardiomyopathy by endothelin-converting enzyme-1 ablation through prevention of mitochondrial biogenesis impairment
    Kazuya Miyagawa
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki, Chuo, 650 0017 Kobe, Japan
    Hypertension 55:738-46. 2010
    ..This was mainly induced by decreased endothelin-1 levels and an enhanced atrial natriuretic peptide-cGMP pathway. Thus, the inhibition of ECE-1 may be a new therapeutic strategy for doxorubicin-induced cardiomyopathy...
  11. ncbi request reprint Taurine prevents the decrease in expression and secretion of extracellular superoxide dismutase induced by homocysteine: amelioration of homocysteine-induced endoplasmic reticulum stress by taurine
    H Nonaka
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Circulation 104:1165-70. 2001
    ..Taurine restores the secretion and expression of EC-SOD by ameliorating ER stress induced by homocysteine...
  12. ncbi request reprint Alterations of circadian expressions of clock genes in Dahl salt-sensitive rats fed a high-salt diet
    Takao Mohri
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki, Chuo, Kobe, 650 0017, Japan
    Hypertension 42:189-94. 2003
    ..Detailed analyses of the relation between circadian expression of clock genes and blood pressure regulation might reveal a role for chronologic therapy of cardiovascular disease...
  13. ncbi request reprint [Gene, molecular structure, and biosynthesis of the endothelin system]
    Noriaki Emoto
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
    Nihon Rinsho 62:584-7. 2004
  14. doi request reprint Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition
    Bambang Widyantoro
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Circulation 121:2407-18. 2010
    ..The underlying mechanism, however, remains elusive. Here, we hypothesize that ET-1 might contribute to the accumulation of cardiac fibroblasts through an endothelial-to-mesenchymal transition in diabetic hearts...
  15. ncbi request reprint Molecular isolation and characterization of novel four subisoforms of ECE-2
    Shoko Ikeda
    Division of Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki, Chuo, Kobe 6500017, Japan
    Biochem Biophys Res Commun 293:421-6. 2002
    ..Detailed analysis of ECE-2 subisoforms will provide crucial information to clarify the physiological function of ECE-2...
  16. ncbi request reprint The effects of phosphoramidon on the expression of human endothelin-converting enzyme-1 (ECE-1) isoforms
    Daiji Isaka
    Division of Molecular Medicine, International Center for Medical Research, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki, Chuo, Kobe 650 0017, Japan
    J Cardiovasc Pharmacol 42:136-41. 2003
    ..Taken together, our results demonstrate that phosphoramidon differentially affects the expression of three human ECE-1 isoforms...
  17. ncbi request reprint Molecular identification and characterization of a novel nuclear protein whose expression is up-regulated in insulin-resistant animals
    Koji Ikeda
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
    J Biol Chem 278:3514-20. 2003
    ..Taken together, these data suggest that DARP is a novel nuclear protein potentially involved in the energy metabolism. Detailed analysis of DARP may provide new insights in the energy metabolism...
  18. ncbi request reprint Role of angiotensin and the clock system in the circadian regulation of plasminogen activator inhibitor-1
    Yoko Masuda
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Kobe J Med Sci 54:E264-71. 2009
    ....
  19. doi request reprint Vascular endothelial cell-derived endothelin-1 mediates vascular inflammation and neointima formation following blood flow cessation
    Dyah W Anggrahini
    Division of Cardiovascular Medicine, Department of Internal Medicine, 7 5 1 Kusunoki, Chuo, Kobe 650 0017, Japan
    Cardiovasc Res 82:143-51. 2009
    ..In this study, we determined the role of vascular endothelial ET-1 on vascular inflammation and neointima formation using vascular endothelial ET-1-knockout [ET-1(f/f); Tie2-Cre (+)] mice...
  20. ncbi request reprint Circadian expression of clock genes in human peripheral leukocytes
    Hiroyuki Fukuya
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Biochem Biophys Res Commun 354:924-8. 2007
    ..These observations suggest that monitoring Per1 mRNA expression in human leukocytes may be useful for investigating the function of the circadian system in physiological and pathophysiological states...
  21. ncbi request reprint Decreased ornithine decarboxylase activity in the kidneys of Dahl salt-sensitive rats
    Takeshi Hayashi
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Hypertens Res 25:787-95. 2002
    ..ODC protein was suggested to increase in compensation for the inhibition of its activity. Impaired ODC activity and polyamine production in the kidney may exaggerate salt-sensitive hypertension in SS rats...
  22. ncbi request reprint [Genetically altered rodent models in the endothelin-related genes]
    Noriaki Emoto
    Division of Cardiovascular and Respiratory Medicine, Department of Inter nal Medicine, Kobe University Graduate School of Medicine
    Nihon Rinsho 64:311-5. 2006
  23. ncbi request reprint [Rodent models with genetically altered endothelin receptor gene]
    Noriaki Emoto
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
    Nihon Rinsho 62:598-601. 2004
  24. ncbi request reprint Expression, purification and characterization of the monomeric and dimeric forms of soluble bovine endothelin converting enzyme-1a
    Raviraj Kulathila
    Novartis Institute for Biomedical Research, 556 Morris Avenue, Summit, NJ 07901, U S A
    Clin Sci (Lond) 103:94S-97S. 2002
    ..The present protocol can be utilized to prepare large quantities of both forms of ECE-1a for further biochemical and structural characterization...
  25. doi request reprint Augmentation of vascular remodeling by uncoupled endothelial nitric oxide synthase in a mouse model of diabetes mellitus
    Naoto Sasaki
    Department of General Medicine, Nakatsu Saiseikai Hospital, 2 10 39 Shibata, Kita ku, Osaka 530 0012, Japan
    Arterioscler Thromb Vasc Biol 28:1068-76. 2008
    ..Without enough BH4, eNOS is uncoupled to L-arginine and produces superoxide rather than NO. We examined the role of uncoupled eNOS in vascular remodeling in diabetes...
  26. ncbi request reprint Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes
    Koichi Misawa
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    J Biol Chem 278:36176-82. 2003
    ..These data provide a novel pathway by which HNF-4 potentiates the SREBP functions and stimulates expression of SREBP-responsive genes in enterohepatic cells...