Zen Kobayashi

Summary

Country: Japan

Publications

  1. ncbi request reprint Thalamic hypoperfusion in early stage of progressive supranuclear palsy (Richardson's syndrome): report of an autopsy-confirmed case
    Zen Kobayashi
    Department of Neurology, JA Toride Medical Center, Ibaraki, Japan Electronic address
    J Neurol Sci 335:224-7. 2013
  2. doi request reprint Failure of mefloquine therapy in progressive multifocal leukoencephalopathy: report of two Japanese patients without human immunodeficiency virus infection
    Zen Kobayashi
    Department of Neurology, JA Toride Medical Center, Ibaraki, Japan
    J Neurol Sci 324:190-4. 2013
  3. doi request reprint An autopsy case of chronic active Epstein-Barr virus infection (CAEBV): distribution of central nervous system (CNS) lesions
    Zen Kobayashi
    Department of Neurology, Tsuchiura Kyodo Hospital, Ibaraki, 300 0053, Japan
    J Neurol Sci 275:170-7. 2008
  4. ncbi request reprint Fatal encephalitis in a case of hypereosinophilic syndrome: MRI and autopsy findings
    Zen Kobayashi
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Japan
    Intern Med 50:1219-25. 2011
  5. doi request reprint FALS with Gly72Ser mutation in SOD1 gene: report of a family including the first autopsy case
    Zen Kobayashi
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo, 156 8585, Japan
    J Neurol Sci 300:9-13. 2011
  6. doi request reprint Clinicopathological characteristics of FTLD-TDP showing corticospinal tract degeneration but lacking lower motor neuron loss
    Zen Kobayashi
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    J Neurol Sci 298:70-7. 2010
  7. doi request reprint Occurrence of basophilic inclusions and FUS-immunoreactive neuronal and glial inclusions in a case of familial amyotrophic lateral sclerosis
    Zen Kobayashi
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Tokyo, Japan
    J Neurol Sci 293:6-11. 2010
  8. ncbi request reprint Pseudopolyneuritic form of ALS revisited: clinical and pathological heterogeneity
    Zen Kobayashi
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Tokyo
    Neuropathology 30:372-80. 2010
  9. doi request reprint Metastatic CNS lymphoma presenting with periventricular dissemination - MRI and neuropathological findings in an autopsy case
    Zen Kobayashi
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, 113 8519, Japan
    J Neurol Sci 277:109-13. 2009
  10. ncbi request reprint Japanese encephalitis - serial CT findings and neuropathology in an autopsy case
    Z Kobayashi
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Clin Neuropathol 28:422-9. 2009

Detail Information

Publications24

  1. ncbi request reprint Thalamic hypoperfusion in early stage of progressive supranuclear palsy (Richardson's syndrome): report of an autopsy-confirmed case
    Zen Kobayashi
    Department of Neurology, JA Toride Medical Center, Ibaraki, Japan Electronic address
    J Neurol Sci 335:224-7. 2013
    ..Our definite PSP-RS case suggests that thalamic hypoperfusion may provide helpful evidence to support a diagnosis of PSP-RS in the early stage of the disease. ..
  2. doi request reprint Failure of mefloquine therapy in progressive multifocal leukoencephalopathy: report of two Japanese patients without human immunodeficiency virus infection
    Zen Kobayashi
    Department of Neurology, JA Toride Medical Center, Ibaraki, Japan
    J Neurol Sci 324:190-4. 2013
    ..Both patients died about 4 months and 2 months after initiation of mefloquine, respectively. Further studies are necessary to clarify the differences between mefloquine responders and non-responders in PML...
  3. doi request reprint An autopsy case of chronic active Epstein-Barr virus infection (CAEBV): distribution of central nervous system (CNS) lesions
    Zen Kobayashi
    Department of Neurology, Tsuchiura Kyodo Hospital, Ibaraki, 300 0053, Japan
    J Neurol Sci 275:170-7. 2008
    ..The CD3 positive cells of the brainstem were EBV-encoded RNA 1 positive. This is the first autopsy case of chronic active EBV infection (CAEBV) in which severe and extensive CNS involvement was demonstrated...
  4. ncbi request reprint Fatal encephalitis in a case of hypereosinophilic syndrome: MRI and autopsy findings
    Zen Kobayashi
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Japan
    Intern Med 50:1219-25. 2011
    ..Immunohistochemistry for herpes simplex virus type 1 and human herpesvirus 6 was negative. This case suggests that fatal encephalitis may develop in association with hypereosinophilic syndrome...
  5. doi request reprint FALS with Gly72Ser mutation in SOD1 gene: report of a family including the first autopsy case
    Zen Kobayashi
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo, 156 8585, Japan
    J Neurol Sci 300:9-13. 2011
    ..Involvement of Onuf's nucleus may be a characteristic pathological feature in FALS with Gly72Ser mutation in the SOD1 gene...
  6. doi request reprint Clinicopathological characteristics of FTLD-TDP showing corticospinal tract degeneration but lacking lower motor neuron loss
    Zen Kobayashi
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    J Neurol Sci 298:70-7. 2010
    ..This study clarified that FTLD-MND-P cases have characteristic clinicopathological features distinct from those of FTLD-MND-A...
  7. doi request reprint Occurrence of basophilic inclusions and FUS-immunoreactive neuronal and glial inclusions in a case of familial amyotrophic lateral sclerosis
    Zen Kobayashi
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Tokyo, Japan
    J Neurol Sci 293:6-11. 2010
    ..These findings support the idea that both BIs and FUS-ir structures are pathological hallmarks of a subset of ALS cases...
  8. ncbi request reprint Pseudopolyneuritic form of ALS revisited: clinical and pathological heterogeneity
    Zen Kobayashi
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Tokyo
    Neuropathology 30:372-80. 2010
    ..In this case only, Bunina bodies were not demonstrated. In this study, we clarified the clinical and pathological heterogeneity of this form of ALS...
  9. doi request reprint Metastatic CNS lymphoma presenting with periventricular dissemination - MRI and neuropathological findings in an autopsy case
    Zen Kobayashi
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, 113 8519, Japan
    J Neurol Sci 277:109-13. 2009
    ..We considered that the lymphoma cells entered the ventricular system through the choroid plexus of the lateral ventricle, followed by dissemination of the periventricular parenchyma...
  10. ncbi request reprint Japanese encephalitis - serial CT findings and neuropathology in an autopsy case
    Z Kobayashi
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Clin Neuropathol 28:422-9. 2009
    ..We discussed for the first time the correlation of CT and neuropathological findings in a patient with Japanese encephalitis...
  11. doi request reprint Intractable hiccup caused by medulla oblongata lesions: a study of an autopsy patient with possible neuromyelitis optica
    Zen Kobayashi
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, 113 8519, Japan
    J Neurol Sci 285:241-5. 2009
    ..Although animal experiments have shown that NTS is a critical structure in the hiccup reflex, we demonstrated for the first time the involvement of the NTS in an autopsy patient with intractable hiccup...
  12. doi request reprint Morel's laminar sclerosis showing apraxia of speech: distribution of cortical lesions in an autopsy case
    Zen Kobayashi
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo 156 8585, Japan Email
    Neuropathology 30:76-83. 2010
    ..The lesions were mainly located in the bilateral primary motor cortices. Involvement of the lower part of the left primary motor cortex may be associated with apraxia of speech in our case...
  13. doi request reprint Progressive nonfluent aphasia: a rare clinical subtype of FTLD-TDP in Japan
    Naoya Aoki
    Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
    Neuropathology 32:272-9. 2012
    ..A few dystrophic neurites and neuronal intranuclear inclusions were also seen. FTLD-TDP showing PNFA seems to be rare but does exist in Japan, similar to that in other countries...
  14. doi request reprint Atypical FTLD-FUS associated with ALS-TDP: a case report
    Zen Kobayashi
    Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, 2 1 6 Kamikitazawa, Setagaya Ku, Tokyo 156 8506, Japan
    Neuropathology 33:83-6. 2013
    ..To our knowledge, this is the first report of a case in which FTLD-FUS pathology is of a dystrophic neurites-predominant type and FTLD-FUS is associated with ALS-TDP...
  15. ncbi request reprint Pathological features of FTLD-FUS in a Japanese population: analyses of nine cases
    Zen Kobayashi
    Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan Department of Neurology, JA Toride Medical Center, Toride, Ibaraki, Japan
    J Neurol Sci 335:89-95. 2013
    ..Redistribution of FUS from the nucleus to the cytoplasm could be associated with the formation of abnormal FUS aggregates in FTLD-FUS. ..
  16. doi request reprint Localization of fused in sarcoma (FUS) protein to the post-synaptic density in the brain
    Naoya Aoki
    Dementia Project, Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, 2 1 6 Kamikitazawa, Setagaya Ku, Tokyo, 156 8506, Japan
    Acta Neuropathol 124:383-94. 2012
    ..The increase in Alzheimer's disease (AD) is less remarkable but still significant. The dendritic localization of FUS and its increase in FTLD-TDP and AD may have some implication for the pathophysiology of neurodegenerative diseases...
  17. doi request reprint FUS/TLS-immunoreactive neuronal and glial cell inclusions increase with disease duration in familial amyotrophic lateral sclerosis with an R521C FUS/TLS mutation
    Naoki Suzuki
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    J Neuropathol Exp Neurol 71:779-88. 2012
    ..The distribution of FUS/TLS-immunoreactive inclusions in FUS/TLS-mutated FALS with BIs was broader than that of BIs alone, suggesting that the pathogenetic mechanism may have originated from the FUS/TLS proteinopathy...
  18. doi request reprint Frontotemporal lobar degeneration with motor neuron disease showing severe and circumscribed atrophy of anterior temporal lobes
    Hiroya Kuwahara
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Neurol Sci 297:92-6. 2010
    ..This case report showed typical features of FTLD-MND in clinical course and TDP-43 pathology with unusual severity and distribution of cerebral atrophy, suggesting a unique manifestation of FTLD-MND...
  19. doi request reprint Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy
    Tetsuaki Arai
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, Tokyo, Japan
    Neuropathology 30:170-81. 2010
    ..Understanding the mechanism of phosphorylation and truncation of TDP-43 and aggregate formation may be crucial for clarifying the pathogenesis of TDP-43 proteinopathy and for developing useful therapeutics...
  20. doi request reprint Cryptococcal meningitis accompanying lymphocytic inflammation predominantly in cerebral deep white matter: a possible manifestation of immune reconstitution inflammatory syndrome
    Hiroya Kuwahara
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan Department of Neurology, Yokosuka Kyosai Hospital, Kanagawa, Japan
    Neuropathology 34:45-8. 2014
    ..This is the first report of a case suggesting that cryptococcal meningitis can accompany lymphocytic inflammation predominantly in cerebral deep white matter as a possible manifestation of immune reconstitution inflammatory syndrome. ..
  21. ncbi request reprint Epstein-Barr virus-associated meningitis presenting with hearing impairment
    Tomoyuki Miyashita
    Department of Neurology, JA Toride Medical Center, Japan
    Intern Med 51:1755-7. 2012
    ..We presume that the hearing impairment was due to auditory nerve neuritis related to extension of inflammation of the meninges. This is the first reported case of EBV-associated meningitis showing hearing impairment...
  22. doi request reprint Gray matter lesions in Nasu-Hakola disease: a report on three autopsy cases
    Naoya Aoki
    Tokyo Institute of Psychiatry, Japan
    Neuropathology 31:135-43. 2011
    ..These gray matter pathologies are considered to be responsible for some of the clinical manifestations of the disease, including extrapyramidal symptoms...
  23. doi request reprint Brain perfusion abnormalities in a sibship with parkin-linked parkinsonism
    Zen Kobayashi
    Department of Neurology, Musashino Red Cross Hospital, 1 26 1 Kyonan cho, Musashino shi, Tokyo 180 8610, Japan
    Parkinsonism Relat Disord 14:581-3. 2008
    ..These findings may reflect their executive dysfunction demonstrated by neuropsychological tests...
  24. ncbi request reprint Leptomeningeal enhancement in acute cerebellitis associated with Epstein-Barr virus
    Yuji Hashimoto
    Department of Neurology, Tsuchiura Kyodo Hospital, Tsuchiura, Japan
    Intern Med 47:331-2. 2008