Toru Yasuda

Summary

Affiliation: Kitasato University
Country: Japan

Publications

  1. doi request reprint The regulatory role of α-synuclein and parkin in neuronal cell apoptosis; possible implications for the pathogenesis of Parkinson's disease
    Toru Yasuda
    Department of Neurology, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Apoptosis 15:1312-21. 2010
  2. ncbi request reprint Alteration in the differentiation-related molecular expression in the subventricular zone in a mouse model of Parkinson's disease
    Hideki Oizumi
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo, Tokyo 113 8421, Japan
    Neurosci Res 60:15-21. 2008
  3. doi request reprint Parkin-mediated protection of dopaminergic neurons in a chronic MPTP-minipump mouse model of Parkinson disease
    Toru Yasuda
    Department of Neurology, Kitasato University School of Medicine, Minami Ku, Sagamihara, Kanagawa, Japan
    J Neuropathol Exp Neurol 70:686-97. 2011
  4. doi request reprint Accumulation of α-synuclein triggered by presynaptic dysfunction
    Yasuto Nakata
    Department of Neurology, Division of Neuroregenerative Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa 252 0374, Japan
    J Neurosci 32:17186-96. 2012
  5. doi request reprint Ectopic expression of α-synuclein affects the migration of neural stem cells in mouse subventricular zone
    Momo Tani
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    J Neurochem 115:854-63. 2010
  6. doi request reprint Adeno-associated viral vector-mediated gene transduction in mesencephalic slice culture
    Tomoko Nihira
    Department of Neurology, Kitasato University School of Medicine, Minami Ku, Sagamihara, Kanagawa, Japan
    J Neurosci Methods 201:55-60. 2011
  7. ncbi request reprint Recombinant human granulocyte colony-stimulating factor protects against MPTP-induced dopaminergic cell death in mice by altering Bcl-2/Bax expression levels
    Xu Qing Cao
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    J Neurochem 99:861-7. 2006
  8. doi request reprint Iron accumulation in Parkinson's disease
    Hideki Mochizuki
    Department of Neurology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    J Neural Transm 119:1511-4. 2012
  9. doi request reprint Use of growth factors for the treatment of Parkinson's disease
    Toru Yasuda
    Kitasato University School of Medicine, Kanagawa, Japan
    Expert Rev Neurother 10:915-24. 2010
  10. pmc Α-synuclein and neuronal cell death
    Toru Yasuda
    Department of Neurology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Neurobiol 47:466-83. 2013

Collaborators

Detail Information

Publications12

  1. doi request reprint The regulatory role of α-synuclein and parkin in neuronal cell apoptosis; possible implications for the pathogenesis of Parkinson's disease
    Toru Yasuda
    Department of Neurology, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Apoptosis 15:1312-21. 2010
    ..In this review, we will focus on the regulatory roles of αSyn and parkin proteins in DA neuronal cell apoptosis and provide evidence for the possible therapeutic action of parkin in sporadic patients with PD...
  2. ncbi request reprint Alteration in the differentiation-related molecular expression in the subventricular zone in a mouse model of Parkinson's disease
    Hideki Oizumi
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo, Tokyo 113 8421, Japan
    Neurosci Res 60:15-21. 2008
    ..Our results suggest that neuroinflammation related to the caspase-11 cascade in the striatum regulates differentiation of neural stem cells in the SVZ of our mouse model of PD...
  3. doi request reprint Parkin-mediated protection of dopaminergic neurons in a chronic MPTP-minipump mouse model of Parkinson disease
    Toru Yasuda
    Department of Neurology, Kitasato University School of Medicine, Minami Ku, Sagamihara, Kanagawa, Japan
    J Neuropathol Exp Neurol 70:686-97. 2011
    ..On the other hand, upregulation of p53 and mitochondrial alterations induced by chronic MPTP administration were barely suppressed by parkin. These results suggest that the neuroprotective actions of parkin may be impaired in severe PD...
  4. doi request reprint Accumulation of α-synuclein triggered by presynaptic dysfunction
    Yasuto Nakata
    Department of Neurology, Division of Neuroregenerative Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa 252 0374, Japan
    J Neurosci 32:17186-96. 2012
    ..Our present results suggest that SNARE dysfunction is the initial trigger of mislocalization and accumulation of αSyn, and probably is an important pathomechanism of α-synucleinopathies...
  5. doi request reprint Ectopic expression of α-synuclein affects the migration of neural stem cells in mouse subventricular zone
    Momo Tani
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    J Neurochem 115:854-63. 2010
    ..These results indicate that α-syn affects the generation of NSC and suggest that this protein could serve as a tool for the design of potentially useful therapy for PD patients...
  6. doi request reprint Adeno-associated viral vector-mediated gene transduction in mesencephalic slice culture
    Tomoko Nihira
    Department of Neurology, Kitasato University School of Medicine, Minami Ku, Sagamihara, Kanagawa, Japan
    J Neurosci Methods 201:55-60. 2011
    ..Our method should be useful for in vitro investigations of pathological changes in DA neurons following transduction with foreign genes...
  7. ncbi request reprint Recombinant human granulocyte colony-stimulating factor protects against MPTP-induced dopaminergic cell death in mice by altering Bcl-2/Bax expression levels
    Xu Qing Cao
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    J Neurochem 99:861-7. 2006
    ..Our findings indicate that G-CSF provides neuroprotection against MPTP-induced cell death and this effect is mediated by increasing Bcl-2 expression levels and decreasing Bax expression levels in C57BL/6 mice...
  8. doi request reprint Iron accumulation in Parkinson's disease
    Hideki Mochizuki
    Department of Neurology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    J Neural Transm 119:1511-4. 2012
    ..The review provides an opportunity to revisit the possible roles of iron accumulation in the pathogenic cascade(s) of PD...
  9. doi request reprint Use of growth factors for the treatment of Parkinson's disease
    Toru Yasuda
    Kitasato University School of Medicine, Kanagawa, Japan
    Expert Rev Neurother 10:915-24. 2010
    ..This article summarizes a series of neurotrophic factors that provide neuroprotection or restoration for dopaminergic neurons in PD, and the potential clinical availability of this approach for the treatment of patients with PD...
  10. pmc Α-synuclein and neuronal cell death
    Toru Yasuda
    Department of Neurology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Neurobiol 47:466-83. 2013
    ..In this review, we will focus on αSyn-triggered neuronal cell death and provide possible disease-modifying therapies targeting abnormally accumulating αSyn...
  11. ncbi request reprint Genetic vitamin E deficiency does not affect MPTP susceptibility in the mouse brain
    Yong Ri Ren
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    J Neurochem 98:1810-6. 2006
    ..Our results suggest that vitamin E does not play a major protective role in MPTP-induced nigrostriatal dopaminergic neurodegeneration in the brain...
  12. ncbi request reprint Expression levels of vascular endothelial growth factor and its receptors in Parkinson's disease
    Keiichirou Wada
    Department of Neurology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Neuroreport 17:705-9. 2006
    ..Such overexpression may participate in vascular remodeling and neurogenesis in the substantia nigra of Parkinson's disease...