Hideyuki Yamawaki

Summary

Affiliation: Kitasato University
Country: Japan

Publications

  1. Kameshima S, Okada M, Yamawaki H. Eukaryotic elongation factor 2 (eEF2) kinase/eEF2 plays protective roles against glucose deprivation-induced cell death in H9c2 cardiomyoblasts. Apoptosis. 2019;24:359-368 pubmed publisher
    ..In conclusion, we for the first time revealed that eEF2K/eEF2 axis under GD condition mediates the inhibition of apoptotic H9c2 cell death at least in part via promotion of autophagy through AMPK╬▒/ULK1 signaling pathway. ..
  2. Elbadawy M, Usui T, Yamawaki H, Sasaki K. Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals. Int J Mol Sci. 2018;19: pubmed publisher
    ..We also discuss small molecule inhibitors of DAPKs and their potential as therapeutic targets against human diseases. ..
  3. Kodama T, Okada M, Yamawaki H. Mechanisms underlying the relaxation by A484954, a eukaryotic elongation factor 2 kinase inhibitor, in rat isolated mesenteric artery. J Pharmacol Sci. 2018;137:86-92 pubmed publisher
    ..We for the first time revealed that A484954 induces relaxation through opening smooth muscle Kir (Kir2.2) channel and through endothelium-derived NO in MA. ..
  4. Sugiyama A, Hirano Y, Okada M, Yamawaki H. Endostatin Stimulates Proliferation and Migration of Myofibroblasts Isolated from Myocardial Infarction Model Rats. Int J Mol Sci. 2018;19: pubmed publisher
    ..In summary, we demonstrated for the first time that endostatin might be an important factor in the healing process after myocardial infarction through the activation of myofibroblasts. ..
  5. Kunimoto H, Kazama K, Takai M, Oda M, Okada M, Yamawaki H. Chemerin promotes the proliferation and migration of vascular smooth muscle and increases mouse blood pressure. Am J Physiol Heart Circ Physiol. 2015;309:H1017-28 pubmed publisher
  6. Kameshima S, Kazama K, Okada M, Yamawaki H. Eukaryotic elongation factor 2 kinase mediates monocrotaline-induced pulmonary arterial hypertension via reactive oxygen species-dependent vascular remodeling. Am J Physiol Heart Circ Physiol. 2015;308:H1298-305 pubmed publisher
    ..In conclusion, the present results suggest that eEF2K at least partly mediates MCT-induced PAH via stimulation of vascular structural remodeling perhaps through NADPH oxidase-1/ROS/matrix metalloproteinase-2 pathway. ..
  7. Otani K, Okada M, Yamawaki H. Expression pattern and function of tyrosine receptor kinase B isoforms in rat mesenteric arterial smooth muscle cells. Biochem Biophys Res Commun. 2015;467:683-9 pubmed publisher
    ..This study firstly defined expression level of TrkB isoforms and partly revealed their functions in peripheral vascular cells. ..
  8. Otani K, Yokoya M, Kodama T, Hori K, Matsumoto K, Okada M, et al. Plasma exosomes regulate systemic blood pressure in rats. Biochem Biophys Res Commun. 2018;503:776-783 pubmed publisher
    ..We for the first time demonstrated that plasma exosomes can modulate systemic blood pressure as well as structure and function of cardiovascular tissues in both normotensive and hypertensive rats. ..
  9. Elbadawy M, Usui T, Yamawaki H, Sasaki K. Development of an Experimental Model for Analyzing Drug Resistance in Colorectal Cancer. Cancers (Basel). 2018;10: pubmed publisher
    ..It contained numerous cancer stem cells and showed resistance to 5-fluorouracil and Irinotecan. In this review, we introduce conventional and our established models for studying drug resistance in CRC. ..

More Information

Publications22

  1. Usui T, Sakurai M, Umata K, Elbadawy M, Ohama T, Yamawaki H, et al. Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture. Int J Mol Sci. 2018;19: pubmed publisher
    ..These findings suggest that Hedgehog signals mediate anti-cancer drug resistance in colorectal tumor patient-derived ALI organoids and that the inhibitors are useful as a combinational therapeutic strategy against colorectal cancer. ..
  2. Kazama K, Okada M, Yamawaki H. Adipocytokine, omentin inhibits doxorubicin-induced H9c2 cardiomyoblasts apoptosis through the inhibition of mitochondrial reactive oxygen species. Biochem Biophys Res Commun. 2015;457:602-7 pubmed publisher
    ..These results indicate omentin as an attractive pharmaco-therapeautic target against DOX-induced cardiac side effect. ..
  3. Kazama K, Okada M, Yamawaki H. A novel adipocytokine, omentin, inhibits monocrotaline-induced pulmonary arterial hypertension in rats. Biochem Biophys Res Commun. 2014;452:142-6 pubmed publisher
    ..In conclusion, we for the first time demonstrate that chronic omentin treatment inhibits MCT-induced PAH in rats via inhibiting vascular structural remodeling and abnormal contractile reactivity. ..
  4. Yamawaki H. Mechanisms of action of novel adipocytokines on the vascular system. Nihon Yakurigaku Zasshi. 2011;137:131-5 pubmed publisher
  5. Kameshima S, Okada M, Yamawaki H. Expression and localization of calmodulin-related proteins in brain, heart and kidney from spontaneously hypertensive rats. Biochem Biophys Res Commun. 2016;469:654-8 pubmed publisher
    ..The present results indicate that the increased HDAC4 in brain and increased eEF2K in LV might be at least in part related to the development of hypertension. ..
  6. request reprint
    Yamawaki H. Vascular effects of novel adipocytokines: focus on vascular contractility and inflammatory responses. Biol Pharm Bull. 2011;34:307-10 pubmed
    ..These novel adipocytokines may be important future targets for the development of drugs and therapy for treating metabolic vascular disorders. ..
  7. Kazama K, Okada M, Yamawaki H. A novel adipocytokine, omentin, inhibits platelet-derived growth factor-BB-induced vascular smooth muscle cell migration through antioxidative mechanism. Am J Physiol Heart Circ Physiol. 2014;306:H1714-9 pubmed publisher
    ..Our data suggest that omentin may be protective against hypertension development by inhibiting vascular structural remodeling. ..
  8. Usui T, Morita T, Okada M, Yamawaki H. Histone deacetylase 4 controls neointimal hyperplasia via stimulating proliferation and migration of vascular smooth muscle cells. Hypertension. 2014;63:397-403 pubmed publisher
  9. Yamawaki H, Kameshima S, Usui T, Okada M, Hara Y. A novel adipocytokine, chemerin exerts anti-inflammatory roles in human vascular endothelial cells. Biochem Biophys Res Commun. 2012;423:152-7 pubmed publisher
    ..The effect is mediated via inhibiting activation of NF-?B and p38 through stimulation of Akt/eNOS signaling and NO production. ..
  10. Yamawaki H, Takahashi M, Mukohda M, Morita T, Okada M, Hara Y. A novel adipocytokine, nesfatin-1 modulates peripheral arterial contractility and blood pressure in rats. Biochem Biophys Res Commun. 2012;418:676-81 pubmed publisher
    ..The results are the first to demonstrate that nesfatin-1 modulates blood pressure through directly acting on peripheral arterial resistance. ..
  11. Yamawaki H, Kuramoto J, Kameshima S, Usui T, Okada M, Hara Y. Omentin, a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells. Biochem Biophys Res Commun. 2011;408:339-43 pubmed publisher
    ..Omentin inhibits COX-2 induction via preventing the JNK activation presumably through activation of AMPK/eNOS/NO pathways. ..
  12. Okamura Y, Otani K, Sekiguchi A, Kogane T, Kakuda C, Sakamoto Y, et al. Vasculo-protective effect of BMS-309403 is independent of its specific inhibition of fatty acid-binding protein 4. Pflugers Arch. 2017;469:1177-1188 pubmed publisher
    ..These results indicate that BMS-309403 would be useful for developing a new pharmacotherapeutic agent against obesity-associated hypertension and complications. ..
  13. Sakamoto Y, Kameshima S, Kakuda C, Okamura Y, Kodama T, Okada M, et al. Visceral adipose tissue-derived serine protease inhibitor prevents the development of monocrotaline-induced pulmonary arterial hypertension in rats. Pflugers Arch. 2017;469:1425-1432 pubmed publisher
    ..In summary, we for the first time demonstrate that vaspin prevents MCT-induced PAH at least in part via inhibiting ROS/MMP-2/fibrosis pathway. ..