Noriyuki Yamaotsu

Summary

Affiliation: Kitasato University
Country: Japan

Publications

  1. ncbi request reprint Determination of ligand-binding sites on proteins using long-range hydrophobic potential
    Noriyuki Yamaotsu
    Laboratory of Physical Chemistry for Drug Design, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
    Biol Pharm Bull 31:1552-8. 2008
  2. doi request reprint Identification of the three-dimensional pharmacophore of kappa-opioid receptor agonists
    Noriyuki Yamaotsu
    School of Pharmacy, Kitasato University, Minato ku, Tokyo 108 8641, Japan
    Bioorg Med Chem 18:4446-52. 2010
  3. ncbi request reprint 3D-pharmacophore identification for kappa-opioid agonists using ligand-based drug-design techniques
    Noriyuki Yamaotsu
    School of Pharmacy, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Top Curr Chem 299:277-307. 2011
  4. ncbi request reprint Essential structure of opioid κ receptor agonist nalfurafine for binding to κ receptor 1: synthesis of decahydroisoquinoline derivatives and their pharmacologies
    Hiroshi Nagase
    School of Pharmacy, Kitasato University, 5 9 1 Shirokane, Tokyo 108 8641, Japan
    Chem Pharm Bull (Tokyo) 60:945-8. 2012
  5. doi request reprint Drug design and synthesis of a novel kappa opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology
    Hiroshi Nagase
    School of Pharmacy, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Bioorg Med Chem Lett 20:121-4. 2010
  6. ncbi request reprint Three-dimensional quantitative structure-activity relationship analysis of inhibitors of human and rat cytochrome P4503A enzymes
    Koichi Handa
    School of Pharmacy, Kitasato University, Tokyo, Japan
    Drug Metab Pharmacokinet 28:345-55. 2013
  7. ncbi request reprint In silico study on the inhibitory interaction of drugs with wild-type CYP2D6.1 and the natural variant CYP2D6.17
    Koichi Handa
    School of Pharmacy, Kitasato University
    Drug Metab Pharmacokinet 29:52-60. 2014
  8. doi request reprint In silico multi-filter screening approaches for developing novel beta-secretase inhibitors
    Taku Fujimoto
    School of Pharmaceutical Sciences, Kitasato University, 5 9 1, Shirokane, Minato ku, Tokyo, Japan
    Bioorg Med Chem Lett 18:2771-5. 2008
  9. doi request reprint NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin
    Hiroaki Gouda
    School of Pharmacy, Kitasato University, Minato ku, Tokyo, Japan
    Bioorg Med Chem 18:5835-44. 2010

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Determination of ligand-binding sites on proteins using long-range hydrophobic potential
    Noriyuki Yamaotsu
    Laboratory of Physical Chemistry for Drug Design, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
    Biol Pharm Bull 31:1552-8. 2008
    ..Surprisingly, the binding sites on sugar binding proteins were the most hydrophobic sites. It implies that the hydrophobic interaction plays an important role in the formation of protein-ligand complexes...
  2. doi request reprint Identification of the three-dimensional pharmacophore of kappa-opioid receptor agonists
    Noriyuki Yamaotsu
    School of Pharmacy, Kitasato University, Minato ku, Tokyo 108 8641, Japan
    Bioorg Med Chem 18:4446-52. 2010
    ....
  3. ncbi request reprint 3D-pharmacophore identification for kappa-opioid agonists using ligand-based drug-design techniques
    Noriyuki Yamaotsu
    School of Pharmacy, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Top Curr Chem 299:277-307. 2011
    ..This utilizes conformational sampling of agonists by high-temperature molecular dynamics and pharmacophore extraction through a series of molecular superpositions...
  4. ncbi request reprint Essential structure of opioid κ receptor agonist nalfurafine for binding to κ receptor 1: synthesis of decahydroisoquinoline derivatives and their pharmacologies
    Hiroshi Nagase
    School of Pharmacy, Kitasato University, 5 9 1 Shirokane, Tokyo 108 8641, Japan
    Chem Pharm Bull (Tokyo) 60:945-8. 2012
    ..These findings that the simple decahydroisoquinoline derivatives showed the affinities for the opioid receptors, especially some of the compounds showed κ selectivity, are the first example in the opioid field...
  5. doi request reprint Drug design and synthesis of a novel kappa opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology
    Hiroshi Nagase
    School of Pharmacy, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Bioorg Med Chem Lett 20:121-4. 2010
    ..2.2]octane skeleton. KNT-63 showed profound antinociceptive effects via the kappa receptor which were as potent as that of TRK-820...
  6. ncbi request reprint Three-dimensional quantitative structure-activity relationship analysis of inhibitors of human and rat cytochrome P4503A enzymes
    Koichi Handa
    School of Pharmacy, Kitasato University, Tokyo, Japan
    Drug Metab Pharmacokinet 28:345-55. 2013
    ..The 3D-QSAR models for human and rat CYP3A family inhibitors predicted the potency of inhibitors and could be useful for assessing DDIs at an early stage in drug discovery...
  7. ncbi request reprint In silico study on the inhibitory interaction of drugs with wild-type CYP2D6.1 and the natural variant CYP2D6.17
    Koichi Handa
    School of Pharmacy, Kitasato University
    Drug Metab Pharmacokinet 29:52-60. 2014
    ..92). Finally, we were able to successfully explain the different abilities of CYP2D6.1 and CYP2D6.17 to metabolize drugs in different ethnic groups with reference to their 3D-structures...
  8. doi request reprint In silico multi-filter screening approaches for developing novel beta-secretase inhibitors
    Taku Fujimoto
    School of Pharmaceutical Sciences, Kitasato University, 5 9 1, Shirokane, Minato ku, Tokyo, Japan
    Bioorg Med Chem Lett 18:2771-5. 2008
    ....
  9. doi request reprint NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin
    Hiroaki Gouda
    School of Pharmacy, Kitasato University, Minato ku, Tokyo, Japan
    Bioorg Med Chem 18:5835-44. 2010
    ..The improved total electrostatic component was derived from more favorable electrostatic interactions. Therefore, we conclude that dipeptide 2 was also better optimized against SmChiB than 1 in an electrostatic point of view...