Noriyuki Yamaotsu

Summary

Affiliation: Kitasato University
Country: Japan

Publications

  1. ncbi Determination of ligand-binding sites on proteins using long-range hydrophobic potential
    Noriyuki Yamaotsu
    Laboratory of Physical Chemistry for Drug Design, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
    Biol Pharm Bull 31:1552-8. 2008
  2. ncbi Identification of the three-dimensional pharmacophore of kappa-opioid receptor agonists
    Noriyuki Yamaotsu
    School of Pharmacy, Kitasato University, Minato ku, Tokyo 108 8641, Japan
    Bioorg Med Chem 18:4446-52. 2010
  3. ncbi 3D-pharmacophore identification for kappa-opioid agonists using ligand-based drug-design techniques
    Noriyuki Yamaotsu
    School of Pharmacy, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Top Curr Chem 299:277-307. 2011
  4. ncbi Essential structure of opioid κ receptor agonist nalfurafine for binding to κ receptor 1: synthesis of decahydroisoquinoline derivatives and their pharmacologies
    Hiroshi Nagase
    School of Pharmacy, Kitasato University, 5 9 1 Shirokane, Tokyo 108 8641, Japan
    Chem Pharm Bull (Tokyo) 60:945-8. 2012
  5. ncbi Drug design and synthesis of a novel kappa opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology
    Hiroshi Nagase
    School of Pharmacy, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Bioorg Med Chem Lett 20:121-4. 2010
  6. ncbi In silico multi-filter screening approaches for developing novel beta-secretase inhibitors
    Taku Fujimoto
    School of Pharmaceutical Sciences, Kitasato University, 5 9 1, Shirokane, Minato ku, Tokyo, Japan
    Bioorg Med Chem Lett 18:2771-5. 2008
  7. ncbi NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin
    Hiroaki Gouda
    School of Pharmacy, Kitasato University, Minato ku, Tokyo, Japan
    Bioorg Med Chem 18:5835-44. 2010

Collaborators

Detail Information

Publications7

  1. ncbi Determination of ligand-binding sites on proteins using long-range hydrophobic potential
    Noriyuki Yamaotsu
    Laboratory of Physical Chemistry for Drug Design, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
    Biol Pharm Bull 31:1552-8. 2008
    ..Surprisingly, the binding sites on sugar binding proteins were the most hydrophobic sites. It implies that the hydrophobic interaction plays an important role in the formation of protein-ligand complexes...
  2. ncbi Identification of the three-dimensional pharmacophore of kappa-opioid receptor agonists
    Noriyuki Yamaotsu
    School of Pharmacy, Kitasato University, Minato ku, Tokyo 108 8641, Japan
    Bioorg Med Chem 18:4446-52. 2010
    ....
  3. ncbi 3D-pharmacophore identification for kappa-opioid agonists using ligand-based drug-design techniques
    Noriyuki Yamaotsu
    School of Pharmacy, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Top Curr Chem 299:277-307. 2011
    ..This utilizes conformational sampling of agonists by high-temperature molecular dynamics and pharmacophore extraction through a series of molecular superpositions...
  4. ncbi Essential structure of opioid κ receptor agonist nalfurafine for binding to κ receptor 1: synthesis of decahydroisoquinoline derivatives and their pharmacologies
    Hiroshi Nagase
    School of Pharmacy, Kitasato University, 5 9 1 Shirokane, Tokyo 108 8641, Japan
    Chem Pharm Bull (Tokyo) 60:945-8. 2012
    ..These findings that the simple decahydroisoquinoline derivatives showed the affinities for the opioid receptors, especially some of the compounds showed κ selectivity, are the first example in the opioid field...
  5. ncbi Drug design and synthesis of a novel kappa opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology
    Hiroshi Nagase
    School of Pharmacy, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Bioorg Med Chem Lett 20:121-4. 2010
    ..2.2]octane skeleton. KNT-63 showed profound antinociceptive effects via the kappa receptor which were as potent as that of TRK-820...
  6. ncbi In silico multi-filter screening approaches for developing novel beta-secretase inhibitors
    Taku Fujimoto
    School of Pharmaceutical Sciences, Kitasato University, 5 9 1, Shirokane, Minato ku, Tokyo, Japan
    Bioorg Med Chem Lett 18:2771-5. 2008
    ....
  7. ncbi NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin
    Hiroaki Gouda
    School of Pharmacy, Kitasato University, Minato ku, Tokyo, Japan
    Bioorg Med Chem 18:5835-44. 2010
    ..The improved total electrostatic component was derived from more favorable electrostatic interactions. Therefore, we conclude that dipeptide 2 was also better optimized against SmChiB than 1 in an electrostatic point of view...