Masahiko Watanabe

Summary

Affiliation: Kitasato University
Country: Japan

Publications

  1. ncbi request reprint Prognostic significance of Ki-67 in chemotherapy-naive breast cancer patients with 10-year follow-up
    Hiroshi Nishimiya
    FACS, Department of Surgery, Kitasato University School of Medicine, 1 15 1, Kitasato, Minami Ku, Sagamihara, Japan
    Anticancer Res 34:259-68. 2014
  2. pmc Study protocol of the SACURA trial: a randomized phase III trial of efficacy and safety of UFT as adjuvant chemotherapy for stage II colon cancer
    Megumi Ishiguro
    Department of Surgical Oncology, Tokyo Medical and Dental University, Graduate School, 1 5 45 Yushima, Tokyo 113 8519, Japan
    BMC Cancer 12:281. 2012
  3. ncbi request reprint Perineural invasion and preoperative serum CA19-9 as predictors of survival in biliary tract cancer
    Hiroshi Kawamata
    Department of Surgery, Medical School, Kitasato University, Address Kitasato 1 15 1, Minami Ku, Sagamihara, Kanagawa 252 0374, Japan
    Anticancer Res 33:583-94. 2013
  4. doi request reprint Phosphatase of regenerating liver-3 as a convergent therapeutic target for lymph node metastasis in esophageal squamous cell carcinoma
    Akira Ooki
    Department of Surgery, Kitasato University Hospital, Sagamihara, Kanagawa, Japan
    Int J Cancer 127:543-54. 2010
  5. ncbi request reprint Randomized controlled trial of the efficacy of adjuvant immunochemotherapy and adjuvant chemotherapy for colorectal cancer, using different combinations of the intracutaneous streptococcal preparation OK-432 and the oral pyrimidines 1-hexylcarbamoyl-5-flu
    Masahiko Watanabe
    Department of Surgery, Kitasato University School of Medicine, 1 15 1 Kitasato, 228 8555, Sagamihara, Japan
    Int J Clin Oncol 9:98-106. 2004
  6. doi request reprint Laparoscopy-assisted pancreas- and spleen-preserving total gastrectomy for gastric cancer as compared with open total gastrectomy
    Shinichi Sakuramoto
    Department of Surgery, Kitasato University School of Medicine, 2 1 1 Asamizodai, Sagamihara, Kanagawa, 228 8520, Japan
    Surg Endosc 23:2416-23. 2009
  7. ncbi request reprint Laparoscopic resection of a gastrointestinal stromal tumor of the rectum after treatment with imatinib mesylate: report of a case
    Takatoshi Nakamura
    Department of Surgery, School of Medicine, Kitasato University, 1 15 1 Kitasato, Minami Ku, Sagamihara Kanagawa, 252 0374, Japan
    Surg Today 42:1096-9. 2012
  8. ncbi request reprint Cancer chemotherapy chemosensitivity testing is useful in evaluating the appropriate adjuvant cancer chemotherapy for stages III/IV gastric cancers without peritoneal dissemination
    Tetsuro Kubota
    Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Anticancer Res 23:583-7. 2003
  9. doi request reprint Efficacy of the coadministration of granulocyte colony-stimulating factor and stem cell factor in the activation of intrinsic cells after spinal cord injury in mice
    Takahiro Osada
    Department of Neurosurgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Neurosurg Spine 13:516-23. 2010
  10. doi request reprint Neoadjuvant chemoradiation therapy using concurrent S-1 and irinotecan in rectal cancer: impact on long-term clinical outcomes and prognostic factors
    Takatoshi Nakamura
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Int J Radiat Oncol Biol Phys 89:547-55. 2014

Detail Information

Publications82

  1. ncbi request reprint Prognostic significance of Ki-67 in chemotherapy-naive breast cancer patients with 10-year follow-up
    Hiroshi Nishimiya
    FACS, Department of Surgery, Kitasato University School of Medicine, 1 15 1, Kitasato, Minami Ku, Sagamihara, Japan
    Anticancer Res 34:259-68. 2014
    ..In order to define accurate survival outcome in breast cancer, 10-year follow-up is required and such long-term survival information are few and difficult to gather...
  2. pmc Study protocol of the SACURA trial: a randomized phase III trial of efficacy and safety of UFT as adjuvant chemotherapy for stage II colon cancer
    Megumi Ishiguro
    Department of Surgical Oncology, Tokyo Medical and Dental University, Graduate School, 1 5 45 Yushima, Tokyo 113 8519, Japan
    BMC Cancer 12:281. 2012
    ..The major Western guidelines recommend adjuvant chemotherapy for "high-risk stage II" cancer, but this is not clearly defined and the efficacy has not been confirmed...
  3. ncbi request reprint Perineural invasion and preoperative serum CA19-9 as predictors of survival in biliary tract cancer
    Hiroshi Kawamata
    Department of Surgery, Medical School, Kitasato University, Address Kitasato 1 15 1, Minami Ku, Sagamihara, Kanagawa 252 0374, Japan
    Anticancer Res 33:583-94. 2013
    ..Billiary tract cancer requires invasive surgical procedures for cure, and the risk factors related to patient prognosis remain controversial...
  4. doi request reprint Phosphatase of regenerating liver-3 as a convergent therapeutic target for lymph node metastasis in esophageal squamous cell carcinoma
    Akira Ooki
    Department of Surgery, Kitasato University Hospital, Sagamihara, Kanagawa, Japan
    Int J Cancer 127:543-54. 2010
    ..Moreover, the expression status may be a landmark to select patients with benefit from PRL-3-targeted therapy. Thus, PRL-3 could be a convergent therapeutic target against ESCC with LNM...
  5. ncbi request reprint Randomized controlled trial of the efficacy of adjuvant immunochemotherapy and adjuvant chemotherapy for colorectal cancer, using different combinations of the intracutaneous streptococcal preparation OK-432 and the oral pyrimidines 1-hexylcarbamoyl-5-flu
    Masahiko Watanabe
    Department of Surgery, Kitasato University School of Medicine, 1 15 1 Kitasato, 228 8555, Sagamihara, Japan
    Int J Clin Oncol 9:98-106. 2004
    ....
  6. doi request reprint Laparoscopy-assisted pancreas- and spleen-preserving total gastrectomy for gastric cancer as compared with open total gastrectomy
    Shinichi Sakuramoto
    Department of Surgery, Kitasato University School of Medicine, 2 1 1 Asamizodai, Sagamihara, Kanagawa, 228 8520, Japan
    Surg Endosc 23:2416-23. 2009
    ..To assess the safety and usefulness of LATG, we compared the outcomes of LATG with those of open total gastrectomy (OTG)...
  7. ncbi request reprint Laparoscopic resection of a gastrointestinal stromal tumor of the rectum after treatment with imatinib mesylate: report of a case
    Takatoshi Nakamura
    Department of Surgery, School of Medicine, Kitasato University, 1 15 1 Kitasato, Minami Ku, Sagamihara Kanagawa, 252 0374, Japan
    Surg Today 42:1096-9. 2012
    ..There was no evidence of recurrence 2 years 6 months after surgery. Preoperative adjuvant chemotherapy with imatinib mesylate may permit the use of less invasive treatment procedures, allowing anal preservation...
  8. ncbi request reprint Cancer chemotherapy chemosensitivity testing is useful in evaluating the appropriate adjuvant cancer chemotherapy for stages III/IV gastric cancers without peritoneal dissemination
    Tetsuro Kubota
    Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Anticancer Res 23:583-7. 2003
    ..In the present study, we compared the chemosensitivity and clinical outcomes of patients with Stages III and IV gastric cancer...
  9. doi request reprint Efficacy of the coadministration of granulocyte colony-stimulating factor and stem cell factor in the activation of intrinsic cells after spinal cord injury in mice
    Takahiro Osada
    Department of Neurosurgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Neurosurg Spine 13:516-23. 2010
    ..The object of this study was to investigate the effects of these cytokines on BM stem cells, intrinsic cells, and motor function recovery in spinal cord-injured mice...
  10. doi request reprint Neoadjuvant chemoradiation therapy using concurrent S-1 and irinotecan in rectal cancer: impact on long-term clinical outcomes and prognostic factors
    Takatoshi Nakamura
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Int J Radiat Oncol Biol Phys 89:547-55. 2014
    ..To assess the long-term outcomes of patients with rectal cancer who received neoadjuvant chemoradiation therapy (NCRT) with concurrent S-1 and irinotecan (S-1/irinotecan) therapy...
  11. ncbi request reprint Diminishing impact of preoperative carcinoembryonic antigen (CEA) in prognosis of Dukes' C colorectal cancer
    Hiroshi Katoh
    Department of Surgery, Kitasato University Hospital, Kitasato 1 15 1, Sagamihara 228 8555, Kanagawa, Japan
    Anticancer Res 28:1933-41. 2008
    ..However, data remains insufficient to support its clinical use. The aim of the current study was to validate the prognostic impact of preCEA in Dukes' C CRC...
  12. doi request reprint A Phase II trial of neoadjuvant preoperative chemoradiotherapy with S-1 plus irinotecan and radiation in patients with locally advanced rectal cancer: clinical feasibility and response rate
    Takeo Sato
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Int J Radiat Oncol Biol Phys 79:677-83. 2011
    ..We aimed to validate our hypothesis that a preoperative chemoradiotherapy regimen with S-1 plus irinotecan is feasible, safe, and active for the management of locally advanced rectal cancer in a single-arm Phase II setting...
  13. doi request reprint Lymphatic tumor emboli detected by D2-40 immunostaining can more accurately predict lymph-node metastasis
    Hiromitsu Moriya
    Department of Surgery, School of Medicine, Kitasato University, Tokyo, Japan
    World J Surg 35:2031-7. 2011
    ..This present study was designed to determine the accuracy of LY grade for predicting the risk of N...
  14. ncbi request reprint Possible chemoresistance-related genes for gastric cancer detected by cDNA microarray
    Kazuhiro Suganuma
    Department of Surgery, School of Medicine, Keio University, Sinjuku ku, Tokyo 160 8582, Japan
    Cancer Sci 94:355-9. 2003
    ..The present study demonstrated that oligonucleotide microarrays can provide information regarding chemoresistance factors in cancer...
  15. doi request reprint Lymph node ratio is a critical prognostic predictor in gastric cancer treated with S-1 chemotherapy
    Akira Ema
    Department of Surgery, Kitasato University School of Medicine, Sagamihara, Japan
    Gastric Cancer 17:67-75. 2014
    ..Candidates for more intense adjuvant treatments need to be identified, particularly among patients with stage III cancer...
  16. doi request reprint Retrospective, matched case-control study comparing the oncologic outcomes between laparoscopic surgery and open surgery in patients with right-sided colon cancer
    Takatoshi Nakamura
    Department of Surgery, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa, 228 8555, Japan
    Surg Today 39:1040-5. 2009
    ..This study was undertaken to compare the morbidity and mortality after either a laparoscopic right hemicolectomy (LRHC) or an open right hemicolectomy (ORHC) for this type of tumor...
  17. pmc Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer
    Akira Ooki
    Department of Surgery, Kitasato University Hospital, Kitasato 1 15 1, Sagamihara 228 8555, Kanagawa, Japan
    BMC Cancer 11:122. 2011
    ..In the present study, we examined the mechanisms regulating PRL-3 expression, and assessed the clinical potential of PRL-3-targeted therapy in gastric cancer...
  18. ncbi request reprint Liver metastasis of colorectal cancer by protein-tyrosine phosphatase type 4A, 3 (PRL-3) is mediated through lymph node metastasis and elevated serum tumor markers such as CEA and CA19-9
    Kazuhiko Hatate
    Department of Surgery, Kitasato University, Kanagawa, Japan
    Oncol Rep 20:737-43. 2008
    ..Our data suggested that liver metastasis by PRL-3 is putatively mediated through lymph node metastasis and elevated tumor markers in the serum and the PRL-3 expression may not represent a direct causative mechanism of liver metastasis...
  19. pmc Cancer specific promoter CpG Islands hypermethylation of HOP homeobox (HOPX) gene and its potential tumor suppressive role in pancreatic carcinogenesis
    Mina Waraya
    Department of Surgery, Kitasato University Hospital, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa, 252 0375, Japan
    BMC Cancer 12:397. 2012
    ..In this current study, we for the first time examined methylation level of HOPX and tested the functional relevance in pancreatic cancer (PC)...
  20. ncbi request reprint No cross-resistance of taxotere and taxol to conventional chemotherapeutic agents against gastric cancers as detected by MTT assay
    Shingo Maeda
    Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Anticancer Res 23:3147-50. 2003
    ..In conclusion, taxanes may be useful for clinical application against gastric cancer due to their different antitumor spectrum as compared to conventional agents...
  21. doi request reprint Host prostaglandin EP3 receptor signaling relevant to tumor-associated lymphangiogenesis
    Hidefumi Kubo
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, Japan
    Biomed Pharmacother 64:101-6. 2010
    ..Host EP3 blockade together with COX-2 inhibition may be a novel therapeutic strategy to suppress tumor-associated lymphangiogenesis...
  22. ncbi request reprint Irinotecan and S-1 neoadjuvant chemoradiation therapy in patients with advanced rectal cancer
    Takeo Sato
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Hepatogastroenterology 54:1391-3. 2007
    ..Preoperative chemoradiotherapy with a combination of S-1 and CPT-11 may be a new treatment for rectal cancer...
  23. ncbi request reprint Antitumor activity of doxorubicin in combination with docetaxel against human breast cancer xenografts
    Tomohisa Egawa
    Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    In Vivo 17:23-8. 2003
    ..In conclusion, DOCE may increase the antitumor activity of DXR against P-gp-positive breast cancer xenografts, such that the DOCE and DXR combination may be a useful treatment in clinical breast cancer...
  24. ncbi request reprint Phosphatase of regenerating liver-3 as a prognostic biomarker in histologically node-negative gastric cancer
    Akira Ooki
    Department of Surgery, Kitasato University Hospital, Sagamihara 228 8555, Kanagawa, Japan
    Oncol Rep 21:1467-75. 2009
    ..We propose that PRL-3 expression can have a clinical potential as a prognostic biomarker that may facilitate the development of adjuvant chemotherapy for advanced gastric cancer with stage I disease...
  25. doi request reprint Neoadjuvant chemotherapy of triplet regimens of docetaxel/cisplatin/5-FU (DCF NAC) may improve patient prognosis of cStage II/III esophageal squamous cell carcinoma-propensity score analysis
    Keishi Yamashita
    Department of Surgery, Kitasato University School of Medicine, Kitasato 1 15 1, Minami Ku, Sagamihara, Kanagawa, 252 0374, Japan
    Gen Thorac Cardiovasc Surg 64:209-15. 2016
    ..We have recently reported preliminary potentiality of short-term survival benefit by NAC with DCF (docetaxel/cisplatin/5-FU)...
  26. ncbi request reprint Clinical usefulness of chemosensitivity test for advanced colorectal cancer
    Yasuo Kabeshima
    Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Anticancer Res 22:3033-7. 2002
    ..0158) and the surgery-alone group (p = 0.0004). Our results suggest that the MTT assay may be useful in evaluating the optimum adjuvant chemotherapy for patients with advanced colorectal cancer...
  27. ncbi request reprint Combination chemotherapy with JTE-522, a novel selective cyclooxygenase-2 inhibitor, and cisplatin against gastric cancer cell lines in vitro and in vivo
    Tsudoi Sugiura
    Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    In Vivo 17:229-33. 2003
    ..We conclude that JT is a potent antitumor agent in vitro and in vivo and that, in combination with CDDP, it might be a useful treatment strategy for gastric cancer...
  28. pmc COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems
    Hiroshi Katoh
    Department of Pharmacology, Kitasato University, School of Medicine, Kitasato 1 15 1, Sagamihara, Kanagawa, 228 8555, Japan
    Am J Pathol 176:1469-83. 2010
    ....
  29. doi request reprint mPGES-1-expressing bone marrow-derived cells enhance tumor growth and angiogenesis in mice
    Hiroki Kamata
    Department of Pharmacology, Kitasato University School of Medicine, Kitasato 1 15 1, Kanagawa 252 0374, Japan
    Biomed Pharmacother 64:409-16. 2010
    ..Taken together, these data suggest that regulation of mPGES-1-expressing BM cell recruitment to the site of primary tumors may be a novel strategy for the treatment of solid tumors...
  30. ncbi request reprint Randomized trial of the efficacy of adjuvant chemotherapy for colon cancer with combination therapy incorporating the oral pyrimidine 1-hexylcarbamoyl-5-fluorouracil
    Masahiko Watanabe
    Department of Surgery, School of Medicine, Kitasato University, 1 15 1, Kitasato, Sagamihara, Kanagawa, 228 8555, Japan
    Langenbecks Arch Surg 391:330-7. 2006
    ..The purpose of the present trial was to clarify the efficacy of postoperative adjuvant chemotherapy including an oral fluoropyrimidine anticancer drug, the 1-hexylcarbamoyl-5-fluorouracil (HCFU), for the treatment of colon cancer...
  31. ncbi request reprint Independent antitumor spectrum of UCN-01 (7-hydroxystaurosporine) against gastric and colorectal cancers as detected by MTT assay
    Sadanori Abe
    Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shihjuku ku, Tokyo 160 8582, Japan
    Anticancer Res 22:3605-10. 2002
    ..In conclusion, UCN-01 may be useful for clinical application against gastric and colorectal cancer due to its different antitumor spectrum from conventionally available agents...
  32. doi request reprint Laparoscopy versus open distal gastrectomy by expert surgeons for early gastric cancer in Japanese patients: short-term clinical outcomes of a randomized clinical trial
    Shinichi Sakuramoto
    Department of Surgery, Kitasato University School of Medicine, 2 1 1 Asamizodai, Sagamihara, Kanagawa 228 8520, Japan
    Surg Endosc 27:1695-705. 2013
    ..The purpose of this study was to compare laparoscopic versus ODG with respect to specific primary and secondary short-term outcomes...
  33. doi request reprint Clinical experience of laparoscopy-assisted proximal gastrectomy with Toupet-like partial fundoplication in early gastric cancer for preventing reflux esophagitis
    Shinichi Sakuramoto
    Department of Surgery, Kitasato University School of Medicine, 2 1 1 Asamizodai, Sagamihara, Kanagawa, Japan
    J Am Coll Surg 209:344-51. 2009
    ..Clinical outcomes are described here in patients with reconstruction by esophagogastrostomy with Toupet-like partial fundoplication (TPF) in LAPG...
  34. doi request reprint Oncological outcomes of laparoscopic surgery in elderly patients with colon cancer: a comparison of patients 64 years or younger with those 75 years or older
    Takatoshi Nakamura
    Department of Surgery, Kitasato University, Kanagawa, Japan
    Hepatogastroenterology 58:1200-4. 2011
    ..We compared the results of laparoscopic resection of colon cancer between patients 75 years or older and those 64 years or younger, to confirm whether this procedure is warranted in elderly patients...
  35. doi request reprint Technique of esophagojejunostomy using transoral placement of the pretilted anvil head after laparoscopic gastrectomy for gastric cancer
    Shinichi Sakuramoto
    Department of Surgery, Kitasato University School of Medicine, 2 1 1 Asamizodai, Sagamihara, Kanagawa 228 8520, Japan
    Surgery 147:742-7. 2010
    ..The authors report on a method modified for laparoscopy-assisted, esophagojejunostomy performed by placing the pretilted anvil head via the transoral approach...
  36. doi request reprint Genetic alterations of K-ras may reflect prognosis in stage III colon cancer patients below 60 years of age
    Wataru Onozato
    Department of Surgery, Kitasato University Hospital, Sagamihara, Kanagawa, Japan
    J Surg Oncol 103:25-33. 2011
    ..Genetic alterations that are closely associated with patient prognosis can be landmarks of definitive therapeutic targets as well as useful biomarkers in human cancer clinics...
  37. ncbi request reprint Thymidylate synthetase (TS) genotype and TS/dihydropyrimidine dehydrogenase mRNA level as an indicator in determining chemosensitivity to 5-fluorouracil in advanced gastric carcinoma
    Fumiki Toriumi
    Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Anticancer Res 24:2455-63. 2004
    ....
  38. ncbi request reprint A potential important role for thymidylate synthetase inhibition on antitumor activity of fluoropyrimidine and raltitexed
    Yasuo Kabeshima
    Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Anticancer Res 22:3245-52. 2002
    ..Because thymidylate synthetase (TS) is a key enzyme in DNA synthesis, it has been used as a target for cancer chemotherapy...
  39. doi request reprint Treatment of advanced or recurrent colorectal cancer with irinotecan in Japan and elsewhere
    Takeo Sato
    Kitasato University East Hospital, Department of Surgery, 2 1 1, Asamizodai, Sagamihara, Kanagawa, 228 8520, Japan
    Expert Opin Pharmacother 9:1223-8. 2008
    ....
  40. pmc Epigenetic regulation of ZEB1-RAB25/ESRP1 axis plays a critical role in phenylbutyrate treatment-resistant breast cancer
    Mariko Kikuchi
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Oncotarget 7:1741-53. 2016
    ..The genes associated with PB sensitivity are downstream targets of ZEB1. Epigenetic regulation of ZEB1 may prove valuable as a critical biomarker for predicting resistance to breast cancer therapies...
  41. doi request reprint Laparoscopic surgery for obese patients with colon cancer: a case-matched control study
    Takatoshi Nakamura
    Department of Surgery, Kitasato University, School of Medicine, Sagamihara, Japan
    Surg Today 43:763-8. 2013
    ....
  42. doi request reprint Short- and long-term outcomes of laparoscopic surgery in patients with pathological stage II and III colon cancer
    Takatoshi Nakamura
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Hepatogastroenterology 58:1947-50. 2011
    ..We studied the safety and outcomes of laparoscopic surgery in patients with pathological stage II and III colon cancer...
  43. doi request reprint Predictors of psychological distress after diagnosis in breast cancer patients and patients with benign breast problems
    Noriko Ando
    Department of Medical Psychology, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa, Japan
    Psychosomatics 52:56-64. 2011
    ..The objective of this study was to determine how age and psychological characteristics assessed prior to diagnosis could predict psychological distress in outpatients immediately after disclosure of their diagnosis...
  44. ncbi request reprint TSU-68 (SU6668) inhibits local tumor growth and liver metastasis of human colon cancer xenografts via anti-angiogenesis
    Kyoko Yorozuya
    Department of Surgery, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    Oncol Rep 14:677-82. 2005
    ..3%, respectively. As TSU-68 significantly inhibited tumor growth and liver metastasis formation of human colon cancer xenografts, probably through anti-angiogenic activity, this agent may be useful for the treatment of colon cancer...
  45. doi request reprint IQ-ArfGEF/BRAG1 is associated with synaptic ribbons in the mouse retina
    Osamu Katsumata
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    Eur J Neurosci 30:1509-16. 2009
    ..These findings indicate that IQ-ArfGEF/BRAG1 is a novel component of retinal synaptic ribbons and forms a protein complex with RIBEYE...
  46. ncbi request reprint Phase I trial of neoadjuvant preoperative chemotherapy with S-1 and irinotecan plus radiation in patients with locally advanced rectal cancer
    Takeo Sato
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Int J Radiat Oncol Biol Phys 69:1442-7. 2007
    ..To determine the maximum tolerated dose (MTD) and recommended dose (RD) of irinotecan combined with preoperative chemoradiotherapy with S-1 in patients with locally advanced rectal cancer...
  47. ncbi request reprint Gastrointestinal stromal tumor of the rectum resected by laparoscopic surgery: report of a case
    Takatoshi Nakamura
    Department of Surgery, Kitasato University Hospital, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Surg Today 37:1004-8. 2007
    ..Laparoscopic surgery is therefore considered to be useful for a resection of the rectum, because the magnifying effect allows surgical maneuvers with a favorable visual field within the pelvis...
  48. doi request reprint Short-term surgical outcomes from a randomized controlled trial to evaluate laparoscopic and open D3 dissection for stage II/III colon cancer: Japan Clinical Oncology Group Study JCOG 0404
    Seiichiro Yamamoto
    Division of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan Department of Gastroenterological Surgery, Oita University Faculty of Medicine, Oita, Japan JCOG Data Center, Multi institutional Clinical Trial Support Center, National Cancer Center, Tokyo, Japan Department of Surgery, Jichi Medical University Saitama Medical Center, Saitama, Japan Department of Surgical Oncology, Tokyo Medical and Dental University, Tokyo, Japan and Department of Surgery, Kitasato University Hospital, Kanagawa, Japan
    Ann Surg 260:23-30. 2014
    ..A randomized controlled trial to confirm the non-inferiority of laparoscopic surgery to open surgery in terms of overall survival was conducted, and short-term surgical outcomes are demonstrated...
  49. doi request reprint Survival outcome of laparoscopic gastrectomy for clinical early (cT1) gastric cancer
    Keishi Yamashita
    Department of Surgery, Kitasato University School of Medicine, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa 252 0374, Japan
    Surg Today 43:1013-8. 2013
    ..Laparoscopy-assisted gastrectomy (LAG) for clinical early (cT1) gastric cancer (EGC) is superior to open gastrectomy in terms of the short-term outcome; however, long-term survival outcome remains elusive...
  50. ncbi request reprint TZT-1027 elucidates antitumor activity through direct cytotoxicity and selective blockade of blood supply
    Naoko Hashiguchi
    Department of Surgery, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Anticancer Res 24:2201-8. 2004
    ..TZT-1027 is a newly developed antitumor agent derived from dolastatin 10...
  51. doi request reprint FANCD2 mRNA overexpression is a bona fide indicator of lymph node metastasis in human colorectal cancer
    Heita Ozawa
    Department of Surgery, Kitasato University School of Medicine, Sagamihara, Japan
    Ann Surg Oncol 17:2341-8. 2010
    ..Therefore, there is an urgent need to identify molecular markers that can be used to predict lymph node metastasis...
  52. doi request reprint SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses
    Masahiro Fukaya
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    J Neurochem 116:1122-37. 2011
    ..Taken together, these findings suggest that synArfGEF functions as a novel regulator of Arf6 at inhibitory synapses and associates with the dystrophin-associated glycoprotein complex and S-SCAM...
  53. ncbi request reprint Clinical significance of total gastrectomy for proximal gastric cancer
    Akira Ooki
    Department of Surgery, Kitasato University Hospital, Kitasato 1 15 1, Sagamihara 228 8555, Kanagawa, Japan
    Anticancer Res 28:2875-83. 2008
    ..The principal difference between total gastrectomy (TG) and proximal gastrectomy (PG) is whether lymph node (LN) 4d is dissected by radical lymphadenectomy...
  54. doi request reprint Intratumoral lymphangiogenesis of esophageal squamous cell carcinoma and relationship with regulatory factors and prognosis
    Akemi Inoue
    Department of Biological Structure, Kitasato University Graduate School of Medical Sciences, Kitasato, Kanagawa, Japan
    Pathol Int 58:611-9. 2008
    ..Multivariate analysis using Cox proportional hazard method showed that invasion depth, lymph node metastasis and ITL were independent prognostic factors...
  55. doi request reprint Surgical resection of stage IV colorectal cancer and prognosis
    Hiroshi Katoh
    Department of Surgery, Kitasato University Hospital, Kitasato 1 15 1, Sagamihara 228 8555, Kanagawa, Japan
    World J Surg 32:1130-7. 2008
    ..Colorectal cancer (CRC) harbors accumulated genetic alterations with cancer progression, which results in uncontrollable disease. To regulate the most malignant CRC, we have to know the most dismal phenotype of stage IV disease...
  56. pmc Laparoscopic Surgery is Useful for Preventing Recurrence of Small Bowel Obstruction After Surgery for Postoperative Small Bowel Obstruction
    Takatoshi Nakamura
    Department of Surgery, Kitasato University, School of Medicine, Sagamihara, Japan
    Surg Laparosc Endosc Percutan Tech 26:e1-4. 2016
    ..Risk factors for recurrence postoperative small bowel obstruction in patients who have postoperative abdominal surgery remain unclear...
  57. doi request reprint Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment
    Hirotoki Ohkubo
    Department of Pharmacology, Kitasato University School of Medicine, 1 15 1 Kitasato, Minami, Sagamihara Kanagawa, 252 0374, Japan
    FASEB J 27:3132-43. 2013
    ....
  58. pmc Epigenetic silencing of HOPX promotes cancer progression in colorectal cancer
    Hiroshi Katoh
    Department of Surgery, Kitasato University School of Medicine, Sagamihara, Japan
    Neoplasia 14:559-71. 2012
    ..014). In conclusion, HOPX-β promoter methylation is a frequent and cancer-specific event in CRC progression. This epigenetic alteration may have clinical ramifications in the diagnosis and treatment of CRC patients...
  59. doi request reprint Benefits of a straight laparoscopic restorative proctocolectomy with ileal pouch anal anastomosis for ulcerative colitis: a retrospective case-matched study
    Heita Ozawa
    Department of Surgery, Tochigi Cancer Center, Tochigi, Japan
    Surg Laparosc Endosc Percutan Tech 22:118-21. 2012
    ..The aim of this study was to evaluate the benefit of straight laparoscopic restorative proctocolectomy (sLRP) with ileal pouch anal anastomosis for ulcerative colitis (UC)...
  60. doi request reprint Risk factors for wound infection after surgery for colorectal cancer
    Takatoshi Nakamura
    Department of Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    World J Surg 32:1138-41. 2008
    ..This study was designed to clarify the incidence, risk factors, and pathogens responsible for wound infections after surgery for colorectal cancer...
  61. ncbi request reprint The potential for a selective cyclooxygenase-2 inhibitor in the prevention of liver metastasis in human colorectal cancer
    Takeyoshi Yamauchi
    Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Anticancer Res 23:245-9. 2003
    ..The aim of the present study was to clarify the role of COX-2 in liver metastasis and to examine the potential for a selective COX-2 inhibitor as a novel therapeutic agent in the treatment of colorectal cancer...
  62. doi request reprint Abnormal expression of p16(INK4a), cyclin D1, cyclin-dependent kinase 4 and retinoblastoma protein in gastric carcinomas
    Ichiro Kishimoto
    Department of Surgery, National Hospital Organization Sagamihara Hospital, Kanagawa, Japan
    J Surg Oncol 98:60-6. 2008
    ..The aim of this study was to assess the relationship between their abnormalities and clinicopathological features in gastric carcinomas...
  63. ncbi request reprint Comparison of long-term outcome of laparoscopic and conventional surgery for advanced colon and rectosigmoid cancer
    Takatoshi Nakamura
    Department of Surgery, Kitasato University Hospital, Kanagawa, Japan
    Hepatogastroenterology 53:351-3. 2006
    ..In this study we tested the null hypothesis that there is no difference in the outcome of advanced colorectal cancer according to whether it is treated by laparoscopic or conventional open resection...
  64. ncbi request reprint Pre-operative tumor assessment of patients with gastric cancer based on virtual endoscopy using multidetector-row computer tomography
    Shiro Kikuchi
    Department of Surgery, School of Medicine, Kitasato University, 1 15 1 Kitasato, Sagamihara shi, Japan
    Anticancer Res 26:4641-5. 2006
    ..The aim of the present study was to evaluate the pre-operative assessment of gastric cancer tumors using 32-multidetector row-CT...
  65. ncbi request reprint Analysis of the risk factors for wound infection after surgical treatment of colorectal cancer: a matched case control study
    Takatoshi Nakamura
    Department of Surgery, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Hepatogastroenterology 56:1316-20. 2009
    ....
  66. doi request reprint Telomere shortening in Barrett's mucosa and esophageal adenocarcinoma and its association with loss of heterozygosity
    Hiroaki Shiraishi
    Departments of Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Scand J Gastroenterol 44:538-44. 2009
    ....
  67. ncbi request reprint Pioglitazone, a ligand for peroxisome proliferator-activated receptor-gamma acts as an inhibitor of colon cancer liver metastasis
    Shota Takano
    Department of Surgery, Keio University School of Medicine, Shinanomachi 35, Shinjuku ku, Tokyo 160 8582, Japan
    Anticancer Res 28:3593-9. 2008
    ..Liganded PPARgamma can inhibit cancer cell proliferation. The in vitro and in vivo inhibitory effect of the synthetic ligands, ciglitazone (CGZ) and pioglitazone (PGZ), on human colon cancer was investigated...
  68. doi request reprint Increased risk for CRC in diabetic patients with the nonrisk allele of SNPs at 8q24
    Shinya Ishimaru
    Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan
    Ann Surg Oncol 19:2853-8. 2012
    ..Colorectal cancer (CRC) oncogenesis was considered to be determined by interactions between genetic and environmental factors. Specific interacting factors that influence CRC morbidity have yet to be fully investigated...
  69. ncbi request reprint [Neoadjuvant chemotherapy for colorectal cancer]
    Takeo Sato
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Gan To Kagaku Ryoho 39:871-5. 2012
    ..Studying how treatment regimens highly effective against unresectable or recurrent colorectal cancer can be adapted to patients with resectable disease is thus an important issue...
  70. ncbi request reprint Diffusion-weighted imaging of malignant breast tumors: the usefulness of apparent diffusion coefficient (ADC) value and ADC map for the detection of malignant breast tumors and evaluation of cancer extension
    Reiko Woodhams
    Department of Radiology, Kitasato University School of Medicine, Kanagawa, Japan
    J Comput Assist Tomogr 29:644-9. 2005
    ..Benign proliferative change showed a low ADC value. The authors conclude that DWI has a potential for clinical appreciation in detecting breast cancer...
  71. ncbi request reprint Lymph node metastasis density (ND)-factor association with malignant degree and ND40 as "non-curative factor" in gastric cancer
    Keishi Yamashita
    Department of Surgery, Kitasato University Hospital, Kitasato 1 15 1, Sagamihara 228 8555, Kanagawa, Japan
    Anticancer Res 28:435-41. 2008
    ..Interestingly, ND40 relevance was validated in the prospective and independent set of gastric cancer patients (p = 0.002)...
  72. doi request reprint Delayed accumulation of activated macrophages and inhibition of remyelination after spinal cord injury in an adult rodent model
    Masaaki Imai
    Department of Neurosurgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Neurosurg Spine 8:58-66. 2008
    ..The object of this study was to investigate the mechanisms underlying the failure of significant remyelination after SCI...
  73. doi request reprint The postsynaptic density protein, IQ-ArfGEF/BRAG1, can interact with IRSp53 through its proline-rich sequence
    Masashi Sanda
    Department of Anatomy, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Brain Res 1251:7-15. 2009
    ..Our present findings suggest that IQ-ArfGEF/BRAG1 may play roles downstream of NMDA receptors through the interaction with multivalent PSD proteins such as IRSp53 and PSD-95...
  74. ncbi request reprint Strong association of lymph node metastasis with intraperitoneal free cancer cell (IFCC) in advanced gastric cancer
    Keishi Yamashita
    Department of Surgery, Kitasato University Higashi Hospital, Kanagawa, Japan
    Hepatogastroenterology 55:1873-7. 2008
    ..Advanced gastric cancer is a disease with dismal prognosis, which is mainly characterized by the emerging intraperitoneal free gastric cancer cells (IFCC). Our interest is to elucidate a causative phenotype linking to IFCC...
  75. ncbi request reprint Gene expression in colorectal cancer and in vitro chemosensitivity to 5-fluorouracil: a study of 88 surgical specimens
    Kentaro Yoshinare
    Department of Surgery, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    Cancer Sci 94:633-8. 2003
    ..6 and 0.4, respectively. The sensitivity of colorectal cancer to 5-FU may be regulated by DPD, the rate-limiting enzyme of catabolism, and NT, an important transmembrane transporter of nucleosides...
  76. ncbi request reprint Transfusion alert for patients with curable cancer
    Keishi Yamashita
    Department of Surgery, Kitasato University Hospital, Kanagawa, Japan
    World J Surg 31:2315-22. 2007
    ..However, the prognostic independence among related factors and clinical significance of the interaction remains elusive...
  77. ncbi request reprint Lymph node metastasis density and growth pattern as independent prognostic factors in advanced esophageal squamous cell carcinoma
    Akira Ooki
    Department of Surgery, Kitasato University Higashi Hospital, Asamizodai 2 1 1, Sagamihara 228 8520 Kanagawa, Japan
    World J Surg 31:2184-91. 2007
    ..Thus staging could be expanded to make the prognosis a valuable clinical tool, and to improve knowledge of the biological traits of advanced ESCC...
  78. ncbi request reprint Comparison of staging between the old (6th edition) and new (7th edition) TNM classifications in advanced gastric cancer
    Shiro Kikuchi
    Department of Surgery, School of Medicine, Kitasato University, 1 15 1, Kitasato, Minami Ku, Sagamihara, Kanagawa 252 0374, Japan
    Anticancer Res 31:2361-5. 2011
    ....
  79. ncbi request reprint A new diagnostic method for early gastric cancer: volume measurement by 3-dimensional endoscopic ultrasonography in early gastric cancer and its clinical significance
    Nobue Futawatari
    Department of Surgery, School of Medicine, Kitasato University, Sagamihara shi, Kanagawa 228, Japan
    Anticancer Res 28:2907-12. 2008
    ..The objective of the present study was to measure the volume of early gastric cancer using 3-dimensional endoscopic ultrasonography (3D-EUS) and to ascertain the clinical significance of this new diagnostic method...
  80. doi request reprint Laparoscopy-assisted distal gastrectomy for early gastric cancer with complete situs inversus: report of a case
    Nobue Futawatari
    Department of Surgery, School of Medicine, Kitasato University, 2 1 1 Asamizodai, Sagamihara, Kanagawa, 228 8520, Japan
    Surg Today 40:64-7. 2010
    ..Based on a histopathological examination, a 5.0 x 5.0-cm, mucosal, poorly differentiated adenocarcinoma (pT1, pN0, sH0, sP0, sM0, Stage IA) was diagnosed...
  81. doi request reprint Prognostic significance of preoperative bowel obstruction in stage III colorectal cancer
    Hiroshi Katoh
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Ann Surg Oncol 18:2432-41. 2011
    ..If such a detrimental effect is preserved in each stage of advanced (stage II or III) CRC, we can identify high-risk patients...
  82. ncbi request reprint Neoadjuvant chemotherapy of irinotecan, 5-fluorouracil and leucovorin in patients with advanced rectal cancer. Report of two cases
    Hirotoshi Hasegawa
    Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Hepatogastroenterology 49:891-3. 2002
    ..The combination of irinotecan/5-fluorouracil/leucovorin appears to be feasible and effective, and to have a potential as an optimal neoadjuvant therapy in patients with advanced rectal cancer...