Hiroyuki Sakagami

Summary

Affiliation: Kitasato University
Country: Japan

Publications

  1. doi request reprint Distinct synaptic localization patterns of brefeldin A-resistant guanine nucleotide exchange factors BRAG2 and BRAG3 in the mouse retina
    Hiroyuki Sakagami
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 252 0374, Japan
    J Comp Neurol 521:860-76. 2013
  2. doi request reprint IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts with PSD-95 at postsynaptic density of excitatory synapses
    Hiroyuki Sakagami
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara 228 8555, Japan
    Neurosci Res 60:199-212. 2008
  3. ncbi request reprint The EFA6 family: guanine nucleotide exchange factors for ADP ribosylation factor 6 at neuronal synapses
    Hiroyuki Sakagami
    Department of Anatomy, Kitasato University School of Medicine
    Tohoku J Exp Med 214:191-8. 2008
  4. doi request reprint Vezatin, a potential target for ADP-ribosylation factor 6, regulates the dendritic formation of hippocampal neurons
    Masashi Sanda
    Department of Anatomy, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara 228 8555, Kanagawa, Japan
    Neurosci Res 67:126-36. 2010
  5. doi request reprint SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses
    Masahiro Fukaya
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    J Neurochem 116:1122-37. 2011
  6. doi request reprint Roles of prostaglandin E2-EP3/EP4 receptor signaling in the enhancement of lymphangiogenesis during fibroblast growth factor-2-induced granulation formation
    Kanako Hosono
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, 228 8555, Japan
    Arterioscler Thromb Vasc Biol 31:1049-58. 2011
  7. doi request reprint IQ-ArfGEF/BRAG1 is associated with synaptic ribbons in the mouse retina
    Osamu Katsumata
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    Eur J Neurosci 30:1509-16. 2009
  8. doi request reprint The postsynaptic density protein, IQ-ArfGEF/BRAG1, can interact with IRSp53 through its proline-rich sequence
    Masashi Sanda
    Department of Anatomy, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Brain Res 1251:7-15. 2009
  9. doi request reprint Host prostaglandin EP3 receptor signaling relevant to tumor-associated lymphangiogenesis
    Hidefumi Kubo
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, Japan
    Biomed Pharmacother 64:101-6. 2010
  10. doi request reprint Predominant localization of EFA6A, a guanine nucleotide exchange factor for ARF6, at the perisynaptic photoreceptor processes
    Osamu Katsumata
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara 228 8555, Japan
    Brain Res 1234:44-9. 2008

Collaborators

Detail Information

Publications58

  1. doi request reprint Distinct synaptic localization patterns of brefeldin A-resistant guanine nucleotide exchange factors BRAG2 and BRAG3 in the mouse retina
    Hiroyuki Sakagami
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 252 0374, Japan
    J Comp Neurol 521:860-76. 2013
    ..These findings suggest that BRAG/IQSEC family members have key roles in the function and organization of distinct excitatory and inhibitory synapses in the retina...
  2. doi request reprint IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts with PSD-95 at postsynaptic density of excitatory synapses
    Hiroyuki Sakagami
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara 228 8555, Japan
    Neurosci Res 60:199-212. 2008
    ..Taken together, IQ-ArfGEF/BRAG1 forms a postsynaptic protein complex containing PSD-95 and NMDA receptors at excitatory synapses, where it may function as a GEF for Arf6...
  3. ncbi request reprint The EFA6 family: guanine nucleotide exchange factors for ADP ribosylation factor 6 at neuronal synapses
    Hiroyuki Sakagami
    Department of Anatomy, Kitasato University School of Medicine
    Tohoku J Exp Med 214:191-8. 2008
    ..Here, I will review the recent advances in the expression and functions of the EFA6 family in the nervous system...
  4. doi request reprint Vezatin, a potential target for ADP-ribosylation factor 6, regulates the dendritic formation of hippocampal neurons
    Masashi Sanda
    Department of Anatomy, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara 228 8555, Kanagawa, Japan
    Neurosci Res 67:126-36. 2010
    ..Our present study suggests that vezatin may regulate dendritic formation as a downstream effector of ARF6...
  5. doi request reprint SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses
    Masahiro Fukaya
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    J Neurochem 116:1122-37. 2011
    ..Taken together, these findings suggest that synArfGEF functions as a novel regulator of Arf6 at inhibitory synapses and associates with the dystrophin-associated glycoprotein complex and S-SCAM...
  6. doi request reprint Roles of prostaglandin E2-EP3/EP4 receptor signaling in the enhancement of lymphangiogenesis during fibroblast growth factor-2-induced granulation formation
    Kanako Hosono
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, 228 8555, Japan
    Arterioscler Thromb Vasc Biol 31:1049-58. 2011
    ..However, it remains unknown whether they enhance lymphangiogenesis. We examined the roles of cyclooxygenase-2 (COX-2) and PGE2 receptor signaling in enhancement of lymphangiogenesis during proliferative inflammation...
  7. doi request reprint IQ-ArfGEF/BRAG1 is associated with synaptic ribbons in the mouse retina
    Osamu Katsumata
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    Eur J Neurosci 30:1509-16. 2009
    ..These findings indicate that IQ-ArfGEF/BRAG1 is a novel component of retinal synaptic ribbons and forms a protein complex with RIBEYE...
  8. doi request reprint The postsynaptic density protein, IQ-ArfGEF/BRAG1, can interact with IRSp53 through its proline-rich sequence
    Masashi Sanda
    Department of Anatomy, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Brain Res 1251:7-15. 2009
    ..Our present findings suggest that IQ-ArfGEF/BRAG1 may play roles downstream of NMDA receptors through the interaction with multivalent PSD proteins such as IRSp53 and PSD-95...
  9. doi request reprint Host prostaglandin EP3 receptor signaling relevant to tumor-associated lymphangiogenesis
    Hidefumi Kubo
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, Japan
    Biomed Pharmacother 64:101-6. 2010
    ..Host EP3 blockade together with COX-2 inhibition may be a novel therapeutic strategy to suppress tumor-associated lymphangiogenesis...
  10. doi request reprint Predominant localization of EFA6A, a guanine nucleotide exchange factor for ARF6, at the perisynaptic photoreceptor processes
    Osamu Katsumata
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara 228 8555, Japan
    Brain Res 1234:44-9. 2008
    ..These findings suggest that EFA6A-ARF6 pathway may play a specific role at a subcompartment of perisynaptic photoreceptor processes...
  11. doi request reprint Thromboxane A(2) receptor signaling promotes liver tissue repair after toxic injury through the enhancement of macrophage recruitment
    Tsutomu Minamino
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa 252 0374, Japan
    Toxicol Appl Pharmacol 259:104-14. 2012
    ....
  12. doi request reprint Pilt is a coiled-coil domain-containing protein that localizes at the trans-Golgi complex and regulates its structure
    Hideaki Tamaki
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara 252 0374, Japan
    FEBS Lett 586:3064-70. 2012
    ..Silencing of endogenous Pilt disrupted the Golgi structure. The present findings suggest the functional involvement of Pilt in the maintenance of the Golgi structure...
  13. doi request reprint Vascular endothelial growth factor receptor-1 signaling promotes liver repair through restoration of liver microvasculature after acetaminophen hepatotoxicity
    Tetsuki Kato
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa 252 0374, Japan
    Toxicol Sci 120:218-29. 2011
    ....
  14. doi request reprint Localization of EFA6A, a guanine nucleotide exchange factor for ARF6, in spermatogenic cells of testes of adult mice
    Ryoji Suzuki
    Department of Anatomy, School of Medicine, Akita University, 1 1 1 Hondo, Akita 010 8543, Japan
    J Mol Histol 40:77-80. 2009
    ..This suggests a possible involvement of EFA6A-ARF6 signaling in the karyokinesis and cytokinesis...
  15. doi request reprint Microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice
    Masako Isono
    Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    Life Sci 88:693-700. 2011
    ..To investigate the validity of mPGES-1 as a therapeutic target, we evaluated bone cancer pain-related behaviors in mPGES-1 knockout (PGES-1-/-) mice...
  16. doi request reprint Accumulation of α-synuclein triggered by presynaptic dysfunction
    Yasuto Nakata
    Department of Neurology, Division of Neuroregenerative Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa 252 0374, Japan
    J Neurosci 32:17186-96. 2012
    ..Our present results suggest that SNARE dysfunction is the initial trigger of mislocalization and accumulation of αSyn, and probably is an important pathomechanism of α-synucleinopathies...
  17. pmc Less invasive and less technically demanding decompressive procedure for lumbar spinal stenosis--appropriate for general orthopaedic surgeons?
    Masashi Takaso
    Department of Orthopaedic Surgery, Kitasato University, School of Medicine, Kitasato1 15 1, Sagamihara, Kanagawa, Japan
    Int Orthop 35:67-73. 2011
    ..The described technique of MSPO yielded promising results with few complications. The authors believe MSPO is less technically demanding and appropriate for general orthopaedic surgeons, occasional spine surgeons and chief residents...
  18. pmc Surgical management of severe scoliosis with high risk pulmonary dysfunction in Duchenne muscular dystrophy: patient function, quality of life and satisfaction
    Masashi Takaso
    Department of Orthopaedic Surgery, School of Medicine, Kitasato University, Kitasato 1 15 1, Sagamihara, Kanagawa, Japan
    Int Orthop 34:695-702. 2010
    ..6% per year. Most patients and parents believed scoliosis surgery improved their function, sitting balance and quality of life even though patients were at high risk for major complications. Their satisfaction was also high...
  19. doi request reprint Type I phosphatidylinositol 4-phosphate 5-kinase γ is required for neuronal migration in the mouse developing cerebral cortex
    Yoshinobu Hara
    Department of Anatomy, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa, 252 0374, Japan
    Eur J Neurosci 38:2659-71. 2013
    ..These findings suggest an essential role of PIP5KIγ, particularly PIP5KIγ_i2, in neuronal migration, possibly through recruitment of adhesion components to the plasma membrane. ..
  20. ncbi request reprint Effect of erythropoietin on angiogenesis with the increased adhesion of platelets to the microvessels in the hind-limb ischemia model in mice
    Shintaro Kato
    Department of Pharmacology, Kitasato University School of Medicine, Kitasato, Sagamihara 228 8555, Japan
    J Pharmacol Sci 112:167-75. 2010
    ..These results suggest that EPO administration enhances recovery from hind-limb ischemia, and platelet adhesion to the microvessels is a key event to enhance the angiogenesis in the ischemic tissues...
  21. pmc Epigenetic silencing of HOPX promotes cancer progression in colorectal cancer
    Hiroshi Katoh
    Department of Surgery, Kitasato University School of Medicine, Sagamihara, Japan
    Neoplasia 14:559-71. 2012
    ..014). In conclusion, HOPX-β promoter methylation is a frequent and cancer-specific event in CRC progression. This epigenetic alteration may have clinical ramifications in the diagnosis and treatment of CRC patients...
  22. pmc COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems
    Hiroshi Katoh
    Department of Pharmacology, Kitasato University, School of Medicine, Kitasato 1 15 1, Sagamihara, Kanagawa, 228 8555, Japan
    Am J Pathol 176:1469-83. 2010
    ....
  23. doi request reprint Oxidative stress in mature rat testis and its developmental changes
    Yasuhiro Sakai
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    Dev Growth Differ 52:657-63. 2010
    ..The present findings aid our understanding of the defensive mechanism against oxidative stress in developing and mature testes...
  24. ncbi request reprint Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family
    Taisuke Miyazaki
    Department of Anatomy, Hokkaido University, School of Medicine, Sapporo, Japan
    FEBS Lett 580:4057-64. 2006
    ..Because cerebellar maturation and plasticity require metabotropic glutamate receptor signaling and resulting PKC activation, BSRPs are likely involved in ER functions supporting PKCalpha activation in PCs...
  25. doi request reprint Differential expression of SNAP-25 family proteins in the mouse brain
    Saori Yamamori
    Department of Biochemistry, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    J Comp Neurol 519:916-32. 2011
    ..These results indicate that the three SNAP-25 family proteins display a differential distribution in the brain as well as in neuronal cells, and possibly play distinct roles...
  26. pmc Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins
    Shigeki Moriguchi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Graduate School of Medicine, Tohoku University, Sendai 980, Japan
    Proc Natl Acad Sci U S A 103:10811-6. 2006
    ..Therefore, JPs seem to have an essential role in neural excitability fundamental to plasticity and integrated functions...
  27. ncbi request reprint Somatodendritic localization of EFA6A, a guanine nucleotide exchange factor for ADP-ribosylation factor 6, and its possible interaction with alpha-actinin in dendritic spines
    Hiroyuki Sakagami
    Division of Histology, Department of Cell Biology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Sendai 980 8575, Japan
    Eur J Neurosci 25:618-28. 2007
    ..Our present findings suggest that EFA6A may form a protein complex with alpha-actinin and activate ARF6 in close proximity of the actin cytoskeleton and membrane proteins in the dendritic spines...
  28. ncbi request reprint Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth
    Akifumi Kamata
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Japan
    Neurosci Res 57:86-97. 2007
    ....
  29. ncbi request reprint A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins
    Tatsuo Suzuki
    Department of Neuroplasticity, Institute on Ageing and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Eur J Neurosci 21:339-50. 2005
    ..These results suggest that TANC protein may work as a postsynaptic scaffold component by forming a multiprotein complex with various postsynaptic density proteins...
  30. ncbi request reprint Functional assay of EFA6A, a guanine nucleotide exchange factor for ADP-ribosylation factor 6 (ARF6), in dendritic formation of hippocampal neurons
    Hiroyuki Sakagami
    Department of Cell Biology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Methods Enzymol 404:232-42. 2005
    ..This reliable and consistent neuronal transfection method will also be applicable for the vector-based RNA interference method...
  31. ncbi request reprint NIDD, a novel DHHC-containing protein, targets neuronal nitric-oxide synthase (nNOS) to the synaptic membrane through a PDZ-dependent interaction and regulates nNOS activity
    Fuminori Saitoh
    Department of Neuroplasticity Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Biol Chem 279:29461-8. 2004
    ..These results suggested that NIDD plays an important role in the regulation of the NO signaling pathway at postsynaptic sites through targeting of nNOS to the postsynaptic membrane...
  32. ncbi request reprint Distinct spatiotemporal expression of EFA6D, a guanine nucleotide exchange factor for ARF6, among the EFA6 family in mouse brain
    Hiroyuki Sakagami
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, Sendai 980 8574, Japan
    Brain Res 1093:1-11. 2006
    ..Furthermore, immunoblot analysis revealed that EFA6D was highly concentrated in the postsynaptic density fraction. These findings suggest differential spatiotemporal regulation of ARF6 by three members of the EFA6 family in the brain...
  33. ncbi request reprint Prominent expression and activity-dependent nuclear translocation of Ca2+/calmodulin-dependent protein kinase Idelta in hippocampal neurons
    Hiroyuki Sakagami
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, Sendai 980 8575, Japan
    Eur J Neurosci 22:2697-707. 2005
    ..Our present study provides the first evidence for the possible involvement of CaMKIdelta in nuclear functions through its nuclear translocation in response to stimuli that trigger intracellular Ca2+ influx...
  34. ncbi request reprint BAALC 1-6-8 protein is targeted to postsynaptic lipid rafts by its N-terminal myristoylation and palmitoylation, and interacts with alpha, but not beta, subunit of Ca/calmodulin-dependent protein kinase II
    Xin Wang
    Department of Neuroplasticity, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Neurochem 92:647-59. 2005
    ..These findings suggest that BAALC 1-6-8 protein play a synaptic role at the postsynaptic lipid raft possibly through interaction with CaMKIIalpha...
  35. ncbi request reprint Interaction of LDL receptor-related protein 4 (LRP4) with postsynaptic scaffold proteins via its C-terminal PDZ domain-binding motif, and its regulation by Ca/calmodulin-dependent protein kinase II
    Qing Bao Tian
    Department of Neuroplasticity, Institute on Ageing and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Eur J Neurosci 23:2864-76. 2006
    ..These findings suggest a postsynaptic role for LRP4, a putative endocytic multiligand receptor, and a mechanism in which CaMKII regulates PDZ-dependent protein-protein interactions and receptor dynamics...
  36. ncbi request reprint p55 protein is a member of PSD scaffold proteins in the rat brain and interacts with various PSD proteins
    Zhang Jing-Ping
    Department of Neuroplasticity, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Brain Res Mol Brain Res 135:204-16. 2005
    ..r-p55 protein may form a basic structure, which interlinks diverse functional molecules of the PSD necessary for postsynaptic signaling and synaptic adhesion...
  37. pmc ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons
    Lidong Liu
    Department of Environmental Health, University of Washington, Seattle, WA 98195 7234, USA
    Proc Natl Acad Sci U S A 100:8532-7. 2003
    ..These data suggest that ERK5 activation of myocyte enhancer factor 2-induced gene expression may play an important and novel role in the development of the CNS by mediating NT-promoted survival of embryonic neurons...
  38. ncbi request reprint Cellular and subcellular localization of EFA6C, a third member of the EFA6 family, in adult mouse Purkinje cells
    Shigetsune Matsuya
    Division of Histology, Department of Cell Biology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Neurochem 93:674-85. 2005
    ..These findings suggest that EFA6C may be involved in the regulation of the membrane dynamics of the somatodendritic compartments of Purkinje cells through the activation of ARF6...
  39. ncbi request reprint Cloning, characterization and expression of two alternatively splicing isoforms of Ca2+/calmodulin-dependent protein kinase I gamma in the rat brain
    Hideki Nishimura
    Division of Histology, Department of Cell Biology, Graduate School of Medical Sciences, Tohoku University, Sendai, Japan
    J Neurochem 85:1216-27. 2003
    ..These findings suggest that both isoforms of CaMKI gamma may be involved in Ca2+ signal transduction in the cytoplasmic compartment of certain neuronal population...
  40. ncbi request reprint Cloning and characterization of a novel variant (mM-rdgBbeta1) of mouse M-rdgBs, mammalian homologs of Drosophila retinal degeneration B gene proteins, and its mRNA localization in mouse brain in comparison with other M-rdgBs
    Nobuo Takano
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Neurochem 84:829-39. 2003
    ..Taken together, mM-rdgBbeta1 is suggested to play a role in the phosphoinositide-mediated signaling in the neural development...
  41. ncbi request reprint Developmental expression of the SRF co-activator MAL in brain: role in regulating dendritic morphology
    Jun Shiota
    Department of Biological Chemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama City, Japan
    J Neurochem 98:1778-88. 2006
    ..Taken together, these findings indicate that the MAL-SRF signaling pathway plays a key role in regulating dendritic morphology...
  42. ncbi request reprint Brain-specific potential guanine nucleotide exchange factor for Arf, synArfGEF (Po), is localized to postsynaptic density
    Yuji Inaba
    Department of Neuroplasticity, Research Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Neurochem 89:1347-57. 2004
    ..Thus, both the mRNA and the protein were localized in the postsynaptic compartments. These results suggest a postsynaptic role of synArfGEF in the brain...
  43. ncbi request reprint Somatodendritic localization of the mRNA for EFA6A, a guanine nucleotide exchange protein for ARF6, in rat hippocampus and its involvement in dendritic formation
    Hiroyuki Sakagami
    Division of Histology, Department of Cell Biology, Tohoku University Graduate School of Medicine, Japan
    Eur J Neurosci 19:863-70. 2004
    ..The present findings suggest that EFA6A is intimately involved in the regulation of the dendritic development of hippocampal neurons...
  44. ncbi request reprint Coexpression of junctophilin type 3 and type 4 in brain
    Miyuki Nishi
    Department of Medical Chemistry, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Brain Res Mol Brain Res 118:102-10. 2003
    ..The results obtained suggest the collaborative contribution of JP-3 and JP-4 to the subsurface cistern formation in neurons...
  45. ncbi request reprint Structural and functional characterization of mouse glutamate decarboxylase 67 gene promoter
    Takashi Kobayashi
    Department of Biochemistry, Institute of Development, Aging and Cancer, Tohoku University, Seiryomachi, Aoba ku, Sendai 980 8575, Japan
    Biochim Biophys Acta 1628:156-68. 2003
    ..These results suggest that the 10.2 kb DNA fragment of the mGAD67 gene contains regulatory elements essential for its targeted expression in GABAergic neurons, islet cells and spermatocytes...
  46. ncbi request reprint Localization of brain-type fatty acid-binding protein in Kupffer cells of mice and its transient decrease in response to lipopolysaccharide
    Soha Abdelkawi Abdelwahab
    Division of Histology, Department of Cell Biology, Graduate School of Medical Science, Tohoku University, 980 8575 Sendai, Japan
    Histochem Cell Biol 119:469-75. 2003
    ....
  47. ncbi request reprint Enhanced expression of adipocyte-type fatty acid binding protein in murine lymphocytes in response to dexamethasone treatment
    Soha Abdelkawi Abdelwahab
    Division of Histology, Department of Cell Biology, Graduate School of Medical Science, Tohoku University, Tohoku, Sendai, 980 8575, Japan
    Mol Cell Biochem 299:99-107. 2007
    ..The present findings altogether suggest that A-FABP and its ligands, fatty acids, play an important role in the process of apoptosis and the immune modulation induced by DEX...
  48. ncbi request reprint Transgenic mouse lines expressing synaptopHluorin in hippocampus and cerebellar cortex
    Rikita Araki
    Department of Developmental Biology and Neurosciences, Tohoku University Graduate School of Life Sciences, and CREST, JST, Sendai, Japan
    Genesis 42:53-60. 2005
    ..These transgenic lines are expected to facilitate morphological and physiological studies of presynaptic terminals in a variety of regions of the brain...
  49. ncbi request reprint Rat leucine-rich protein binds and activates the promoter of the beta isoform of Ca2+/calmodulin-dependent protein kinase II gene
    Nagahiro Ochiai
    Department of Biochemistry, Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima 770 8505, Japan
    Neurosci Res 58:67-76. 2007
    ..These results indicate that rLRP157 is one of the proteins binding to, and regulating the activity of, the promoter of beta CaM kinase II...
  50. pmc Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity
    Sho Kakizawa
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    EMBO J 26:1924-33. 2007
    ..Therefore, JPs support the Ca(2+)-mediated communication between voltage-gated Ca(2+) channels, RyRs and SK channels, which modulates the excitability of PCs and is fundamental to cerebellar LTD and motor functions...
  51. ncbi request reprint Synaptic vesicle dynamics in the mossy fiber-CA3 presynaptic terminals of mouse hippocampus
    Shigetomo Suyama
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University, Tochigi, Japan
    Neurosci Res 59:481-90. 2007
    ..Therefore, the fidelity of transmission is suggested to be ensured by the rapid refilling rate of RRP...
  52. ncbi request reprint Altered emotional behavioral responses in mice lacking brain-type fatty acid-binding protein gene
    Yuji Owada
    Division of Histology, Graduate School of Medical Science, Tohoku University, 2 1 Seiryo machi, Aobaku, Sendai 980 8575, Japan
    Eur J Neurosci 24:175-87. 2006
    ..These data indicate that B-FABP is crucially involved in the fear memory and anxiety through its binding with FAs and/or its own direct effects on pertinent metabolism/signaling of FAs...
  53. doi request reprint CLIC4 interacts with histamine H3 receptor and enhances the receptor cell surface expression
    Kay Maeda
    Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, Sendai 980 8575, Japan
    Biochem Biophys Res Commun 369:603-8. 2008
    ..These results indicate that, by binding to the C-terminus of H3R, CLIC4 plays a critical role in regulation of the receptor cell surface expression...
  54. pmc Extracellular signal-regulated kinase (ERK) 5 is necessary and sufficient to specify cortical neuronal fate
    Lidong Liu
    Toxicology Program, Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 103:9697-702. 2006
    ....
  55. ncbi request reprint Occurrence of immunoreactivity for adipocyte-type fatty acid binding protein in degenerating granulosa cells in atretic antral follicles of mouse ovary
    Mohammad Reza Nourani
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, Sendai, Japan
    J Mol Histol 36:491-7. 2005
    ..The present findings suggest that A-FABP is involved in the apoptosis of ovarian granulosa cells, probably through its interaction with peroxisome proliferator activated receptors...
  56. ncbi request reprint Epidermal-type fatty acid binding protein as a negative regulator of IL-12 production in dendritic cells
    Noriko Kitanaka
    Department of Histology, Graduate School of Medicine, Tohoku University, Japan
    Biochem Biophys Res Commun 345:459-66. 2006
    ..Collectively, it is suggested that E-FABP may be a novel negative regulator of IL-12 production in DCs, and this regulation may be exerted via its involvement in the p38MAPK-mediated transcription of IL-12p35...
  57. ncbi request reprint Localization of epidermal-type fatty acid binding protein in macrophages in advanced atretic follicles of adult mice
    Mohammad Reza Nourani
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, Aoba ku, Sendai, Japan
    J Mol Histol 36:391-400. 2005
    ....
  58. ncbi request reprint Transient up-regulation of elongation factor-2 kinase (Ca2+/calmodulin-dependent protein kinase III) messenger RNA in developing mouse brain
    Hiroyuki Sakagami
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, Sendai 980 8575, Japan
    Neurosci Lett 330:41-4. 2002
    ..These findings suggest that eEF-2K may be involved in early neuronal events such as proliferation, differentiation, and establishment of synaptic connections...