Tetuo Mikami

Summary

Affiliation: Kitasato University
Country: Japan

Publications

  1. doi Small gastrointestinal stromal tumor in the stomach: identification of precursor for clinical gastrointestinal stromal tumor using c-kit and α-smooth muscle actin expression
    Tetuo Mikami
    Department of Pathology, Toho University School of Medicine, Ota ku, Tokyo 143 8540, Japan Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa 252 0374, Japan Electronic address
    Hum Pathol 44:2628-35. 2013
  2. ncbi A Kaposi-like variant of splenic angiosarcoma lacking association with human herpesvirus 8
    Tetuo Mikami
    Department of Pathology, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara si, Kanagawa, 228 8555, Japan
    Arch Pathol Lab Med 126:191-4. 2002
  3. ncbi Bottom-up cell proliferation with cyclin A and p27Kip1 expression in ulcerative colitis-associated dysplasia
    Tetuo Mikami
    Department of Pathology, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan
    Pathol Int 56:10-6. 2006
  4. pmc Invasive behavior of ulcerative colitis-associated carcinoma is related to reduced expression of CD44 extracellular domain: comparison with sporadic colon carcinoma
    Tetuo Mikami
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan
    Diagn Pathol 6:30. 2011
  5. doi High expression of L-type amino-acid transporter 1 (LAT1) in gastric carcinomas: comparison with non-cancerous lesions
    Masaaki Ichinoe
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Pathol Int 61:281-9. 2011
  6. doi Tumor budding is predictive of lymphatic involvement and lymph node metastases in submucosal invasive colorectal adenocarcinomas and in non-polypoid compared with polypoid growths
    Taishi Ogawa
    Department of Pathology, Kitasato University School of Medicine, Kitasato, Sagamihara, Kanagawa, Japan
    Scand J Gastroenterol 44:605-14. 2009
  7. doi Mucosal remodeling in long-standing ulcerative colitis with colorectal neoplasia: significant alterations of NCAM+ or alpha-SMA+ subepithelial myofibroblasts and interstitial cells
    Isao Okayasu
    Department of Pathology, Kitasato University, Kanagawa, Japan
    Pathol Int 59:701-11. 2009
  8. ncbi Significant increase of colonic mutated crypts correlates with age in sporadic cancer and diverticulosis cases, with higher frequency in the left- than right-side colorectum
    Isao Okayasu
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    Cancer Sci 97:362-7. 2006
  9. ncbi Cytoglobin expression of rectal subepithelial myofibroblasts: significant alterations of cytoglobin+ stromal cells in long-standing ulcerative colitis
    Isao Okayasu
    Department of Pathology, School of Medicine, Kitasato University, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa, Japan
    Histol Histopathol 26:679-88. 2011
  10. ncbi Midkine expression in colorectal tumors: correlation with Ki-67 labeling in sporadic, but not ulcerative colitis-associated ones
    Wataru Tokuyama
    Department of Pathology, Kitasato University, School of Medicine, Sagamihara, Japan
    Pathol Int 57:260-7. 2007

Collaborators

Detail Information

Publications42

  1. doi Small gastrointestinal stromal tumor in the stomach: identification of precursor for clinical gastrointestinal stromal tumor using c-kit and α-smooth muscle actin expression
    Tetuo Mikami
    Department of Pathology, Toho University School of Medicine, Ota ku, Tokyo 143 8540, Japan Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa 252 0374, Japan Electronic address
    Hum Pathol 44:2628-35. 2013
    ..The mutation of KIT is considered as an early event in tumorigenesis of GIST. ..
  2. ncbi A Kaposi-like variant of splenic angiosarcoma lacking association with human herpesvirus 8
    Tetuo Mikami
    Department of Pathology, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara si, Kanagawa, 228 8555, Japan
    Arch Pathol Lab Med 126:191-4. 2002
    ..Although the histologic findings were similar, this Kaposi-like variant of splenic angiosarcoma must be considered distinct from Kaposi sarcoma...
  3. ncbi Bottom-up cell proliferation with cyclin A and p27Kip1 expression in ulcerative colitis-associated dysplasia
    Tetuo Mikami
    Department of Pathology, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan
    Pathol Int 56:10-6. 2006
    ..It is considered that tumorigenesis with UC-associated dysplasia is of the bottom-up type, related to altered expression of cyclin A and p27(Kip1)...
  4. pmc Invasive behavior of ulcerative colitis-associated carcinoma is related to reduced expression of CD44 extracellular domain: comparison with sporadic colon carcinoma
    Tetuo Mikami
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan
    Diagn Pathol 6:30. 2011
    ..To elucidate relations of invasion of ulcerative colitis (UC)-associated carcinoma with its prognosis, the characteristics of invasive fronts were analyzed in comparison with sporadic colonic carcinomas...
  5. doi High expression of L-type amino-acid transporter 1 (LAT1) in gastric carcinomas: comparison with non-cancerous lesions
    Masaaki Ichinoe
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Pathol Int 61:281-9. 2011
    ..Lower levels were found in adenomas. In conclusion, LAT 1 expression may be linked with cell proliferation and prognosis of gastric carcinomas, and offers a potential target for future anticancer therapy by inhibitors...
  6. doi Tumor budding is predictive of lymphatic involvement and lymph node metastases in submucosal invasive colorectal adenocarcinomas and in non-polypoid compared with polypoid growths
    Taishi Ogawa
    Department of Pathology, Kitasato University School of Medicine, Kitasato, Sagamihara, Kanagawa, Japan
    Scand J Gastroenterol 44:605-14. 2009
    ....
  7. doi Mucosal remodeling in long-standing ulcerative colitis with colorectal neoplasia: significant alterations of NCAM+ or alpha-SMA+ subepithelial myofibroblasts and interstitial cells
    Isao Okayasu
    Department of Pathology, Kitasato University, Kanagawa, Japan
    Pathol Int 59:701-11. 2009
    ..Mucosal remodeling with alterations of NCAM+ or alpha-SMA+ subepithelial and interstitial cells may play a critical role in UC-associated tumorigenesis...
  8. ncbi Significant increase of colonic mutated crypts correlates with age in sporadic cancer and diverticulosis cases, with higher frequency in the left- than right-side colorectum
    Isao Okayasu
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    Cancer Sci 97:362-7. 2006
    ..Furthermore, the environment in the right side of the colon may be different from that in the left side in this regard...
  9. ncbi Cytoglobin expression of rectal subepithelial myofibroblasts: significant alterations of cytoglobin+ stromal cells in long-standing ulcerative colitis
    Isao Okayasu
    Department of Pathology, School of Medicine, Kitasato University, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa, Japan
    Histol Histopathol 26:679-88. 2011
    ..Mucosal remodeling with alterations of Cygb+ and/or αSMA+/HSP47+ stromal cells might have some relation to UC-associated tumorigenesis...
  10. ncbi Midkine expression in colorectal tumors: correlation with Ki-67 labeling in sporadic, but not ulcerative colitis-associated ones
    Wataru Tokuyama
    Department of Pathology, Kitasato University, School of Medicine, Sagamihara, Japan
    Pathol Int 57:260-7. 2007
    ..These results suggest that MK is involved in genesis/development of sporadic colorectal tumors as well as of UC-associated tumors, but might contribute differently to genesis/development in these two types of tumors...
  11. doi Association of D2-40 and MMP-1 expression with cyst formation in lung metastatic lesions of cutaneous angiosarcoma on the scalp: immunohistochemical analysis of 23 autopsy cases
    Mamiko Masuzawa
    Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Kanagawa 252 0374, Japan Electronic address
    Hum Pathol 44:2751-9. 2013
    ..Two extremely aggressive cases showed cystic metastasis with central necrosis that was not observed in other cases. These results suggest a pathogenesis of thin-walled cysts in some progressive cases. ..
  12. doi Clinicopathologic characteristics of pancreatic neuroendocrine tumors and relation of somatostatin receptor type 2A to outcomes
    Kosuke Okuwaki
    Department of Gastroenterology, Kitasato University East Hospital, Kanagawa, Japan
    Cancer 119:4094-102. 2013
    ..The impact of somatostatin receptor type 2 (SSTR-2a) expression levels on outcomes in patients with pancreatic neuroendocrine tumors (PNETs) has not been evaluated...
  13. doi Tumor budding, myofibroblast proliferation, and fibrosis in obstructing colon carcinoma: the roles of Hsp47 and basic fibroblast growth factor
    Chuan jie Xu
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan
    Pathol Res Pract 209:69-74. 2013
    ..Correlative Hsp47 expression in fibroblasts with bFGF in inflammatory cells may contribute to stromal fibrosis...
  14. ncbi Low frequency of promoter methylation of O6-methylguanine DNA methyltransferase and hMLH1 in ulcerative colitis-associated tumors: comparison with sporadic colonic tumors
    Tetuo Mikami
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan
    Am J Clin Pathol 127:366-73. 2007
    ..Decrease of expression of MGMT, hMLH1, and p16INK4 was significantly correlated with methylation. Thus, compared with the sporadic type, contribution of methylation to UC-associated tumorigenesis seems to be low...
  15. doi Appearance of epithelial and stromal genomic instability in background colorectal mucosa of sporadic colorectal cancer patients: relation to age and gender
    Harue Umeto
    Department of Cellular and Histo pathology, Kitasato University Postgraduate School of Medical Sciences, Sagamihara, Japan
    J Gastroenterol 44:1036-45. 2009
    ..To assess the increasing risk of carcinogenesis in the colorectum with aging, we examined genomic instability in both epithelia and stroma in the background noncancerous mucosa of patients with colorectal carcinomas...
  16. doi Telomere shortening in Barrett's mucosa and esophageal adenocarcinoma and its association with loss of heterozygosity
    Hiroaki Shiraishi
    Departments of Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Scand J Gastroenterol 44:538-44. 2009
    ....
  17. doi Papillary thyroid carcinoma with heterotopic ossification is a special subtype with extensive progression
    Masahiko Takeda
    Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University School of Medicine, Sagamihara, Japan
    Am J Clin Pathol 139:587-98. 2013
    ..Papillary carcinoma with IHO was correlated with expression of bFGF, BMP-2, and VEGF in the carcinoma cells, leading to neovascularization...
  18. doi High expression of L-type amino acid transporter 1 (LAT1) predicts poor prognosis in pancreatic ductal adenocarcinomas
    Nobuyuki Yanagisawa
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    J Clin Pathol 65:1019-23. 2012
    ..Molecular target therapy against L-type amino acid transporter 1 (LAT1) is unique and expected to be developed soon. LAT1 expression was investigated in pancreatic cancer as a prognostic predictor...
  19. ncbi Early genetic instability of both epithelial and stromal cells in esophageal squamous cell carcinomas, contrasted with Barrett's adenocarcinomas
    Hiroaki Shiraishi
    Department of Pathology, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara 228 8555, Japan
    J Gastroenterol 41:1186-96. 2006
    ..We assessed whether similar differences in genetic alteration might exist between squamous cell carcinomas (SCCs) and Barrett's adenocarcinomas (BACs) of the esophagus...
  20. ncbi Disruption of the p53-p53r2 DNA repair system in ulcerative colitis contributes to colon tumorigenesis
    Tsutomu Yoshida
    Department of Pathology, Kitasato University School of Medicine, Kitasato, Sagamihara, Kanagawa, Japan
    Int J Cancer 118:1395-403. 2006
    ..Since failure of the p53-G(1) checkpoint may cause dysfunction of repair under the influence of butyrate, gene alterations may increase and spread through the genome, leading to tumorigenesis...
  21. ncbi Gastric large cell neuroendocrine carcinomas: a distinct clinicopathologic entity
    Shi Xu Jiang
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    Am J Surg Pathol 30:945-53. 2006
    ..0001), and some ACNEDs might actually have been LCNECs, and survival analysis showed that > 20% positivity of NE markers could be enough to characterize LCNEC, as long as light microscopic NE morphology was present in the tumor...
  22. doi A clinical study of transoral pharyngectomies to treat superficial hypopharyngeal cancers
    Meijin Nakayama
    Department of Otorhinolaryngology, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa 252 0374, Japan
    Jpn J Clin Oncol 43:782-7. 2013
    ..The advent of the narrow band imaging system combined endoscopy and various endoscopic approaches shed light on the new era of the minimum invasive management of superficial cancers in hypopharyngeal regions...
  23. ncbi Apoptosis regulation differs between ulcerative colitis-associated and sporadic colonic tumors. Association with survivin and bcl-2
    Tetuo Mikami
    Dept of Pathology, School of Medicine, Kitasato University, 1 15 1 Kitasato, Sagamihara si, Kanagawa, 228 8555, Japan
    Am J Clin Pathol 119:723-30. 2003
    ..Apoptosis is less frequent in UC-associated than in sporadic invasive colon carcinomas, this being linked to elevated survivin expression. The control of apoptosis may be different in the 2 types of tumorigenesis...
  24. doi Diagnostic findings of ultrasound-guided fine-needle aspiration cytology for gastrointestinal stromal tumors: proposal of a combined cytology with newly defined features and histology diagnosis
    Satoko Yoshida
    Department of Pathology, Kitasato University East Hospital, Sagamihara, Kanagawa, Japan
    Pathol Int 59:712-9. 2009
    ..Thus, the combined cytology with newly defined features, and classification and histological diagnostic method for EUS-FNA materials can contribute to improved routine diagnosis for GIST...
  25. ncbi Unique and selective expression of L-amino acid transporter 1 in human tissue as well as being an aspect of oncofetal protein
    Norihiro Nakada
    Department of Pathology, and Department of Cellular and Histopathology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Histol Histopathol 29:217-27. 2014
    ..In addition, ubiquitous LAT2 expression was confirmed immunohistochemically in systemic tissues, indicating constitutional function. ..
  26. doi Autocrine and paracrine roles of VEGF/VEGFR-2 and VEGF-C/VEGFR-3 signaling in angiosarcomas of the scalp and face
    Wataru Tokuyama
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    Hum Pathol 41:407-14. 2010
    ..These results suggest that not only VEGFR-2-mediated signal but also VEGFR-3-mediated signal may contribute to proliferation of vascular tumor cells as autocrine and paracrine signaling factors...
  27. ncbi Background submucosal cysts in early gastric cancer cases have unique clinicopathologic features suggestive of postgastritis and significant smoking association
    Masaaki Ichinoe
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan
    Am J Clin Pathol 128:746-52. 2007
    ..The Brinkman index was also significantly higher. Cases of gastric cancer with SMC show characteristic clinicopathologic features, and SMC formation may be caused by gastritis and influenced by smoking...
  28. ncbi Dysplasia and carcinoma development in a repeated dextran sulfate sodium-induced colitis model
    Isao Okayasu
    Department of Pathology, School of Medicine, Kitasato University, Sagamihara Kanagawa, Japan
    J Gastroenterol Hepatol 17:1078-83. 2002
    ..In the present study, a dysplasia-carcinoma sequence in a novel repeated colitis model in mice is documented...
  29. ncbi Significant correlation of morphological remodeling in ulcerative colitis with disease duration and between elevated p53 and p21 expression in rectal mucosa and neoplastic development
    Jun Mitsuhashi
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Pathol Int 55:113-21. 2005
    ..Accumulated damage to DNA, reflected by increased p53 and p21(WAF1) labeling indices, might be involved in cancer development, as well as longstanding inflammation...
  30. doi Submucosal fibrosis and basic-fibroblast growth factor-positive neutrophils correlate with colonic stenosis in cases of ulcerative colitis
    Masaru Yamagata
    Department of Gastroenterology, Kitasato University East Hospital, Sagamihara, Japan
    Digestion 84:12-21. 2011
    ..The aim of the present study was to assess stenosis in UC cases using immunostaining and to analyze differences between stenotic and nonstenotic cases, focusing on basic-fibroblast growth factor (b-FGF) expression and myofibroblasts...
  31. ncbi Correlation of enhanced cell turnover with prognosis of gastrointestinal stromal tumors of the stomach: relevance of cellularity and p27kip1
    Yuta Nemoto
    Department of Surgery, School of Medicine, Kitasato University, Sagamihara, Japan
    Pathol Int 56:724-31. 2006
    ..Ki-67, ssDNA, and cyclin A are useful for prediction of prognosis, with cellularity and p27(Kip1) expression as further prognostic factors in high-risk cases...
  32. doi CITED2 is activated in ulcerative colitis and induces p53-dependent apoptosis in response to butyric acid
    Tsutomu Yoshida
    Department of Pathology, Kitasato University School of Medicine, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa 252 0374, Japan
    J Gastroenterol 46:339-49. 2011
    ..However, factors active in the link between BA and p53 have yet to be clarified. Here, we identified a gene activated by BA specifically in UC-associated cancer cell lines and ascertained the mechanism of its activation of p53...
  33. ncbi Diverse p53 alterations in ulcerative colitis-associated low-grade dysplasia: full-length gene sequencing in microdissected single crypts
    Tsutomu Yoshida
    Department of Pathology, Kitasato University School of Medicine, 1 15 1, Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    J Pathol 199:166-75. 2003
    ..At the single crypt level, however, p53 point mutations were not always linked to p53 overexpression, indicating a discrepancy between gene alteration and protein accumulation in LGD...
  34. ncbi Significant increase of colonic mutated crypts in ulcerative colitis correlatively with duration of illness
    Isao Okayasu
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    Cancer Res 62:2236-8. 2002
    ..0001) were found to be increased significantly, compared with controls. The observed correlation with ulcerative colitis duration (r = 0.892 and 0.853, respectively) supports a chronic inflammation-carcinoma sequence...
  35. ncbi Diagnostic findings of bronchial brush cytology for pulmonary large cell neuroendocrine carcinomas: comparison with poorly differentiated adenocarcinomas, squamous cell carcinomas, and small cell carcinomas
    Hirokuni Kakinuma
    Department of Pathology, Kitasato University Hospital, Sagamihara, Kanagawa, Japan
    Cancer 99:247-54. 2003
    ..Large cell neuroendocrine carcinoma (LCNEC) of the lung has been proposed as a new disease entity. To establish diagnostic features, bronchial brush cytologic findings were evaluated...
  36. doi Lewy body pathology in a patient with a homozygous parkin deletion
    Saori Miyakawa
    Department of Neurology, Kitasato University School of Medicine, Kanagawa, Japan
    Mov Disord 28:388-91. 2013
    ..We report neuropathologic findings in a patient with homozygous deletions of exons 2 to 4 of parkin...
  37. doi Heparin-induced thrombocytopenia with multiple organized thrombi accompanied by unusual cholesterin deposition: autopsy case after long-term follow up
    Masaaki Ichinoe
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan
    Pathol Int 59:757-61. 2009
    ..The findings suggest that HIT accompanied by marked hypercholesterolemia of long duration contributes to a characteristic form of thromboembolism that needs careful management...
  38. ncbi Microsatellite instability in chronic cholecystitis is indicative of an early stage in gallbladder carcinogenesis
    Nobuyuki Yanagisawa
    Dept of Pathology, Kitasato University, School of Medicine, Kitasato 1 15 1, Sagamihara, Kanagawa 228 8555, Japan
    Am J Clin Pathol 120:413-7. 2003
    ..MSI was observed not only in gallbladder tumors but also in severe chronic cholecystitis and background mucosa, suggesting that it may have an important role in early-stage gallbladder carcinogenesis...
  39. doi Familial motor neuron disease with prominent onion-bulb-like structures and axonal swelling restricted to the spinal ventral root: autopsy findings in two siblings
    Wataru Tokuyama
    Department of Pathology, Kitasato University, School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    Neuropathology 30:61-70. 2010
    ..Our two cases are a hitherto unreported type of MND, which shows focal giant axonopathy and prominent formation of onion-bulb-like structures due to Schwann cell proliferation restricted to the spinal ventral roots...
  40. doi Clinical significance of positive Delphian node in supracricoid laryngectomy with cricohyoidoepiglottopexy
    Meijin Nakayama
    Department of Otorhinolaryngology, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa 252 0374, Japan
    Jpn J Clin Oncol 41:987-91. 2011
    ..To elucidate the clinical significance of positive Delphian node metastasis in supracricoid laryngectomized patients, we conducted a thorough clinical review...
  41. ncbi A resected perivascular epithelioid cell tumor (PEComa) of the pancreas diagnosed using endoscopic ultrasound-guided fine-needle aspiration
    Kosuke Okuwaki
    Department of Gastroenterology, Kitasato University School of Medicine, Japan
    Intern Med 52:2061-6. 2013
    ..A PEComa was thus diagnosed. If an adequate tumor specimen can be obtained using EUS-FNA, immunostaining may facilitate the diagnosis of extremely rare diseases and therefore assist in deciding the treatment policy. ..
  42. doi Double-endoscope endoscopic submucosal dissection for the treatment of early gastric cancer accompanied by an ulcer scar (with video)
    Katsuhiko Higuchi
    Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan
    Gastrointest Endosc 78:266-73. 2013
    ..Endoscopic submucosal dissection (ESD) for early gastric cancer accompanied by an ulcer scar remains challenging. Several counter-traction techniques have been attempted to facilitate ESD, but a standard procedure remains to be established...