Affiliation: Kitasato University
Majima M, Ito Y, Hosono K, Amano H. CGRP/CGRP Receptor Antibodies: Potential Adverse Effects Due to Blockade of Neovascularization?. Trends Pharmacol Sci. 2018;: pubmed publisher
..We also suggest that CGRP antibodies may also be used as novel antitumor agents by suppressing tumor-associated angiogenesis. ..
Oba K, Hosono K, Amano H, Okizaki S, Ito Y, Shichiri M, et al
. Downregulation of the proangiogenic prostaglandin E receptor EP3 and reduced angiogenesis in a mouse model of diabetes mellitus. Biomed Pharmacother. 2014;68:1125-33 pubmed publisher
..Stimulation of EP3 signaling restored angiogenesis in a sponge implant model in mice with DM. This suggests that topical application of an EP3 agonist could be a novel strategy to treat foot ulcers in patients with DM. ..
Okizaki S, Ito Y, Hosono K, Oba K, Ohkubo H, Amano H, et al
. Suppressed recruitment of alternatively activated macrophages reduces TGF-Î²1 and impairs wound healing in streptozotocin-induced diabetic mice. Biomed Pharmacother. 2015;70:317-25 pubmed publisher
Matsuda H, Hosono K, Tsuru S, Kurashige C, Sekiguchi K, Akira S, et al
. Roles of mPGES-1, an inducible prostaglandin E synthase, in enhancement of LPS-induced lymphangiogenesis in a mouse peritonitis model. Life Sci. 2015;142:1-7 pubmed publisher
..The present results suggest that mPGES-1 plays a significant role in lymphangiogenesis during inflammation, and represents a novel target for controlling IL. ..
Minamino T, Ito Y, Ohkubo H, Shimuzu Y, Kojo K, Nishizwa N, et al
. Adhesion of platelets through thromboxane Aâ‚‚ receptor signaling facilitates liver repair during acute chemical-induced hepatotoxicity. Life Sci. 2015;132:85-92 pubmed publisher
..These results suggested that TP receptor signaling facilitates liver repair and sinusoidal restoration from acute liver injury through HGF release from platelets adhering to the sinusoids. ..
Kamata M, Hosono K, Fujita T, Kamata K, Majima M. Role of cyclooxygenase-2 in the development of interstitial fibrosis in kidneys following unilateral ureteral obstruction in mice. Biomed Pharmacother. 2015;70:174-80 pubmed publisher
..The present study demonstrates that COX-2 plays a protective role against fibrosis in UUO kidneys and suggests that supplementation of COX-2 products, such as PG analogues, will be a good option for preventing interstitial fibrosis. ..
Okizaki S, Ito Y, Hosono K, Oba K, Ohkubo H, Kojo K, et al
. Vascular Endothelial Growth Factor Receptor Type 1 Signaling Prevents Delayed Wound Healing in Diabetes by Attenuating the Production of IL-1? by Recruited Macrophages. Am J Pathol. 2016;186:1481-98 pubmed publisher
Amano H, Nakamura M, Ito Y, Kakutani H, Eshima K, Kitasato H, et al
. Thromboxane A synthase enhances blood flow recovery from hindlimb ischemia. J Surg Res. 2016;204:153-63 pubmed publisher
..These results indicated that local administration of C57-mTXAS-induced angiogenesis by activated platelets that bind to PSGL-1 on ischemic endothelial cells. ..
Maehana S, Nakamura M, Ogawa F, Imai R, Murakami R, Kojima F, et al
. Suppression of lymphangiogenesis by soluble vascular endothelial growth factor receptor-2 in a mouse lung cancer model. Biomed Pharmacother. 2016;84:660-665 pubmed publisher
..Accordingly, sVEGFR-2 might be a promising target for treatment of cancer by regulating lymphangiogenesis and lymphogenic metastasis. ..