W Koizumi

Summary

Affiliation: Kitasato University
Country: Japan

Publications

  1. pmc Randomised phase II study of S-1/cisplatin plus TSU-68 vs S-1/cisplatin in patients with advanced gastric cancer
    W Koizumi
    Department of Gastroenterology, Kitasato University East Hospital, Sagamihara 228 8520, Japan
    Br J Cancer 109:2079-86. 2013
  2. pmc Late-onset benefit in progressive advanced hepatocellular carcinoma with continued sorafenib therapy: a case report
    Yusuke Okuwaki
    Department of Gastroenterology, Kitasato University East Hospital, 2 1 1 Asamizodai, Minami Ku, Sagamihara, Kanagawa 252 0380, Japan
    J Med Case Rep 6:38. 2012
  3. doi request reprint Impacts of fluorouracil-metabolizing enzymes on the outcomes of patients treated with S-1 alone or S-1 plus cisplatin for first-line treatment of advanced gastric cancer
    Wasaburo Koizumi
    Department of Internal Medicine, Kitasato University School of Medicine, 2 1 1 Asamizodai, Sagamihara, Kanagawa 228 8520, Japan
    Int J Cancer 126:162-70. 2010
  4. ncbi request reprint Sequence-dependence of cisplatin and 5-fluorouracil in advanced and recurrent gastric cancer
    Wasaburo Koizumi
    Department of Gastroenterology, Higashi Hospital, Kitasato University, School of Medicine, 2 1 1 Asamizodai, Sagamihara shi, Kanagawa Prefecture 228 8520, Japan
    Oncol Rep 12:557-61. 2004
  5. ncbi request reprint Randomized phase II study comparing mitomycin, cisplatin plus doxifluridine with cisplatin plus doxifluridine in advanced unresectable gastric cancer
    Wasaburo Koizumi
    The Tokyo Cooperative Oncology Group, Department of Internal Medicine, Kitasato University School of Medicine, 2 1 1 Asamozodai Sagamihara shi, Kanagawa 228 8520, Japan
    Anticancer Res 24:2465-70. 2004
  6. ncbi request reprint Efficacy and tolerability of cancer pain management with controlled-release oxycodone tablets in opioid-naive cancer pain patients, starting with 5 mg tablets
    Wasaburo Koizumi
    Department of Gastroenterolgy, East Hospital, Kitasato University, Sagamihara, Kanagawa 228 8520, Japan
    Jpn J Clin Oncol 34:608-14. 2004
  7. ncbi request reprint Optimal dose-finding study of bi-weekly paclitaxel in unresectable advanced or recurrent gastric cancer
    Wasaburo Koizumi
    Department of Gastroenterology, Kitasato University East Hospital, 2 1 1 Asamizodai, Sagamihara, Kanagawa 228 8520, Japan
    Anticancer Res 26:3797-802. 2006
  8. ncbi request reprint Available options in chemotherapy for advanced gastric cancer: the current developments in Japan
    Wasaburo Koizumi
    Kitasato University School of Medicine, 2 1 1 Asamizodai, Sagamihara City, Kanagawa 228 8520, Japan
    Expert Opin Pharmacother 6:225-31. 2005
  9. ncbi request reprint Phase 1/11 study of bi-weekly irinotecan plus cisplatin in the treatment of advanced gastric cancer
    W Koizumi
    Department of Gastroenterology Medical Oncology, Kitasato University East Hospital, 2 1 1 Asamizodai, Sagamihara, Kanagawa 228 8520, Japan
    Anticancer Res 25:1257-62. 2005
  10. doi request reprint Quadruple therapy with ecabet sodium, omeprazole, amoxicillin and metronidazole is effective for eradication of Helicobacter pylori after failure of first-line therapy (KDOG0201 Study)
    W Koizumi
    Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara shi, Japan
    J Clin Pharm Ther 35:303-7. 2010

Detail Information

Publications82

  1. pmc Randomised phase II study of S-1/cisplatin plus TSU-68 vs S-1/cisplatin in patients with advanced gastric cancer
    W Koizumi
    Department of Gastroenterology, Kitasato University East Hospital, Sagamihara 228 8520, Japan
    Br J Cancer 109:2079-86. 2013
    ....
  2. pmc Late-onset benefit in progressive advanced hepatocellular carcinoma with continued sorafenib therapy: a case report
    Yusuke Okuwaki
    Department of Gastroenterology, Kitasato University East Hospital, 2 1 1 Asamizodai, Minami Ku, Sagamihara, Kanagawa 252 0380, Japan
    J Med Case Rep 6:38. 2012
    ..abstract:..
  3. doi request reprint Impacts of fluorouracil-metabolizing enzymes on the outcomes of patients treated with S-1 alone or S-1 plus cisplatin for first-line treatment of advanced gastric cancer
    Wasaburo Koizumi
    Department of Internal Medicine, Kitasato University School of Medicine, 2 1 1 Asamizodai, Sagamihara, Kanagawa 228 8520, Japan
    Int J Cancer 126:162-70. 2010
    ..Our results suggest that these biomarkers are useful for selection of patients with advanced gastric cancer in whom treatment with S-1 alone will yield survival benefit...
  4. ncbi request reprint Sequence-dependence of cisplatin and 5-fluorouracil in advanced and recurrent gastric cancer
    Wasaburo Koizumi
    Department of Gastroenterology, Higashi Hospital, Kitasato University, School of Medicine, 2 1 1 Asamizodai, Sagamihara shi, Kanagawa Prefecture 228 8520, Japan
    Oncol Rep 12:557-61. 2004
    ..Our results suggest that CDDP should be given before 5-FU in patients with gastric cancer when treated with a combination of CDDP and 5-FU...
  5. ncbi request reprint Randomized phase II study comparing mitomycin, cisplatin plus doxifluridine with cisplatin plus doxifluridine in advanced unresectable gastric cancer
    Wasaburo Koizumi
    The Tokyo Cooperative Oncology Group, Department of Internal Medicine, Kitasato University School of Medicine, 2 1 1 Asamozodai Sagamihara shi, Kanagawa 228 8520, Japan
    Anticancer Res 24:2465-70. 2004
    ..Regimen B was identical to regimen A without MMC...
  6. ncbi request reprint Efficacy and tolerability of cancer pain management with controlled-release oxycodone tablets in opioid-naive cancer pain patients, starting with 5 mg tablets
    Wasaburo Koizumi
    Department of Gastroenterolgy, East Hospital, Kitasato University, Sagamihara, Kanagawa 228 8520, Japan
    Jpn J Clin Oncol 34:608-14. 2004
    ..We conducted an open-label, dose titration study to assess the efficacy and tolerability of controlled-release oxycodone in the therapy of cancer pain management, starting with a newly developed 5 mg tablet every 12 h...
  7. ncbi request reprint Optimal dose-finding study of bi-weekly paclitaxel in unresectable advanced or recurrent gastric cancer
    Wasaburo Koizumi
    Department of Gastroenterology, Kitasato University East Hospital, 2 1 1 Asamizodai, Sagamihara, Kanagawa 228 8520, Japan
    Anticancer Res 26:3797-802. 2006
    ..The present study was conducted to determine the optimal dose of bi-weekly paclitaxel and evaluate safety and antitumor effect...
  8. ncbi request reprint Available options in chemotherapy for advanced gastric cancer: the current developments in Japan
    Wasaburo Koizumi
    Kitasato University School of Medicine, 2 1 1 Asamizodai, Sagamihara City, Kanagawa 228 8520, Japan
    Expert Opin Pharmacother 6:225-31. 2005
    ..Above all, S-1 plus cisplatin therapy showed high efficacy and expected to be a standard therapy for advanced gastric cancer. Further evaluation by well-controlled clinical trials is still required...
  9. ncbi request reprint Phase 1/11 study of bi-weekly irinotecan plus cisplatin in the treatment of advanced gastric cancer
    W Koizumi
    Department of Gastroenterology Medical Oncology, Kitasato University East Hospital, 2 1 1 Asamizodai, Sagamihara, Kanagawa 228 8520, Japan
    Anticancer Res 25:1257-62. 2005
    ..To conduct a phase I/II study of irinotecan with cisplatin to establish a recommended dose, and assess the safety, efficacy and feasibility of this regimen in unresectable advanced or recurrent gastric cancer...
  10. doi request reprint Quadruple therapy with ecabet sodium, omeprazole, amoxicillin and metronidazole is effective for eradication of Helicobacter pylori after failure of first-line therapy (KDOG0201 Study)
    W Koizumi
    Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara shi, Japan
    J Clin Pharm Ther 35:303-7. 2010
    ..The aim of the present study was to clinically examine whether eradication therapy, which includes ecabet sodium, is effective in eradication of H. pylori after failure of first-line therapy...
  11. doi request reprint S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial
    Wasaburo Koizumi
    Kitasato University School of Medicine, Sagamihara, Japan
    Lancet Oncol 9:215-21. 2008
    ....
  12. doi request reprint Prediction of the effect of capecitabine in gastric cancer by immunohistochemical staining of thymidine phosphorylase and dihydropyrimidine dehydrogenase
    Wasaburo Koizumi
    Department of Gastroenterology, East Hospital, Kitasato University School of Medicine, Sagamihara City, Kanagawa, Japan
    Anticancer Drugs 19:819-24. 2008
    ..028) in patients with TP-positive and DPD-negative tumors (RR=60%, 6/10) than in the remaining patients (RR=13%, 2/15). TP and DPD expression profiles are useful for predicting a response to capecitabine...
  13. doi request reprint Second-line chemotherapy with biweekly paclitaxel after failure of fluoropyrimidine-based treatment in patients with advanced or recurrent gastric cancer: a report from the gastrointestinal oncology group of the Tokyo cooperative oncology group, TCOG GC-0
    Wasaburo Koizumi
    Department of Gastroenterology, Kitasato University East Hospital, 2 1 1 Asamizodai, Sagamihara, Kanagawa 228 8520, Japan
    Jpn J Clin Oncol 39:713-9. 2009
    ..A multicenter trial was conducted to evaluate the efficacy and safety of paclitaxel every 2 weeks in patients with advanced or recurrent gastric cancer who had previously received fluoropyrimidine-based chemotherapy...
  14. pmc Phase II study of S-1 plus leucovorin in patients with metastatic colorectal cancer
    W Koizumi
    Department of Internal Medicine, Kitasato University School of Medicine, 2 1 1 Asamizodai, Sagamihara shi, Kanagawa, Japan
    Ann Oncol 21:766-71. 2010
    ..This study aimed to evaluate the safety and efficacy of S-1 combined with oral leucovorin (LV) to enhance antitumor activity in chemotherapy-naive patients with mCRC...
  15. doi request reprint Phase II study of oxaliplatin plus S-1 as first-line treatment for advanced gastric cancer (G-SOX study)
    W Koizumi
    Department of Gastroenterology Gastrointestinal Oncology, Kitasato University School of Medicine, Sagamihara, Japan
    Ann Oncol 21:1001-5. 2010
    ..The efficacy and safety of oxaliplatin combined with S-1 (SOX regimen) for unresectable advanced or recurrent gastric cancer were investigated...
  16. doi request reprint A multicenter phase II study of combined chemotherapy with docetaxel, cisplatin, and S-1 in patients with unresectable or recurrent gastric cancer (KDOG 0601)
    Wasaburo Koizumi
    Department of Gastroenterology Gastrointestinal Oncology, Kitasato University East Hospital, 2 1 1 Asamizodai, Sagamihara, Kanagawa 228 8520, Japan
    Cancer Chemother Pharmacol 69:407-13. 2012
    ..We conducted a phase II study to evaluate the efficacy and safety of a triplet regimen of docetaxel, cisplatin, and S-1 in patients with unresectable or recurrent gastric cancer...
  17. pmc Phase I/II study of S-1 combined with cisplatin in patients with advanced gastric cancer
    W Koizumi
    Department of Gastroenterology, School of Medicine, East Hospital, Kitasato University, Kanagawa, Japan
    Br J Cancer 89:2207-12. 2003
    ..8 and 26.3%, respectively, but all were manageable. The RR was 74% (14/19, 95% confidence interval: 54.9-90.6%), and the median survival day was 383. This regimen is considered to be active against AGC with acceptable toxicity...
  18. ncbi request reprint Effect of anti-Helicobacter pylori IgG antibody titer following eradication of Helicobacter pylori infection
    Wasaburo Koizumi
    Department of Gastroenterology, East Hospital Kitasato University School of Medicine, 2 1 1 Asamizodai, Sagamihara shi, Kanagawa 228 8520, Japan
    Hepatogastroenterology 50:293-6. 2003
    ..We measured the levels of IgG antibody in patients treated for H. pylori infection using four commercially available ELISA (enzyme linked immunosorbent assay) kits...
  19. ncbi request reprint A pilot phase II study of capecitabine in advanced or recurrent gastric cancer
    Wasaburo Koizumi
    Department of Gastroenterology, East Hospital, Kitasato University School of Medicine, 2 1 1 Asamizodai, Sagamihara City, Kanagawa 228 8520, Japan
    Oncology 64:232-6. 2003
    ..To evaluate the efficacy and safety of capecitabine in patients with advanced or recurrent gastric cancer, we conducted a pilot phase II study in Japan...
  20. ncbi request reprint Inhibition of peptic ulcer relapse by ranitidine and ecabet independently of eradication of Helicobacter pylori: a prospective, controlled study versus ranitidine
    Wasaburo Koizumi
    Department of Gastroenterology, School of Medicine, Kitasato University, 2 1 1 Asamizodai, Sagamihara, Kanagawa, 228 8520, Japan
    Hepatogastroenterology 50:577-81. 2003
    ..These actions result from inhibition of urease and ATPase in Helicobacter pylori, a mechanism distinct from that of antibiotics...
  21. ncbi request reprint Questionnaire for early detection of occult anemia
    Wasaburo Koizumi
    Department of Gastroenterology, Kitasato University East Hospital, 2 1 1 Asamizodai, Sagamihara, Kanagawa, 228 8520 Japan
    Hepatogastroenterology 50:121-5. 2003
    ..Anemia is a common condition that is often missed. We aimed to devise a questionnaire for detection of occult anemia...
  22. ncbi request reprint Phase II study of S-1, a novel oral derivative of 5-fluorouracil, in advanced gastric cancer. For the S-1 Cooperative Gastric Cancer Study Group
    W Koizumi
    Department of Gastroenterology, East Hospital, Kitasato University, School of Medicine, Kanagawa, Japan
    Oncology 58:191-7. 2000
    ..To assess the efficacy and safety of S-1, a novel oral fluoropyrimidine derivative, we conducted a multicenter late phase II study in patients with advanced gastric cancer...
  23. ncbi request reprint Phase I dose-escalation trial of ZD9331 in Japanese patients with refractory, solid malignancies
    Wasaburo Koizumi
    Department of Gastroenterology Medical Oncology, Kitasato University East Hospital, Kanagawa, Japan
    Anticancer Drugs 14:S1-5. 2003
    ..This phase I dose-escalation trial investigated the tolerability, efficacy and pharmacokinetics of ZD9331 in Japanese patients with refractory, solid malignancies...
  24. ncbi request reprint Successful treatment of S-1 + CDDP followed by salvage EMR for a case with metastatic Barrett's esophageal cancer
    K Nakatani
    Department of Gastroenterology, Kitasato University East Hospital, School of Medicine, 2 1 1, Asamizodai, Sagamihara, Kanagawa, Japan
    Dis Esophagus 20:173-7. 2007
    ..This is a rare case of metastatic Barrett's esophageal cancer in which the metastases were eradicated by S-1 + cisplatin, and the primary tumor successfully excised by endoscopic mucosal resection after downstaging...
  25. pmc Phase I/II study of docetaxel and S-1 in patients with advanced gastric cancer
    K Yamaguchi
    Department of Gastroenterology, Saitama Cancer Centre, Ina machi, Kitaadachi gun, Japan
    Br J Cancer 94:1803-8. 2006
    ..3-17.3 months), respectively. The most common grade 3/4 toxicity was neutropenia (67% of patients), which was predictable and manageable. This regimen showed promising activity with moderate toxicities in advanced gastric cancer...
  26. doi request reprint Narrow band imaging for detecting superficial squamous cell carcinoma of the head and neck in patients with esophageal squamous cell carcinoma
    C Katada
    Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara 228 8555, Japan
    Endoscopy 42:185-90. 2010
    ..This prospective study evaluated the detection rate of superficial SCC within the head and neck region (superficial SCCHN) with NBI-ME in patients with esophageal SCC...
  27. ncbi request reprint Expansion of the indications for endoscopic mucosal resection in patients with superficial esophageal carcinoma
    K Higuchi
    Department of Gastroenterology, Kitasato University East Hospital, Sagamihara, Japan
    Endoscopy 39:36-40. 2007
    ..The use of EMR in patients with m3 or sm1 SEC remains controversial, however. The aim of this retrospective study was to evaluate the histopathological risk factors for lymph-node metastasis and recurrence in patients with m3 or sm1 SEC...
  28. ncbi request reprint [Controversial issues in chemotherapy for inoperable gastric cancer]
    Wasaburo Koizumi
    Department of Internal Medicine, Kitasato University School of Medicine, Kitasato University, East Hospital, 2 1 1 Asamizodai, Sagamihara, Kanagawa 228 8520, Japan
    Gan To Kagaku Ryoho 30:1249-55. 2003
    ..We need to develop new agents and combination chemotherapy regimens to achieve greater survival benefit in AGC...
  29. doi request reprint Propofol sedation with bispectral index monitoring is useful for endoscopic submucosal dissection: a randomized prospective phase II clinical trial
    T Sasaki
    Department of Gastroenterology, Kitasato University School of Medicine, Kanagawa, Japan
    Endoscopy 44:584-9. 2012
    ..However, the treatment time tends to be relatively long and insufflation and manipulation of the endoscope can increase pain and discomfort. We aimed to find an optimal method for sedation during ESD...
  30. ncbi request reprint Phase I trial of neoadjuvant preoperative chemotherapy with S-1 and irinotecan plus radiation in patients with locally advanced rectal cancer
    Takeo Sato
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Int J Radiat Oncol Biol Phys 69:1442-7. 2007
    ..To determine the maximum tolerated dose (MTD) and recommended dose (RD) of irinotecan combined with preoperative chemoradiotherapy with S-1 in patients with locally advanced rectal cancer...
  31. ncbi request reprint A phase II study of combined chemotherapy with methotrexate, 5-fluorouracil, and low-dose cisplatin (MFP) for histologically diffuse-type advanced and recurrent gastric cancer (KDOG9501)
    Norisuke Nakayama
    Kitasato Digestive Disease and Oncology Group KDOG, Department of Gastroenterology, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa, 228 8555, Japan
    Gastric Cancer 9:185-91. 2006
    ..We evaluated the efficacy of a low dose of cisplatin combined with methotrexate and 5-fluorouracil (MFP therapy) in diffuse-type advanced gastric cancer...
  32. ncbi request reprint [Combination chemotherapy of TS-1 +cisplatin for inoperable gastric cancer]
    Wasaburo Koizumi
    Department of Internal Medicine I, Kitasato University, 2 1 1 Asamizodai, Sagamihara 228 8520, Japan
    Gan To Kagaku Ryoho 31:1957-61. 2004
    ....
  33. doi request reprint Phase II study of S-1 as first-line treatment for elderly patients over 75 years of age with advanced gastric cancer: the Tokyo Cooperative Oncology Group study
    Wasaburo Koizumi
    Department of Gastroenterology and Gastrointestinal Oncology, Kitasato University School of Medicine, Kitasato University East Hospital, 2 1 1 Asamizodai, Sagamihara, Kanagawa, 228 8520, Japan
    Cancer Chemother Pharmacol 65:1093-9. 2010
    ..This prospective multicenter phase II study was carried out to investigate the efficacy, safety and pharmacokinetics of S-1 monotherapy in elderly patients over 75 years of age, with unresectable advanced or recurrent gastric cancer...
  34. doi request reprint Endoscopic management of malignant biliary obstruction by means of covered metallic stents: primary stent placement vs. re-intervention
    M Kida
    Department of Gastroenterology, Kitasato University East Hospital, Sagamihara, Japan
    Endoscopy 43:1039-44. 2011
    ..The aim of the current study was to evaluate the effectiveness and safety of the primary placement and secondary placement (re-intervention) of covered metallic stents and to assess the feasibility and safety of stent removal...
  35. ncbi request reprint Phase II study of paclitaxel with 3-h infusion in patients with advanced gastric cancer
    Kensei Yamaguchi
    Department of Gastroenterology, Saitama Cancer Center Hospital, 818 Komuro, Ina machi, Saitama 362 0806, Japan
    Gastric Cancer 5:90-5. 2002
    ....
  36. doi request reprint Fine needle aspiration using forward-viewing endoscopic ultrasonography
    M Kida
    Department of Gastroenterology, Kitasato University East Hospital, 2 1 1 Asamizodai, Sagamihara, Kanagawa, Japan
    Endoscopy 43:796-801. 2011
    ..We had the opportunity to use this forward-viewing echo endoscope and to study its clinical usefulness, mainly for diagnostic EUS-FNA...
  37. ncbi request reprint TS-1 as first-line therapy for gastric linitis plastica: historical control study
    Tohru Sasaki
    Department of Gastroenterology, Kitasato University East Hospital, Kanagawa, Japan
    Anticancer Drugs 17:581-6. 2006
    ..2 and 20.9% in the non-TS-1 group. We conclude that greater anti-tumor effects and longer survival time can be expected from chemotherapy including TS-1 for gastric LP compared with conventional chemotherapy...
  38. pmc Clinicopathological evaluation of duodenal well-differentiated endocrine tumors
    Kenji Ishido
    Department of Gastroenterology, Kitasato University East Hospital, 2 1 1 Asamizodai, Minami Ku, Sagamihara, Kanagawa 252 0380, Japan
    World J Gastroenterol 16:4583-8. 2010
    ..To assess the clinicopathological characteristics of duodenal well-differentiated endocrine tumors...
  39. ncbi request reprint Differences in clinicopathological findings, cell kinetics and p53 expression between early gastric cancers with and without Helicobacter pylori infection
    Jun Mitsuhashi
    Department of Internal Medicine, School of Medicine, Kitasato University East Hospital, Sagamihara, Kanagawa, Japan
    Hepatogastroenterology 51:1636-40. 2004
    ....
  40. doi request reprint Re-appearance of hepatitis B virus following therapy with rituximab for lymphoma is not rare in Japanese patients with past hepatitis B virus infection
    Masaaki Watanabe
    Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Liver Int 31:340-7. 2011
    ..This research was conducted to evaluate the incidence of and clinical features associated with re-appearance of serum HBV DNA following chemo-immunosuppressive therapy in Japanese patients with past HBV infection...
  41. doi request reprint A phase I trial of definitive chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil (DCF-R) for advanced esophageal carcinoma: Kitasato digestive disease & oncology group trial (KDOG 0501)
    Katsuhiko Higuchi
    Department of Gastroenterology, and Kitasato University School of Medicine, Kanagawa, Japan
    Radiother Oncol 87:398-404. 2008
    ..A dose-escalation study of docetaxel combined with cisplatin, 5-fluorouracil, and concurrent radiotherapy (DCF-R) was performed to determine the optimal dose in patients with advanced esophageal carcinoma...
  42. doi request reprint Narrow band imaging for detecting metachronous superficial oropharyngeal and hypopharyngeal squamous cell carcinomas after chemoradiotherapy for head and neck cancers
    Chikatoshi Katada
    Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan
    Laryngoscope 118:1787-90. 2008
    ..Thus, it may serve as an ideal surveillance mode after chemoradiotherapy for head and neck cancers...
  43. ncbi request reprint Clinical outcome of endoscopic aspiration mucosectomy for early stage gastric cancer
    Satoshi Tanabe
    Department of Gastroenterology and Pathology, Kitasato, University East Hospital, Sagamihara, Kanagawa, Japan
    Gastrointest Endosc 56:708-13. 2002
    ....
  44. doi request reprint Entecavir is an optional agent to prevent hepatitis B virus (HBV) reactivation: a review of 16 patients
    Masaaki Watanabe
    Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Eur J Intern Med 21:333-7. 2010
    ..We examined the effect of preventive entecavir (ETV), a new nucleoside analogue on HBV reactivation during chemotherapy or immunosuppressive therapy...
  45. doi request reprint A patient with stage IV type 4 advanced gastric cancer who had a complete pathological response to short-term treatment with S-1 alone
    Kenji Ishido
    Department of aGastroenterology, Kitasato University East Hospital, Sagamihara, Kanagawa, Japan
    Anticancer Drugs 19:921-5. 2008
    ..Histologically, the tumor had a complete pathological response to S-1. Two years after surgery, the patient is alive, with no evidence of metastasis or recurrence...
  46. doi request reprint Narrow band imaging in the diagnosis of intra-epithelial and invasive laryngeal squamous cell carcinoma: a preliminary report of two cases
    Takashi Masaki
    Department of Otorhinolaryngology, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Japan
    Auris Nasus Larynx 36:712-6. 2009
    ..Based on our results, the vascular neoplastic changes of carcinoma in situ of the larynx could be similar to carcinoma in situ of the esophagus...
  47. ncbi request reprint Helicobacter pylori may survive ampicillin treatment in the remnant stomach
    Yoshio Hosaka
    Department of Microbiology, Kitasato University School of Medicine, Kanagawa, Japan
    J Antibiot (Tokyo) 55:495-8. 2002
    ..pylori with the chance to acquire drug resistance and to transfer drug resistance genes. This could be one reason why H. pylori is difficult to eradicate in the remnant stomach...
  48. ncbi request reprint Irinotecan and S-1 neoadjuvant chemoradiation therapy in patients with advanced rectal cancer
    Takeo Sato
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Hepatogastroenterology 54:1391-3. 2007
    ..Preoperative chemoradiotherapy with a combination of S-1 and CPT-11 may be a new treatment for rectal cancer...
  49. doi request reprint Eosinophilic gastroenteritis associated with giant folds
    Kenji Ishido
    Department of Gastroenterology, Kitasato University East Hospital, Kanagawa, Japan
    Dig Endosc 22:312-5. 2010
    ..Because the leukocyte and eosinophil counts continued to increase, the patient was given suplatast, an anti-allergic agent. The symptoms and hematological values improved promptly. The patient recovered uneventfully, with no recurrence...
  50. ncbi request reprint Usefulness of EMR with an oblique aspiration mucosectomy device compared with strip biopsy in patients with superficial esophageal cancer
    Satoshi Tanabe
    Current affiliations Department of Gastroenterology and Pathology, Kitasato University East Hospital, Sagamihara, Kanagawa, Japan
    Gastrointest Endosc 59:558-63. 2004
    ..Endoscopic oblique aspiration mucosectomy with an oblique aspiration mucosectomy device was performed, and the results were compared retrospectively with those of conventional strip biopsy...
  51. ncbi request reprint A phase II study of doxifluridine in elderly patients with advanced gastric cancer: the Japan Clinical Oncology Group Study (JCOG 9410)
    Nobumasa Ikeda
    Department of Internal Medicine, Mitoyo General Hospital, Mitoyo gun, Kagawa, Japan
    Jpn J Clin Oncol 32:90-4. 2002
    ..The objectives of this study were to evaluate efficacy and feasibility of this agent for elderly patients...
  52. ncbi request reprint An extensive metabolizer with recurrent ulcer responding to high dose of lansoprazole
    Katsuhiko Higuchi
    Department of Gastroenterology, Kitasato University East Hospital, Sagamihara, Kanagawa, Japan
    Hepatogastroenterology 51:774-6. 2004
    ..8% of a 24-hour period, as compared with a previous value of 88.3%. After 3 weeks of treatment, endoscopic examination showed that a red scar had formed at the ulcer site...
  53. ncbi request reprint Narrow band imaging for detecting superficial oral squamous cell carcinoma: a report of two cases
    Chikatoshi Katada
    Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan
    Laryngoscope 117:1596-9. 2007
    ..Because NBI combined with magnifying GIE shows a well-demarcated brownish area and scattered foci of microvascular proliferation, it may play an important role in the management of superficial squamous cell carcinoma in the oral cavity...
  54. ncbi request reprint A new strategy for evaluation of the eradication treatment of Helicobacter pylori: validation of the analysis of mucin composition in human gastric juice
    T Ichikawa
    Department of Biochemistry, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Clin Chim Acta 303:69-73. 2001
    ..pylori was commonly observed in all the patients. These results indicate that the mucin compositional analysis in the gastric luminal mucin may be a very useful tool for the assessment of H. pylori eradication...
  55. ncbi request reprint Endoscopic mucosal resection in the management of gastric carcinoid tumors
    J Ichikawa
    Gastroenterology Division, Department of Internal Medicine, Kitasato University East Hospital, 2 1 1 Asamizo dai, Sagamihara City, Kanagawa ken 228 8520, Japan
    Endoscopy 35:203-6. 2003
    ..We studied the outcome of EMR in patients with gastric carcinoids who were treated at our hospital and discuss the indications for endoscopic treatment...
  56. ncbi request reprint A double-blind, crossover, randomized comparison of granisetron and ramosetron for the prevention of acute and delayed cisplatin-induced emesis in patients with gastrointestinal cancer: is patient preference a better primary endpoint?
    Wasaburo Koizumi
    Department of Gastroenterology, East Hospital, Kitasato University, Sagamihara, Kanagawa, Japan
    Chemotherapy 49:316-23. 2003
    ..We therefore performed a double-blind, crossover, randomized, controlled trial comparing the efficacy of granisetron and ramosetron, using patient preference as the primary endpoint...
  57. ncbi request reprint Spraying of phenol red dye as a screening test for Helicobacter pylori infection in surgically resected stomach specimens
    Jun Mitsuhashi
    Department of Internal Medicine, School of Medicine, Kitasato University East Hospital, 2 1 1 Asamizo dai, 228 8520, Sagamihara, Japan
    J Gastroenterol 38:1049-52. 2003
    ..We examined whether the phenol red test could be used to detect H. pylori in surgically resected stomachs...
  58. ncbi request reprint Chemotherapy is more active against proximal than distal gastric carcinoma
    Katsuhiko Higuchi
    Department of Gastroenterology, Kitasato University East Hospital, Sagamihara, Japan
    Oncology 66:269-74. 2004
    ..However, it remains uncertain whether the location of the primary tumor influences the effect of chemotherapy in advanced gastric carcinoma...
  59. doi request reprint Viral level is an indicator of long-term outcome of hepatitis B virus e antigen-negative carriers with persistently normal serum alanine aminotransferase levels
    T Nakazawa
    Department of Gastroenterology, Kitasato University East Hospital, Sagamihara, Japan
    J Viral Hepat 18:e191-9. 2011
    ..As the baseline HBV DNA level reflects the future level, appropriate clinical management according to the viral level is expected to decrease future risk...
  60. ncbi request reprint Characterization of pKU701, a 2.5-kb plasmid, in a Japanese Helicobacter pylori isolate
    Yoshio Hosaka
    Department of Microbiology, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara shi, Kanagawa 228 8555, Japan
    Plasmid 47:193-200. 2002
    ..The ability of drug resistance plasmids to replicate in H. pylori is probably limited, so chromosomal mutation may be a more likely cause of resistance...
  61. pmc Use of the restriction enzyme EcoRI for pulsed-field gel electrophoretic analysis of Helicobacter pylori
    Yoshio Hosaka
    Department of Microbiology, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara shi, Kanagawa 228, Japan
    J Clin Microbiol 43:931-2. 2005
    ..We adapted the PFGE analysis for H. pylori by using EcoRI and slightly modified our laboratory methods to improve the typing of isolates (typeability was 97%)...
  62. doi request reprint Clinical significance of evaluating primary lesions in patients with gastric cancer who receive chemotherapy
    Kento Nakatani
    Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Gastric Cancer 13:36-42. 2010
    ..In Japan, the response of primary lesions is assessed according to local Japanese criteria. We compared the response to chemotherapy as evaluated by these two sets of criteria...
  63. doi request reprint Clinical outcomes of endoscopic oblique aspiration mucosectomy for superficial esophageal cancer
    Satoshi Tanabe
    Department of Gastroenterology, Kitasato University East Hospital, Sagamihara, Japan
    Gastrointest Endosc 67:814-20. 2008
    ..EMR is now a widely accepted option for the treatment for superficial esophageal cancer (SEC). However, studies of medium-term to long-term outcomes are scarce...
  64. pmc Fulminant amoebic colitis during chemotherapy for advanced gastric cancer
    Noboru Hanaoka
    Department of Gastroenterology, Kitasato University School of Medicine, 2 1 1 Asamizodai, Sagamihara City, Kanagawa 228 8520, Japan
    World J Gastroenterol 15:3445-7. 2009
    ..The patient died 50 d after surgery. Fulminant amoebic colitis is very rarely associated with chemotherapy. Amoebic colitis should be considered in the differential diagnosis of patients who have bloody stools during chemotherapy...
  65. doi request reprint Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers
    Takako Ae
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, Japan
    Am J Physiol Gastrointest Liver Physiol 299:G1139-46. 2010
    ..The present results suggest that mPGES-1 enhances the ulcer-healing processes and the angiogenesis indispensable to ulcer healing, and that a selective mPGES-1 inhibitor should be used with care in patients with gastric ulcers...
  66. ncbi request reprint Meeting report of the 76th Congress of the Japanese Gastric Cancer Association
    Nobuaki Kaibara
    Gastric Cancer 7:185-95. 2004
  67. ncbi request reprint A Japanese phase I study of continuous oral capecitabine in patients with malignant solid tumors
    Toshiaki Saeki
    Department of Clinical Research and Surgery, National Hospital Organization Shikoku Cancer Center, Ehime, Japan
    Int J Clin Oncol 10:51-7. 2005
    ..This study aimed to evaluate the tolerability and pharmacokinetics of capecitabine, given twice daily for 6 weeks without interruption, and to identify the maximum tolerated dose (MTD) and the suggested phase II schedule...
  68. ncbi request reprint A novel mutant allele of the CYP2A6 gene (CYP2A6*11 ) found in a cancer patient who showed poor metabolic phenotype towards tegafur
    Satoshi Daigo
    Laboratory of Drug Metabolism, Division of Pharmacobiodynamics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan
    Pharmacogenetics 12:299-306. 2002
    ..From these results, we conclude that the poor metabolic phenotype of patient 1 was caused by the existence of the two mutant alleles, CYP2A6*4C and the new variant CYP2A6*11...
  69. ncbi request reprint [A gastric stromal tumor (GIST) with a prolonged partial response to a reduced dose of imatinib mesilate]
    Kento Nakatani
    Dept of Internal Medicine I, Kitasato University
    Gan To Kagaku Ryoho 33:997-1000. 2006
    ..The adverse reactions resolved promptly, and a partial response of both the primary tumor and liver metastasis to imatinib mesilate has been maintained for 28 months. Strategies for lowering the dose of imatinib mesilate are reviewed...
  70. ncbi request reprint Pharmacodynamic studies of gefitinib in tumor biopsy specimens from patients with advanced gastric carcinoma
    Federico Rojo
    Medical Oncology Service, Vall d Hebron University Hospital, Barcelona, Spain
    J Clin Oncol 24:4309-16. 2006
    ..The objective of this study was to assess the in situ biologic activity of the EGFR tyrosine kinase inhibitor gefitinib in gastric tumor samples in a phase II study...
  71. ncbi request reprint [A case of long-term survival of 3-years 4 months after combination chemotherapy of MTX, 5-FU and low-dose CDDP (MFP) for type 4 gastric cancer with pleuritis, peritoneal dissemination and Krukenberg tumor]
    Norisuke Nakayama
    Dept of Gastroenterology, Kitasato University School of Medicine
    Gan To Kagaku Ryoho 33:1641-4. 2006
    ..Chemotherapy with methotrexate, 5-fluorouracil, and low-dose cisplatin may thus be an effective therapeutic option in patients who have advanced gastric cancer with peritoneal dissemination...
  72. ncbi request reprint A case of suspected S-1 induced interstitial pneumonia
    Kohei Shitara
    Department of Medical Oncology, Misawa City Hospital
    Gan To Kagaku Ryoho 34:619-22. 2007
    ..Although a definite causal relationship between pneumonia and S-1 is still unproven, S-1-induced pneumonia needs to be considered in the differential diagnosis when patients present with dyspnea are treated with S-1...
  73. ncbi request reprint [Therapeutic strategy for type 4 gastric cancer from the clinical oncologist standpoint]
    Tohru Sasaki
    Dept of Gastroenterology, Kitasato University East Hospital
    Gan To Kagaku Ryoho 34:988-92. 2007
    ..Therefore,irinotecan should be administered carefully before intestinal obstruction occurs...
  74. ncbi request reprint Relationship between expression of vascular endothelial growth factor in tumor tissue from gastric cancers and chemotherapy effects: comparison between S-1 alone and the combination of S-1 plus CDDP
    Narikazu Boku
    Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Sunto, Shizuoka, Japan
    Jpn J Clin Oncol 37:509-14. 2007
    ..In this study, the relationship between VEGF expression and effects of S-1 with and without CDDP is investigated...
  75. ncbi request reprint Long-term survival and prognostic factors in patients with metastatic gastric cancers treated with chemotherapy in the Japan Clinical Oncology Group (JCOG) study
    Motoki Yoshida
    Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Jpn J Clin Oncol 34:654-9. 2004
    ..The aim of this analysis was to investigate prognostic factors for patients with metastatic gastric cancer treated by chemotherapy, and to identify the characteristics of long-term survivors...
  76. ncbi request reprint [A feasibility study of oxaliplatin (L-OHP) in combination with infusional 5-FU/l-LV (FOLFOX4 regimen) for advanced colorectal cancer]
    Mitsukuni Suenaga
    Cancer Institute Hospital, Japanese Foundation for Cancer Research
    Gan To Kagaku Ryoho 35:255-60. 2008
    ..There were no treatment-related deaths. Neuro-sensory toxicity was a highly-frequent adverse event (78.9%), but no grade 3/4 neurotoxicity was seen. The FOLFOX4 regimen was acceptable to Japanese patients with ACRC in at least 3 cycles...
  77. doi request reprint A phase II study of sequential methotrexate and 5-fluorouracil chemotherapy in previously treated gastric cancer: a report from the Gastrointestinal Oncology Group of the Japan Clinical Oncology Group, JCOG 9207 trial
    Tetsuya Hamaguchi
    Division of Gastrointestinal Oncology, National Cancer Center Hospital, Tokyo, Japan
    Jpn J Clin Oncol 38:432-7. 2008
    ..Therefore, we conducted a phase II study to evaluate the efficacy and toxicity of sequential treatment with methotrexate (MTX) and also 5-FU as second-line chemotherapy in patients with advanced gastric cancer...
  78. doi request reprint A multicenter, phase I dose-escalating study of docetaxel, cisplatin and S-1 for advanced gastric cancer (KDOG0601)
    Norisuke Nakayama
    Division of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan
    Oncology 75:1-7. 2008
    ..This dose-escalation study of a combination of docetaxel, cisplatin and S-1 investigated the dose-limiting toxicity (DLT), maximum-tolerated dose (MTD), recommended dose (RD) and antitumor activity in advanced gastric cancer...
  79. ncbi request reprint Melanoidin, a food protein-derived advanced maillard reaction product, suppresses Helicobacter pylori in vitro and in vivo
    Shigeru Hiramoto
    Research Laboratory, Nisshin Pharma INC Oimachi, Saitama, Japan
    Helicobacter 9:429-35. 2004
    ..In addition, we have determined the anticolonization effect of melanoidin I, prepared by the Maillard reaction between casein and lactose, in an animal model and in human subjects infected with this bacterium...
  80. ncbi request reprint Phase II study of a 4-week capecitabine regimen in advanced or recurrent gastric cancer
    Junichi Sakamoto
    Department of Epidemiological and Clinical Research Information Management, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Anticancer Drugs 17:231-6. 2006
    ..We conclude that this 4-week regimen of capecitabine showed promising activity and was well tolerated as first-line therapy for advanced/metastatic gastric cancer. Further investigation of this regimen is warranted...
  81. ncbi request reprint Epidermal growth factor receptor and epidermal growth factor receptor variant III gene expression in metastatic colorectal cancer
    Mizutomo Azuma
    Division of Medical Oncology, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 90033, USA
    Clin Colorectal Cancer 6:214-8. 2006
    ..Our aim was to indicate the frequency of gene expressions of EGFRvIII and EGFR in metastatic colorectal cancer (mCRC)...
  82. ncbi request reprint [Progress in chemotherapy of gastric cancer]
    Wasaburo Koizumi
    Nihon Naika Gakkai Zasshi 94:85-91. 2005