Y Kameda


Affiliation: Kitasato University
Country: Japan


  1. request reprint
    Kameda Y, Watari Goshima N, Nishimaki T, Chisaka O. Disruption of the Hoxa3 homeobox gene results in anomalies of the carotid artery system and the arterial baroreceptors. Cell Tissue Res. 2003;311:343-52 pubmed
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    Kameda Y. Expression of glial progenitor markers p75NTR and S100 protein in the developing mouse parathyroid gland. Cell Tissue Res. 2007;327:15-23 pubmed
    ..The neural progenitor markers, neurofilament 160 and TuJ1, are also absent from the parathyroid. Taken together, we suggest that Gcm2 supplies only some glial progenitor characteristics to the parathyroid rudiment. ..
  3. Kameda Y. Follicular cell lineage in persistent ultimobranchial remnants of mammals. Cell Tissue Res. 2019;376:1-18 pubmed publisher
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    Kameda Y, Arai Y, Nishimaki T. Ultrastructural localization of vimentin immunoreactivity and gene expression in tanycytes and their alterations in hamsters kept under different photoperiods. Cell Tissue Res. 2003;314:251-62 pubmed
    ..These changes in the tanycytes under different photoperiods may influence the portal circulation system and also the cell activity of the pars tuberalis, and may thus participate in photoperiodic regulation of the endocrine system. ..
  5. Kameda Y. Hoxa3 and signaling molecules involved in aortic arch patterning and remodeling. Cell Tissue Res. 2009;336:165-78 pubmed publisher
    ..Defects in these genes result in malformations of the arch artery derivatives. This review should deepen our understanding of congenital human syndromes with abnormal patterns of pharyngeal arch arteries. ..
  6. Kameda Y, Ito M, Nishimaki T, Gotoh N. FRS2 alpha 2F/2F mice lack carotid body and exhibit abnormalities of the superior cervical sympathetic ganglion and carotid sinus nerve. Dev Biol. 2008;314:236-47 pubmed publisher
    ..We propose that the sympathetic ganglion provides glomus cell precursors into the third arch artery derivative in the presence of sensory fibers of the glossopharyngeal nerve...
  7. Kameda Y, Saitoh T, Nemoto N, Katoh T, Iseki S, Fujimura T. Hes1 is required for the development of pharyngeal organs and survival of neural crest-derived mesenchymal cells in pharyngeal arches. Cell Tissue Res. 2013;353:9-25 pubmed publisher
    ..We propose that the defective survival of neural-crest-derived mesenchymal cells in pharyngeal arches directly or indirectly leads to deficiencies of pharyngeal organs...
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    Kameda Y, Nishimaki T, Takeichi M, Chisaka O. Homeobox gene hoxa3 is essential for the formation of the carotid body in the mouse embryos. Dev Biol. 2002;247:197-209 pubmed
    ..The superior cervical ganglion rather showed hypertrophic features in Hoxa3 homozygous mutants lacking the carotid body. ..
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    Kameda Y, Arai Y, Nishimaki T, Chisaka O. The role of Hoxa3 gene in parathyroid gland organogenesis of the mouse. J Histochem Cytochem. 2004;52:641-51 pubmed
    ..These results indicate that lack of the Hoxa3 gene affects the intrinsic ability of the third pharyngeal pouch to form the parathyroid rudiment and has no detectable effect on the migration of neural crest cells. ..

More Information


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    Kameda Y. Mash1 is required for glomus cell formation in the mouse carotid body. Dev Biol. 2005;283:128-39 pubmed
    ..Many cells immunoreactive for the S-100 protein, a sustentacular cell marker, appear in the mutant carotid body during fetal development. The Mash1 gene is thus required for the genesis of glomus cells but not for sustentacular cells. ..
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    Kameda Y, Nishimaki T, Miura M, Jiang S, Guillemot F. Mash1 regulates the development of C cells in mouse thyroid glands. Dev Dyn. 2007;236:262-70 pubmed
    ..Thus, in the mutant mice, the ultimobranchial body fails to complete its differentiation program and finally dies. These results indicate that Mash1 enhances survival of the C-cell progenitors by inhibiting apoptosis...
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    Kameda Y, Nishimaki T, Chisaka O, Iseki S, Sucov H. Expression of the epithelial marker E-cadherin by thyroid C cells and their precursors during murine development. J Histochem Cytochem. 2007;55:1075-88 pubmed
    ..These results indicated that murine thyroid C cells are derived from the endodermal epithelial cells of the fourth pharyngeal pouch and do not originate from neural crest cells. ..
  4. Kameda Y, Ito M, Nishimaki T, Gotoh N. FRS2alpha is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus. Dev Dyn. 2009;238:503-13 pubmed publisher
    ..Thus, the separation, migration, and survival of the pharyngeal organs were impaired in the FRS2alpha(2F/2F) mutants. ..
  5. Kameda Y, Saitoh T, Fujimura T. Hes1 regulates the number and anterior-posterior patterning of mesencephalic dopaminergic neurons at the mid/hindbrain boundary (isthmus). Dev Biol. 2011;358:91-101 pubmed publisher
    ..Thus, the loss of Hes1 resulted in disturbances in the inductive and repulsive activities of the isthmic organizer. It is proposed that Hes1 plays a role in regulating the location and density of mesDA neurons. ..
  6. Kameda Y, Saitoh T, Nemoto N, Katoh T, Iseki S. Hes1 is required for the development of the superior cervical ganglion of sympathetic trunk and the carotid body. Dev Dyn. 2012;241:1289-300 pubmed publisher
    ..5% of the value in wild-types at E17.5-E18.5. These results suggest that Hes1 plays a critical role in regulating the development of neural crest derivatives in the mouse cervical region. ..