Takahiro Iizuka

Summary

Affiliation: Kitasato University
Country: Japan

Publications

  1. ncbi request reprint [Update on anti-NMDA receptor encephalitis]
    Takahiro Iizuka
    Department of Neurology, School of Medicine, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Brain Nerve 62:331-8. 2010
  2. pmc Anti-NMDA receptor encephalitis in Japan: long-term outcome without tumor removal
    T Iizuka
    Department of Neurology, School of Medicine, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa, 228 8555, Japan
    Neurology 70:504-11. 2008
  3. ncbi request reprint Glycine receptor antibodies are detected in progressive encephalomyelitis with rigidity and myoclonus (PERM) but not in saccadic oscillations
    Takahiro Iizuka
    Department of Neurology, Kitasato University, School of Medicine, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa 252 0374, Japan
    J Neurol 259:1566-73. 2012
  4. ncbi request reprint [Anti-NMDA receptor antibody-mediated encephalitis/encephalopathy]
    Takahiro Iizuka
    Department of Neurology, School of Medicine, Kitasato University, Sagamihara 228 8555, Japan
    Rinsho Byori 57:252-61. 2009
  5. doi request reprint Progressive carotid artery stenosis with a novel tRNA phenylalanine mitochondrial DNA mutation
    Takahiro Iizuka
    Department of Neurology, School of Medicine, Kitasato University, Kanagawa, Japan
    J Neurol Sci 278:35-40. 2009
  6. pmc Reversible brain atrophy in anti-NMDA receptor encephalitis: a long-term observational study
    Takahiro Iizuka
    Department of Neurology, School of Medicine, Kitasato University, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa, 252 0374, Japan
    J Neurol 257:1686-91. 2010
  7. ncbi request reprint Regional cerebral blood flow and cerebrovascular reactivity during chronic stage of stroke-like episodes in MELAS -- implication of neurovascular cellular mechanism
    Takahiro Iizuka
    Department of Neurology, School of Medicine, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa, 228 8555, Japan
    J Neurol Sci 257:126-38. 2007
  8. ncbi request reprint Implication of augmented vasogenic leakage in the mechanism of persistent aura in sporadic hemiplegic migraine
    T Iizuka
    Department of Neurology, School of Medicine, Kitasato University, Kanagawa, Japan
    Cephalalgia 26:332-5. 2006
  9. doi request reprint Neurovascular changes in prolonged migraine aura in FHM with a novel ATP1A2 gene mutation
    Takahiro Iizuka
    Department of Neurology, Kitasato University, School of Medicine, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa 252 0374, Japan
    J Neurol Neurosurg Psychiatry 83:205-12. 2012
  10. ncbi request reprint Pathogenesis of stroke-like episodes in MELAS: analysis of neurovascular cellular mechanisms
    Takahiro Iizuka
    Department of Medicine Neurology, School of Medicine, Kitasato University, Kitasato, Kanagawa, Japan
    Curr Neurovasc Res 2:29-45. 2005

Collaborators

Detail Information

Publications27

  1. ncbi request reprint [Update on anti-NMDA receptor encephalitis]
    Takahiro Iizuka
    Department of Neurology, School of Medicine, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Brain Nerve 62:331-8. 2010
    ..In a recent case, a microscopic teratoma was detected on autopsy; therefore exploratory laparotomy may be considered in severe refractory cases...
  2. pmc Anti-NMDA receptor encephalitis in Japan: long-term outcome without tumor removal
    T Iizuka
    Department of Neurology, School of Medicine, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa, 228 8555, Japan
    Neurology 70:504-11. 2008
    ....
  3. ncbi request reprint Glycine receptor antibodies are detected in progressive encephalomyelitis with rigidity and myoclonus (PERM) but not in saccadic oscillations
    Takahiro Iizuka
    Department of Neurology, Kitasato University, School of Medicine, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa 252 0374, Japan
    J Neurol 259:1566-73. 2012
    ..GlyR and GAD antibodies can co-exist in PERM and follow the clinical course. Although saccadic oscillations are a feature of this condition, GlyR antibodies are not commonly found in patients with isolated saccadic oscillations...
  4. ncbi request reprint [Anti-NMDA receptor antibody-mediated encephalitis/encephalopathy]
    Takahiro Iizuka
    Department of Neurology, School of Medicine, Kitasato University, Sagamihara 228 8555, Japan
    Rinsho Byori 57:252-61. 2009
    ..A recent study suggested that these disorders are identical...
  5. doi request reprint Progressive carotid artery stenosis with a novel tRNA phenylalanine mitochondrial DNA mutation
    Takahiro Iizuka
    Department of Neurology, School of Medicine, Kitasato University, Kanagawa, Japan
    J Neurol Sci 278:35-40. 2009
    ....
  6. pmc Reversible brain atrophy in anti-NMDA receptor encephalitis: a long-term observational study
    Takahiro Iizuka
    Department of Neurology, School of Medicine, Kitasato University, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa, 252 0374, Japan
    J Neurol 257:1686-91. 2010
    ..This suggests that a functional rather than a structural neuronal damage underlies the pathogenesis of this disorder...
  7. ncbi request reprint Regional cerebral blood flow and cerebrovascular reactivity during chronic stage of stroke-like episodes in MELAS -- implication of neurovascular cellular mechanism
    Takahiro Iizuka
    Department of Neurology, School of Medicine, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa, 228 8555, Japan
    J Neurol Sci 257:126-38. 2007
    ..Ischemic vascular hypothesis as a causative role in the pathogenesis of stroke-like episodes in MELAS remains to be debated...
  8. ncbi request reprint Implication of augmented vasogenic leakage in the mechanism of persistent aura in sporadic hemiplegic migraine
    T Iizuka
    Department of Neurology, School of Medicine, Kitasato University, Kanagawa, Japan
    Cephalalgia 26:332-5. 2006
    ..Based on these results, we speculate that augmented vasogenic leakage from the leptomeningeal vessels, probably associated with activation of the trigeminovascular system, may delay the recovery of hemiplegic migraine aura...
  9. doi request reprint Neurovascular changes in prolonged migraine aura in FHM with a novel ATP1A2 gene mutation
    Takahiro Iizuka
    Department of Neurology, Kitasato University, School of Medicine, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa 252 0374, Japan
    J Neurol Neurosurg Psychiatry 83:205-12. 2012
    ..To report cerebral blood flow changes during attacks of hemiplegic migraine with prolonged aura (HMPA) longer than 24 h in patients with familial hemiplegic migraine (FHM) with a novel gene mutation...
  10. ncbi request reprint Pathogenesis of stroke-like episodes in MELAS: analysis of neurovascular cellular mechanisms
    Takahiro Iizuka
    Department of Medicine Neurology, School of Medicine, Kitasato University, Kitasato, Kanagawa, Japan
    Curr Neurovasc Res 2:29-45. 2005
    ..As a consequence, susceptible neuronal population in the cortex may result in neuronal loss with a laminar or pseudo-laminar distribution...
  11. ncbi request reprint Slowly progressive spread of the stroke-like lesions in MELAS
    Takahiro Iizuka
    Department of Medicine Neurology, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan
    Neurology 61:1238-44. 2003
    ..Little is known about temporal and spatial progression of the stroke-like lesion during the acute stage of the stroke-like episode in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)...
  12. ncbi request reprint Response to sumatriptan in headache of MELAS syndrome
    Takahiro Iizuka
    Department of Medicine Neurology, School of Medicine, Kitasato University, Kanagawa, Japan
    Neurology 61:577-8. 2003
  13. ncbi request reprint Neuronal hyperexcitability in stroke-like episodes of MELAS syndrome
    T Iizuka
    Department of Medicine, School of Medicine, Kitasato University, Kanagawa, Japan
    Neurology 59:816-24. 2002
    ..The pathogenesis of stroke-like episodes in patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) remains unknown...
  14. pmc Pseudo-piano playing motions and nocturnal hypoventilation in anti-NMDA receptor encephalitis: response to prompt tumor removal and immunotherapy
    Akiko Uchino
    Department of Neurology, Kitasato University, School of Medicine, Japan
    Intern Med 50:627-30. 2011
    ..Non-jerky elaborate finger movements suggest antibody-mediated disinhibition of the cortico-striatal systems...
  15. ncbi request reprint [Unique clinical features and pathophysiology of anti-NMDA receptor encephalitis]
    Takahiro Iizuka
    Department of Neurology, School of Medicine, Kitasato University
    Rinsho Shinkeigaku 49:774-8. 2009
    ..However, exploratory laparotomy may increase the chance to identify microscopic teratoma and improve the outcome if patients who were refractory to immunotherapy had anti-NMDAR antibodies and ovarian cyst...
  16. ncbi request reprint [Clinical features and pathogenesis of anti-NMDA receptor encephalitis]
    Takahiro Iizuka
    Department of Neurology, School of Medicine, Kitasato University
    Rinsho Shinkeigaku 48:920-2. 2008
    ....
  17. ncbi request reprint An improved method for estimating the heart-to-mediastinum ratio from cardiac sympathetic nerve imaging with low-energy high-resolution collimators
    Yusuke Inoue
    Department of Diagnostic Radiology, Kitasato University School of Medicine, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa, 252 0374, Japan
    J Nucl Cardiol 21:614-21. 2014
    ..We aimed to improve the method of estimating the H/M ratios using the LEHR collimator...
  18. ncbi request reprint [Anti-nMDA receptor encephalitis--clinical manifestations and pathophysiology]
    Takahiro Iizuka
    Department of Neurology, School of Medicine, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa, 228 8555, Japan
    Brain Nerve 60:1047-60. 2008
    ..In this review, we also discuss the relationship between anti-NMDAR encephalitis and related disorders, including acute diffuse lymphocytic meningoencephalitis and acute juvenile female non-herpetic encephalitis (AJFNHE)...
  19. doi request reprint Septal penetration in iodine-123 metaiodobenzylguanidine cardiac sympathetic imaging using a medium-energy collimator
    Yusuke Inoue
    Department of Diagnostic Radiology, Kitasato University School of Medicine, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa, 252 0374, Japan
    J Nucl Cardiol 21:71-7. 2014
    ..We investigated the effect of septal penetration on the estimation of H/M ratios using an ME collimator...
  20. pmc Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen
    Eric Lancaster
    Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Lancet Neurol 9:67-76. 2010
    ..Some encephalitides or seizure disorders once thought idiopathic now seem to be immune mediated. We aimed to describe the clinical features of one such disorder and to identify the autoantigen involved...
  21. doi request reprint Investigation of IgG4-positive cell infiltration in biopsy specimens from cases of hypertrophic pachymeningitis
    Satoshi Utsuki
    Department of Neurosurgery, Kitasato University School of Medicine, Kanagawa, Japan
    Clin Neuropathol 32:84-90. 2013
    ..Hypertrophic pachymeningitis with IgG4-positive cells may have some kind of relation to other systemic autoimmune diseases...
  22. ncbi request reprint [Pathogenesis and treatment of stroke-like episodes in MELAS]
    Takahiro Iizuka
    Department of Neurology, School of Medicine, Kitasato University
    Rinsho Shinkeigaku 48:1006-9. 2008
    ..As a consequence, most susceptible layers of the cortex may result in neuronal loss. Therapeutic targets include each ongoing process of the disease...
  23. ncbi request reprint Botulinum toxin type A for migraine prophylaxis in the Japanese population: an open-label prospective trial
    Kosuke Suzuki
    Department of Neurology, School of Medicine, Kitasato University, Sagamihara
    Intern Med 46:959-63. 2007
    ..To evaluate the efficacy and tolerability of Botulinum Toxin Type A (BoNT-A) for migraine prophylaxis...
  24. ncbi request reprint [Prophylactic treatment with botulinum toxin type A]
    Kosuke Suzuki
    Department of Neurology, School of Medicine, Kitasato University
    Nihon Rinsho 63:1815-20. 2005
    ..In this paper, we review the results of recently published controlled trials, touching on its methodology, optimal dose, patient selection, and possible mechanisms, as well as on going clinical trial in our university...
  25. doi request reprint Acquisition protocols and correction methods for estimation of the heart-to-mediastinum ratio in 123I-metaiodobenzylguanidine cardiac sympathetic imaging
    Yusuke Inoue
    Department of Diagnostic Radiology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    J Nucl Med 54:707-13. 2013
    ..We investigated acquisition protocols (collimator choice and energy window setting) and correction methods for estimating the heart-to-mediastinum (H/M) ratio in cardiac (123)I-metaiodobenzylguanidine (MIBG) imaging...
  26. ncbi request reprint [Cerebrovascular accidents with familial antithrombin III deficiency--gene analysis study]
    Shinya Tsukahara
    Department of Internal Medicine Neurology, School of Medicine, Kitasato University
    Rinsho Shinkeigaku 42:207-11. 2002
    ..AT III type I deficiency caused by frame shift insertion has been reported only twelve pedigrees. This is the first case report of AT III type I deficiency caused by frame shift insertion in Japan...
  27. ncbi request reprint [Neurosarcoidosis]
    Takahiro Iizuka
    Department of Medicine Neurology, School of Medicine, Kitasato University
    Nihon Rinsho 60:1785-93. 2002
    ..Although corticosteroids are the main stay of therapy, refractory cases can be treated by immunosuppressive and radiation therapy...