Research Topics
Genomes and Genes | Seisuke HattoriSummaryAffiliation: Kitasato University Country: Japan Publications
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Publications
Identification of protein kinase substrates by proteomic approachesSeisuke Hattori
Division of Biochemistry, School of Pharmaceutical Science, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo, Japan
Expert Rev Proteomics 5:497-505. 2008..The final section contains an expert opinion on the current strategies and the issues we are going to challenge in the next 5 years...
Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1Yutaka Harita
Division of Cellular Proteomics BML and Department of Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
J Biol Chem 284:8951-62. 2009..Given the profound effect of PLC-gamma in diverse cellular functions, regulation of the Ca(2+) signaling by Nephrin may be important in modulating the glomerular filtration barrier function...- Phosphoproteomics-based modeling defines the regulatory mechanism underlying aberrant EGFR signalingShinya Tasaki
Medical Proteomics Laboratory, Institute of Medical Science, University of Tokyo, Tokyo, Japan
PLoS ONE 5:e13926. 2010..Here, we report a phosphoproteomics-based methodology for characterizing the regulatory mechanism underlying aberrant EGFR signaling using computational network modeling... - Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transportHidetaka Kosako
Division of Cellular Proteomics BML, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
Nat Struct Mol Biol 16:1026-35. 2009..Thus, we propose that ERK phosphorylates various nucleoporins to regulate nucleocytoplasmic transport... - Serum antibodies against the 70k polypeptides of the U1 ribonucleoprotein complex are associated with psychiatric syndromes in systemic lupus erythematosus: a retrospective studyYasuhiro Katsumata
Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
Mod Rheumatol 23:71-80. 2013..We assessed the association between serum autoantibodies against the 70-kDa polypeptide of the U1-ribonucleoprotein (RNP) complex (U1-70k) and the central nervous system (CNS) syndromes in systemic lupus erythematosus (SLE) patients... - Extracellular signal-regulated kinase/mitogen-activated protein kinase regulates actin organization and cell motility by phosphorylating the actin cross-linking protein EPLINMei Ying Han
Division of Cellular Proteomics BML, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
Mol Cell Biol 27:8190-204. 2007..We propose that ERK-mediated phosphorylation of EPLIN contributes to actin filament reorganization and enhanced cell motility... - Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2Yutaka Harita
Division of Cellular Proteomics BML, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
J Biol Chem 283:9177-86. 2008..Thus, SFK orchestrates a wide spectrum of protein-protein interactions and intracellular signaling networks at SD through tyrosine phosphorylation... 
Global analysis of dynamic changes in lipid raft proteins during T-cell activationMichimoto Kobayashi
Division of Cellular Proteomics BML, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, Japan
Electrophoresis 28:2035-43. 2007..We also demonstrated that these proteins assembled at the T-cell/APC interface. These results indicate the efficacy of our system to systematically analyze dynamics of lipid raft proteins during extracellular stimulation...- Identification of three new autoantibodies associated with systemic lupus erythematosus using two proteomic approachesYasuhiro Katsumata
Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
Mol Cell Proteomics 10:M110.005330. 2011..The combined immunoproteomic approaches used in this study are reliable and effective methods for identifying SLE autoantigens... - SIRP-alpha-CD47 system functions as an intercellular signal in the renal glomerulusHidetake Kurihara
Department of Anatomy, Juntendo University School of Medicine, Tokyo, Japan
Am J Physiol Renal Physiol 299:F517-27. 2010..The data suggest that the CD47-SIRP-alpha interaction may be functionally important in cell-cell communication in the diseased glomerulus... - Adaptor protein complex of FRS2β and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulationYuriko Minegishi
Division of Systems Biomedical Technology, The University of Tokyo, Tokyo, Japan
Cancer Sci 104:345-52. 2013..Molecular targeting drugs that can increase or stabilize the ErbB2-FRS2β-CIN85/CD2AP-Cbl axis may have promise for the control of ErbB2-overexpressing tumors... - I(2020)T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson's disease, has a higher intracellular degradation rate than the wild-type moleculeEtsuro Ohta
Division of Clinical Immunology, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa 228 8555, Japan
Biochem Biophys Res Commun 390:710-5. 2009..Our results indicate a novel molecular feature characteristic to I(2020)T LRRK2, and provide a new insight into the mechanism of neurodegeneration caused by LRRK2... - Temporal perturbation of tyrosine phosphoproteome dynamics reveals the system-wide regulatory networksMasaaki Oyama
Medical Proteomics Laboratory, Institute of Medical Science, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan
Mol Cell Proteomics 8:226-31. 2009..Our methodology provides a system-wide view of the regulatory network clusters involved in signal transduction that is essential to refine the literature-based network structures for a systems biology analysis... - Proteomic identification of Bcl2-associated athanogene 2 as a novel MAPK-activated protein kinase 2 substrateKoji Ueda
Division of Cellular Proteomics, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
J Biol Chem 279:41815-21. 2004..We confirmed that MAPKAP kinase 2 is also required for phosphorylation of BAG2 in vivo. Thus, p38 MAPK-MAPKAP kinase 2-BAG2 phosphorylation cascade may be a novel signaling pathway for response to extracellular stresses... - Purification of phosphoproteins by immobilized metal affinity chromatography and its application to phosphoproteome analysisMitsuyo Machida
Division of Cellular Proteomics BML, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 6639, Japan
FEBS J 274:1576-87. 2007..These results demonstrate the efficacy of phosphoprotein enrichment by IMAC and suggest that this procedure will be of general use in phosphoproteome research... - Tyrosine kinase signaling in kidney glomerular podocytesSeisuke Hattori
Division of Biochemistry, School of Pharmaceutical Science, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
J Signal Transduct 2011:317852. 2011..An Src family tyrosine kinase, Fyn, plays a major role in this signaling pathway. Here, we review the current understanding of this important signal transduction system and its role in the development and the maintenance of podocytes... - JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteinsFuminori Tsuruta
Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, Japan
EMBO J 23:1889-99. 2004..Collectively, these results have revealed a key mechanism of Bax regulation in stress-induced apoptosis...