Seisuke Hattori

Summary

Affiliation: Kitasato University
Country: Japan

Publications

  1. doi request reprint Identification of protein kinase substrates by proteomic approaches
    Seisuke Hattori
    Division of Biochemistry, School of Pharmaceutical Science, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo, Japan
    Expert Rev Proteomics 5:497-505. 2008
  2. pmc Tyrosine kinase signaling in kidney glomerular podocytes
    Seisuke Hattori
    Division of Biochemistry, School of Pharmaceutical Science, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    J Signal Transduct 2011:317852. 2011
  3. pmc Phosphoproteomics-based modeling defines the regulatory mechanism underlying aberrant EGFR signaling
    Shinya Tasaki
    Medical Proteomics Laboratory, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    PLoS ONE 5:e13926. 2010
  4. pmc Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1
    Yutaka Harita
    Division of Cellular Proteomics BML and Department of Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 284:8951-62. 2009
  5. ncbi request reprint Proteomic identification of autoantibodies in sera from patients with ovarian cancer as possible diagnostic biomarkers
    Koichi Yoneyama
    Department of Obstetrics and Gynecology, Nippon Medical School Main Hospital, Tokyo, Japan
    Anticancer Res 35:881-9. 2015
  6. doi request reprint Serum antibodies against the 70k polypeptides of the U1 ribonucleoprotein complex are associated with psychiatric syndromes in systemic lupus erythematosus: a retrospective study
    Yasuhiro Katsumata
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Mod Rheumatol 23:71-80. 2013
  7. doi request reprint Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport
    Hidetaka Kosako
    Division of Cellular Proteomics BML, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Nat Struct Mol Biol 16:1026-35. 2009
  8. pmc Extracellular signal-regulated kinase/mitogen-activated protein kinase regulates actin organization and cell motility by phosphorylating the actin cross-linking protein EPLIN
    Mei Ying Han
    Division of Cellular Proteomics BML, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Mol Cell Biol 27:8190-204. 2007
  9. pmc Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2
    Yutaka Harita
    Division of Cellular Proteomics BML, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    J Biol Chem 283:9177-86. 2008
  10. doi request reprint Epithelial protein lost in neoplasm modulates platelet-derived growth factor-mediated adhesion and motility of mesangial cells
    Haruko Tsurumi
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Kidney Int 86:548-57. 2014

Collaborators

Detail Information

Publications24

  1. doi request reprint Identification of protein kinase substrates by proteomic approaches
    Seisuke Hattori
    Division of Biochemistry, School of Pharmaceutical Science, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo, Japan
    Expert Rev Proteomics 5:497-505. 2008
    ..The final section contains an expert opinion on the current strategies and the issues we are going to challenge in the next 5 years...
  2. pmc Tyrosine kinase signaling in kidney glomerular podocytes
    Seisuke Hattori
    Division of Biochemistry, School of Pharmaceutical Science, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    J Signal Transduct 2011:317852. 2011
    ..An Src family tyrosine kinase, Fyn, plays a major role in this signaling pathway. Here, we review the current understanding of this important signal transduction system and its role in the development and the maintenance of podocytes...
  3. pmc Phosphoproteomics-based modeling defines the regulatory mechanism underlying aberrant EGFR signaling
    Shinya Tasaki
    Medical Proteomics Laboratory, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    PLoS ONE 5:e13926. 2010
    ..Here, we report a phosphoproteomics-based methodology for characterizing the regulatory mechanism underlying aberrant EGFR signaling using computational network modeling...
  4. pmc Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1
    Yutaka Harita
    Division of Cellular Proteomics BML and Department of Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 284:8951-62. 2009
    ..Given the profound effect of PLC-gamma in diverse cellular functions, regulation of the Ca(2+) signaling by Nephrin may be important in modulating the glomerular filtration barrier function...
  5. ncbi request reprint Proteomic identification of autoantibodies in sera from patients with ovarian cancer as possible diagnostic biomarkers
    Koichi Yoneyama
    Department of Obstetrics and Gynecology, Nippon Medical School Main Hospital, Tokyo, Japan
    Anticancer Res 35:881-9. 2015
    ..The aim of the present study was to identify antigens for autoantibodies in sera from patients with ovarian cancer, especially clear cell carcinoma (CCC), as novel diagnostic markers for the disease...
  6. doi request reprint Serum antibodies against the 70k polypeptides of the U1 ribonucleoprotein complex are associated with psychiatric syndromes in systemic lupus erythematosus: a retrospective study
    Yasuhiro Katsumata
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Mod Rheumatol 23:71-80. 2013
    ..We assessed the association between serum autoantibodies against the 70-kDa polypeptide of the U1-ribonucleoprotein (RNP) complex (U1-70k) and the central nervous system (CNS) syndromes in systemic lupus erythematosus (SLE) patients...
  7. doi request reprint Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport
    Hidetaka Kosako
    Division of Cellular Proteomics BML, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Nat Struct Mol Biol 16:1026-35. 2009
    ..Thus, we propose that ERK phosphorylates various nucleoporins to regulate nucleocytoplasmic transport...
  8. pmc Extracellular signal-regulated kinase/mitogen-activated protein kinase regulates actin organization and cell motility by phosphorylating the actin cross-linking protein EPLIN
    Mei Ying Han
    Division of Cellular Proteomics BML, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Mol Cell Biol 27:8190-204. 2007
    ..We propose that ERK-mediated phosphorylation of EPLIN contributes to actin filament reorganization and enhanced cell motility...
  9. pmc Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2
    Yutaka Harita
    Division of Cellular Proteomics BML, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    J Biol Chem 283:9177-86. 2008
    ..Thus, SFK orchestrates a wide spectrum of protein-protein interactions and intracellular signaling networks at SD through tyrosine phosphorylation...
  10. doi request reprint Epithelial protein lost in neoplasm modulates platelet-derived growth factor-mediated adhesion and motility of mesangial cells
    Haruko Tsurumi
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Kidney Int 86:548-57. 2014
    ..Thus, changes in expression and localization of cytoskeletal regulators underlie phenotypic changes in mesangial cells in glomerulonephritis. ..
  11. doi request reprint Adaptor protein complex of FRS2β and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation
    Yuriko Minegishi
    Division of Systems Biomedical Technology, The University of Tokyo, Tokyo, Japan
    Cancer Sci 104:345-52. 2013
    ..Molecular targeting drugs that can increase or stabilize the ErbB2-FRS2β-CIN85/CD2AP-Cbl axis may have promise for the control of ErbB2-overexpressing tumors...
  12. ncbi request reprint Global analysis of dynamic changes in lipid raft proteins during T-cell activation
    Michimoto Kobayashi
    Division of Cellular Proteomics BML, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, Japan
    Electrophoresis 28:2035-43. 2007
    ..We also demonstrated that these proteins assembled at the T-cell/APC interface. These results indicate the efficacy of our system to systematically analyze dynamics of lipid raft proteins during extracellular stimulation...
  13. pmc Identification of three new autoantibodies associated with systemic lupus erythematosus using two proteomic approaches
    Yasuhiro Katsumata
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Mol Cell Proteomics 10:M110.005330. 2011
    ..The combined immunoproteomic approaches used in this study are reliable and effective methods for identifying SLE autoantigens...
  14. doi request reprint SIRP-alpha-CD47 system functions as an intercellular signal in the renal glomerulus
    Hidetake Kurihara
    Department of Anatomy, Juntendo University School of Medicine, Tokyo, Japan
    Am J Physiol Renal Physiol 299:F517-27. 2010
    ..The data suggest that the CD47-SIRP-alpha interaction may be functionally important in cell-cell communication in the diseased glomerulus...
  15. doi request reprint Afadin regulates RhoA/Rho-associated protein kinase signaling to control formation of actin stress fibers in kidney podocytes
    Koji Saito
    Division of Cell Biology, Department of Biosciences, School of Science, Kitasato University, Kanagawa, Japan
    Cytoskeleton (Hoboken) 72:146-56. 2015
    ..Thus, afadin mediates RhoA/ROCK signaling and contributes to the formation of actin stress fibers in podocyte cells. © 2015 Wiley Periodicals, Inc. ..
  16. doi request reprint Proteomic identification of p38 MAP kinase substrates using in vitro phosphorylation
    Naoyuki Iida
    Division of Biochemistry, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
    Electrophoresis 35:554-62. 2014
    ..Seven selected candidates were phosphorylated by p38 MAP kinase in vitro and in p38 MAP kinase-activated cells. This proteomic approach can be applied to any protein kinase, allowing global identification of novel substrates. ..
  17. doi request reprint I(2020)T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson's disease, has a higher intracellular degradation rate than the wild-type molecule
    Etsuro Ohta
    Division of Clinical Immunology, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa 228 8555, Japan
    Biochem Biophys Res Commun 390:710-5. 2009
    ..Our results indicate a novel molecular feature characteristic to I(2020)T LRRK2, and provide a new insight into the mechanism of neurodegeneration caused by LRRK2...
  18. doi request reprint Temporal perturbation of tyrosine phosphoproteome dynamics reveals the system-wide regulatory networks
    Masaaki Oyama
    Medical Proteomics Laboratory, Institute of Medical Science, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan
    Mol Cell Proteomics 8:226-31. 2009
    ..Our methodology provides a system-wide view of the regulatory network clusters involved in signal transduction that is essential to refine the literature-based network structures for a systems biology analysis...
  19. ncbi request reprint Proteomic identification of Bcl2-associated athanogene 2 as a novel MAPK-activated protein kinase 2 substrate
    Koji Ueda
    Division of Cellular Proteomics, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 279:41815-21. 2004
    ..We confirmed that MAPKAP kinase 2 is also required for phosphorylation of BAG2 in vivo. Thus, p38 MAPK-MAPKAP kinase 2-BAG2 phosphorylation cascade may be a novel signaling pathway for response to extracellular stresses...
  20. ncbi request reprint Proteomic identification of dihydrolipoamide dehydrogenase as a target of autoantibodies in patients with endometrial cancer
    Koichi Yoneyama
    Department of Obstetrics and Gynecology, Nippon Medical School Hospital, Tokyo, Japan
    Anticancer Res 34:5021-7. 2014
    ..The aim of the present study was to identify antigens for autoantibodies in sera from endometrial cancer patients as novel diagnostic markers for the disease...
  21. pmc Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity
    Tatsuhiro Sato
    From the Division of Biochemistry, School of Pharmaceutical Sciences, Kitasato University, Tokyo 108 8641, Japan and
    J Biol Chem 290:1096-105. 2015
    ..These results establish CAD as a downstream effector of Rheb and suggest a possible role of Rheb in regulating de novo pyrimidine nucleotide synthesis. ..
  22. doi request reprint An efficient screening system for influenza virus cap-dependent endonuclease inhibitors
    Yoshio Shibagaki
    Division of Biochemistry, School of Pharmaceutical Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan Electronic address
    J Virol Methods 202:8-14. 2014
    ..A known inhibitor for the cap-snatching reaction was evaluated by the pull-down assay, demonstrating the efficacy of the established screening system...
  23. ncbi request reprint Purification of phosphoproteins by immobilized metal affinity chromatography and its application to phosphoproteome analysis
    Mitsuyo Machida
    Division of Cellular Proteomics BML, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 6639, Japan
    FEBS J 274:1576-87. 2007
    ..These results demonstrate the efficacy of phosphoprotein enrichment by IMAC and suggest that this procedure will be of general use in phosphoproteome research...
  24. pmc JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins
    Fuminori Tsuruta
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo, Japan
    EMBO J 23:1889-99. 2004
    ..Collectively, these results have revealed a key mechanism of Bax regulation in stress-induced apoptosis...