Y Dobashi

Summary

Affiliation: Kitasato University
Country: Japan

Publications

  1. ncbi request reprint Simultaneous suppression of cdc2 and cdk2 activities induces neuronal differentiation of PC12 cells
    Y Dobashi
    Department of Pathology, Kitasato University School of Medicine, 1 15 1, Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    J Biol Chem 275:12572-80. 2000
  2. ncbi request reprint CDK4, a possible critical regulator of apoptosis in rat pheochromocytoma PC12 cells
    Y Dobashi
    Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan
    Biochem Biophys Res Commun 253:609-13. 1998
  3. ncbi request reprint Combined clear and granular cell leiomyoma of soft tissue: evidence of transformation to a histiocytic phenotype
    Y Dobashi
    Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan
    Histopathology 34:526-31. 1999
  4. ncbi request reprint A novel apoptotic cascade mediated by CDK4 in rat pheochromocytoma PC12 cells
    Y Dobashi
    Department of Pathology, Kitasato University School of Medicine, 1 15 1, Kitasato, Sagamihara, Kanagawa, 228 8555, Japan
    Biochem Biophys Res Commun 260:806-12. 1999
  5. ncbi request reprint APC protein is required for initiation of neuronal differentiation in rat pheochromocytoma PC12 cells
    Y Dobashi
    Department of Pathology, Kitasato University School of Medicine, 1 15 1, Kitasato, Kanagawa, 228 8555, Japan
    Biochem Biophys Res Commun 279:685-91. 2000
  6. ncbi request reprint Hyalinizing spindle cell tumor with giant rosettes: report of a case showing remarkable myofibroblastic differentiation
    Y Dobashi
    Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan
    Pathol Res Pract 197:691-7. 2001
  7. ncbi request reprint CDK-inhibitors-associated kinase activity: a possible determinant of malignant potential in smooth muscle tumors of the external soft tissue
    Y Dobashi
    Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan
    Int J Cancer 94:353-62. 2001
  8. ncbi request reprint Cell cycle control with minimal participation of Cdk2 in a murine fibrosarcoma clone cultured in protein-free medium
    Y Dobashi
    Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan
    Biochem Biophys Res Commun 232:622-5. 1997
  9. ncbi request reprint Overexpression of cdk4/cyclin D1 induces apoptosis in PC12 cells in the presence of trophic support
    K Katayama
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    FEBS Lett 509:382-8. 2001
  10. ncbi request reprint Differential expression and pathological significance of autocrine motility factor/glucose-6-phosphate isomerase expression in human lung carcinomas
    Y Dobashi
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan
    J Pathol 210:431-40. 2006

Detail Information

Publications11

  1. ncbi request reprint Simultaneous suppression of cdc2 and cdk2 activities induces neuronal differentiation of PC12 cells
    Y Dobashi
    Department of Pathology, Kitasato University School of Medicine, 1 15 1, Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    J Biol Chem 275:12572-80. 2000
    ..These results suggest that simultaneous down-regulation of cdc2 and cdk2 activity is sufficient and necessary for neuronal differentiation in PC12 cells...
  2. ncbi request reprint CDK4, a possible critical regulator of apoptosis in rat pheochromocytoma PC12 cells
    Y Dobashi
    Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan
    Biochem Biophys Res Commun 253:609-13. 1998
    ..The change in CDK4 kinase activity almost paralleled that of CDK4 protein expression. These results suggest that CDK4 kinase activity is one of the critical regulators in the apoptotic cascade in PC12 cells...
  3. ncbi request reprint Combined clear and granular cell leiomyoma of soft tissue: evidence of transformation to a histiocytic phenotype
    Y Dobashi
    Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan
    Histopathology 34:526-31. 1999
    ..We present an unusual case of leiomyoma with a clear and granular cell pattern in which there was immunohistochemical evidence of transformation to a histiocytic phenotype...
  4. ncbi request reprint A novel apoptotic cascade mediated by CDK4 in rat pheochromocytoma PC12 cells
    Y Dobashi
    Department of Pathology, Kitasato University School of Medicine, 1 15 1, Kitasato, Sagamihara, Kanagawa, 228 8555, Japan
    Biochem Biophys Res Commun 260:806-12. 1999
    ..This apoptotic cascade should eventually converge with the cascade induced by serum withdrawal in normal PC12 cells. We discuss the interactions among these apoptotic cascades and the points where anti-apoptotic agents act...
  5. ncbi request reprint APC protein is required for initiation of neuronal differentiation in rat pheochromocytoma PC12 cells
    Y Dobashi
    Department of Pathology, Kitasato University School of Medicine, 1 15 1, Kitasato, Kanagawa, 228 8555, Japan
    Biochem Biophys Res Commun 279:685-91. 2000
    ....
  6. ncbi request reprint Hyalinizing spindle cell tumor with giant rosettes: report of a case showing remarkable myofibroblastic differentiation
    Y Dobashi
    Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan
    Pathol Res Pract 197:691-7. 2001
    ..We interpreted this case of HSCGR as a low grade fibrosarcoma with remarkable differentiation of myofibroblastic lineage, and with focally accumulated, morphologically normal collagenous fibrils...
  7. ncbi request reprint CDK-inhibitors-associated kinase activity: a possible determinant of malignant potential in smooth muscle tumors of the external soft tissue
    Y Dobashi
    Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan
    Int J Cancer 94:353-62. 2001
    ..Moreover, immunohistochemical detection of CKIs may provide a useful tool for evaluating patients' prognosis...
  8. ncbi request reprint Cell cycle control with minimal participation of Cdk2 in a murine fibrosarcoma clone cultured in protein-free medium
    Y Dobashi
    Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan
    Biochem Biophys Res Commun 232:622-5. 1997
    ..PF was also resistant against the selective inhibitor of cdk2, butyrolactone I. These findings suggest that tumor cell proliferation and tumor progression can be promoted by the activation of a molecule(s) downstream of cdk2...
  9. ncbi request reprint Overexpression of cdk4/cyclin D1 induces apoptosis in PC12 cells in the presence of trophic support
    K Katayama
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    FEBS Lett 509:382-8. 2001
    ..These results suggest that upregulation of cdk4 kinase activity is a primary and critical mediator of apoptosis in PC12 cells under physiological conditions...
  10. ncbi request reprint Differential expression and pathological significance of autocrine motility factor/glucose-6-phosphate isomerase expression in human lung carcinomas
    Y Dobashi
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan
    J Pathol 210:431-40. 2006
    ..Furthermore, higher mRNA expression may be related to the high metastatic potential of NSCLC and increased protein secretion, leading to a more aggressive phenotype, such as the invasiveness of SmCC and LCC...
  11. ncbi request reprint Polymorphisms in the human DNA polymerase beta gene
    Y Dobashi
    Department of Urology, Yokohama City University School of Medicine, Kanagawa, Japan
    Hum Genet 95:389-90. 1995
    ..Unexpectedly, we found six regions that were polymorphic. This information should be taken into consideration at the time of sequence analysis of the DNA polymerase beta gene...