Hiroaki Yajima

Summary

Affiliation: Kirin Brewery Co
Country: Japan

Publications

  1. ncbi Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated receptor alpha and gamma and reduce insulin resistance
    Hiroaki Yajima
    Central Laboratories for Key Technology, Kirin Brewery Co, Ltd, Kanagawa 236 0004, Japan
    J Biol Chem 279:33456-62. 2004
  2. ncbi Prevention of diet-induced obesity by dietary isomerized hop extract containing isohumulones, in rodents
    H Yajima
    Central Laboratories for Key Technology, Kirin Brewery Co, Ltd, Kanagawa, Japan
    Int J Obes (Lond) 29:991-7. 2005
  3. ncbi Identification of peroxisome-proliferator responsive element in the mouse HSL gene
    Hiroaki Yajima
    Central Laboratories for Frontier Technology, Kirin Brewery Co, Ltd, Yokohama 236 0004, Japan
    Biochem Biophys Res Commun 352:526-31. 2007
  4. ncbi Prevention of diet-induced obesity by dietary black tea polyphenols extract in vitro and in vivo
    Satoshi Uchiyama
    Functional Food Business Project, Kirin Holdings Co, Ltd, Takasaki, Gunma, Japan
    Nutrition 27:287-92. 2011
  5. ncbi Isohumulones, the bitter component of beer, improve hyperglycemia and decrease body fat in Japanese subjects with prediabetes
    Kuniaki Obara
    Research and Development Laboratory, Kirin Beverage Company Ltd, Yokohama, Japan
    Clin Nutr 28:278-84. 2009
  6. ncbi Constituents from the leaves of Nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice
    Emika Ohkoshi
    Kirin Brewery Co, Ltd, Central Laboratories for Frontier Technology, Kanagawa, Japan
    Planta Med 73:1255-9. 2007

Collaborators

Detail Information

Publications6

  1. ncbi Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated receptor alpha and gamma and reduce insulin resistance
    Hiroaki Yajima
    Central Laboratories for Key Technology, Kirin Brewery Co, Ltd, Kanagawa 236 0004, Japan
    J Biol Chem 279:33456-62. 2004
    ..1 and 6.4%, respectively, versus week 0). These results suggest that isohumulones can improve insulin sensitivity in high fat diet-fed mice with insulin resistance and in patients with type 2 diabetes...
  2. ncbi Prevention of diet-induced obesity by dietary isomerized hop extract containing isohumulones, in rodents
    H Yajima
    Central Laboratories for Key Technology, Kirin Brewery Co, Ltd, Kanagawa, Japan
    Int J Obes (Lond) 29:991-7. 2005
    ..Isomerized hop extract (IHE), which consists mainly of isohumulones and is required in the beer brewing process, was investigated for its effects on diet-induced obesity in two strains of mice...
  3. ncbi Identification of peroxisome-proliferator responsive element in the mouse HSL gene
    Hiroaki Yajima
    Central Laboratories for Frontier Technology, Kirin Brewery Co, Ltd, Yokohama 236 0004, Japan
    Biochem Biophys Res Commun 352:526-31. 2007
    ..These results indicate that the HSL gene is transcriptionally regulated by PPARgamma/RXRalpha heterodimer, and suggest that a cis-acting element regulates the HSL gene expression...
  4. ncbi Prevention of diet-induced obesity by dietary black tea polyphenols extract in vitro and in vivo
    Satoshi Uchiyama
    Functional Food Business Project, Kirin Holdings Co, Ltd, Takasaki, Gunma, Japan
    Nutrition 27:287-92. 2011
    ..The effectiveness of oral administration of the BTPE was examined in in vitro and in vivo experiments...
  5. ncbi Isohumulones, the bitter component of beer, improve hyperglycemia and decrease body fat in Japanese subjects with prediabetes
    Kuniaki Obara
    Research and Development Laboratory, Kirin Beverage Company Ltd, Yokohama, Japan
    Clin Nutr 28:278-84. 2009
    ..This study was to investigate the efficacy and safety of isohumulones for subjects with prediabetes...
  6. ncbi Constituents from the leaves of Nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice
    Emika Ohkoshi
    Kirin Brewery Co, Ltd, Central Laboratories for Frontier Technology, Kanagawa, Japan
    Planta Med 73:1255-9. 2007
    ..Our results indicate that the effects of NN in preventing diet-induced obesity appear to be due to various flavonoids and that the activation of beta-AR pathway was involved, at least in part...