Hajime Nozawa

Summary

Affiliation: Kirin Brewery Co
Country: Japan

Publications

  1. ncbi request reprint Intake of beer inhibits azoxymethane-induced colonic carcinogenesis in male Fischer 344 rats
    Hajime Nozawa
    Central Laboratories for Key Technology, Kirin Brewery Co, Ltd, Yokohama, Japan
    Int J Cancer 108:404-11. 2004
  2. ncbi request reprint Inhibitory effects of beer on heterocyclic amine-induced mutagenesis and PhIP-induced aberrant crypt foci in rat colon
    Hajime Nozawa
    Central Laboratories for Key Technology, Kirin Brewery Co Ltd, 1 13 5 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Mutat Res 559:177-87. 2004
  3. ncbi request reprint Inhibition of PhIP-induced mammary carcinogenesis in female rats by ingestion of freeze-dried beer
    Hajime Nozawa
    Central Laboratories for Key Technology, Kirin Brewery Co Ltd, 1 13 5 Fukuura, Yokohama 236 0004, Japan
    Cancer Lett 235:121-9. 2006
  4. ncbi request reprint Dietary supplement of isohumulones inhibits the formation of aberrant crypt foci with a concomitant decrease in prostaglandin E2 level in rat colon
    Hajime Nozawa
    Applied Bioresearch Center, Kirin Brewery Co, Ltd, Takasaki shi Gunma, Japan
    Mol Nutr Food Res 49:772-8. 2005
  5. ncbi request reprint Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A(y) mice
    Hajime Nozawa
    R and D Laboratory, Functional Food Division, Kirin Brewery Co, Ltd, 3 Miyahara, Takasaki, Gunma 370 1295, Japan
    Biochem Biophys Res Commun 336:754-61. 2005
  6. ncbi request reprint Prenylflavonoids and phloroglucinol derivatives from hops (Humulus lupulus)
    Feng Zhao
    Central Laboratories for Key Technology, Kirin Brewery Co, Ltd, Yokohama shi, Kanagawa 236 0004, Japan
    J Nat Prod 68:43-9. 2005
  7. ncbi request reprint Inhibitors of nitric oxide production from hops (Humulus lupulus L.)
    Feng Zhao
    Central Laboratories for Key Technology, Kirin Brewery Co, Ltd, 1 13 5 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 004, Japan
    Biol Pharm Bull 26:61-5. 2003

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Intake of beer inhibits azoxymethane-induced colonic carcinogenesis in male Fischer 344 rats
    Hajime Nozawa
    Central Laboratories for Key Technology, Kirin Brewery Co, Ltd, Yokohama, Japan
    Int J Cancer 108:404-11. 2004
    ..These results suggest that components of beer have chemopreventive effects on colonic carcinogenesis induced by AOM and that intake of beer may contribute to a reduction in the risk of cancer susceptibility...
  2. ncbi request reprint Inhibitory effects of beer on heterocyclic amine-induced mutagenesis and PhIP-induced aberrant crypt foci in rat colon
    Hajime Nozawa
    Central Laboratories for Key Technology, Kirin Brewery Co Ltd, 1 13 5 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Mutat Res 559:177-87. 2004
    ..These results suggest that beer inhibits the genotoxic effects of HCAs and may reduce the risk of carcinogenesis caused by food borne carcinogens...
  3. ncbi request reprint Inhibition of PhIP-induced mammary carcinogenesis in female rats by ingestion of freeze-dried beer
    Hajime Nozawa
    Central Laboratories for Key Technology, Kirin Brewery Co Ltd, 1 13 5 Fukuura, Yokohama 236 0004, Japan
    Cancer Lett 235:121-9. 2006
    ..In conclusion, our results suggest that intake of FD beer may reduce the risk of carcinogenesis caused by heterocyclic amines...
  4. ncbi request reprint Dietary supplement of isohumulones inhibits the formation of aberrant crypt foci with a concomitant decrease in prostaglandin E2 level in rat colon
    Hajime Nozawa
    Applied Bioresearch Center, Kirin Brewery Co, Ltd, Takasaki shi Gunma, Japan
    Mol Nutr Food Res 49:772-8. 2005
    ..7 cells was also reduced by treatment with IHE and isohumulone in a dose-dependent manner. These observations suggest that isohumulones show chemopreventive effects on ACF formation in rat colon by inhibiting the production of PGE2...
  5. ncbi request reprint Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A(y) mice
    Hajime Nozawa
    R and D Laboratory, Functional Food Division, Kirin Brewery Co, Ltd, 3 Miyahara, Takasaki, Gunma 370 1295, Japan
    Biochem Biophys Res Commun 336:754-61. 2005
    ..From the present results, it is suggested that XN acts on FXR through a selective bile acid receptor modulator (SBARM) like guggulsterone or polyunsaturated fatty acids, which have previously been reported as SBARMs...
  6. ncbi request reprint Prenylflavonoids and phloroglucinol derivatives from hops (Humulus lupulus)
    Feng Zhao
    Central Laboratories for Key Technology, Kirin Brewery Co, Ltd, Yokohama shi, Kanagawa 236 0004, Japan
    J Nat Prod 68:43-9. 2005
    ..The structures were determined on the basis of physiochemical properties and spectroscopic analysis. Their inhibitory activities on the production of NO in macrophage RAW 264.7 cells were examined...
  7. ncbi request reprint Inhibitors of nitric oxide production from hops (Humulus lupulus L.)
    Feng Zhao
    Central Laboratories for Key Technology, Kirin Brewery Co, Ltd, 1 13 5 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 004, Japan
    Biol Pharm Bull 26:61-5. 2003
    ..The chalcones, including xanthohumol, significantly inhibited the production of NO by suppressing the expression of iNOS...