Affiliation: Kirin Brewery Co
- Intake of beer inhibits azoxymethane-induced colonic carcinogenesis in male Fischer 344 ratsHajime Nozawa
Central Laboratories for Key Technology, Kirin Brewery Co, Ltd, Yokohama, Japan
Int J Cancer 108:404-11. 2004..These results suggest that components of beer have chemopreventive effects on colonic carcinogenesis induced by AOM and that intake of beer may contribute to a reduction in the risk of cancer susceptibility...
- Inhibitory effects of beer on heterocyclic amine-induced mutagenesis and PhIP-induced aberrant crypt foci in rat colonHajime Nozawa
Central Laboratories for Key Technology, Kirin Brewery Co Ltd, 1 13 5 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
Mutat Res 559:177-87. 2004..These results suggest that beer inhibits the genotoxic effects of HCAs and may reduce the risk of carcinogenesis caused by food borne carcinogens...
- Inhibition of PhIP-induced mammary carcinogenesis in female rats by ingestion of freeze-dried beerHajime Nozawa
Central Laboratories for Key Technology, Kirin Brewery Co Ltd, 1 13 5 Fukuura, Yokohama 236 0004, Japan
Cancer Lett 235:121-9. 2006..In conclusion, our results suggest that intake of FD beer may reduce the risk of carcinogenesis caused by heterocyclic amines...
- Dietary supplement of isohumulones inhibits the formation of aberrant crypt foci with a concomitant decrease in prostaglandin E2 level in rat colonHajime Nozawa
Applied Bioresearch Center, Kirin Brewery Co, Ltd, Takasaki shi Gunma, Japan
Mol Nutr Food Res 49:772-8. 2005..7 cells was also reduced by treatment with IHE and isohumulone in a dose-dependent manner. These observations suggest that isohumulones show chemopreventive effects on ACF formation in rat colon by inhibiting the production of PGE2...
- Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A(y) miceHajime Nozawa
R and D Laboratory, Functional Food Division, Kirin Brewery Co, Ltd, 3 Miyahara, Takasaki, Gunma 370 1295, Japan
Biochem Biophys Res Commun 336:754-61. 2005..From the present results, it is suggested that XN acts on FXR through a selective bile acid receptor modulator (SBARM) like guggulsterone or polyunsaturated fatty acids, which have previously been reported as SBARMs...
- Prenylflavonoids and phloroglucinol derivatives from hops (Humulus lupulus)Feng Zhao
Central Laboratories for Key Technology, Kirin Brewery Co, Ltd, Yokohama shi, Kanagawa 236 0004, Japan
J Nat Prod 68:43-9. 2005..The structures were determined on the basis of physiochemical properties and spectroscopic analysis. Their inhibitory activities on the production of NO in macrophage RAW 264.7 cells were examined...
- Inhibitors of nitric oxide production from hops (Humulus lupulus L.)Feng Zhao
Central Laboratories for Key Technology, Kirin Brewery Co, Ltd, 1 13 5 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 004, Japan
Biol Pharm Bull 26:61-5. 2003..The chalcones, including xanthohumol, significantly inhibited the production of NO by suppressing the expression of iNOS...