O Yoshie

Summary

Affiliation: Kinki University
Country: Japan

Publications

  1. ncbi [Lymphocyte subsets and chemokine receptors]
    Osamu Yoshie
    Tanpakushitsu Kakusan Koso 47:2206-13. 2002
  2. ncbi Expression and function of FRA2/JUND in cutaneous T-cell lymphomas
    Takashi Nakayama
    Department of Microbiology, Kinki University Faculty of Medicine, Osaka Sayama, Osaka, Japan
    Anticancer Res 32:1367-73. 2012
  3. ncbi Extensive expansion and diversification of the chemokine gene family in zebrafish: identification of a novel chemokine subfamily CX
    Hisayuki Nomiyama
    Department of Molecular Enzymology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860 8556, Japan
    BMC Genomics 9:222. 2008
  4. ncbi Role of chemokines in trafficking of lymphocytes and dendritic cells
    O Yoshie
    Department of Bacteriology, Kinki University School of Medicine, Osaka Sayama, Japan
    Int J Hematol 72:399-407. 2000
  5. ncbi [CCR4, HTLV-1 infection, and ATL oncogenesis]
    Osamu Yoshie
    Department of Microbiology, Kinki University School of Medicine, Osaka 589 8511, Japan
    Uirusu 58:125-40. 2008
  6. ncbi Chemokines in immunity
    O Yoshie
    Department of Microbiology, Kinki University School of Medicine, Osaka Sayama, Osaka 589 8511, Japan
    Adv Immunol 78:57-110. 2001
  7. ncbi Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1-transformed T cells
    Osamu Yoshie
    Department of Microbiology, Kinki University School of Medicine, Osaka, Japan
    Blood 99:1505-11. 2002
  8. ncbi Expression of CCR4 in adult T-cell leukemia
    Osamu Yoshie
    Department of Microbiology, Kinki University School of Medicine, Osaka, Japan
    Leuk Lymphoma 46:185-90. 2005
  9. ncbi Structure and expression of two highly related genes encoding SCM-1/human lymphotactin
    T Yoshida
    Shionogi Institute for Medical Science, Osaka, Japan
    FEBS Lett 395:82-8. 1996
  10. ncbi Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor
    T Yoshida
    Shionogi Institute for Medical Science, Osaka, Japan
    FEBS Lett 458:37-40. 1999

Collaborators

Detail Information

Publications86

  1. ncbi [Lymphocyte subsets and chemokine receptors]
    Osamu Yoshie
    Tanpakushitsu Kakusan Koso 47:2206-13. 2002
  2. ncbi Expression and function of FRA2/JUND in cutaneous T-cell lymphomas
    Takashi Nakayama
    Department of Microbiology, Kinki University Faculty of Medicine, Osaka Sayama, Osaka, Japan
    Anticancer Res 32:1367-73. 2012
    ..Our results, thus, demonstrate the presence of a common oncogenic cascade initiated by FRA2/JUND in CCR4-expressing mature T-cell malignancies such as ATLL and CTCLs...
  3. ncbi Extensive expansion and diversification of the chemokine gene family in zebrafish: identification of a novel chemokine subfamily CX
    Hisayuki Nomiyama
    Department of Molecular Enzymology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860 8556, Japan
    BMC Genomics 9:222. 2008
    ..Prior to this study, however, only incomplete lists of the zebrafish chemokine genes were reported...
  4. ncbi Role of chemokines in trafficking of lymphocytes and dendritic cells
    O Yoshie
    Department of Bacteriology, Kinki University School of Medicine, Osaka Sayama, Japan
    Int J Hematol 72:399-407. 2000
    ..Immune chemokines are thus key elements in the genesis, maintenance, and function of the immune system...
  5. ncbi [CCR4, HTLV-1 infection, and ATL oncogenesis]
    Osamu Yoshie
    Department of Microbiology, Kinki University School of Medicine, Osaka 589 8511, Japan
    Uirusu 58:125-40. 2008
    ..Thus, Fra-2 is a novel oncogene of ATL, and CCR4 may be regarded as a useful tumor marker of ATL...
  6. ncbi Chemokines in immunity
    O Yoshie
    Department of Microbiology, Kinki University School of Medicine, Osaka Sayama, Osaka 589 8511, Japan
    Adv Immunol 78:57-110. 2001
    ..The immune chemokines and their receptors are also likely to be important future targets for therapeutic intervention of our immune responses...
  7. ncbi Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1-transformed T cells
    Osamu Yoshie
    Department of Microbiology, Kinki University School of Medicine, Osaka, Japan
    Blood 99:1505-11. 2002
    ..Thus, HTLV-1-infected CCR4(+) T cells may have growth advantages by deviating host immune responses to Th2. CCR4 expression may also account for frequent infiltration of ATL into tissues such as skin and lymph nodes...
  8. ncbi Expression of CCR4 in adult T-cell leukemia
    Osamu Yoshie
    Department of Microbiology, Kinki University School of Medicine, Osaka, Japan
    Leuk Lymphoma 46:185-90. 2005
    ..Furthermore, CCR4 is known to be selectively expressed by Th2 and regulatory T cells. Thus, the majority of ATL may predominantly originate from either Th2 or regulatory T cells...
  9. ncbi Structure and expression of two highly related genes encoding SCM-1/human lymphotactin
    T Yoshida
    Shionogi Institute for Medical Science, Osaka, Japan
    FEBS Lett 395:82-8. 1996
    ..The biological activities of SCM-1alpha and SCM-1beta, which have two amino acid differences at positions 7 and 8 in the mature proteins, remain to be compared...
  10. ncbi Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor
    T Yoshida
    Shionogi Institute for Medical Science, Osaka, Japan
    FEBS Lett 458:37-40. 1999
    ..In spleen, CD8+ cells and NK1.1+ cells were found to express mXCR1. Identification of mXCR1 will now allow us to study the role of this unique cytokine system in the mouse models of inflammation and immunity...
  11. ncbi Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3
    M Kitaura
    Shionogi Institute for Medical Science, Osaka 566 0022, Kinki University School of Medicine, Osaka 589 8511, Japan
    J Biol Chem 274:27975-80. 1999
    ..The strategy used in this study may also be applicable to identification of other unknown chemokine genes...
  12. ncbi Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus
    I Ishikawa-Mochizuki
    Shionogi Institute for Medical Science, Osaka, Japan
    FEBS Lett 460:544-8. 1999
    ..Furthermore, ILC is strongly and selectively expressed in the skin where infection of MCV also takes place. Thus, ILC is likely to be the original chemokine of MC148R...
  13. ncbi Small amino acid changes in the V3 loop of human immunodeficiency virus type 2 determines the coreceptor usage for CXCR4 and CCR5
    Y Isaka
    Shionogi Institute for Medical Science, Osaka, 566 0022, Japan
    Virology 264:237-43. 1999
    ..Notably, the shift in the coreceptor usage from CCR5 to CXCR4 is associated with an increase in the net positive charge in the V3 region...
  14. ncbi Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3 alpha/CCL20 by epidermal keratinocytes and its role in atopic dermatitis
    T Nakayama
    Department of Bacteriology, Kinki University School of Medicine, Osaka Sayama 589 8511, Japan
    Int Immunol 13:95-103. 2001
    ..LARC/CCL20 may not, however, play a major role in homeostatic migration of Langerhans cells into the skin...
  15. ncbi Proinflammatory cytokines induce liver and activation-regulated chemokine/macrophage inflammatory protein-3alpha/CCL20 in mucosal epithelial cells through NF-kappaB [correction of NK-kappaB]
    S Fujiie
    Department of Surgery II, Kinki University School of Medicine, Osaka-Sayama, Osaka 589-8511, Japan
    Int Immunol 13:1255-63. 2001
    ..Collectively, LARC expression in intestinal epithelial-type cells is induced by proinflammatory cytokines such as IL-1 and TNF-alpha primarily through activation of NF-kappaB...
  16. ncbi Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic structure, and expression
    M Nagira
    Shionogi Institute for Medical Science, Osaka, Japan
    Cell Immunol 157:144-57. 1994
    ..These results together with the comparison of the structures of 5' flanking sequences of these genes indicate distinct regulations of gene expression for these four members of TM4SF...
  17. ncbi A single amino acid change at Leu-188 in the reverse transcriptase of HIV-2 and SIV renders them sensitive to non-nucleoside reverse transcriptase inhibitors
    Y Isaka
    Discovery Research Laboratories, Shionogi and Co. Ltd, Osaka, Japan
    Arch Virol 146:743-55. 2001
    ..Furthermore, the observed substitutions in RT of HIV-2 and SIVmac support the common mechanism of action of NNRTIs against HIV-1, HIV-2 and SIV...
  18. ncbi Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3
    M Kitaura
    Shionogi Institute for Medical Science, Osaka, Japan
    J Biol Chem 271:7725-30. 1996
    ....
  19. ncbi Identification of a highly specific surface marker of T-cell acute lymphoblastic leukemia and neuroblastoma as a new member of the transmembrane 4 superfamily
    S Takagi
    Shionogi Institute for Medical Science, Osaka, Japan
    Int J Cancer 61:706-15. 1995
    ..Like ME491, CO-029 and L6, TALLA-1 may be another TM4SF member behaving as a potential tumor-associated antigen...
  20. ncbi Identification of membrane antigen C33 recognized by monoclonal antibodies inhibitory to human T-cell leukemia virus type 1 (HTLV-1)-induced syncytium formation: altered glycosylation of C33 antigen in HTLV-1-positive T cells
    K Fukudome
    Shionogi Institute for Medical Science, Osaka, Japan
    J Virol 66:1394-401. 1992
    ..Therefore, C33 antigen has only N-linked carbohydrates, the modification of which appears to be substantially altered in the presence of the HTLV-1 genome...
  21. ncbi Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82
    T Imai
    Shionogi Institute for Medical Science, Osaka, Japan
    J Immunol 155:1229-39. 1995
    ..It is, therefore, suggested that CD4 exists at least in two physical states, one associated with p56lck and another associated with CD81 and CD82 in the absence or uncoupling of p56lck...
  22. ncbi Selective expression of liver and activation-regulated chemokine (LARC) in intestinal epithelium in mice and humans
    Y Tanaka
    Shionogi Institute for Medical Science, Osaka, Osaka Sayama, Japan
    Eur J Immunol 29:633-42. 1999
    ..Thus, in both humans and mice, LARC may be physiologically involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells toward epithelial cells...
  23. ncbi Aberrant expression of Fra-2 promotes CCR4 expression and cell proliferation in adult T-cell leukemia
    T Nakayama
    Department of Microbiology, Kinki University School of Medicine, Osaka, Japan
    Oncogene 27:3221-32. 2008
    ..As Fra-2, these proto-oncogenes were highly expressed in primary ATL cells but not in normal CD4+ T cells. Collectively, aberrantly expressed Fra-2 in association with JunD may play a major role in CCR4 expression and oncogenesis in ATL...
  24. ncbi Development of a sensitive enzyme-linked immunosorbent assay for eotaxin and measurement of its levels in human blood
    A Morita
    Diagnostic Science Division, Shionogi and Company, Settsu, Osaka, Japan
    J Immunol Methods 226:159-67. 1999
    ..Our new ELISA is an accurate and useful method for quantifying human eotaxin in blood and demonstrates that the process of preparing blood samples affects the measurement of the eotaxin levels...
  25. ncbi Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma
    T Nakayama
    Department of Bacteriology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    FEBS Lett 453:77-80. 1999
    ..By Northern blot analysis, N-copine and OS-9 were co-expressed in the same regions of human brain. These results reveal that OS-9 is a potential target of N-copine...
  26. ncbi Fractalkine-mediated endothelial cell injury by NK cells
    O Yoneda
    Department of Internal Medicine, Department of Periodontology, Osaka Dental University, Osaka, Japan
    J Immunol 164:4055-62. 2000
    ..Our results suggest that fractalkine plays an important role not only in the binding of NK cells to endothelial cells, but also in NK cell-mediated endothelium damage, which may result in vascular injury...
  27. ncbi Molecular cloning of a novel C or gamma type chemokine, SCM-1
    T Yoshida
    Shionogi Institute for Medical Science, Osaka, Japan
    FEBS Lett 360:155-9. 1995
    ..SCM-1 and lymphotactin may thus represent the human and murine prototypes of a novel C or gamma type chemokine family...
  28. ncbi Cutting edge: profile of chemokine receptor expression on human plasma cells accounts for their efficient recruitment to target tissues
    Takashi Nakayama
    Department of Microbiology, Kinki University School of Medicine, Osaka-Sayama, Osaka, Japan
    J Immunol 170:1136-40. 2003
    ..CXCR6 may also contribute to tissue localization of plasma cells through its direct binding to membrane-anchored CXCL16...
  29. ncbi Dopamine selectively induces migration and homing of naive CD8+ T cells via dopamine receptor D3
    Yoshiko Watanabe
    Department of Microbiology, Kinki University School of Medicine, Osaka-Sayama, Osaka, Japan
    J Immunol 176:848-56. 2006
    ..Collectively, naive CD8+ T cells selectively express D3 in both humans and mice, and dopamine plays a significant role in migration and homing of naive CD8+ T cells via D3...
  30. ncbi Selective induction of Th2-attracting chemokines CCL17 and CCL22 in human B cells by latent membrane protein 1 of Epstein-Barr virus
    Takashi Nakayama
    Department of Microbiology, Kinki University School of Medicine, Osaka Sayama, Osaka 589 8511, Japan
    J Virol 78:1665-74. 2004
    ....
  31. ncbi Expression of CCR9 in HTLV-1+ T cells and ATL cells expressing Tax
    Daisuke Nagakubo
    Department of Microbiology and SORST, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    Int J Cancer 120:1591-7. 2007
    ..Collectively, CCR9 is inducible in ATL cells expressing Tax and may play a role in the gastrointestinal involvement of ATL...
  32. ncbi Tax-inducible production of CC chemokine ligand 22 by human T cell leukemia virus type 1 (HTLV-1)-infected T cells promotes preferential transmission of HTLV-1 to CCR4-expressing CD4+ T cells
    Kunio Hieshima
    Department of Microbiology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    J Immunol 180:931-9. 2008
    ..Thus, HTLV-1-infected T cells produce CCL22 through Tax and selectively interact with CCR4+CD4+ T cells, resulting in preferential transmission of HTLV-1 to CCR4+CD4+ T cells...
  33. ncbi CC chemokine ligands 25 and 28 play essential roles in intestinal extravasation of IgA antibody-secreting cells
    Kunio Hieshima
    Department of Microbiology, Kinki University School of Medicine, Osaka, Japan
    J Immunol 173:3668-75. 2004
    ..Collectively, CCL25 and CCL28 play essential roles in intestinal homing of IgA ASCs primarily by mediating their extravasation into intestinal lamina propria...
  34. ncbi C33 antigen and M38 antigen recognized by monoclonal antibodies inhibitory to syncytium formation by human T cell leukemia virus type 1 are both members of the transmembrane 4 superfamily and associate with each other and with CD4 or CD8 in T cells
    T Imai
    Shionogi Institute for Medical Science, Osaka, Japan
    J Immunol 151:6470-81. 1993
    ..Furthermore, the regular association of C33 Ag and M38 Ag (TAPA-1) with CD4 or CD8 might indicate that they play a role in expression and/or function of the CD4/CD8 co-receptor complex...
  35. ncbi Corneal epithelial cells and stromal keratocytes efficently produce CC chemokine-ligand 20 (CCL20) and attract cells expressing its receptor CCR6 in mouse herpetic stromal keratitis
    Jumi Shirane
    Department of Ophthalmology, Kinki University School of Medicine, Osaka-Sayama, Osaka, Japan
    Curr Eye Res 28:297-306. 2004
    ..CONCLUSIONS: Not only epithelial cells but also stromal keratocytes are efficient producers of CCL20 in the cornea and recruit CCR6-expressing cells such as dendritic cells into inflamed cornea...
  36. ncbi C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63
    T Imai
    Shionogi Institute for Medical Science, Osaka, Japan
    J Immunol 149:2879-86. 1992
    ..PHA stimulation also induced the dramatic size changes in the N-linked sugars previously shown to accompany human T cell leukemia virus type 1-induced transformation of CD4+ T cells...
  37. ncbi Evidence for direct association of Vpr and matrix protein p17 within the HIV-1 virion
    A Sato
    Shionogi Institute for Medical Science, Osaka, Japan
    Virology 220:208-12. 1996
    ..Association of Vpr and the matrix protein p17 within the mature virion is consistent with their collaborative role in the nuclear transportation of the viral preintegration complex in nondividing cells such as macrophages...
  38. ncbi [Chemokine receptors and HIV-1 infection]
    Kunio Hieshima
    Department of Microbiology, Kinki University School of Medicine
    Nippon Rinsho 60:681-7. 2002
    ....
  39. ncbi CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity
    Kunio Hieshima
    Department of Microbiology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    J Immunol 170:1452-61. 2003
    ..Collectively, CCL28 may play dual roles in mucosal immunity as a chemoattractant for cells expressing CCR10 and/or CCR3 such as plasma cells and also as a broad-spectrum antimicrobial protein secreted into low-salt body fluids...
  40. ncbi Liver-expressed chemokine/CC chemokine ligand 16 attracts eosinophils by interacting with histamine H4 receptor
    Takashi Nakayama
    Department of Microbiology, Kinki University School of Medicine, Osaka, Japan
    J Immunol 173:2078-83. 2004
    ..Collectively, CCL16 is a novel functional ligand for H4 and may have a role in trafficking of eosinophils...
  41. ncbi [Role of chemokines and chemokine receptors in leukocyte trafficking]
    Osamu Yoshie
    Department of Microbiology, Kinki University School of Medicine
    Nippon Rinsho 63:437-43. 2005
  42. ncbi 1,25-dihydroxyvitamin D3 induces CCR10 expression in terminally differentiating human B cells
    Aiko Konno Shirakawa
    Department of Microbiology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    J Immunol 180:2786-95. 2008
    ..Furthermore, the human CCR10 promoter is cooperatively activated by Ets-1 and vitamin D receptor in the presence of 1,25-(OH)2D3...
  43. ncbi Human B cells immortalized with Epstein-Barr virus upregulate CCR6 and CCR10 and downregulate CXCR4 and CXCR5
    Takashi Nakayama
    Department of Microbiology, Kinki University School of Medicine, Osaka Sayama, Osaka 589 8511, Japan
    J Virol 76:3072-7. 2002
    ..EBV-associated opportunistic lymphomas also tend to occur in extranodal sites. These preferred sites of in vivo localization are consistent with the unique profile of chemokine receptor expression exhibited by EBV-immortalized B cells...
  44. ncbi Expression of CCL28 by Reed-Sternberg cells defines a major subtype of classical Hodgkin's disease with frequent infiltration of eosinophils and/or plasma cells
    Hitoshi Hanamoto
    Department of Hematology, Nephrology, and Rheumatology, Kinki University School of Medicine, Osaka-Sayama, Osaka, Japan
    Am J Pathol 164:997-1006. 2004
    ..The frequent expression of CCR10 in H-RS cells themselves also supports their close relationship to plasma cells...
  45. ncbi Expression of CCL17 and CCL22 by latent membrane protein 1-positive tumor cells in age-related Epstein-Barr virus-associated B-cell lymphoproliferative disorder
    Sumio Takegawa
    Department of Microbiology, Kinki University School of Medicine, Osaka Sayama, 589 8511, Japan
    Cancer Sci 99:296-302. 2008
    ..Collectively, our data show production of CCL17 and CCL22 by LMP1(+) large-sized tumor cells and accumulation of CCR4-expressing cells including regulatory T cells in ALPD...
  46. ncbi CXCR7 is inducible by HTLV-1 Tax and promotes growth and survival of HTLV-1-infected T cells
    Zhe Jin
    Department of Microbiology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    Int J Cancer 125:2229-35. 2009
    ..Taken together, CXCR7 is inducible by Tax and may play an important role in HTLV-1-induced immortalization of T cells by promoting growth and survival of HTLV-1-infected T cells...
  47. ncbi Novel antiviral activity of chemokines
    Takashi Nakayama
    Department of Microbiology, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan
    Virology 350:484-92. 2006
    ..Thus, some chemokines have a significant direct antiviral activity against HSV-1 in vitro and may have a potential role in host defense against HSV-1 as a direct antiviral agent...
  48. ncbi Distribution and kinetics of SR-PSOX/CXCL16 and CXCR6 expression on human dendritic cell subsets and CD4+ T cells
    Sumie Tabata
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan
    J Leukoc Biol 77:777-86. 2005
    ....
  49. ncbi Dual functions of fractalkine/CX3C ligand 1 in trafficking of perforin+/granzyme B+ cytotoxic effector lymphocytes that are defined by CX3CR1 expression
    Miyuki Nishimura
    KAN Research Institute, Kyoto, Japan
    J Immunol 168:6173-80. 2002
    ....
  50. ncbi Differential expression of CCL19 by DC-Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skin
    Fuminori Katou
    Department of Oral and Maxillofacial Surgery I, Tohoku University School of Dentistry, Sendai, Japan
    J Pathol 199:98-106. 2003
    ..In normal skin, on the other hand, no cells immunoreactive for CCL19, CCL21, or CCR7 were found. The present study thus reveals a striking difference in the function of mature DCs between LNs and chronically inflamed skin...
  51. ncbi Selective infiltration of CCR5(+)CXCR3(+) T lymphocytes in human colorectal carcinoma
    Hiroaki Musha
    Department of Surgery, Tohoku University School of Medicine, Japan
    Int J Cancer 116:949-56. 2005
    ....
  52. ncbi Survey of chemokine receptor expression reveals frequent co-expression of skin-homing CCR4 and CCR10 in adult T-cell leukemia/lymphoma
    Hitomi Harasawa
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Leuk Lymphoma 47:2163-73. 2006
    ..Collectively, the frequent co-expression of CCR4 and CCR10, the known pair of skin-homing chemokine receptors, may play an important role in ATLL invasion into the skin...
  53. ncbi RANKL-induced CCL22/macrophage-derived chemokine produced from osteoclasts potentially promotes the bone metastasis of lung cancer expressing its receptor CCR4
    Eliane Shizuka Nakamura
    Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama, Toyama, 930 0194, Japan
    Clin Exp Metastasis 23:9-18. 2006
    ..Collectively, these results suggest that osteoclasts may promote bone metastasis of cancer cells expressing CCR4 in the bone marrow by producing its ligand CCL22...
  54. ncbi Chemokines generally exhibit scavenger receptor activity through their receptor-binding domain
    Takeshi Shimaoka
    Graduate School of Biostudies and Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan
    J Biol Chem 279:26807-10. 2004
    ..Taken together, chemokines generally have scavenger receptor-like activity through their receptor-binding domain, suggesting a close evolutionary relationship between chemokines and scavenger receptors...
  55. ncbi Migration of CX3CR1-positive T cells producing type 1 cytokines and cytotoxic molecules into the synovium of patients with rheumatoid arthritis
    Toshihiro Nanki
    Department of Bioregulatory Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Arthritis Rheum 46:2878-83. 2002
    ..In this study, we examined the role of CX3CL1/fractalkine and its receptor CX3C chemokine receptor 1 (CX3CR1) in the T cell migration into RA synovium...
  56. ncbi Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus
    Tomoo Ueno
    Division of Experimental Immunology, Institute for Genome Research, The University of Tokushima and Laboratory of Immune System Development, RIKEN Research Center for Allergy and Immunology, 3 18 15 Kuramoto, 770 8503, Tokushima, Japan
    Immunity 16:205-18. 2002
    ..In the thymus, CCL19 is predominantly localized in the medulla including endothelial venules. These results indicate a CCL19- and CCR7-dependent pathway of thymic emigration, which represents a major pathway of neonatal T cell export...
  57. ncbi Fractalkine in vascular biology: from basic research to clinical disease
    Hisanori Umehara
    Department of Rheumatology and Clinical Immunology, Clinical Science for Pathological Organs, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Arterioscler Thromb Vasc Biol 24:34-40. 2004
    ....
  58. ncbi Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow
    Mika Shimonaka
    Bayer Chair, Dept of Molecular Immunology and Allergy, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 161:417-27. 2003
    ..Spa1 effectively suppressed this polarization after SLC treatment. This unique characteristic of Rap1 may control chemokine-induced lymphocyte extravasation...
  59. ncbi Cell surface-anchored SR-PSOX/CXC chemokine ligand 16 mediates firm adhesion of CXC chemokine receptor 6-expressing cells
    Takeshi Shimaoka
    Kyoto University, Shogoin Kawahara cho 53, Sakyo ku, Kyoto 606 8507, Japan
    J Leukoc Biol 75:267-74. 2004
    ..Thus, SR-PSOX/CXCL16 is a unique molecule that not only attracts T cells and NKT cells toward DCs but also supports their firm adhesion to DCs...
  60. ncbi Infiltration of CD8+ T cells containing RANTES/CCL5+ cytoplasmic granules in actively inflammatory lesions of human chronic gastritis
    Noriko Ohtani
    Department of Pathology, Tohoku University Graduate School of Medicine, Japan
    Lab Invest 84:368-75. 2004
    ..Our data also suggest a self-recruiting mechanism involving CCR5 and CCL5 for tissue accumulation of such T cells...
  61. ncbi NF-kappaB-mediated activation of the chemokine CCL22 by the product of the human cytomegalovirus gene UL144 escapes regulation by viral IE86
    Emma Poole
    Department of Medicine, Box 157, University of Cambridge, Level 5 Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, United Kingdom
    J Virol 82:4250-6. 2008
    ....
  62. ncbi Chemokine/chemokine receptor nomenclature
    Kevin Bacon
    J Interferon Cytokine Res 22:1067-8. 2002
  63. ncbi CCR7 mediates the migration of Foxp3+ regulatory T cells to the paracortical areas of peripheral lymph nodes through high endothelial venules
    Satoshi Ueha
    Department of Molecular Preventive Medicine and SORST, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Tokyo, Japan
    J Leukoc Biol 82:1230-8. 2007
    ..Taken together, these data provide the evidence that CCR7 mediates nTreg migration to the paracortical areas of lymph nodes under steady-state conditions; however, CCR7-independent migration also takes place in the medulla...
  64. ncbi Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists
    Akio Mori
    Clinical Research Center for Allergy and Rheumatology, National Sagamihara Hospital, 18 1 Sakuradai, Sagamihara, Kanagawa 228 8522, Japan
    Int Immunol 19:913-21. 2007
    ....
  65. ncbi CCL17 transgenic mice show an enhanced Th2-type response to both allergic and non-allergic stimuli
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Eur J Immunol 36:2116-27. 2006
    ..AD-like conditions such as increased number of mast cells and elevated levels of serum IgE were observed. Thus, CCL17 may participate in the pathogenesis of skin diseases such as AD by regulating both allergic and irritant inflammation...
  66. ncbi CCL27-transgenic mice show enhanced contact hypersensitivity to Th2, but not Th1 stimuli
    Shinji Kagami
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Eur J Immunol 38:647-57. 2008
    ..These results indicated that CCL27 modified inflammation by attracting CCR10-positive and CCR4-positive cells into the lesional skin, and may participate in the pathogenesis of Th2-shifted skin diseases such as atopic dermatitis...
  67. ncbi The chemokine and chemokine receptor superfamilies and their molecular evolution
    Albert Zlotnik
    Neurocrine Biosciences, Inc, Department of Molecular Medicine, 12790 El Camino Real, San Diego, CA 92130, USA
    Genome Biol 7:243. 2006
    ..This means that care needs to be taken when extrapolating experimental results on some chemokines from mouse to human...
  68. ncbi Antagonist of interferon-inducible protein 10/CXCL10 ameliorates the progression of autoimmune sialadenitis in MRL/lpr mice
    Hitoshi Hasegawa
    First Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan
    Arthritis Rheum 54:1174-83. 2006
    ..We undertook the present study to investigate the expression of chemokines during the development of autoimmune sialadenitis in MRL/lpr mice and the therapeutic effect of chemokine antagonists on sialadenitis...
  69. ncbi Altered expression of Th1-type chemokine receptor CXCR3 on CD4+ T cells in myasthenia gravis patients
    Yasushi Suzuki
    Department of Neurology, Tohoku University School of Medicine, and Division of Thoracic and Cardiovascular Surgery, Sendai National Hospital, Japan
    J Neuroimmunol 172:166-74. 2006
    ..The slow clinical improvement of MG symptoms after treatment may be explained partly by the gradual normalization of CXCR3-mediated signaling...
  70. ncbi Variations in the human Th2-specific chemokine TARC gene
    Takashi Sekiya
    Department of Allergy and Rheumatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Immunogenetics 54:742-5. 2003
    ..However, when the genotypes at the SNP site were determined for 158 healthy individuals, 105 patients with BA and 148 patients with AD, we observed no significant association of the SNP with susceptibility to BA or AD...
  71. ncbi Comparative DNA sequence analysis of mouse and human CC chemokine gene clusters
    Hisayuki Nomiyama
    Department of Biochemistry, Kumamoto University Medical School, Honjo, Kumamoto 860 0811, Japan
    J Interferon Cytokine Res 23:37-45. 2003
    ..In addition, phylogenetic analysis and comparison of the genomic sequences unambiguously identified the orthologous relationships of some of the chemokine genes in the mouse and human CC gene clusters...
  72. ncbi Infiltrating CD8+ T cells in oral lichen planus predominantly express CCR5 and CXCR3 and carry respective chemokine ligands RANTES/CCL5 and IP-10/CXCL10 in their cytolytic granules: a potential self-recruiting mechanism
    Wakana Iijima
    Division of Oral Diagnosis and Radiology, Tohoku University Graduate School of Dentistry, Sendai, Japan
    Am J Pathol 163:261-8. 2003
    ..Furthermore, the presence of CCL5 and CXCL10 in the cytolytic granules of tissue-infiltrating CD8(+) T cells expressing CCR5 and CXCR3 reveals a potential self-recruiting mechanism involving activated effector cytotoxic T cells...
  73. ncbi Antitumor effect by interleukin-11 receptor alpha-locus chemokine/CCL27, introduced into tumor cells through a recombinant adenovirus vector
    Jian-Qing Gao
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan
    Cancer Res 63:4420-5. 2003
    ..Furthermore, mFKN appeared to have an angiogenic activity, which might have masked its tumor suppressive activity. Collectively, ILC/CCL27 may be a good candidate molecule for cancer gene therapy...
  74. ncbi IFN-gamma-inducible expression of thymus and activation-regulated chemokine/CCL17 and macrophage-derived chemokine/CCL22 in epidermal keratinocytes and their roles in atopic dermatitis
    Tatsuya Horikawa
    Division of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan
    Int Immunol 14:767-73. 2002
    ....
  75. ncbi Concerted expression of eotaxin-1, eotaxin-2, and eotaxin-3 in human bronchial epithelial cells
    Akiko Komiya
    Department of Allergy and Rheumatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    Cell Immunol 225:91-100. 2003
    ..In addition to eotaxin-1 expression, but also eotaxin-2 and eotaxin-3 expression in the bronchial epithelium should be taken into consideration when developing the therapeutic strategies to treat eosinophilic airway diseases...
  76. ncbi Chondroitin sulfate B exerts its inhibitory effect on secondary lymphoid tissue chemokine (SLC) by binding to the C-terminus of SLC
    Jun Hirose
    Molecular and Cellular Recognition, Osaka University Graduate School of Medicine C8, 2-2, Yamada-oka, Suita, Osaka 565-0871, Japan
    Biochim Biophys Acta 1571:219-24. 2002
    ....
  77. ncbi Anti-tumor activity of chemokine is affected by both kinds of tumors and the activation state of the host's immune system: implications for chemokine-based cancer immunotherapy
    Naoki Okada
    Department of Biopharmaceutics, Kyoto Pharmaceutical University, 5 Nakauchi cho, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Biochem Biophys Res Commun 317:68-76. 2004
    ..Altogether, our results suggest that the tumor-suppressive activity of chemokine-gene immunotherapy is greatly influenced by the kind of tumor and the activation state of the host's immune system...
  78. ncbi RANKL-induced DC-STAMP is essential for osteoclastogenesis
    Toshio Kukita
    Division of Oral Biological Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
    J Exp Med 200:941-6. 2004
    ..Furthermore, DC-STAMP directly induced the expression of the osteoclast marker tartrate-resistant acid phosphatase. These data demonstrate for the first time that DC-STAMP has an essential role in osteoclastogenesis...
  79. ncbi Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus
    Takako Hirata
    Laboratory of Molecular and Cellular Recognition, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Biol Chem 279:51775-82. 2004
    ..2 cells resulted in reduced chemotaxis to CCL27. These findings suggest a role for PSGL-1 in regulating chemokine-mediated responses, in addition to its role as a selectin ligand...
  80. ncbi Accumulation of CCR5+ T cells around RANTES+ granulomas in Crohn's disease: a pivotal site of Th1-shifted immune response?
    Motoji Oki
    Department of Internal Medicine Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Lab Invest 85:137-45. 2005
    ..Together with the notion that granuloma cells are possible antigen-presenting cells, our results suggest that the noncaseating granulomas could be one of the crucial sites of Th1-shifted immune responses in Crohn's disease...
  81. ncbi Identification of genes differentially expressed in osteoclast-like cells
    Hisayuki Nomiyama
    Department of Molecular Enzymology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860 8556, Japan
    J Interferon Cytokine Res 25:227-31. 2005
    ..Characterization of these inducible genes will provide an insight into the biology of osteoclasts and the mechanism of bone-related diseases...
  82. ncbi Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: impact on cell motility
    Sabine Gesierich
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, University of Heidelberg, Heidelberg, Germany
    Clin Cancer Res 11:2840-52. 2005
    ..CONCLUSION: alpha6beta4 is selectively up-regulated in pancreatic and colorectal cancer. The association of alpha6beta4 with CD151 and CO-029 correlates with increased tumor cell motility...
  83. ncbi Anti-tumor responses induced by chemokine CCL19 transfected into an ovarian carcinoma model via fiber-mutant adenovirus vector
    Jian-Qing Gao
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University, Japan
    Biol Pharm Bull 28:1066-70. 2005
    ....
  84. ncbi Identification of cutaneous lymphocyte-associated antigen as sialyl 6-sulfo Lewis X, a selectin ligand expressed on a subset of skin-homing helper memory T cells
    Katsuyuki Ohmori
    Department of Clinical Pathology, Kyoto University School of Medicine, Japan
    Blood 107:3197-204. 2006
    ..We propose that CLA, which is expressed without any activation stimuli on peripheral skin-homing helper memory T cells in healthy persons, is at least partly the sialyl 6-sulfo Le(x) determinant...
  85. ncbi Antagonist of monocyte chemoattractant protein 1 ameliorates the initiation and progression of lupus nephritis and renal vasculitis in MRL/lpr mice
    Hitoshi Hasegawa
    First Department of Internal Medicine, Ehime University School of Medicine, Shigenobu, Ehime, Japan
    Arthritis Rheum 48:2555-66. 2003
    ..To examine whether chemokine antagonists inhibit the initiation and progression of lupus nephritis in MRL/lpr mice...
  86. ncbi Presence of high contents of thymus and activation-regulated chemokine in platelets and elevated plasma levels of thymus and activation-regulated chemokine and macrophage-derived chemokine in patients with atopic dermatitis
    Takao Fujisawa
    Department of Pediatrics and Allergy, National Mie Hospital, Tsu, Japan
    J Allergy Clin Immunol 110:139-46. 2002
    ..Thus platelets might play an important role in AD pathogenesis by releasing T(H)2-attracting TARC on activation. Furthermore, circulating levels of TARC and MDC, but not those of eotaxin, correlate well with the disease activity of AD...