Kiyotaka Okuno

Summary

Affiliation: Kinki University
Country: Japan

Publications

  1. ncbi request reprint Recent advances in active specific cancer vaccine treatment for colorectal cancer
    Kiyotaka Okuno
    Department of Surgery, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama 589 8511, Japan
    Curr Pharm Biotechnol 13:1439-45. 2012
  2. ncbi request reprint Pylorotomy in pylorus-preserving pancreaticoduodenectomy
    Takuya Nakai
    First Department of Surgery, Kinki University School of Medicine, Osaka, Japan
    Hepatogastroenterology 53:947-9. 2006
  3. ncbi request reprint Clinical trial of a 7-Peptide cocktail vaccine with oral chemotherapy for patients with metastatic colorectal cancer
    Kiyotaka Okuno
    Department of Surgery, Kinki University Faculty of Medicine, Osaka Sayama, Osaka, Japan
    Anticancer Res 34:3045-52. 2014
  4. pmc Cancer classification using the Immunoscore: a worldwide task force
    Jerome Galon
    INSERM, U872, Laboratory of Integrative Cancer Immunology, Paris, F 75006, France
    J Transl Med 10:205. 2012
  5. ncbi request reprint Surgical treatment for digestive cancer. Current issues - colon cancer
    Kiyotaka Okuno
    Division of Colorectal Surgery, Department of Surgery, Kinki University School of Medicine, Osaka Sayama, Japan
    Dig Surg 24:108-14. 2007
  6. doi request reprint Prognostic factors in gastrointestinal perforation
    Kiyotaka Okuno
    Department of Surgery, Kinki University School of Medicine, Osaka Sayama, Japan
    Hepatogastroenterology 58:1598-602. 2011
  7. ncbi request reprint Efficacy of orally administered Lentinula edodes mycelia extract for advanced gastrointestinal cancer patients undergoing cancer chemotherapy: a pilot study
    Kiyotaka Okuno
    Department of Surgery, Kinki University School of Medicine, Osaka, Japan
    Asian Pac J Cancer Prev 12:1671-4. 2011
  8. ncbi request reprint Comparison of long-term functional results of colonic J-pouch and straight anastomosis after low anterior resection for rectal cancer: a five-year follow-up
    Jin ichi Hida
    First Department of Surgery, Kinki University School of Medicine, Osaka, Japan
    Dis Colon Rectum 47:1578-85. 2004
  9. ncbi request reprint Long-term functional outcome of colonic J-pouch reconstruction after low anterior resection for rectal cancer
    Jin ichi Hida
    Department of Surgery, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    Surg Today 36:441-9. 2006
  10. ncbi request reprint Long-term functional changes after low anterior resection for rectal cancer compared between a colonic J-pouch and a straight anastomosis
    Jin ichi Hida
    Department of Surgery, Kinki University School of Medicine, 377 2, Ohno Higashi, Osaka Sayama Osaka 589 8511, Japan
    Hepatogastroenterology 54:407-13. 2007

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Recent advances in active specific cancer vaccine treatment for colorectal cancer
    Kiyotaka Okuno
    Department of Surgery, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama 589 8511, Japan
    Curr Pharm Biotechnol 13:1439-45. 2012
    ..The preliminary study yielded promising results regarding specific T cell responses to peptides and survival benefits. In this review, we summarize these results and discuss future perspectives...
  2. ncbi request reprint Pylorotomy in pylorus-preserving pancreaticoduodenectomy
    Takuya Nakai
    First Department of Surgery, Kinki University School of Medicine, Osaka, Japan
    Hepatogastroenterology 53:947-9. 2006
    ..The incidence of delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy has been reported to be 30% to 70%...
  3. ncbi request reprint Clinical trial of a 7-Peptide cocktail vaccine with oral chemotherapy for patients with metastatic colorectal cancer
    Kiyotaka Okuno
    Department of Surgery, Kinki University Faculty of Medicine, Osaka Sayama, Osaka, Japan
    Anticancer Res 34:3045-52. 2014
    ..Conclusion: A 7-peptide vaccine used with UFT/LV is safe and is recommended for further trials in patients with metastatic colorectal cancer. ..
  4. pmc Cancer classification using the Immunoscore: a worldwide task force
    Jerome Galon
    INSERM, U872, Laboratory of Integrative Cancer Immunology, Paris, F 75006, France
    J Transl Med 10:205. 2012
    ..The results of this international validation may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM-I (TNM-Immune)...
  5. ncbi request reprint Surgical treatment for digestive cancer. Current issues - colon cancer
    Kiyotaka Okuno
    Division of Colorectal Surgery, Department of Surgery, Kinki University School of Medicine, Osaka Sayama, Japan
    Dig Surg 24:108-14. 2007
    ..5 times in the last 25 years. In this review, the recent results of surgical treatment for colonic cancer and the future perspectives in Japan are described...
  6. doi request reprint Prognostic factors in gastrointestinal perforation
    Kiyotaka Okuno
    Department of Surgery, Kinki University School of Medicine, Osaka Sayama, Japan
    Hepatogastroenterology 58:1598-602. 2011
    ..Postoperative complications associated with gastrointestinal (GI) perforation may lead to a poor prognosis. The goal of the study was to identify factors required for the establishment of appropriate perioperative procedures in such cases...
  7. ncbi request reprint Efficacy of orally administered Lentinula edodes mycelia extract for advanced gastrointestinal cancer patients undergoing cancer chemotherapy: a pilot study
    Kiyotaka Okuno
    Department of Surgery, Kinki University School of Medicine, Osaka, Japan
    Asian Pac J Cancer Prev 12:1671-4. 2011
    ..These results suggest that concomitant use of LEM with chemotherapy can decrease the incidence of adverse effects from cancer chemotherapy among patients with advanced cancer...
  8. ncbi request reprint Comparison of long-term functional results of colonic J-pouch and straight anastomosis after low anterior resection for rectal cancer: a five-year follow-up
    Jin ichi Hida
    First Department of Surgery, Kinki University School of Medicine, Osaka, Japan
    Dis Colon Rectum 47:1578-85. 2004
    ..This prospective study compares the functional outcome of colonic J-pouch and straight anastomosis five years after low anterior resection for rectal cancer...
  9. ncbi request reprint Long-term functional outcome of colonic J-pouch reconstruction after low anterior resection for rectal cancer
    Jin ichi Hida
    Department of Surgery, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    Surg Today 36:441-9. 2006
    ..To evaluate the long-term functional outcome of colonic J-pouch reconstruction after low anterior resection (LAR) for rectal cancer in a prospective study...
  10. ncbi request reprint Long-term functional changes after low anterior resection for rectal cancer compared between a colonic J-pouch and a straight anastomosis
    Jin ichi Hida
    Department of Surgery, Kinki University School of Medicine, 377 2, Ohno Higashi, Osaka Sayama Osaka 589 8511, Japan
    Hepatogastroenterology 54:407-13. 2007
    ..We prospectively compared changes in function between colonic J-pouch and straight anastomoses from 1 to 5 years after low anterior resection for rectal cancer...
  11. ncbi request reprint Number versus distribution in classifying regional lymph node metastases from colon cancer
    Jin ichi Hida
    Department of Surgery, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    J Am Coll Surg 201:217-22. 2005
    ..In the Japanese General Rules for Clinical and Pathologic Studies on Cancer of the Colon, Rectum, and Anus (JGR), node metastases are classified into four grades based on the distribution of metastatic nodes...
  12. ncbi request reprint Depth of mesorectal invasion has prognostic significance in T3N0 low rectal cancer
    Tadao Tokoro
    Department of Surgery, Kinki University School of Medicine, 377 2 Oohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Hepatogastroenterology 56:124-7. 2009
    ..To investigate mesorectal fat invasion as a prognostic factor for T3N0 low rectal adenocarcinoma following sharp mesorectal excision...
  13. ncbi request reprint Optimal ligation level of the primary feeding artery and bowel resection margin in colon cancer surgery: the influence of the site of the primary feeding artery
    Jin ichi Hida
    Department of Surgery, Kinki University School of Medicine, Osaka, Japan
    Dis Colon Rectum 48:2232-7. 2005
    ..However, there is little evidence to unequivocally support such extensive lymphovascular resection...
  14. pmc Analysis of the clinical factors associated with anal function after intersphincteric resection for very low rectal cancer
    Tadao Tokoro
    Department of Surgery, Kinki University, Faculty of Medicine, Osaka Sayama, Osaka, Japan
    World J Surg Oncol 11:24. 2013
    ..Intersphincteric resection (ISR) has been used to avoid permanent colostomy in very low rectal cancer patients. This study aimed to assess the surgical safety and oncologic and functional outcomes of ISR...
  15. doi request reprint Immunological evaluation of personalized peptide vaccination in combination with UFT and UZEL for metastatic colorectal carcinoma patients
    Takashi Hattori
    Department of Surgery, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Cancer Immunol Immunother 58:1843-52. 2009
    ..0215). The safety and immunological responsiveness of the present therapy suggest that this combination would be of clinical benefit for mCRC patients, and further trials are merited...
  16. ncbi request reprint Long-term functional outcome of low anterior resection with colonic J-pouch reconstruction for rectal cancer in the elderly
    Jin ichi Hida
    First Department of Surgery, Kinki University School of Medicine, Osaka, Japan
    Dis Colon Rectum 47:1448-54. 2004
    ..This study evaluated the function of colonic J-pouch reconstruction in elderly patients aged 75 years or older...
  17. doi request reprint Histogenesis and prognostic value of myenteric spread in colorectal cancer: a Japanese multi-institutional study
    Hideki Ueno
    Department of Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, 359 8513, Japan
    J Gastroenterol 49:400-7. 2014
    ..The histogenesis of the pattern of cancer spread along Auerbach's plexus (myenteric spread: MS) remains unclear and its prognostic value in colorectal cancer (CRC) has not been thoroughly investigated...
  18. ncbi request reprint Osteopontin induced by macrophages contribute to metachronous liver metastases in colorectal cancer
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, Ohno Higashi Osaka Sayama, Osaka, Japan
    Am Surg 77:1515-20. 2011
    ..31, m-LV 28.2 ± 3.18, P < 0.05). These results suggest that the risk of metachronous liver metastasis could be well predicted by immunohistochemical staining of OPN in the central areas, and CD68 in the invasive margins of tumors...
  19. doi request reprint Unresectable colorectal liver metastases: the safety and efficacy of conversion therapy using hepatic arterial infusion immunochemotherapy with 5-fluorouracil and polyethylene glycol-interferon α-2a
    Takuya Nakai
    Department of Surgery, Faculty of Medicine, Kinki University, 377 2 Ohno Higashi, Osaka Sayama, 589 8511 Osaka, Japan
    World J Surg 37:1919-26. 2013
    ..The purpose of this study was to investigate the safety and efficacy of conversion therapy following HAI immunochemotherapy...
  20. doi request reprint High ligation of the inferior mesenteric artery in rectal cancer surgery
    Jin ichi Hida
    Department of Surgery, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Surg Today 43:8-19. 2013
    ....
  21. ncbi request reprint [General considerations in nodule-aggregating lesions of the colon]
    Tadao Tokoro
    Department of Surgery, Kinki University School of Medicine
    Nihon Rinsho 61:282-5. 2003
  22. ncbi request reprint Role of sialyl Lewis X in liver metastasis in view of liver-associated immunity
    Kiyotaka Okuno
    First Department of Surgery, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama 589 8511, Japan
    Hepatogastroenterology 50:756-60. 2003
    ..However, little is known about the interaction between sialyl Lewis X and hepatic immune cells. We evaluated the role of sialyl Lewis X in liver metastasis in view of liver-associated immunity...
  23. ncbi request reprint An immunohistochemical study of osteopontin in pigment gallstone formation
    Motohiro Imano
    Department of Surgery, Kinki University School of Medicine, Osaka, Japan
    Am Surg 76:91-5. 2010
    ..Our results indicate that Opn, an acidic glycoprotein from the gallbladder epithelium, seems to be involved in lithiasis. Opn from macrophages and/or the epithelium seems to help form the matrix protein...
  24. ncbi request reprint Effect of chemoradiotherapy for neural invasion in an advanced esophageal cancer
    Akira Tanaka
    Surgery, Sakai Hospital, School of Medicine, Kinki University, Sakai, Osaka 590 0132, Japan
    Hepatogastroenterology 55:963-6. 2008
    ..This study examined utility of chemoradiotherapy for neural invasion, a risk factor for local recurrence, and a poor prognosis factor...
  25. doi request reprint Characterization of perineural invasion as a component of colorectal cancer staging
    Hideki Ueno
    Departments of Surgery Laboratory Medicine Laboratory for Mathematics, National Defense Medical College, Tokorozawa Department of Surgery, Kurume University Faculty of Medicine, Kurume Departments of Human Pathology Surgery, Tokyo Medical and Dental University Department of Pathology, National Cancer Center Hospital Department of Pathology, Jikei University School of Medicine, Tokyo Department of Surgery, Coloproctology Center, Takano Hospital, Kumamoto Department of Surgery, Keiyukai Sappro Hospital, Sapporo Department of Surgery, Hirosaki University School of Medicine, Hirosaki Department of Surgery, Kinki University School of Medicine, Osakasayama Department of Surgery, Yamagata Prefectural Central Hospital, Yamagata Division of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Sciences, Course for Molecular and Cellular Medicine, Niigata University, Niigata Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Am J Surg Pathol 37:1542-9. 2013
    ..The value of cancer staging could be enhanced by PN assessment using site-specific criteria and a simple grading system based on PN location within the bowel. ..
  26. ncbi request reprint [Japanese General Rules and TNM System in the regional lymph node classification of colon cancer]
    Jin ichi Hida
    Department of Surgery, Kinki University School of Medicine
    Nihon Rinsho 61:262-8. 2003
  27. doi request reprint Pouch operation for rectal cancer
    Jin ichi Hida
    Department of Surgery, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    Surg Today 40:307-14. 2010
    ..At a time when the indications for abdominoperineal excision appear to be reduced for low rectal cancer, the demand for colonic J-pouch reconstruction (the best technique in pouch operations) is therefore likely to increase...
  28. doi request reprint Treatment strategies for gastric cancer patients with peritoneal metastasis
    Motohiro Imano
    Surgery Department, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    Surg Today 44:399-404. 2014
    ..Although catumaxomab and intraperitoneally administered paclitaxel are not generally used in Japan at present, these treatment strategies might therefore be effectively used in Japan in the near future. ..
  29. pmc Gene amplification of EGFR, HER2, FGFR2 and MET in esophageal squamous cell carcinoma
    Hiroaki Kato
    Department of Surgery, Kinki University Faculty of Medicine, Osaka 589 8511, Japan
    Int J Oncol 42:1151-8. 2013
    ..In conclusion, the frequent gene amplification of EGFR, HER2 and FGFR2 and the presence of active EGFR mutations were observed in ESCC specimens. Our results strongly encourage the development of molecular targeted therapy for ESCC...
  30. ncbi request reprint Clinical characteristics of hepatitis B core antibody-positive hepatocellular carcinoma
    Takuya Nakai
    First Department of Surgery, Kinki University School of Medicine, 377 2, Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    World J Surg 26:700-3. 2002
    ..Although HBsAg and HCVAb are used for conventional screening of patients with hepatic disorders, we believe that screening is also necessary in patients with positive HBcAb titers for early detection of HCC...
  31. ncbi request reprint Ability of bivariate cytokeratin and deoxyribonucleic acid flow cytometry to determine the biologic aggressiveness of resectable non-small cell lung cancer
    Hiroshi Otsuka
    First Department of Surgery, Kinki University School of Medicine, 377 2 Ohnogashi, Osaka Sayama, Osaka 589 8511, Japan
    J Thorac Cardiovasc Surg 124:293-8. 2002
    ..The purpose of this study was to clarify the significance of bivariate cytokeratin and DNA flow cytometry for analysis of the biologic aggressiveness of resectable non-small cell lung cancer...
  32. ncbi request reprint A series of immune responses leading to the induction of T cell IL-12/IL-18 responsiveness in patients with relatively large tumor burdens
    Kazuko Uno
    Louis Pasteur Center for Medical Research, 103 5, Tanaka monzen cho, Sakyo ku, Kyoto, Kyoto 606 8225, Japan
    Cancer Immunol Immunother 52:33-40. 2003
    ....
  33. ncbi request reprint [Intracellular glutathione (GSH) of monocytes (Mo) directs the development of peritumoral stroma in patients with colon carcinoma]
    Tomohiko Matsuzaki
    Dept of Surgery, Kinki University School of Medicine
    Gan To Kagaku Ryoho 32:1537-9. 2005
    ..We examined the feasibility of predicting stromal growth by measuring the glutathione (GSH) level in monocytes as an indicator of the local redox state of cancer, reflecting anti-tumor immune responses...
  34. ncbi request reprint [A phase I study of combination-therapy using personalized peptide vaccine and UFT/UZEL for advanced or recurrent colorectal cancer]
    Takashi Hattori
    Dept of Surgery, Kinki University School of Medicine
    Gan To Kagaku Ryoho 33:1745-7. 2006
    ..Moreover, the use of UFT/UZEL does not normally interfere with the normal course of immune-therapy...