Naoshi Nishida

Summary

Affiliation: Kinki University
Country: Japan

Publications

  1. doi request reprint Gender differences in the livers of patients with hepatocellular carcinoma and chronic hepatitis C infection
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Faculty of Medicine, Kinki University, 377 2 Ohno Higashi, Osaka Sayama, Osaka, Japan
    Dig Dis 30:547-53. 2012
  2. doi request reprint Recent advancements in comprehensive genetic analyses for human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan
    Oncology 84:93-7. 2013
  3. ncbi request reprint Genome-wide semiquantitative microsatellite analysis of human hepatocellular carcinoma: discrete mapping of smallest region of overlap of recurrent chromosomal gains and losses
    Takafumi Nishimura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Cancer Genet Cytogenet 167:57-65. 2006
  4. doi request reprint Reactive oxygen species induce epigenetic instability through the formation of 8-hydroxydeoxyguanosine in human hepatocarcinogenesis
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osakasayama, Japan
    Dig Dis 31:459-66. 2013
  5. ncbi request reprint Discrete breakpoint mapping and shortest region of overlap of chromosome arm 1q gain and 1p loss in human hepatocellular carcinoma detected by semiquantitative microsatellite analysis
    Takafumi Nishimura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Genes Chromosomes Cancer 42:34-43. 2005
  6. pmc Unique association between global DNA hypomethylation and chromosomal alterations in human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 8:e72312. 2013
  7. doi request reprint Quantification of tumor DNA in serum and vascular invasion of human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan naoshi med kindai ac jp
    Oncology 84:82-7. 2013
  8. doi request reprint Usefulness of contrast-enhanced ultrasonography to evaluate the post-treatment responses of radiofrequency ablation for hepatocellular carcinoma: comparison with dynamic CT
    Tatsuo Inoue
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan
    Oncology 84:51-7. 2013
  9. doi request reprint Hypothermia protects against fulminant hepatitis in mice by reducing reactive oxygen species production
    Toshiharu Sakurai
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osakasayama, Japan
    Dig Dis 31:440-6. 2013
  10. doi request reprint Expression of E-cadherin and vascular endothelial growth factor in noncancerous liver is associated with recurrence of hepatocellular carcinoma after curative resection
    Mutsuko Minata
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Oncology 84:88-92. 2013

Collaborators

Detail Information

Publications42

  1. doi request reprint Gender differences in the livers of patients with hepatocellular carcinoma and chronic hepatitis C infection
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Faculty of Medicine, Kinki University, 377 2 Ohno Higashi, Osaka Sayama, Osaka, Japan
    Dig Dis 30:547-53. 2012
    ..To determine the specific factors that contribute to a male predominance, we analyzed the clinicopathological factors, and genetic and epigenetic alterations of HCCs in male and female patients...
  2. doi request reprint Recent advancements in comprehensive genetic analyses for human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan
    Oncology 84:93-7. 2013
    ..Such analyses will clarify how this malignancy can be treated, diagnosed and prevented more effectively...
  3. ncbi request reprint Genome-wide semiquantitative microsatellite analysis of human hepatocellular carcinoma: discrete mapping of smallest region of overlap of recurrent chromosomal gains and losses
    Takafumi Nishimura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Cancer Genet Cytogenet 167:57-65. 2006
    ..Although some putative oncogenes or tumor suppressor genes mapped in these SRO may be important, relative copy number changes of numerous other genes may affect pathogenesis of HCC...
  4. doi request reprint Reactive oxygen species induce epigenetic instability through the formation of 8-hydroxydeoxyguanosine in human hepatocarcinogenesis
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osakasayama, Japan
    Dig Dis 31:459-66. 2013
    ..We conclude that oxidative stress alters the chromatin status, which leads to abnormal methylation of TSGs, and contributes to hepatocarcinogenesis in CHC patients...
  5. ncbi request reprint Discrete breakpoint mapping and shortest region of overlap of chromosome arm 1q gain and 1p loss in human hepatocellular carcinoma detected by semiquantitative microsatellite analysis
    Takafumi Nishimura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Genes Chromosomes Cancer 42:34-43. 2005
    ..32-p36.22, 5.1 Mb). Four known putative tumor-suppressor genes (TP73, RIZ1, NBL1/DAN, and CDKN2C) were outside the SRO, suggesting the presence of other candidate genes with critical roles in hepatocarcinogenesis...
  6. pmc Unique association between global DNA hypomethylation and chromosomal alterations in human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 8:e72312. 2013
    ..0011, well-differentiated; p=0.0089, moderately/poorly-differentiated HCCs). We conclude that DNA hypomethylation is an important cause of CIN in the earliest step of HCC, especially in a background of non-cirrhotic liver...
  7. doi request reprint Quantification of tumor DNA in serum and vascular invasion of human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan naoshi med kindai ac jp
    Oncology 84:82-7. 2013
    ..Accurate diagnosis of tumor progression is critical for the appropriate management of HCC. Here, we established a sensitive assay to detect and quantify tumor-derived DNA in the serum of HCC patients...
  8. doi request reprint Usefulness of contrast-enhanced ultrasonography to evaluate the post-treatment responses of radiofrequency ablation for hepatocellular carcinoma: comparison with dynamic CT
    Tatsuo Inoue
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan
    Oncology 84:51-7. 2013
    ..Local recurrence rate was used as the gold standard of evaluation...
  9. doi request reprint Hypothermia protects against fulminant hepatitis in mice by reducing reactive oxygen species production
    Toshiharu Sakurai
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osakasayama, Japan
    Dig Dis 31:440-6. 2013
    ..Although cold-inducible RNA-binding protein (CIRP) contributes to the protective effects of hypothermia through extracellular signal-regulated kinase activation in fibroblasts, the effects of hypothermia in the liver remain unclear...
  10. doi request reprint Expression of E-cadherin and vascular endothelial growth factor in noncancerous liver is associated with recurrence of hepatocellular carcinoma after curative resection
    Mutsuko Minata
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Oncology 84:88-92. 2013
    ..The purpose of this study was to examine how background liver affects postoperative recurrence of HCC that underwent curative resection using expression of cancer-related molecules in the adjacent noncancerous liver of HCC patients...
  11. ncbi request reprint Genotype stability and clonal evolution of hepatocellular carcinoma assessed by autopsy-based genome-wide microsatellite analysis
    Takafumi Nishimura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Cancer Genet Cytogenet 161:164-9. 2005
    ..In conclusion, clonal evolution of the HCC cells during metastatic progression seems rare, in contrast to many recurrent chromosomal aberrations that may have accumulated before the clinical manifestation...
  12. doi request reprint Validation of the criteria of transcatheter arterial chemoembolization failure or refractoriness in patients with advanced hepatocellular carcinoma proposed by the LCSGJ
    Tadaaki Arizumi
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Oncology 87:32-6. 2014
    ..The study evaluated the validity of the definition of TACE failure or refractoriness as proposed by the Liver Cancer Study Group of Japan (LCSGJ) through a retrospective analysis of sorafenib treatment...
  13. pmc Cold-inducible RNA-binding protein promotes the development of liver cancer
    Toshiharu Sakurai
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan
    Cancer Sci 106:352-8. 2015
    ..Intriguingly, the risk of human HCC recurrence is positively correlated with Cirp expression in liver. Cirp appears to play a critical carcinogenic function and its expression might be a useful biomarker for HCC risk prediction. ..
  14. doi request reprint Ultrasound elastography correlates treatment response by antiviral therapy in patients with chronic hepatitis C
    Norihisa Yada
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Oncology 87:118-23. 2014
    ..To investigate the relationship between tissue elasticity before and after antiviral therapy and shear wave as well as strain elastography...
  15. doi request reprint Identification of epigenetically inactivated genes in human hepatocellular carcinoma by integrative analyses of methylation profiling and pharmacological unmasking
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan
    Dig Dis 32:740-6. 2014
    ..This study identifies potential TSGs in HCCs using methylation profiling and pharmacological unmasking of methylated TSGs...
  16. doi request reprint Decreased blood flow after sorafenib administration is an imaging biomarker to predict overall survival in patients with advanced hepatocellular carcinoma
    Tadaaki Arizumi
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan
    Dig Dis 32:733-9. 2014
    ..We retrospectively evaluated the association between decreased blood flow and the overall survival (OS) of HCC patients after the initiation of sorafenib therapy...
  17. ncbi request reprint Comprehensive allelotyping of well-differentiated human hepatocellular carcinoma with semiquantitative determination of chromosomal gain or loss
    Takafumi Nishimura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Genes Chromosomes Cancer 35:329-39. 2002
    ..On the other hand, deletions of 13q and 16q were infrequent and were seen only in the most aberrant cases, which suggested that these were late events...
  18. doi request reprint Combination guidance of contrast-enhanced US and fusion imaging in radiofrequency ablation for hepatocellular carcinoma with poor conspicuity on contrast-enhanced US/fusion imaging
    Tomohiro Minami
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Oncology 87:55-62. 2014
    ....
  19. pmc Comparison of systems for assessment of post-therapeutic response to sorafenib for hepatocellular carcinoma
    Tadaaki Arizumi
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    J Gastroenterol 49:1578-87. 2014
    ..1) and modified RECIST (mRECIST), provides for more accurate evaluation of response of patients with hepatocellular carcinoma (HCC) to treatment with sorafenib, a molecularly targeted agent, as assessed by overall survival (OS)...
  20. doi request reprint Heat shock protein A4 controls cell migration and gastric ulcer healing
    Toshiharu Sakurai
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    Dig Dis Sci 60:850-7. 2015
    ..Here, we assessed the involvement of HSPA4 in gastric ulcer healing by using fibroblasts from wild-type and HSPA4-deficient mice, a murine gastric ulcer model, and samples from 65 patients with gastric cancer...
  21. doi request reprint Duration of stable disease is associated with overall survival in patients with advanced hepatocellular carcinoma treated with sorafenib
    Tadaaki Arizumi
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan
    Dig Dis 32:705-10. 2014
    ..This study aimed to clarify the correlation between SD periods and OS in patients with HCC treated with sorafenib...
  22. doi request reprint Impact of peginterferon alpha-2b and entecavir hydrate combination therapy on persistent viral suppression in patients with chronic hepatitis B
    Satoru Hagiwara
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    J Med Virol 85:987-95. 2013
    ..027). The combination regimen is a promising approach to treat chronic hepatitis B and may achieve significant reduction in serum HBV DNA and intrahepatic cccDNA. Wiley Periodicals, Inc...
  23. doi request reprint Risk of hepatocellular carcinoma development in cases of hepatitis C treated by long-term, low-dose PEG-IFNα-2a
    Satoru Hagiwara
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, Japan
    Dig Dis 30:561-7. 2012
    ..The aim of this study was to determine clinical characteristics on the risk of occurrence of HCC in CHC patients receiving maintenance IFN therapy...
  24. doi request reprint Radiofrequency ablation for hepatocellular carcinoma measuring 2 cm or smaller: results and risk factors for local recurrence
    Masashi Kono
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, Osaka Sayama, Japan
    Dig Dis 32:670-7. 2014
    ..The purpose of this study was to evaluate the risk factors for local recurrence with radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) measuring ≤2 cm...
  25. ncbi request reprint Alteration of the p14(ARF) gene and p53 status in human hepatocellular carcinomas
    Teruaki Ito
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Gastroenterol 39:355-61. 2004
    ..Inactivation of RB/p16INK4a was frequently reported, but alterations of the p14ARF gene in hepatocellular carcinoma (HCC) in the Japanese population have been insufficiently analyzed...
  26. doi request reprint The prognostic value of vascular endothelial growth factor in hepatocellular carcinoma for predicting metastasis after curative resection
    Mutsuko Minata
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Oncology 84:75-81. 2013
    ..The purpose of this study was to identify factors predictive for postoperative recurrence of HCC in patients who underwent curative resection using immunohistochemistry...
  27. doi request reprint Association of gankyrin and stemness factor expression in human colorectal cancer
    Hiromasa Mine
    Department of Gastroenterology and Hepatology, Kinki University, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    Dig Dis Sci 58:2337-44. 2013
    ..Although gankyrin is overexpressed in CRC tissues, its roles in the initiation step of colorectal carcinogenesis remain largely unexplored...
  28. doi request reprint Genome-wide profiling of DNA methylation and tumor progression in human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan
    Dig Dis 32:658-63. 2014
    ..To clarify the progression pattern of abnormal DNA methylation during the development of hepatocellular carcinoma (HCC) using a comprehensive methylation assay...
  29. doi request reprint Involvement of heat shock protein a4/apg-2 in refractory inflammatory bowel disease
    Teppei Adachi
    Departments of Gastroenterology and Hepatology, and Biochemistry, Kinki University Faculty of Medicine, Osaka Sayama, Japan and Center for Innovation in Immunoregulative Technology and Therapeutics, and Department of Clinical Molecular Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Inflamm Bowel Dis 21:31-9. 2015
    ..Expression of heat shock protein A4 (HSPA4, also called Apg-2), a member of the HSP110 family, is induced by several forms of stress. The physiological and pathological functions of HSPA4 in the intestine remain to be elucidated...
  30. ncbi request reprint Transcatheter arterial embolization for tumor seeding in the chest wall after radiofrequency ablation for hepatocellular carcinoma
    Toshiya Shibata
    Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Shogoin, Sakyoku, Japan
    Cardiovasc Intervent Radiol 29:479-81. 2006
    ..We conclude that transcatheter arterial embolization was effective for the control of tumor seeding after radiofrequency ablation for hepatocellular carcinoma...
  31. doi request reprint Stress response protein cirp links inflammation and tumorigenesis in colitis-associated cancer
    Toshiharu Sakurai
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan
    Cancer Res 74:6119-28. 2014
    ..Cirp promotes the development of intestinal inflammation and colorectal tumors through regulating apoptosis and production of TNFα and IL23 in inflammatory cells...
  32. doi request reprint Characteristic pattern of reactivation of hepatitis B virus during chemotherapy for solid cancers
    Satoru Hagiwara
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan
    Dig Dis 30:541-6. 2012
    ....
  33. doi request reprint Oxidative stress and epigenetic instability in human hepatocarcinogenesis
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osakasayama, Japan
    Dig Dis 31:447-53. 2013
    ..The decrease of the level of methyl group donors also contributes to the alteration in the methylation status. These mechanisms should act in concert and induce epigenetic instability, leading to HCC...
  34. doi request reprint Characteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Hepatology 56:994-1003. 2012
    ..0001), and number of methylated genes was an independent risk factor for HCC (hazard ratio = 5.21, 95% confidence interval = 2.25-11.76, P = 0.0002)...
  35. doi request reprint Heat shock protein 27 expression is inversely correlated with atrophic gastritis and intraepithelial neoplasia
    Yoshiaki Nagata
    Department of Gastroenterology and Hepatology, Faculty of Medicine, Kinki University, 377 2, Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    Dig Dis Sci 58:381-8. 2013
    ..Intestinal-type gastric carcinomas progress through several sequential steps, including atrophic gastritis, intestinal metaplasia, dysplasia, and cancer...
  36. ncbi request reprint Prognostic impact of multiple allelic losses on metastatic recurrence in hepatocellular carcinoma after curative resection
    Naoshi Nishida
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Oncology 62:141-8. 2002
    ..These findings indicate that accumulation of chromosomal changes is associated with metastatic behavior, and that LOH on 16q was the most useful prognostic indicator for metastasis after curative resection of HCC...
  37. ncbi request reprint Impact of hepatitis virus and aging on DNA methylation in human hepatocarcinogenesis
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo ku, Kyoto, Japan
    Histol Histopathol 25:647-54. 2010
    ..In addition, we proposed age should be taken into consideration for HCC development via epigenetic pathways. Further investigations are required to understand the mechanism of inducing epigenetic instability during hepatocarcinogenesis...
  38. doi request reprint Clinical and histological features of different types of Budd-Chiari syndrome: a comparison of 4 cases
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osakasayama, Japan
    Dig Dis 31:408-14. 2013
    ..Pericellular fibrosis and hypervascular regenerative nodules were also reversible after obstruction removal. Therefore, it is very important to manage this rare disease before it progresses to liver cirrhosis...
  39. pmc Therapeutic response assessment of RFA for HCC: contrast-enhanced US, CT and MRI
    Yasunori Minami
    Yasunori Minami, Naoshi Nishida, Masatoshi Kudo, Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka 589 8511, Japan
    World J Gastroenterol 20:4160-6. 2014
    ..Therefore, we need to carefully address to these imaging findings given the fact that diagnostic difficulties of local recurrence of HCC. Here, we give an overview of the current status of the imaging assessment of HCC response to RFA. ..
  40. doi request reprint Clinical features of vascular disorders associated with chronic hepatitis virus infection
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan
    Dig Dis 32:786-90. 2014
    ..New antiviral drugs for viral hepatitis could improve the prognosis of vascular and renal involvement...
  41. ncbi request reprint Regression of Hodgkin lymphoma in response to antiviral therapy for hepatitis C virus infection
    Ken Takahashi
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan
    Intern Med 51:2745-7. 2012
    ....
  42. ncbi request reprint Benign hepatic nodules in Budd-Chiari syndrome: radiologic-pathologic correlation with emphasis on the central scar
    Yoji Maetani
    Department of Radiology, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, Japan
    AJR Am J Roentgenol 178:869-75. 2002
    ..The purpose of this study was to determine the imaging features of benign hepatic nodules in patients with Budd-Chiari syndrome and to correlate them with pathologic findings, with special attention placed on the presence of a central scar...