Naoshi Nishida

Summary

Affiliation: Kinki University
Country: Japan

Publications

  1. pmc Unique association between global DNA hypomethylation and chromosomal alterations in human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 8:e72312. 2013
  2. doi request reprint Gender differences in the livers of patients with hepatocellular carcinoma and chronic hepatitis C infection
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Faculty of Medicine, Kinki University, 377 2 Ohno Higashi, Osaka Sayama, Osaka, Japan
    Dig Dis 30:547-53. 2012
  3. ncbi request reprint Recent advancements in comprehensive genetic analyses for human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan
    Oncology 84:93-7. 2013
  4. ncbi request reprint Genome-wide semiquantitative microsatellite analysis of human hepatocellular carcinoma: discrete mapping of smallest region of overlap of recurrent chromosomal gains and losses
    Takafumi Nishimura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Cancer Genet Cytogenet 167:57-65. 2006
  5. ncbi request reprint Discrete breakpoint mapping and shortest region of overlap of chromosome arm 1q gain and 1p loss in human hepatocellular carcinoma detected by semiquantitative microsatellite analysis
    Takafumi Nishimura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Genes Chromosomes Cancer 42:34-43. 2005
  6. doi request reprint Risk of hepatocellular carcinoma development in cases of hepatitis C treated by long-term, low-dose PEG-IFNα-2a
    Satoru Hagiwara
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, Japan
    Dig Dis 30:561-7. 2012
  7. ncbi request reprint Usefulness of contrast-enhanced ultrasonography to evaluate the post-treatment responses of radiofrequency ablation for hepatocellular carcinoma: comparison with dynamic CT
    Tatsuo Inoue
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan
    Oncology 84:51-7. 2013
  8. ncbi request reprint Quantification of tumor DNA in serum and vascular invasion of human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan naoshi med kindai ac jp
    Oncology 84:82-7. 2013
  9. ncbi request reprint Expression of E-cadherin and vascular endothelial growth factor in noncancerous liver is associated with recurrence of hepatocellular carcinoma after curative resection
    Mutsuko Minata
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Oncology 84:88-92. 2013
  10. doi request reprint Impact of peginterferon alpha-2b and entecavir hydrate combination therapy on persistent viral suppression in patients with chronic hepatitis B
    Satoru Hagiwara
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    J Med Virol 85:987-95. 2013

Collaborators

Detail Information

Publications28

  1. pmc Unique association between global DNA hypomethylation and chromosomal alterations in human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 8:e72312. 2013
    ..0011, well-differentiated; p=0.0089, moderately/poorly-differentiated HCCs). We conclude that DNA hypomethylation is an important cause of CIN in the earliest step of HCC, especially in a background of non-cirrhotic liver...
  2. doi request reprint Gender differences in the livers of patients with hepatocellular carcinoma and chronic hepatitis C infection
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Faculty of Medicine, Kinki University, 377 2 Ohno Higashi, Osaka Sayama, Osaka, Japan
    Dig Dis 30:547-53. 2012
    ..To determine the specific factors that contribute to a male predominance, we analyzed the clinicopathological factors, and genetic and epigenetic alterations of HCCs in male and female patients...
  3. ncbi request reprint Recent advancements in comprehensive genetic analyses for human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan
    Oncology 84:93-7. 2013
    ..Such analyses will clarify how this malignancy can be treated, diagnosed and prevented more effectively...
  4. ncbi request reprint Genome-wide semiquantitative microsatellite analysis of human hepatocellular carcinoma: discrete mapping of smallest region of overlap of recurrent chromosomal gains and losses
    Takafumi Nishimura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Cancer Genet Cytogenet 167:57-65. 2006
    ..Although some putative oncogenes or tumor suppressor genes mapped in these SRO may be important, relative copy number changes of numerous other genes may affect pathogenesis of HCC...
  5. ncbi request reprint Discrete breakpoint mapping and shortest region of overlap of chromosome arm 1q gain and 1p loss in human hepatocellular carcinoma detected by semiquantitative microsatellite analysis
    Takafumi Nishimura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Genes Chromosomes Cancer 42:34-43. 2005
    ..32-p36.22, 5.1 Mb). Four known putative tumor-suppressor genes (TP73, RIZ1, NBL1/DAN, and CDKN2C) were outside the SRO, suggesting the presence of other candidate genes with critical roles in hepatocarcinogenesis...
  6. doi request reprint Risk of hepatocellular carcinoma development in cases of hepatitis C treated by long-term, low-dose PEG-IFNα-2a
    Satoru Hagiwara
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, Japan
    Dig Dis 30:561-7. 2012
    ..The initial response of serum ALT levels and BMI provides a prognostic value for determining the risk of developing HCC later in life...
  7. ncbi request reprint Usefulness of contrast-enhanced ultrasonography to evaluate the post-treatment responses of radiofrequency ablation for hepatocellular carcinoma: comparison with dynamic CT
    Tatsuo Inoue
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan
    Oncology 84:51-7. 2013
    ..Local recurrence rate was used as the gold standard of evaluation...
  8. ncbi request reprint Quantification of tumor DNA in serum and vascular invasion of human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan naoshi med kindai ac jp
    Oncology 84:82-7. 2013
    ..Accurate diagnosis of tumor progression is critical for the appropriate management of HCC. Here, we established a sensitive assay to detect and quantify tumor-derived DNA in the serum of HCC patients...
  9. ncbi request reprint Expression of E-cadherin and vascular endothelial growth factor in noncancerous liver is associated with recurrence of hepatocellular carcinoma after curative resection
    Mutsuko Minata
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Oncology 84:88-92. 2013
    ..The purpose of this study was to examine how background liver affects postoperative recurrence of HCC that underwent curative resection using expression of cancer-related molecules in the adjacent noncancerous liver of HCC patients...
  10. doi request reprint Impact of peginterferon alpha-2b and entecavir hydrate combination therapy on persistent viral suppression in patients with chronic hepatitis B
    Satoru Hagiwara
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    J Med Virol 85:987-95. 2013
    ..027). The combination regimen is a promising approach to treat chronic hepatitis B and may achieve significant reduction in serum HBV DNA and intrahepatic cccDNA. Wiley Periodicals, Inc...
  11. ncbi request reprint Genotype stability and clonal evolution of hepatocellular carcinoma assessed by autopsy-based genome-wide microsatellite analysis
    Takafumi Nishimura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Cancer Genet Cytogenet 161:164-9. 2005
    ..In conclusion, clonal evolution of the HCC cells during metastatic progression seems rare, in contrast to many recurrent chromosomal aberrations that may have accumulated before the clinical manifestation...
  12. ncbi request reprint Comprehensive allelotyping of well-differentiated human hepatocellular carcinoma with semiquantitative determination of chromosomal gain or loss
    Takafumi Nishimura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Genes Chromosomes Cancer 35:329-39. 2002
    ..On the other hand, deletions of 13q and 16q were infrequent and were seen only in the most aberrant cases, which suggested that these were late events...
  13. doi request reprint Reactive oxygen species induce epigenetic instability through the formation of 8-hydroxydeoxyguanosine in human hepatocarcinogenesis
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osakasayama, Japan
    Dig Dis 31:459-66. 2013
    ..We conclude that oxidative stress alters the chromatin status, which leads to abnormal methylation of TSGs, and contributes to hepatocarcinogenesis in CHC patients...
  14. ncbi request reprint The prognostic value of vascular endothelial growth factor in hepatocellular carcinoma for predicting metastasis after curative resection
    Mutsuko Minata
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Oncology 84:75-81. 2013
    ..The purpose of this study was to identify factors predictive for postoperative recurrence of HCC in patients who underwent curative resection using immunohistochemistry...
  15. ncbi request reprint Alteration of the p14(ARF) gene and p53 status in human hepatocellular carcinomas
    Teruaki Ito
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Gastroenterol 39:355-61. 2004
    ..Inactivation of RB/p16INK4a was frequently reported, but alterations of the p14ARF gene in hepatocellular carcinoma (HCC) in the Japanese population have been insufficiently analyzed...
  16. doi request reprint Association of gankyrin and stemness factor expression in human colorectal cancer
    Hiromasa Mine
    Department of Gastroenterology and Hepatology, Kinki University, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    Dig Dis Sci 58:2337-44. 2013
    ..Although gankyrin is overexpressed in CRC tissues, its roles in the initiation step of colorectal carcinogenesis remain largely unexplored...
  17. ncbi request reprint Transcatheter arterial embolization for tumor seeding in the chest wall after radiofrequency ablation for hepatocellular carcinoma
    Toshiya Shibata
    Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Shogoin, Sakyoku, Japan
    Cardiovasc Intervent Radiol 29:479-81. 2006
    ..We conclude that transcatheter arterial embolization was effective for the control of tumor seeding after radiofrequency ablation for hepatocellular carcinoma...
  18. doi request reprint Hypothermia protects against fulminant hepatitis in mice by reducing reactive oxygen species production
    Toshiharu Sakurai
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osakasayama, Japan
    Dig Dis 31:440-6. 2013
    ..Although cold-inducible RNA-binding protein (CIRP) contributes to the protective effects of hypothermia through extracellular signal-regulated kinase activation in fibroblasts, the effects of hypothermia in the liver remain unclear...
  19. doi request reprint Characteristic pattern of reactivation of hepatitis B virus during chemotherapy for solid cancers
    Satoru Hagiwara
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan
    Dig Dis 30:541-6. 2012
    ....
  20. ncbi request reprint Heat shock protein 27 expression is inversely correlated with atrophic gastritis and intraepithelial neoplasia
    Yoshiaki Nagata
    Department of Gastroenterology and Hepatology, Faculty of Medicine, Kinki University, 377 2, Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    Dig Dis Sci 58:381-8. 2013
    ..Intestinal-type gastric carcinomas progress through several sequential steps, including atrophic gastritis, intestinal metaplasia, dysplasia, and cancer...
  21. ncbi request reprint Characteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Hepatology 56:994-1003. 2012
    ..0001), and number of methylated genes was an independent risk factor for HCC (hazard ratio = 5.21, 95% confidence interval = 2.25-11.76, P = 0.0002)...
  22. ncbi request reprint Impact of hepatitis virus and aging on DNA methylation in human hepatocarcinogenesis
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo ku, Kyoto, Japan
    Histol Histopathol 25:647-54. 2010
    ..In addition, we proposed age should be taken into consideration for HCC development via epigenetic pathways. Further investigations are required to understand the mechanism of inducing epigenetic instability during hepatocarcinogenesis...
  23. doi request reprint Clinical and histological features of different types of Budd-Chiari syndrome: a comparison of 4 cases
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osakasayama, Japan
    Dig Dis 31:408-14. 2013
    ..Pericellular fibrosis and hypervascular regenerative nodules were also reversible after obstruction removal. Therefore, it is very important to manage this rare disease before it progresses to liver cirrhosis...
  24. ncbi request reprint Prognostic impact of multiple allelic losses on metastatic recurrence in hepatocellular carcinoma after curative resection
    Naoshi Nishida
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Oncology 62:141-8. 2002
    ..These findings indicate that accumulation of chromosomal changes is associated with metastatic behavior, and that LOH on 16q was the most useful prognostic indicator for metastasis after curative resection of HCC...
  25. ncbi request reprint Therapeutic response assessment of RFA for HCC: contrast-enhanced US, CT and MRI
    Yasunori Minami
    Yasunori Minami, Naoshi Nishida, Masatoshi Kudo, Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka 589 8511, Japan
    World J Gastroenterol 20:4160-6. 2014
    ..Therefore, we need to carefully address to these imaging findings given the fact that diagnostic difficulties of local recurrence of HCC. Here, we give an overview of the current status of the imaging assessment of HCC response to RFA. ..
  26. ncbi request reprint Regression of Hodgkin lymphoma in response to antiviral therapy for hepatitis C virus infection
    Ken Takahashi
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan
    Intern Med 51:2745-7. 2012
    ....
  27. ncbi request reprint Benign hepatic nodules in Budd-Chiari syndrome: radiologic-pathologic correlation with emphasis on the central scar
    Yoji Maetani
    Department of Radiology, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, Japan
    AJR Am J Roentgenol 178:869-75. 2002
    ..The purpose of this study was to determine the imaging features of benign hepatic nodules in patients with Budd-Chiari syndrome and to correlate them with pathologic findings, with special attention placed on the presence of a central scar...
  28. doi request reprint Oxidative stress and epigenetic instability in human hepatocarcinogenesis
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osakasayama, Japan
    Dig Dis 31:447-53. 2013
    ..The decrease of the level of methyl group donors also contributes to the alteration in the methylation status. These mechanisms should act in concert and induce epigenetic instability, leading to HCC...