Nobuo Nagai

Summary

Affiliation: Kinki University
Country: Japan

Publications

  1. doi Urokinase-type plasminogen activator receptor (uPAR) augments brain damage in a murine model of ischemic stroke
    Nobuo Nagai
    Department of Physiology, Kinki University School of Medicine, Ohnohigashi 377 2, Osakasayama, Osaka 589 8511, Japan
    Neurosci Lett 432:46-9. 2008
  2. doi Initial brain lesion size affects the extent of subsequent pathophysiological responses
    Nobuo Nagai
    Department of Physiology, Kinki University School of Medicine, Japan
    Brain Res 1322:109-17. 2010
  3. doi Systemic transplantation of embryonic stem cells accelerates brain lesion decrease and angiogenesis
    Nobuo Nagai
    Department of Physiology, Kinki University School of Medicine, Osaka, Japan
    Neuroreport 21:575-9. 2010
  4. doi Profibrinolytic effect of Enzamin, an extract of metabolic products from Bacillus subtilis AK and Lactobacillus
    Yukinori Tamura
    Department of Physiology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka 589 8511, Japan
    J Thromb Thrombolysis 32:195-200. 2011
  5. doi Enhancement of fibrinolytic activity in vascular endothelial cells by heterologous expression of adenine nucleotide translocase-1
    Chikako Ishida
    Department of Physiology, Kinki University School of Medicine, Ohno Higashi, Osakasayama, Osaka, Japan
    Blood Coagul Fibrinolysis 21:272-8. 2010
  6. doi Lack of both α2-antiplasmin and plasminogen activator inhibitor type-1 induces high IgE production
    Kiyotaka Okada
    Department of Physiology, Kinki University, Faculty of Medicine, Osakasayama, Japan
    Life Sci 93:89-95. 2013
  7. doi Role of plasminogen in macrophage accumulation during liver repair
    Naoyuki Kawao
    Department of Physiology, Kinki University School of Medicine, 377 2 Ohnohigashi, Osakasayama 589 8511, Japan
    Thromb Res 125:e214-21. 2010
  8. ncbi Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor-related protein
    Yasuhiro Suzuki
    Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu, Japan, Japan
    Blood 114:3352-8. 2009
  9. doi Spatiotemporal differences in vascular permeability after ischaemic brain damage
    Masato Yano
    Department of Physiology, Kinki University Faculty of Medicine, Ohnohigashi, Osakasayama, Japan
    Neuroreport 22:424-7. 2011
  10. pmc In vivo diagnostic imaging using micro-CT: sequential and comparative evaluation of rodent models for hepatic/brain ischemia and stroke
    Naoto Hayasaka
    Department of Anatomy and Neurobiology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    PLoS ONE 7:e32342. 2012

Collaborators

Detail Information

Publications22

  1. doi Urokinase-type plasminogen activator receptor (uPAR) augments brain damage in a murine model of ischemic stroke
    Nobuo Nagai
    Department of Physiology, Kinki University School of Medicine, Ohnohigashi 377 2, Osakasayama, Osaka 589 8511, Japan
    Neurosci Lett 432:46-9. 2008
    ..These findings suggest that uPAR expressed by endothelial cells augments the ischemic brain damage via a uPA-independent mechanism...
  2. doi Initial brain lesion size affects the extent of subsequent pathophysiological responses
    Nobuo Nagai
    Department of Physiology, Kinki University School of Medicine, Japan
    Brain Res 1322:109-17. 2010
    ..These findings suggested that the more severe the brain damage, the stronger the subsequent pathophysiological responses...
  3. doi Systemic transplantation of embryonic stem cells accelerates brain lesion decrease and angiogenesis
    Nobuo Nagai
    Department of Physiology, Kinki University School of Medicine, Osaka, Japan
    Neuroreport 21:575-9. 2010
    ..These findings suggested that embryonic stem cell transplantation reduced the brain lesion through the acceleration of angiogenesis by endogenous endothelial cells...
  4. doi Profibrinolytic effect of Enzamin, an extract of metabolic products from Bacillus subtilis AK and Lactobacillus
    Yukinori Tamura
    Department of Physiology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka 589 8511, Japan
    J Thromb Thrombolysis 32:195-200. 2011
    ....
  5. doi Enhancement of fibrinolytic activity in vascular endothelial cells by heterologous expression of adenine nucleotide translocase-1
    Chikako Ishida
    Department of Physiology, Kinki University School of Medicine, Ohno Higashi, Osakasayama, Osaka, Japan
    Blood Coagul Fibrinolysis 21:272-8. 2010
    ....
  6. doi Lack of both α2-antiplasmin and plasminogen activator inhibitor type-1 induces high IgE production
    Kiyotaka Okada
    Department of Physiology, Kinki University, Faculty of Medicine, Osakasayama, Japan
    Life Sci 93:89-95. 2013
    ..We investigated the pathophysiological changes in mice lacking α2-antiplasmin (α2-AP) and plasminogen activator inhibitor type-1 (PAI-1) genes, and elucidated the involvement of these inhibitors for fibrinolysis in immune response...
  7. doi Role of plasminogen in macrophage accumulation during liver repair
    Naoyuki Kawao
    Department of Physiology, Kinki University School of Medicine, 377 2 Ohnohigashi, Osakasayama 589 8511, Japan
    Thromb Res 125:e214-21. 2010
    ..Here, we investigated the role of plasminogen in accumulations of macrophages and neutrophils after liver injury in mice with gene deficient of plasminogen (Plg(-/-)) or its wild type (Plg(+/+))...
  8. ncbi Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor-related protein
    Yasuhiro Suzuki
    Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu, Japan, Japan
    Blood 114:3352-8. 2009
    ..These findings indicate that t-PA deteriorates ICB via MMP-3 induction in endothelial cells, which is regulated through the LRP/nuclear factor-kappaB pathway...
  9. doi Spatiotemporal differences in vascular permeability after ischaemic brain damage
    Masato Yano
    Department of Physiology, Kinki University Faculty of Medicine, Ohnohigashi, Osakasayama, Japan
    Neuroreport 22:424-7. 2011
    ..Furthermore, the extravasation was denser in the regions near the surface than in those further in the infarct region, suggesting a spatial heterogeneity in neovascular permeability...
  10. pmc In vivo diagnostic imaging using micro-CT: sequential and comparative evaluation of rodent models for hepatic/brain ischemia and stroke
    Naoto Hayasaka
    Department of Anatomy and Neurobiology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    PLoS ONE 7:e32342. 2012
    ..However, soft tissue contrast resolution, particularly in the brain, is insufficient for detailed analysis, unlike the current applications of CT in the clinical arena. We address the soft tissue contrast resolution issue in this report...
  11. ncbi Tissue-type plasminogen activator has paradoxical roles in focal cerebral ischemic injury by thrombotic middle cerebral artery occlusion with mild or severe photochemical damage in mice
    Nobuo Nagai
    Department of Physiology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Cereb Blood Flow Metab 22:648-51. 2002
    ....
  12. ncbi Roles of fibrinolytic system components in the nervous system
    Nobuo Nagai
    Department of Physiology, Kinki University School of Medicine, Ohno Higashi 377 2, Osakasayama, Osaka 589 8511, Japan
    Pathophysiology 17:141-7. 2010
    ..This paper reviews the roles of fibrinolytic system components in the nervous system...
  13. ncbi Rat cerebral ischemia induced with photochemical occlusion of proximal middle cerebral artery: a stroke model for MR imaging research
    Feng Chen
    Department of Radiology, University Hospitals, K U Leuven, Herestraat 49, 3000, Leuven, Belgium
    MAGMA 17:103-8. 2004
    ..The present PIT model in rats has been successfully adopted for MRI research, which might be feasible for certain stroke studies and should be beneficial for the evaluation on effects of potential diagnostic and therapeutic approaches...
  14. ncbi Delayed perfusion phenomenon in a rat stroke model at 1.5 T MR: an imaging sign parallel to spontaneous reperfusion and ischemic penumbra?
    Feng Chen
    Department of Radiology, University Hospitals, Catholic University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Eur J Radiol 61:70-8. 2007
    ..Delayed perfusion (DP) sign at MR imaging was reported in stroke patients. We sought to experimentally elucidate its relation to spontaneous reperfusion and ischemic penumbra...
  15. ncbi Rodent stroke induced by photochemical occlusion of proximal middle cerebral artery: evolution monitored with MR imaging and histopathology
    Feng Chen
    Department of Radiology, Faculty of Medicine, Catholic University of Leuven, Belgium
    Eur J Radiol 63:68-75. 2007
    ..To longitudinally investigate stroke in rats after photothrombotic occlusion of proximal middle cerebral artery (MCA) with magnetic resonance imaging (MRI) in correlation with histopathology...
  16. pmc Survivin-dependent angiogenesis in ischemic brain: molecular mechanisms of hypoxia-induced up-regulation
    Edward M Conway
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Gasthuisberg O and N, 9th Floor, Herestraat 49, B 3000 Leuven, Belgium
    Am J Pathol 163:935-46. 2003
    ....
  17. ncbi Essential role of endogenous tissue plasminogen activator through matrix metalloproteinase 9 induction and expression on heparin-produced cerebral hemorrhage after cerebral ischemia in mice
    Bing Qiao Zhao
    Department of Pharmacology, Hamamatsu University School of Medicine, Japan
    Blood 103:2610-6. 2004
    ..Targeting tPA, MMP 9, or both may provide a new approach for preventing cerebral hemorrhage associated with antithrombotic therapy for stroke in humans...
  18. ncbi Microplasmin reduces ischemic brain damage and improves neurological function in a rat stroke model monitored with MRI
    Yasuhiro Suzuki
    Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium
    Stroke 35:2402-6. 2004
    ..Microplasmin (microPli), a derivative of plasmin lacking the 5 "kringle" domains, was studied in a rat thrombotic stroke model with MRI monitoring...
  19. ncbi Visualization of stroke with clinical MR imagers in rats: a feasibility study
    Feng Chen
    Department of Radiology, University Hospitals, K U Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Radiology 233:905-11. 2004
    ..05). There was no difference in lesion size at perfusion-weighted MR imaging between superacute and subacute phases (P > .05). Performance of certain stroke-related research in rats is feasible with clinical MR imagers...
  20. ncbi Microplasmin and tissue plasminogen activator: comparison of therapeutic effects in rat stroke model at multiparametric MR imaging
    Feng Chen
    Department of Radiology, University Hospitals, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Radiology 244:429-38. 2007
    ..To prospectively compare therapeutic and hemorrhagic effects of microplasmin and tissue plasminogen activator (tPA) in stroke therapy by using multiparametric magnetic resonance (MR) imaging in a photothrombotic rat stroke model...
  21. ncbi Protective role of reactive astrocytes in brain ischemia
    Lizhen Li
    Center for Brain Repair and Rehabilitation, Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology at Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    J Cereb Blood Flow Metab 28:468-81. 2008
    ..Thus, reactive astrocytes have a protective role in brain ischemia, and the absence of astrocyte IFs is linked to changes in glutamate transport, ET(B)R-mediated control of gap junctions, and PAI-1 expression...
  22. ncbi Dynamic susceptibility contrast-enhanced perfusion MR imaging at 1.5 T predicts final infarct size in a rat stroke model
    Feng Chen
    Department of Radiology, University Hospitals, K U Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Neurosci Methods 141:55-60. 2005
    ..05) suggests that early source images from DSC-PWI at 1.5T MR scanner is feasible to noninvasively predict the final infarct size in rat models of stroke...