Kazuhiko Matsuo

Summary

Affiliation: Kinki University
Country: Japan

Publications

  1. ncbi request reprint [Development of transcutaneous vaccination system for infectious disease countermeasure]
    Kazuhiko Matsuo
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    Yakugaku Zasshi 132:1443-50. 2012
  2. doi request reprint Development and clinical study of a self-dissolving microneedle patch for transcutaneous immunization device
    Sachiko Hirobe
    Laboratory of Biotechnology and Therapeutics Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Pharm Res 30:2664-74. 2013
  3. doi request reprint A low-invasive and effective transcutaneous immunization system using a novel dissolving microneedle array for soluble and particulate antigens
    Kazuhiko Matsuo
    Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Control Release 161:10-7. 2012
  4. ncbi request reprint Compositional optimization and safety assessment of a hydrogel patch as a transcutaneous immunization device
    Kazuhiko Matsuo
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    Biol Pharm Bull 34:1835-40. 2011
  5. doi request reprint Clinical study of transcutaneous vaccination using a hydrogel patch for tetanus and diphtheria
    Sachiko Hirobe
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Vaccine 30:1847-54. 2012
  6. doi request reprint Analysis of transcutaneous antigenic protein delivery by a hydrogel patch formulation
    Kazuhiko Matsuo
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    J Pharm Sci 102:1936-47. 2013
  7. doi request reprint Transcutaneous vaccination using a hydrogel patch induces effective immune responses to tetanus and diphtheria toxoid in hairless rat
    Kazuhiko Matsuo
    Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Control Release 149:15-20. 2011
  8. ncbi request reprint Characterization of transcutaneous protein delivery by a hydrogel patch in animal, human, and tissue-engineered skin models
    Kazuhiko Matsuo
    Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Yamadaoka, Suita, Japan
    Biol Pharm Bull 34:586-9. 2011
  9. doi request reprint Induction of endoplasmic reticulum-endosome fusion for antigen cross-presentation induced by poly (γ-glutamic acid) nanoparticles
    Yohei Mukai
    Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565 0871, Japan
    J Immunol 187:6249-55. 2011
  10. doi request reprint Transcutaneous immunization using a dissolving microneedle array protects against tetanus, diphtheria, malaria, and influenza
    Kazuhiko Matsuo
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0781, Japan
    J Control Release 160:495-501. 2012

Collaborators

Detail Information

Publications16

  1. ncbi request reprint [Development of transcutaneous vaccination system for infectious disease countermeasure]
    Kazuhiko Matsuo
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    Yakugaku Zasshi 132:1443-50. 2012
    ..In this review, we introduce the research progress resulted from our basic, preclinical, and clinical study for practical use...
  2. doi request reprint Development and clinical study of a self-dissolving microneedle patch for transcutaneous immunization device
    Sachiko Hirobe
    Laboratory of Biotechnology and Therapeutics Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Pharm Res 30:2664-74. 2013
    ..In this study, we developed an improved collagen-free MH (new-MH) and conducted clinical study to evaluate the fundamental properties and safety in human...
  3. doi request reprint A low-invasive and effective transcutaneous immunization system using a novel dissolving microneedle array for soluble and particulate antigens
    Kazuhiko Matsuo
    Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Control Release 161:10-7. 2012
    ..In addition, application of these dissolving microneedle arrays caused only slight skin irritation. These findings suggest that our TCI system can simply, safely, and effectively improve protective immune responses for every vaccine Ag...
  4. ncbi request reprint Compositional optimization and safety assessment of a hydrogel patch as a transcutaneous immunization device
    Kazuhiko Matsuo
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    Biol Pharm Bull 34:1835-40. 2011
    ..TCI using a hydrogel patch induced few local and systemic adverse reactions. Based on these results, we are now advancing translational research to evaluate the safety and efficacy of our novel TCI system in humans...
  5. doi request reprint Clinical study of transcutaneous vaccination using a hydrogel patch for tetanus and diphtheria
    Sachiko Hirobe
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Vaccine 30:1847-54. 2012
    ..This easy-to-use and safe TCI formulation enables mass treatment in an outbreak setting and increased vaccination rates in developing countries, and will greatly contribute to worldwide countermeasures against infectious diseases...
  6. doi request reprint Analysis of transcutaneous antigenic protein delivery by a hydrogel patch formulation
    Kazuhiko Matsuo
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    J Pharm Sci 102:1936-47. 2013
    ..On the basis of the present information, we are planning to modify the patch composition and establish the antigen modification technology for improvement in the efficacy of transcutaneous immunization...
  7. doi request reprint Transcutaneous vaccination using a hydrogel patch induces effective immune responses to tetanus and diphtheria toxoid in hairless rat
    Kazuhiko Matsuo
    Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Control Release 149:15-20. 2011
    ..On the basis of these results, we are now performing translational research to apply TCI for tetanus and diphtheria...
  8. ncbi request reprint Characterization of transcutaneous protein delivery by a hydrogel patch in animal, human, and tissue-engineered skin models
    Kazuhiko Matsuo
    Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Yamadaoka, Suita, Japan
    Biol Pharm Bull 34:586-9. 2011
    ..On the basis of these results, translational research in human is now in progress...
  9. doi request reprint Induction of endoplasmic reticulum-endosome fusion for antigen cross-presentation induced by poly (γ-glutamic acid) nanoparticles
    Yohei Mukai
    Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565 0871, Japan
    J Immunol 187:6249-55. 2011
    ..These findings imply that the ER-endosome complex is key for the efficient cross-presentation of Ags encapsulated in γ-PGA NPs...
  10. doi request reprint Transcutaneous immunization using a dissolving microneedle array protects against tetanus, diphtheria, malaria, and influenza
    Kazuhiko Matsuo
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0781, Japan
    J Control Release 160:495-501. 2012
    ..These findings demonstrate that TCI using a dissolving microneedle array can elicit large immune responses against infectious diseases. Based on these results, we are now preparing translational research for human clinical trials...
  11. ncbi request reprint Frontiers of transcutaneous vaccination systems: novel technologies and devices for vaccine delivery
    Kazuhiko Matsuo
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Vaccine 31:2403-15. 2013
    ..We also introduce basic and clinical research involving our TCI systems that incorporate several original devices...
  12. ncbi request reprint Vaccine efficacy of transcutaneous immunization with amyloid β using a dissolving microneedle array in a mouse model of Alzheimer's disease
    Kazuhiko Matsuo
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Neuroimmunol 266:1-11. 2014
    ..Unfortunately, this TCI system resulted in little significant improvement in cognitive function and Th2-dominant immune responses, suggesting the need for further modification. ..
  13. ncbi request reprint The utility of poly(γ-glutamic acid) nanoparticles as antigen delivery carriers in dendritic cell-based cancer immunotherapy
    Keisuke Matsuo
    Department of Biotechnology and Therapeutics, Osaka University, Japan
    Biol Pharm Bull 33:2003-7. 2010
    ..Immunization with TAA-loaded DCs using γ-PGA NPs inhibited tumor growth by inducing TAA-specific CTLs. These findings indicate that γ-PGA NPs can function as useful antigen delivery carriers in DC-based cancer immunotherapy...
  14. ncbi request reprint [Development of transcutaneous vaccine formulations for the infectious disease countermeasure]
    Kazuhiko Matsuo
    Graduate School of Pharmaceutical Sciences, Osaka University
    Nihon Rinsho 69:1561-6. 2011
    ..Our transcutaneous immunization system using these devices receives a high evaluation as novel, easy-to-use, and low-invasive vaccination method against infections from home and abroad...
  15. doi request reprint A transcutaneous vaccination system using a hydrogel patch for viral and bacterial infection
    Yumiko Ishii
    Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Control Release 131:113-20. 2008
    ..The use of this hydrogel patch transcutaneous vaccination system will facilitate the global distribution of effective and convenient vaccines...
  16. doi request reprint Systemic distribution, nuclear entry and cytotoxicity of amorphous nanosilica following topical application
    Hiromi Nabeshi
    Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biomaterials 32:2713-24. 2011
    ..Our information indicated that further studies of relation between physicochemical properties and biological responses are needed for the development and the safer form of NMs...