Masatoshi Kudo

Summary

Affiliation: Kinki University
Country: Japan

Publications

  1. ncbi Noninvasive evaluation of hepatic fibrosis using serum fibrotic markers, transient elastography (FibroScan) and real-time tissue elastography
    Chie Tatsumi
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Intervirology 51:27-33. 2008
  2. ncbi Real-life clinical practice with sorafenib in advanced hepatocellular carcinoma: a single-center experience
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, Japan
    Dig Dis 30:609-16. 2012
  3. ncbi Targeted therapy for liver cancer: updated review in 2012
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan
    Curr Cancer Drug Targets 12:1062-72. 2012
  4. ncbi Current status of hepatocellular carcinoma treatment in Japan: case study and discussion-voting system
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, Japan
    Clin Drug Investig 32:37-51. 2012
  5. ncbi Hepatocellular carcinoma in 2011 and beyond: from the pathogenesis to molecular targeted therapy
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Ohno Higashi, Osakasayama, Japan
    Oncology 81:1-10. 2011
  6. ncbi Adjuvant therapy after curative treatment for hepatocellular carcinoma
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University, Ohno Higashi, Osakasayama, Japan
    Oncology 81:50-5. 2011
  7. ncbi Diagnostic imaging of hepatocellular carcinoma: recent progress
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osakasayama, Osaka, Japan
    Oncology 81:73-85. 2011
  8. ncbi Identifying and prioritizing strategies for comprehensive liver cancer control in Asia
    John F P Bridges
    Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, 624 N Broadway, Baltimore, MD 212105, USA
    BMC Health Serv Res 11:298. 2011
  9. ncbi A novel biomarker TERTmRNA is applicable for early detection of hepatoma
    Norimasa Miura
    Department of Pathophysiological and Therapeutic Science, Tottori University, Japan
    BMC Gastroenterol 10:46. 2010
  10. ncbi Intranodular blood supply correlates well with biological malignancy grade determined by tumor growth rate in pathologically proven hepatocellular carcinoma
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Oncology 75:55-64. 2008

Detail Information

Publications134 found, 100 shown here

  1. ncbi Noninvasive evaluation of hepatic fibrosis using serum fibrotic markers, transient elastography (FibroScan) and real-time tissue elastography
    Chie Tatsumi
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Intervirology 51:27-33. 2008
    ..g. serum fibrotic markers, transient elastography and real-time tissue elastography, in the diagnosis of hepatic fibrosis, and to determine whether they can replace liver biopsy...
  2. ncbi Real-life clinical practice with sorafenib in advanced hepatocellular carcinoma: a single-center experience
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, Japan
    Dig Dis 30:609-16. 2012
    ..Multivariate analysis revealed treatment duration as a significant prognostic factor. Furthermore, patients who received post-sorafenib treatment had a better outcome than those who did not...
  3. ncbi Targeted therapy for liver cancer: updated review in 2012
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan
    Curr Cancer Drug Targets 12:1062-72. 2012
    ..Furthermore, it also reviews the current status of clinical trials of new agents or combination therapy with sorafenib and standard treatment. Finally, further prospect of the paradigm shift of the HCC treatment is also discussed...
  4. ncbi Current status of hepatocellular carcinoma treatment in Japan: case study and discussion-voting system
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, Japan
    Clin Drug Investig 32:37-51. 2012
    ..Sorafenib should currently not be used as adjuvant therapy or in combination with TACE or HAIC until evidence from ongoing clinical trials shows that it is beneficial in these settings...
  5. ncbi Hepatocellular carcinoma in 2011 and beyond: from the pathogenesis to molecular targeted therapy
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Ohno Higashi, Osakasayama, Japan
    Oncology 81:1-10. 2011
    ....
  6. ncbi Adjuvant therapy after curative treatment for hepatocellular carcinoma
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University, Ohno Higashi, Osakasayama, Japan
    Oncology 81:50-5. 2011
    ..Thus, further research on this issue should be carried out, especially in relation to molecular targeted therapy...
  7. ncbi Diagnostic imaging of hepatocellular carcinoma: recent progress
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osakasayama, Osaka, Japan
    Oncology 81:73-85. 2011
    ....
  8. ncbi Identifying and prioritizing strategies for comprehensive liver cancer control in Asia
    John F P Bridges
    Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, 624 N Broadway, Baltimore, MD 212105, USA
    BMC Health Serv Res 11:298. 2011
    ..We sought to identify strategies for inclusion in a comprehensive liver cancer control for Asia and to compare qualitative and quantitative methods for prioritization...
  9. ncbi A novel biomarker TERTmRNA is applicable for early detection of hepatoma
    Norimasa Miura
    Department of Pathophysiological and Therapeutic Science, Tottori University, Japan
    BMC Gastroenterol 10:46. 2010
    ..alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) are good markers for HCC. In this study, we verified the significance of hTERTmRNA in a large scale multi-centered trial, collating quantified values with clinical course...
  10. ncbi Intranodular blood supply correlates well with biological malignancy grade determined by tumor growth rate in pathologically proven hepatocellular carcinoma
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Oncology 75:55-64. 2008
    ....
  11. ncbi A new prognostic staging system for hepatocellular carcinoma: value of the biomarker combined Japan integrated staging score
    Satoshi Kitai
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, Osaka Sayama, Japan
    Intervirology 51:86-94. 2008
    ....
  12. ncbi Current status of molecularly targeted therapy for hepatocellular carcinoma: clinical practice
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377 2, Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    Int J Clin Oncol 15:242-55. 2010
    ..This review outlines the main pathways involved in the development and progression of HCC and the agents that target these pathways...
  13. ncbi Differentiation of hepatic tumors by color Doppler imaging: role of the maximum velocity and the pulsatility index of the intratumoral blood flow signal
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Intervirology 47:154-61. 2004
    ..In conclusion, in addition to the information obtained by Vmax, simultaneous measurement of PI adds valuable information useful in the noninvasive differentiation among hepatic tumors by Doppler spectral analysis at color Doppler US...
  14. ncbi Early detection and curative treatment of early-stage hepatocellular carcinoma
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan
    Clin Gastroenterol Hepatol 3:S144-8. 2005
    ..Furthermore, advances of prognostic staging system, such as Japan Integrated Staging score, facilitate the management of HCC...
  15. ncbi Early detection and characterization of hepatocellular carcinoma: value of imaging multistep human hepatocarcinogenesis
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Intervirology 49:64-9. 2006
    ..At present, these findings are easily obtained by contrast-enhanced phase invasion harmonic imaging, which is a noninvasive US technology...
  16. ncbi Atypical large well-differentiated hepatocellular carcinoma with benign nature: a new clinical entity
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University, Osaka Sayama, Osaka, Japan
    Intervirology 47:227-37. 2004
    ....
  17. ncbi The 2008 Okuda lecture: Management of hepatocellular carcinoma: from surveillance to molecular targeted therapy
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    J Gastroenterol Hepatol 25:439-52. 2010
    ..In conclusion, it is expected that readers will gain deeper insight into the latest progress and updated diagnosis and treatment of HCC described in this review...
  18. ncbi Validation of a new prognostic staging system for hepatocellular carcinoma: the JIS score compared with the CLIP score
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Hepatology 40:1396-405. 2004
    ..In conclusion, the stratification ability and prognostic predictive power of the JIS score were much better than that of the CLIP score and were simple to obtain and remember...
  19. ncbi Impact of interferon therapy after curative treatment of hepatocellular carcinoma
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Oncology 75:30-41. 2008
    ..6) It may be concluded that IFN treatment after curative treatment of HCC is beneficial at least in HCV-related HCC, since it lowers recurrence and improves survival...
  20. ncbi Liver Cancer Working Group report
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377 2, Ohono Higashi, Osaka Sayama, Osaka, Japan
    Jpn J Clin Oncol 40:i19-27. 2010
    ..Sorafenib is the first systemic therapy to demonstrate prolonged survival vs. the placebo in patients with advanced hepatocellular carcinoma. Various other new molecularly targeted agents are currently under investigation...
  21. ncbi Long-term interferon maintenance therapy improves survival in patients with HCV-related hepatocellular carcinoma after curative radiofrequency ablation. A matched case-control study
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan
    Oncology 72:132-8. 2007
    ..To assess whether low-dose, long-term maintenance interferon (IFN) therapy inhibits recurrence after complete ablation of hepatocellular carcinoma (HCC) and improves patient survival...
  22. ncbi Imaging diagnosis of hepatocellular carcinoma and premalignant/borderline lesions
    M Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan
    Semin Liver Dis 19:297-309. 1999
    ....
  23. ncbi Diagnostic accuracy of imaging for liver cirrhosis compared to histologically proven liver cirrhosis. A multicenter collaborative study
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Intervirology 51:17-26. 2008
    ..To evaluate the diagnostic accuracy of liver cirrhosis by imaging modalities, including CT, MRI and US, compared to results obtained from histopathological diagnoses of resected specimens...
  24. ncbi Imaging blood flow characteristics of hepatocellular carcinoma
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan
    Oncology 62:48-56. 2002
    ..With the advent of rapid and remarkable advances in US harmonic imaging techniques, the diagnostic and therapeutic strategies for HCC are changing drastically...
  25. ncbi Tailor-made therapy for viral hepatitis: recent advances
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Digestion 84:1-4. 2011
    ..The relative etiologic role of prior hepatitis B virus infection in the development of non-B non-C hepatocellular carcinoma is also known in hepatitis B-endemic areas...
  26. ncbi Hepatocellular carcinoma 2009 and beyond: from the surveillance to molecular targeted therapy
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    Oncology 75:1-12. 2008
    ..If positive results are obtained by these trials, its impact on treatment strategy for HCC will be drastically changed...
  27. ncbi Future treatment option for hepatocellular carcinoma: a focus on brivanib
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan
    Dig Dis 29:316-20. 2011
    ....
  28. ncbi Signaling pathway and molecular-targeted therapy for hepatocellular carcinoma
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan
    Dig Dis 29:289-302. 2011
    ..This review outlines the main pathways involved in the development and progression of HCC and the agents that target these pathways. Finally, current status and future perspective will also be discussed...
  29. ncbi Molecular targeted therapy for hepatocellular carcinoma: bench to bedside
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan
    Dig Dis 29:273-7. 2011
    ..The results of these trials are therefore eagerly awaited...
  30. ncbi Phase III study of sorafenib after transarterial chemoembolisation in Japanese and Korean patients with unresectable hepatocellular carcinoma
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Eur J Cancer 47:2117-27. 2011
    ..This phase III trial assessed the efficacy and safety of sorafenib in Japanese and Korean patients with unresectable HCC who responded to TACE...
  31. ncbi mTOR inhibitor for the treatment of hepatocellular carcinoma
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan
    Dig Dis 29:310-5. 2011
    ..In conclusion, RAD001 is a potential targeted agent for HCC and therefore final results of a phase III study are awaited...
  32. ncbi Single HCC between 2 and 5 cm: the grey zone: hepatologist's perspective
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka, Japan
    J Hepatobiliary Pancreat Sci 17:434-7. 2010
    ..In conclusion, RFA achieves outcomes similar to those of operation for Child-Pugh A patients with HCCs measuring 2-5 cm in size...
  33. ncbi Response evaluation of transcatheter arterial chemoembolization in hepatocellular carcinomas: the usefulness of sonazoid-enhanced harmonic sonography
    Yu Xia
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan
    Oncology 75:99-105. 2008
    ..The purpose of this study was to investigate if Sonazoid-enhanced harmonic ultrasonography (US) could be used to evaluate the responses of hepatocellular carcinomas (HCCs) to treatment with transcatheter arterial chemoembolization (TACE)...
  34. ncbi Combination therapy with S-1 and pegylated interferon alpha for advanced hepatocellular carcinoma
    Kazuomi Ueshima
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Oncology 75:106-13. 2008
    ..We evaluated the efficacy and safety of combination therapy with S-1 and pegylated interferon (PEG-IFN)-alpha for advanced HCC...
  35. ncbi Association of interleukin-28B and hepatitis C genotype 1 with a high viral load and response to pegylated interferon plus ribavirin therapy
    Masahiro Takita
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Digestion 84:56-61. 2011
    ..The aims of this study were to analyze the association between the rs8099917 genotype and treatment response in a cohort study of CHC...
  36. ncbi Differential diagnosis of hepatic tumors: value of contrast-enhanced harmonic sonography using the newly developed contrast agent, Sonazoid
    Kinuyo Hatanaka
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, Osaka Sayama, Japan
    Intervirology 51:61-9. 2008
    ..To clarify the value of contrast-enhanced harmonic ultrasonography (US) with Sonazoid, a second-generation US contrast agent, in the differential diagnosis of liver tumors compared to dynamic CT...
  37. ncbi Initial treatment response is essential to improve survival in patients with hepatocellular carcinoma who underwent curative radiofrequency ablation therapy
    Shunsuke Takahashi
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Oncology 72:98-103. 2007
    ..This study was undertaken to assess the outcome of potentially curative radiofrequency ablation (RFA) therapy for early-stage hepatocellular carcinoma (HCC) in patients with Child-Pugh stage A cirrhosis...
  38. ncbi Des-γ-carboxyprothrombin may be a promising biomarker to determine the therapeutic efficacy of sorafenib for hepatocellular carcinoma
    Kazuomi Ueshima
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan
    Dig Dis 29:321-5. 2011
    ..The purpose of this study was to evaluate the role of des-γ-carboxyprothrombin (DCP) as a marker for the efficacy of sorafenib therapy for hepatocellular carcinoma (HCC)...
  39. ncbi PIVKA-II is the best prognostic predictor in patients with hepatocellular carcinoma after radiofrequency ablation therapy
    Shunsuke Takahashi
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, Osaka Sayama, Japan
    Oncology 75:91-8. 2008
    ..This study was undertaken to assess the prognostic predictor in patients with hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA)...
  40. ncbi Prolonged PEG-IFN and RBV is effective in patients with HCV genotype 1 and high viral load who achieved virological response later than 24 weeks
    Taisuke Ueda
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    Intervirology 53:55-9. 2010
    ..However, the effectiveness of extended treatment in patients whose serum HCV RNA become undetectable later than 24 weeks of treatment (ultra-late virological responder; ULVR) has not yet been determined...
  41. ncbi The cancer stem cell marker CD133 is a predictor of the effectiveness of S1+ pegylated interferon α-2b therapy against advanced hepatocellular carcinoma
    Satoru Hagiwara
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka 589 8511, Japan
    J Gastroenterol 46:212-21. 2011
    ..In this study, we attempted to identify factors predicting the effectiveness of this combination therapy...
  42. ncbi Characterization of hepatic tumors: value of contrast-enhanced coded phase-inversion harmonic angio
    Yan Ling Wen
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377-2, Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan
    AJR Am J Roentgenol 182:1019-26. 2004
    ..CONCLUSION: Contrast-enhanced coded harmonic angio is a promising method to provide useful information for the differential diagnosis of hepatic tumors...
  43. ncbi Hepatic arterial infusion chemotherapy using low-dose 5-fluorouracil and cisplatin for advanced hepatocellular carcinoma
    Kazuomi Ueshima
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    Oncology 78:148-53. 2010
    ..We investigated the efficacy and toxicity of HAIC using low-dose FP for patients with advanced HCC as a phase II trial...
  44. ncbi Radiofrequency ablation guided by contrast harmonic sonography using perfluorocarbon microbubbles (Sonazoid) for hepatic malignancies: an initial experience
    Yasunori Minami
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kinki University School of Medicine, Ohno Higashi Osaka Sayama, Japan
    Liver Int 30:759-64. 2010
    ..This study investigated the effectiveness of contrast harmonic sonographic guidance using perfluorocarbon microbubbles (Sonazoid) during RF ablation of hepatic malignancies...
  45. ncbi PEG-IFNalpha/RBV combination therapy for chronic hepatitis C patients increases serum ferritin level while it improves sustained viral response rate
    Norihisa Yada
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    Intervirology 53:60-5. 2010
    ....
  46. ncbi Can the biliary enhancement of Gd-EOB-DTPA predict the degree of liver function?
    Masahiro Okada
    Department of Radiology, Kinki University Faculty of Medicine, Osaka Sayama, Osaka, Japan
    Hepatobiliary Pancreat Dis Int 11:307-13. 2012
    ..The purpose of this study was to investigate the relation between liver and biliary enhancement in patients with or without liver dysfunction, and to compare the tumor-to-liver contrast in these patients...
  47. ncbi Imaging of hepatocellular carcinoma: qualitative and quantitative analysis of postvascular phase contrast-enhanced ultrasonography with sonazoid. Comparison with superparamagnetic iron oxide magnetic resonance images
    Tatsuo Inoue
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, Osaka Sayama, Japan
    Oncology 75:48-54. 2008
    ....
  48. ncbi Prospective comparative study of the EUS guided 25-gauge FNA needle with the 19-gauge Trucut needle and 22-gauge FNA needle in patients with solid pancreatic masses
    Hiroki Sakamoto
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, Ohno Higashi, Osaka Sayama, Japan
    J Gastroenterol Hepatol 24:384-90. 2009
    ....
  49. ncbi Radiofrequency ablation for hepatocellular carcinoma: assistant techniques for difficult cases
    Tatsuo Inoue
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan
    Oncology 78:94-101. 2010
    ..To confirm the safety and effectiveness of techniques to assist radiofrequency ablation (RFA) for difficult cases, we retrospectively evaluated successful treatment rates, early complications and local tumor progressions...
  50. ncbi Outcomes of nontransplant potentially curative therapy for early-stage hepatocellular carcinoma in Child-Pugh stage A cirrhosis is comparable with liver transplantation
    Shunsuke Takahashi
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, Ohno Higashi, Osaka Sayama, Japan
    Dig Dis 25:303-9. 2007
    ....
  51. ncbi Validation of a new prognostic staging system for hepatocellular carcinoma: a comparison of the biomarker-combined Japan Integrated Staging Score, the conventional Japan Integrated Staging Score and the BALAD Score
    Satoshi Kitai
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan
    Oncology 75:83-90. 2008
    ..The aim of this study is to evaluate the performance of these three staging systems...
  52. ncbi Staging hepatocellular carcinoma by a novel scoring system (BALAD score) based on serum markers
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, and Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka-Sayama, Japan
    Clin Gastroenterol Hepatol 4:1528-36. 2006
    ..In addition, stage can be evaluated with the use of only 1 serum sample. It also allows global comparison of patients with HCC or comparison of patients from different time periods with the same standard...
  53. ncbi Clinical characteristics of NonBNonC- HCC: Comparison with HBV and HCV related HCC
    Kinuyo Hatanaka
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan
    Intervirology 50:24-31. 2007
    ....
  54. ncbi Estimation of malignant potential of GI stromal tumors by contrast-enhanced harmonic EUS (with videos)
    Hiroki Sakamoto
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Gastrointest Endosc 73:227-37. 2011
    ..Contrast-enhanced harmonic EUS (CEH-EUS) is a new sonographic technique that uses US contrast agents and depicts intratumoral vessels in real time...
  55. ncbi Percutaneous radiofrequency ablation of sonographically unidentifiable liver tumors. Feasibility and usefulness of a novel guiding technique with an integrated system of computed tomography and sonographic images
    Yasunori Minami
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Oncology 72:111-6. 2007
    ....
  56. ncbi Comparison of three current staging systems for hepatocellular carcinoma: Japan integrated staging score, new Barcelona Clinic Liver Cancer staging classification, and Tokyo score
    Hobyung Chung
    Department of Gastroenterology, Kinki University School of Medicine, Osaka Sayama, Japan
    J Gastroenterol Hepatol 23:445-52. 2008
    ..The aim of the present study was to compare the performance of the currently developed three staging systems: the Japan integrated staging (JIS) score, new Barcelona Clinic Liver Cancer (BCLC) staging classification, and the Tokyo score...
  57. ncbi Characterization of intra-abdominal lesions of undetermined origin by contrast-enhanced harmonic EUS (with videos)
    Yu Xia
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan
    Gastrointest Endosc 72:637-42. 2010
    ..The diagnosis of intra-abdominal lesions of undetermined origin is often a challenge for endoscopists and radiologists...
  58. ncbi Oral branched-chain amino acid granules reduce the incidence of hepatocellular carcinoma and improve event-free survival in patients with liver cirrhosis
    Sosuke Hayaishi
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Sakai Hospital, Osaka, Japan
    Dig Dis 29:326-32. 2011
    ..We investigated the effects of oral BCAA supplementation on the incidence of hepatocellular carcinoma (HCC) and liver-related events in patients with compensated and decompensated cirrhosis...
  59. ncbi Usefulness of the post-vascular phase of contrast-enhanced ultrasonography with sonazoid in the evaluation of gross types of hepatocellular carcinoma
    Kinuyo Hatanaka
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan
    Oncology 78:53-9. 2010
    ....
  60. ncbi Plasma concentrations of angiogenesis-related molecules in patients with pancreatic cancer
    Hiroki Sakamoto
    Department of Genome Biology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Jpn J Clin Oncol 42:105-12. 2012
    ..The aim of this study was to evaluate the plasma concentrations of angiogenesis-related molecules in patients with pancreatic cancer, compared with those with other diseases...
  61. ncbi Usefulness of combination of imaging modalities in the diagnosis of hepatocellular carcinoma using Sonazoid®-enhanced ultrasound, gadolinium diethylene-triamine-pentaacetic acid-enhanced magnetic resonance imaging, and contrast-enhanced computed tomograph
    Alshimaa Alaboudy
    Division of Gastoroenterology and Hepatology, Department of Internal Medicine, Kinki University Faculty of Medicine, Osakasayama, Japan
    Oncology 81:66-72. 2011
    ....
  62. ncbi Diagnosis of gallbladder diseases by contrast-enhanced phase-inversion harmonic ultrasonography
    Tatsuo Inoue
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, Osaka Sayama, Japan
    Ultrasound Med Biol 33:353-61. 2007
    ..Nevertheless, contrast-enhanced US is clearly superior to the other techniques in discriminating biliary sludge from other lesions...
  63. ncbi Depiction of portal supply in early hepatocellular carcinoma and dysplastic nodule: value of pure arterial ultrasound imaging in hepatocellular carcinoma
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan m kudo med kindai ac jp
    Oncology 78:60-7. 2010
    ....
  64. ncbi Tumor markers after radiofrequency ablation therapy for hepatocellular carcinoma
    Chikara Ogawa
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, Osaka Sayama, Japan
    Hepatogastroenterology 55:1454-7. 2008
    ....
  65. ncbi Non-invasive evaluation of hepatic fibrosis for type C chronic hepatitis
    Chie Tatsumi
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Intervirology 53:76-81. 2010
    ..The aim of this study was to investigate liver fibrosis using non-invasive Real-time Tissue Elastography (RTE) and transient elastography (FibroScan) methods...
  66. ncbi Radiofrequency ablation of hepatocellular carcinoma: therapeutic response using contrast-enhanced coded phase-inversion harmonic sonography
    Yan Ling Wen
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377-2, Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan
    AJR Am J Roentgenol 181:57-63. 2003
    ....
  67. ncbi Radiofrequency ablation of hepatocellular carcinoma: value of virtual CT sonography with magnetic navigation
    Yasunori Minami
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    AJR Am J Roentgenol 190:W335-41. 2008
    ..The purpose of this study was to evaluate the efficiency and feasibility of virtual CT sonography for radiofrequency ablation of hypervascular hepatocellular carcinoma poorly defined on B-mode sonography...
  68. ncbi Management of hepatocellular carcinoma in Japan: consensus-based clinical practice manual proposed by the Japan Society of Hepatology
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    Oncology 72:2-15. 2007
    ..In this article, the content of this manual, especially issues on surveillance, diagnosis, staging, and treatment, is summarized...
  69. ncbi Differential diagnosis of nodular lesions in cirrhotic liver by post-vascular phase contrast-enhanced US with Levovist: comparison with superparamagnetic iron oxide magnetic resonance images
    Tatsuo Inoue
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama 589-8511, Japan
    J Gastroenterol 40:1139-47. 2005
    ..CONCLUSIONS: Contrast-enhanced US is a valuable method for predicting the histological grade of HCCs in cirrhotic patients, and may be a good alternative to SPIO-enhanced MRI...
  70. ncbi Elevated serum ALT levels during pegylated interferon monotherapy may be caused by hepatic iron overload
    Miki Nagashima
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Ohno Higashi, Osaka Sayama, Japan
    Intervirology 51:76-85. 2008
    ..We investigated whether elevated serum ALT levels during PEG-IFN therapy are associated with iron overload...
  71. ncbi Antitumor activity of BIBF 1120, a triple angiokinase inhibitor, and use of VEGFR2+pTyr+ peripheral blood leukocytes as a pharmacodynamic biomarker in vivo
    Kanae Kudo
    Department of Genome Biology and Gastroenterology, Kinki University School of Medicine, Osaka, Japan
    Clin Cancer Res 17:1373-81. 2011
    ..This study examined the antitumor effects of BIBF 1120 on hepatocellular carcinoma (HCC) and attempted to identify a pharmacodynamic biomarker for use in early clinical trials...
  72. ncbi Prognostic factors for portal venous invasion in patients with hepatocellular carcinoma
    Satoru Hagiwara
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama 589-8511, Japan
    J Gastroenterol 41:1214-9. 2006
    ..Furthermore, the incidence of PVI was significantly higher in patients with a platelet count of 130 000/mm(3) or more...
  73. ncbi EUS-guided broad plexus neurolysis over the superior mesenteric artery using a 25-gauge needle
    Hiroki Sakamoto
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osakasayama City, Osaka, Japan
    Am J Gastroenterol 105:2599-606. 2010
    ..We compared the effectiveness of standard EUS-CPN and EUS-guided broad plexus neurolysis (EUS-BPN) that extends over the superior mesenteric artery (SMA) using a 25-gauge needle...
  74. ncbi Management of hepatocellular carcinoma in Japan: Consensus-Based Clinical Practice Guidelines proposed by the Japan Society of Hepatology (JSH) 2010 updated version
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan m kudo med kindai ac jp
    Dig Dis 29:339-64. 2011
    ..In this article, the 2010 updated version of this manual, especially issues on prevention, surveillance, pathology, diagnosis, staging, and treatment algorithm are summarized...
  75. ncbi Sonazoid-enhanced ultrasonography for diagnosis of hepatic malignancies: comparison with contrast-enhanced CT
    Kinuyo Hatanaka
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, Osaka Sayama, Japan
    Oncology 75:42-7. 2008
    ..The purpose of this study was to assess the usefulness of Sonazoid-enhanced ultrasonography (US) in the diagnosis of hepatic malignancies in comparison with contrast-enhanced CT findings...
  76. ncbi Small cell carcinoma of the pancreas: role of EUS-FNA and subsequent effective chemotherapy using carboplatin and etoposide
    Hiroki Sakamoto
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    J Gastroenterol 44:432-8. 2009
    ..The aim of this study was to evaluate the effectiveness of combination chemotherapy with carboplatin and etoposide (CE) in SCC of the pancreas...
  77. ncbi Multistep human hepatocarcinogenesis: correlation of imaging with pathology
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, 589 8511, Japan
    J Gastroenterol 44:112-8. 2009
    ....
  78. ncbi Utility of contrast-enhanced endoscopic ultrasonography for diagnosis of small pancreatic carcinomas
    Hiroki Sakamoto
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, Osaka Sayama, Japan
    Ultrasound Med Biol 34:525-32. 2008
    ..0%, 11.0% and 83.3% for CE-CT, PD-EUS and CE-EUS. CE-EUS was significantly more sensitive than PD-EUS and CE-CT. EUS and subsequent CE-EUS are more sensitive than CE-CT in the detection and the differentiation of small pancreatic tumors...
  79. ncbi Comparison of an ecabet sodium and proton pump inhibitor (PPI) combination therapy with PPI alone in the treatment of endoscopic submucosal dissection (ESD)--induced ulcers in early gastric cancer: prospective randomized study
    Yutaka Asakuma
    Department of Gastroenterology and Hepatology, Kinki University, School of Medicine, 377 2 Ohno Higashi, Osaka Sayama 589 8511, Japan
    Hepatogastroenterology 56:1270-3. 2009
    ..The present paper prospectively evaluate the additive benefits of using ES in combination with the rabeprazole proton pump inhibitor (PPI) for the treatment of gastric ulcers after endoscopic submucosal dissection (ESD)...
  80. ncbi Treatment of large and/or multiple hepatic malignancies: open surgical approaches of radiofrequency ablation
    Yasunori Minami
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Hepatogastroenterology 54:2358-60. 2007
    ..The purpose of this study was to determine the safety and efficacy of open intraoperative radiofrequency ablation of unresectable hepatic malignancies with size larger than 4 cm in diameter and/or more than three in number...
  81. ncbi Low-dose, long-term, intermittent interferon-alpha-2b therapy after radical treatment by radiofrequency ablation delays clinical recurrence in patients with hepatitis C virus-related hepatocellular carcinoma
    Yasuhiro Sakaguchi
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka-Sayama, Osaka, Japan
    Intervirology 48:64-70. 2005
    ..25). CONCLUSION: Subsequently after radical RFA therapy, long-term, low-dose, intermittent IFN therapy successfully delayed clinical recurrence of HCC...
  82. ncbi Percutaneous ultrasound-guided radiofrequency ablation with artificial pleural effusion for hepatocellular carcinoma in the hepatic dome
    Yasunori Minami
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377-2 Ohno-Higashi, 589-8511, Osaka-Sayama, Japan
    J Gastroenterol 38:1066-70. 2003
    ..9 months). CONCLUSIONS: Percutaneous RF ablation with artificial pleural effusion in patients with HCC in the hepatic dome may be a safe and feasible therapy...
  83. ncbi Contrast harmonic sonography-guided radiofrequency ablation therapy versus B-mode sonography in hepatocellular carcinoma: prospective randomized controlled trial
    Yasunori Minami
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayma, Osaka 589 8511, Japan
    AJR Am J Roentgenol 188:489-94. 2007
    ..The purpose of this study was to evaluate the effectiveness of contrast harmonic sonographic guidance in radiofrequency ablation of locally progressive hepatocellular carcinoma poorly depicted with B-mode sonography...
  84. ncbi Positioning of a molecular-targeted agent, sorafenib, in the treatment algorithm for hepatocellular carcinoma and implication of many complete remission cases in Japan
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan m kudo med kindai ac jp
    Oncology 78:154-66. 2010
    ..According to a subanalysis of the SHARP study, it is expected that sorafenib in combination with resection, ablation, TACE or HAIC will markedly prolong the overall survival in early-, intermediate- and advanced- stage HCCs...
  85. ncbi Ischemia of rat stomach mobilizes ECL cell histamine
    Masayuki Kitano
    Department of Clinical Pharmacology, Faculty of Medicine, Tottori University, Tottori, Japan
    Am J Physiol Gastrointest Liver Physiol 288:G1084-90. 2005
    ..The lesions develop not because of mobilization of histamine per se but because of ischemia plus reperfusion plus gastric acid...
  86. ncbi New techniques and future perspective of EUS for the differential diagnosis of pancreatic malignancies: contrast harmonic imaging
    Masayuki Kitano
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Dig Endosc 23:46-50. 2011
    ..Contrast-enhanced harmonic EUS also discriminates mural nodules from mucous clots in the intraductal papillary mucinous neoplasms...
  87. ncbi Management of hepatocellular carcinoma: from prevention to molecular targeted therapy
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan m kudo med kindai ac jp
    Oncology 78:1-6. 2010
    ....
  88. ncbi Prognostic staging system for hepatocellular carcinoma (CLIP score): its value and limitations, and a proposal for a new staging system, the Japan Integrated Staging Score (JIS score)
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama 589-8511, Japan
    J Gastroenterol 38:207-15. 2003
    ..Because the JIS score is quite easily obtained and is objective, we strongly propose it for widespread use as a prognostic staging system for HCC in clinical practice...
  89. ncbi Treatment of hepatocellular carcinoma with percutaneous radiofrequency ablation: usefulness of contrast harmonic sonography for lesions poorly defined with B-mode sonography
    Yasunori Minami
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama 589-8511, Japan
    AJR Am J Roentgenol 183:153-6. 2004
    ..002). CONCLUSION: Contrast harmonic sonography helps in the placement of radiofrequency ablation electrodes in hypervascular hepatocellular carcinomas that cannot be adequately depicted by B-mode sonography...
  90. ncbi Will Gd-EOB-MRI change the diagnostic algorithm in hepatocellular carcinoma?
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan m kudo med kindai ac jp
    Oncology 78:87-93. 2010
    ..Thus, Gd-EOB-DTPA MRI will have a significant impact on diagnostic algorithm for HCC...
  91. ncbi Estimation of the malignant potential of gastrointestinal stromal tumors: the value of contrast-enhanced coded phase-inversion harmonics US
    Nobuhiro Fukuta
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, 589-8511, Japan
    J Gastroenterol 40:247-55. 2005
    ..CONCLUSIONS: Contrast-enhanced US image is more closely correlated with the final diagnosis than the histological findings...
  92. ncbi EUS-guided in vivo microdialysis of the pancreas: a novel technique with potential diagnostic and therapeutic application
    Masayuki Kitano
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, Osaka Sayama, Japan
    Gastrointest Endosc 71:176-9. 2010
    ..Microdialysis has been used in vivo to measure dynamic temporal variations in extracellular or interstitial concentrations of non-protein-bound substances that are unstable in the systemic circulation...
  93. ncbi Present status and future perspective of EUS-guided drainage
    Masayuki Kitano
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Japan
    Dig Endosc 21:S66-70. 2009
    ....
  94. ncbi Natural course of small nodular lesions with intranodular preserved portal supply in cirrhotic liver
    Toyokazu Fukunaga
    Division of Gastroenterology, Department of Internal Medicine, Kitano Hospital, Osaka, Japan
    Oncology 72:24-9. 2007
    ..This study was performed to clarify the rate of malignant transformation in such lesions with preserved portal perfusion in cirrhotic liver...
  95. ncbi Value of liver parenchymal phase contrast-enhanced sonography to diagnose premalignant and borderline lesions and overt hepatocellular carcinoma
    Tatsuo Inoue
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, 377 2, Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    AJR Am J Roentgenol 192:698-705. 2009
    ..The objective of our study was to investigate whether liver parenchymal phase contrast-enhanced sonography can provide additional information for assessing histologic grades of hepatocellular carcinoma (HCC)...
  96. ncbi Severe complications of radiofrequency ablation therapy for hepatocellular carcinoma: an analysis of 3,891 ablations in 2,614 patients
    Hiroshi Kasugai
    Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Oncology 72:72-5. 2007
    ..To clarify information on and frequency of complications as well as mortality rate after radiofrequency ablation (RFA) for hepatocellular carcinoma...
  97. ncbi Studies on the variation in clinical laboratory data and safety evaluation of pharmaceuticals
    Morihiro Nomura
    Department of Pharmacy, Kinki University Hospital, Japan
    Yakugaku Zasshi 125:997-1004. 2005
    ....
  98. ncbi Sorafenib inhibits the hepatocyte growth factor-mediated epithelial mesenchymal transition in hepatocellular carcinoma
    Tomoyuki Nagai
    Kazuto Nishio, Department of Genome Biology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Mol Cancer Ther 10:169-77. 2011
    ..Our findings may provide a novel insight into the anti-EMT effect of tyrosine kinase inhibitors in cancer cells...
  99. ncbi Two cases of histopathologically advanced (stage IV) early gastric cancers
    M Shiomi
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    Tumori 87:191-5. 2001
    ..Stage IV factors were N3 in the first and ovarian metastasis (Krukenberg tumor) in the second case...
  100. ncbi Dynamic imaging of pancreatic diseases by contrast enhanced coded phase inversion harmonic ultrasonography
    M Kitano
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, Ohno Higashi, Osaka Sayama, Japan
    Gut 53:854-9. 2004
    ..Our purpose was to employ this novel technique to observe microvessels in pancreatic tumours...
  101. ncbi Percutaneous radiofrequency ablation guided by contrast-enhanced harmonic sonography with artificial pleural effusion for hepatocellular carcinoma in the hepatic dome
    Yasunori Minami
    Department of Internal Medicine, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama 589-8511, Japan
    AJR Am J Roentgenol 182:1224-6. 2004