A Kawabata

Summary

Affiliation: Kinki University
Country: Japan

Publications

  1. ncbi request reprint Receptor-activating peptides for PAR-1 and PAR-2 relax rat gastric artery via multiple mechanisms
    Atsufumi Kawabata
    Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Life Sci 75:2689-702. 2004
  2. pmc The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection
    A Kawabata
    Faculty of Pharmaceutical Sciences, Kinki University, Higashi Osaka, Japan
    J Clin Invest 107:1443-50. 2001
  3. pmc 2-Furoyl-LIGRL-NH2, a potent agonist for proteinase-activated receptor-2, as a gastric mucosal cytoprotective agent in mice
    Atsufumi Kawabata
    Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Koawake, Higashi Osaka 577 8502, Japan
    Br J Pharmacol 144:212-9. 2005
  4. ncbi request reprint Physiology and pathophysiology of proteinase-activated receptors (PARs): PARs in the respiratory system: cellular signaling and physiological/pathological roles
    Atsufumi Kawabata
    Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, Higashi Osaka, Japan
    J Pharmacol Sci 97:20-4. 2005
  5. pmc Gastrointestinal roles for proteinase-activated receptors in health and disease
    A Kawabata
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, Higashi Osaka, Japan
    Br J Pharmacol 153:S230-40. 2008
  6. ncbi request reprint Role of N-methyl-D-aspartate receptors and the nitric oxide pathway in nociception/hyperalgesia elicited by protease-activated receptor-2 activation in mice and rats
    Atsufumi Kawabata
    Department of Pathophysiology and Therapeutics, School of Pharmaceutical Sciences, Kinki University, Higashi Osaka 577 8502, Japan
    Neurosci Lett 329:349-53. 2002
  7. ncbi request reprint Protease-activated receptor-2 (PAR-2) in the pancreas and parotid gland: Immunolocalization and involvement of nitric oxide in the evoked amylase secretion
    Atsufumi Kawabata
    Department of Pathophysiology and Therapeutics, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, 577 8502, Higashi Osaka, Japan
    Life Sci 71:2435-46. 2002
  8. ncbi request reprint [Physiological functions of protease-activated receptor-2]
    Atsufumi Kawabata
    Department of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, Higashi Osaka, Japan
    Nihon Yakurigaku Zasshi 121:411-20. 2003
  9. ncbi request reprint Activation of trigeminal nociceptive neurons by parotid PAR-2 activation in rats
    Atsufumi Kawabata
    Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Neuroreport 15:1617-21. 2004
  10. pmc Involvement of EDHF in the hypotension and increased gastric mucosal blood flow caused by PAR-2 activation in rats
    Atsufumi Kawabata
    School of Pharmaceutical Sciences, Kinki University, Higashi Osaka 577 8502, Japan
    Br J Pharmacol 140:247-54. 2003

Collaborators

Detail Information

Publications80

  1. ncbi request reprint Receptor-activating peptides for PAR-1 and PAR-2 relax rat gastric artery via multiple mechanisms
    Atsufumi Kawabata
    Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Life Sci 75:2689-702. 2004
    ..These findings demonstrate that endothelial PAR-1 and PAR-2, upon activation, dilate the gastric artery via NO and prostanoid formation and also EDHF mechanisms including gap junctions, which would enhance GMBF...
  2. pmc The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection
    A Kawabata
    Faculty of Pharmaceutical Sciences, Kinki University, Higashi Osaka, Japan
    J Clin Invest 107:1443-50. 2001
    ..In contrast, the PAR-2-mediated salivary exocrine secretion appears to be independent of capsaicin-sensitive sensory neurons...
  3. pmc 2-Furoyl-LIGRL-NH2, a potent agonist for proteinase-activated receptor-2, as a gastric mucosal cytoprotective agent in mice
    Atsufumi Kawabata
    Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Koawake, Higashi Osaka 577 8502, Japan
    Br J Pharmacol 144:212-9. 2005
    ..7. Thus, 2-furoyl-LIGRL-NH(2) is considered a potent and orally available gastric mucosal protective agent. Our data also substantiate a role for PAR(2) in gastric mucosal protection and the selective nature of 2-furoyl-LIGRL-NH(2)...
  4. ncbi request reprint Physiology and pathophysiology of proteinase-activated receptors (PARs): PARs in the respiratory system: cellular signaling and physiological/pathological roles
    Atsufumi Kawabata
    Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, Higashi Osaka, Japan
    J Pharmacol Sci 97:20-4. 2005
    ..PARs thus appear to play critical roles in the respiratory systems, and the agonists/antagonists for PARs may serve as the novel therapeutic strategy for treatment of certain respiratory diseases including asthma...
  5. pmc Gastrointestinal roles for proteinase-activated receptors in health and disease
    A Kawabata
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, Higashi Osaka, Japan
    Br J Pharmacol 153:S230-40. 2008
    ..There is also fundamental and clinical evidence for involvement of PAR2 in colonic pain. PARs are thus considered key molecules in regulation of GI functions and targets for development of drugs for treatment of various GI diseases...
  6. ncbi request reprint Role of N-methyl-D-aspartate receptors and the nitric oxide pathway in nociception/hyperalgesia elicited by protease-activated receptor-2 activation in mice and rats
    Atsufumi Kawabata
    Department of Pathophysiology and Therapeutics, School of Pharmaceutical Sciences, Kinki University, Higashi Osaka 577 8502, Japan
    Neurosci Lett 329:349-53. 2002
    ..Our study thus provides a novel mouse model for PAR-2-mediated nociception, and suggests that NMDA receptors are involved in PAR-2-triggered nociception and hyperalgesia, while NO contributes only to the latter...
  7. ncbi request reprint Protease-activated receptor-2 (PAR-2) in the pancreas and parotid gland: Immunolocalization and involvement of nitric oxide in the evoked amylase secretion
    Atsufumi Kawabata
    Department of Pathophysiology and Therapeutics, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, 577 8502, Higashi Osaka, Japan
    Life Sci 71:2435-46. 2002
    ....
  8. ncbi request reprint [Physiological functions of protease-activated receptor-2]
    Atsufumi Kawabata
    Department of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, Higashi Osaka, Japan
    Nihon Yakurigaku Zasshi 121:411-20. 2003
    ..PAR-2 is thus involved in a variety of physiological and pathophysiological functions. PAR-2 is now considered one of the most important molecules as a target for drug development...
  9. ncbi request reprint Activation of trigeminal nociceptive neurons by parotid PAR-2 activation in rats
    Atsufumi Kawabata
    Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Neuroreport 15:1617-21. 2004
    ..Our data thus reveal that activation of PAR-2 in the parotid gland can cause activation of trigeminal nociceptive neurons via capsaicin-sensitive sensory nerves most probably by a non-inflammatory mechanism...
  10. pmc Involvement of EDHF in the hypotension and increased gastric mucosal blood flow caused by PAR-2 activation in rats
    Atsufumi Kawabata
    School of Pharmaceutical Sciences, Kinki University, Higashi Osaka 577 8502, Japan
    Br J Pharmacol 140:247-54. 2003
    ..6. Our data suggest involvement of apamin/charybdotoxin-sensitive K+ channels in the PAR-2-triggered hypotension and increased GMBF, predicting a role of EDHF-like factors...
  11. ncbi request reprint PAR-2: structure, function and relevance to human diseases of the gastric mucosa
    Atsufumi Kawabata
    Department of Pathophysiology and Therapeutics, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Expert Rev Mol Med 4:1-17. 2002
    ..Thus, PAR-2 would appear to be a therapeutic target for treatment of gastric mucosal injury. Agonists and/or antagonists for PAR-2 might also be applicable to the clinical treatment of patients with inflammatory diseases in other organs...
  12. ncbi request reprint Gastrointestinal functions of proteinase-activated receptors
    Atsufumi Kawabata
    Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, 577 8502, Higashi Osaka, Japan
    Life Sci 74:247-54. 2003
    ..Thus, PARs, especially PAR-1 and PAR-2, play extensive roles in modulating the gastrointestinal functions...
  13. ncbi request reprint [Proteinase-activated receptors and gastrointestinal functions]
    Atsufumi Kawabata
    Nihon Yakurigaku Zasshi 128:82-7. 2006
  14. ncbi request reprint A protective role of protease-activated receptor 1 in rat gastric mucosa
    Atsufumi Kawabata
    School of Pharmaceutical Sciences, Kinki University, Higashi Osaka, Japan
    Gastroenterology 126:208-19. 2004
    ..The role of PAR-1, a thrombin receptor, in the stomach remains unknown. We thus examined if the PAR-1 agonist could protect against gastric mucosal injury in rats...
  15. ncbi request reprint Proteinase-activated receptor-2-mediated relaxation in mouse tracheal and bronchial smooth muscle: signal transduction mechanisms and distinct agonist sensitivity
    Atsufumi Kawabata
    Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    J Pharmacol Exp Ther 311:402-10. 2004
    ....
  16. ncbi request reprint Potent and metabolically stable agonists for protease-activated receptor-2: evaluation of activity in multiple assay systems in vitro and in vivo
    Atsufumi Kawabata
    Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    J Pharmacol Exp Ther 309:1098-107. 2004
    ..Furthermore, the data from PAR-2-deficient mice provide ultimate evidence for involvement of PAR-2 in salivation and the selective nature of the 2-furoylated peptides...
  17. ncbi request reprint Capsazepine partially inhibits neurally mediated gastric mucus secretion following activation of protease-activated receptor 2
    Atsufumi Kawabata
    Faculty of Pharmaceutical Sciences, Kinki University, Higashi Osaka, Japan
    Clin Exp Pharmacol Physiol 29:360-1. 2002
    ..3. Thus, activation of VR1 is responsible, at least in part, for the neurally mediated mucosal cytoprotection following activation of PAR2...
  18. pmc Suppression of pancreatitis-related allodynia/hyperalgesia by proteinase-activated receptor-2 in mice
    Atsufumi Kawabata
    Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Br J Pharmacol 148:54-60. 2006
    ....
  19. ncbi request reprint Cross tolerance to environmental stress and endotoxin
    A Kawabata
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Kinki University, Higashi Osaka, Japan
    Life Sci 62:PL 327-33. 1998
    ..These findings indicate the development of cross tolerance to prolonged environmental stress and endotoxin, implying involvement of a common mechanism...
  20. ncbi request reprint Activation of protease-activated receptor-2 (PAR-2) triggers mucin secretion in the rat sublingual gland
    A Kawabata
    Faculty of Pharmaceutical Sciences, Kinki University, Higashi Osaka, Japan
    Biochem Biophys Res Commun 270:298-302. 2000
    ..Thus, PAR-2 is expressed by the three distinct salivary glands in the rat, and sublingual PAR-2 appears to play a role in triggering mucin secretion, at least in part, via activation of tyrosine kinase...
  21. pmc Proteinase-activated receptor-2 (PAR-2): regulation of salivary and pancreatic exocrine secretion in vivo in rats and mice
    A Kawabata
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Kinki University, Higashi Osaka 577 8502, Japan
    Br J Pharmacol 129:1808-14. 2000
    ..Our results indicate that in addition to a potential role in regulating cardiovascular and respiratory functions, PAR-2 may also play a general role in vivo for the direct regulation of glandular exocrine secretion...
  22. pmc Dual modulation by thrombin of the motility of rat oesophageal muscularis mucosae via two distinct protease-activated receptors (PARs): a novel role for PAR-4 as opposed to PAR-1
    A Kawabata
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Br J Pharmacol 131:578-84. 2000
    ..Our data could provide evidence for a novel role of PAR-4 as opposed to PAR-1, although the underlying mechanisms are still open to question...
  23. ncbi request reprint Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle
    A Kawabata
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Kinki University, Higashi Osaka, Japan
    Life Sci 67:2521-30. 2000
    ..Furthermore, non-adrenergic, non-cholinergic nerve neurotransmitter candidates that may modulate K+ channels do not appear to contribute to the relaxation by PAR-1 activation...
  24. pmc In vivo evidence that protease-activated receptors 1 and 2 modulate gastrointestinal transit in the mouse
    A Kawabata
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Br J Pharmacol 133:1213-8. 2001
    ..Our study thus provides novel evidence for the physiological and/or pathophysiological roles of PARs 1 and 2 in the digestive systems, most probably during inflammation...
  25. ncbi request reprint Prostaglandin E2 and pain--an update
    Atsufumi Kawabata
    Division of Pharmacology and Pathophysiology, School of Pharmacy, Kinki University, Higashi Osaka 577 8502, Japan
    Biol Pharm Bull 34:1170-3. 2011
    ..Thus, PGE(2) has a great impact on pain signals, and pharmacological intervention in upstream and downstream signals of PGE(2) may serve as novel therapeutic strategies for the treatment of intractable pain...
  26. ncbi request reprint Distinct roles for protease-activated receptors 1 and 2 in vasomotor modulation in rat superior mesenteric artery
    Atsufumi Kawabata
    Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowake, Higashi Osaka 577 8502, Japan
    Cardiovasc Res 61:683-92. 2004
    ..Protease-activated receptors (PARs) 1 and 2 are expressed in various blood vessels including rat aorta, modulating vascular tone. We investigated the roles of PAR-1 and PAR-2 in vasomotor modulation in rat superior mesenteric artery...
  27. ncbi request reprint Hydrogen sulfide as a novel nociceptive messenger
    Atsufumi Kawabata
    Division of Physiology and Pathophysiology, Department of Pharmacy, School of Pharmacy, Kinki University, Higashi Osaka 577 8502, Japan
    Pain 132:74-81. 2007
    ..Thus, H(2)S appears to function as a novel nociceptive messenger through sensitization of T-type Ca(2+) channels in the peripheral tissues, particularly during inflammation...
  28. ncbi request reprint Antiallodynic effect of etidronate, a bisphosphonate, in rats with adjuvant-induced arthritis: involvement of ATP-sensitive K+ channels
    Atsufumi Kawabata
    Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Neuropharmacology 51:182-90. 2006
    ..Our data demonstrate that repeated etidronate as well as alendronate exhibits antiallodynic activity in arthritic rats, which might be clinically relevant, and suggest involvement of K+ ATP channels in the underlying mechanisms...
  29. ncbi request reprint Factor Xa-evoked relaxation in rat aorta: involvement of PAR-2
    A Kawabata
    Department of Pathophysiology and Therapeutics, Kinki University, Higashi Osaka, 577 8502, Japan
    Biochem Biophys Res Commun 282:432-5. 2001
    ..The factor Xa-PAR-2 pathway might thus contribute to the severe hypotension during sepsis, in which multiple coagulation factors including factor X would become activated and PAR-2 would be induced...
  30. ncbi request reprint Lipopolysaccharide-induced subsensitivity of protease-activated receptor-2 in the mouse salivary glands in vivo
    A Kawabata
    Faculty of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Naunyn Schmiedebergs Arch Pharmacol 364:281-4. 2001
    ....
  31. ncbi request reprint [Proteinase-activated receptor-2 and pain]
    Atsufumi Kawabata
    Nihon Yakurigaku Zasshi 127:133-6, 146. 2006
  32. ncbi request reprint Colonic hyperalgesia triggered by proteinase-activated receptor-2 in mice: involvement of endogenous bradykinin
    Atsufumi Kawabata
    School of Pharmacy, Kinki University, Higashi Osaka 577 8502, Japan
    Neurosci Lett 402:167-72. 2006
    ..Our data thus provide ultimate evidence for role of PAR2 in colonic hypersensitivity, and suggest involvement of the bradykinin-B2 pathway...
  33. doi request reprint Hydrogen sulfide as a novel mediator for pancreatic pain in rodents
    S Nishimura
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3 4 1 Kowakae, Higashi Osaka, 577 8502, Japan
    Gut 58:762-70. 2009
    ..Recently, a pronociceptive role for H(2)S in the processing of somatic pain was identified. Here, the involvement of H(2)S in pancreatic pain is examined...
  34. ncbi request reprint Peripheral PAR-2 triggers thermal hyperalgesia and nociceptive responses in rats
    A Kawabata
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Kinki University, Higashi-Osaka, Osaka, Japan
    Neuroreport 12:715-9. 2001
    ..These data provide novel evidence that activation of peripheral PAR-2 is pro-nociceptive, producing thermal hyperalgesia and also triggering pain sensation, by itself, independently of mast cell degranulation...
  35. ncbi request reprint Hydrogen sulfide-induced colonic mucosal cytoprotection involves T-type calcium channel-dependent neuronal excitation in rats
    M Matsunami
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, Higashi Osaka, Japan
    J Physiol Pharmacol 63:61-8. 2012
    ..2 T-type Ca(2+) channels that are upregulated in the early stage of colitis, leading to colonic mucosal cytoprotection in rats...
  36. ncbi request reprint Mechanisms for modulation of mouse gastrointestinal motility by proteinase-activated receptor (PAR)-1 and -2 in vitro
    Fumiko Sekiguchi
    Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashi Osaka, Osaka 577 8502, Japan
    Life Sci 78:950-7. 2006
    ..Our study thus clarifies the multiple mechanisms for gastrointestinal motility modulation by PAR-1 and -2, and also provides ultimate evidence for involvement of PAR-2...
  37. ncbi request reprint Dual modulation of the tension of isolated gastric artery and gastric mucosal circulation by hydrogen sulfide in rats
    S Kubo
    Division of Physiology and Pathophysiology, School of Pharmacy, Kinki University, 3 4 1 Kowakae, Higashi Osaka, 577 8502, Japan
    Inflammopharmacology 15:288-92. 2007
    ..Together with the in vivo results, our study implies that H2S plays multiple complex roles in regulation of gastric circulation...
  38. ncbi request reprint Secondary somatosensory cortex stimulation facilitates the antinociceptive effect of the NO synthase inhibitor through suppression of spinal nociceptive neurons in the rat
    R Kuroda
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Kinki University, Higashi-Osaka 577-8502, Japan
    Brain Res 903:110-6. 2001
    ....
  39. doi request reprint Luminal hydrogen sulfide plays a pronociceptive role in mouse colon
    M Matsunami
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Gut 58:751-61. 2009
    ..Given recent evidence that hydrogen sulfide (H(2)S), a gasotransmitter, promotes somatic pain through redox modulation of T-type Ca(2+) channels, the roles of colonic luminal H(2)S in visceral nociceptive processing in mice were examined...
  40. doi request reprint Inhibition of T-type calcium channels and hydrogen sulfide-forming enzyme reverses paclitaxel-evoked neuropathic hyperalgesia in rats
    K Okubo
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Neuroscience 188:148-56. 2011
    ..2 and CSE at protein levels, differing from the previous evidence for the neuropathic pain model induced by spinal nerve cutting in which Ca(v)3.2 was dramatically upregulated in DRG...
  41. ncbi request reprint Proteinase-activated receptors in the gastrointestinal system: a functional linkage to prostanoids
    F Sekiguchi
    Division of Physiology and Pathophysiology, School of Pharmacy, Kinki University, 3 4 1 Kowakae, Higashi Osaka, 577 8502, Japan
    Inflammopharmacology 15:246-51. 2007
    ..Collectively, a functional linkage of PAR1 and/or PAR2 to PGs is considered important in the gastrointestinal system...
  42. ncbi request reprint Modulation of capsaicin-evoked visceral pain and referred hyperalgesia by protease-activated receptors 1 and 2
    Naoyuki Kawao
    Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, Osaka, Japan
    J Pharmacol Sci 94:277-85. 2004
    ....
  43. ncbi request reprint Biological activity of Helicobacter pylori components in mammalian cells: is it independent of proteinase-activated receptors?
    F Sekiguchi
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, Higashi Osaka, Japan
    J Physiol Pharmacol 63:571-6. 2012
    ..pylori extracts in A549 and HCT-15 cells or rat platelets, and suggests that they are not mediated by any PAR-activating proteinases, but may involve the other pathogenic factors including LPS...
  44. ncbi request reprint Specific distribution of sialic acids in animal tissues as examined by LC-ESI-MS after derivatization with 1,2-diamino-4,5-methylenedioxybenzene
    N Morimoto
    Faculty of Pharmaceutical Sciences, Kinki University, Higashi-Osaka, Japan
    Anal Chem 73:5422-8. 2001
    ..Further, HPLC-ESI-MS revealed that all the tissues examined in mice and rats commonly contained highly acetylated sialic acids and 8-O-sulfated N-acetylneuraminic acid...
  45. pmc Protease-activated receptor-2 (PAR-2) in the rat gastric mucosa: immunolocalization and facilitation of pepsin/pepsinogen secretion
    Naoyuki Kawao
    School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Br J Pharmacol 135:1292-6. 2002
    ..5. Our study thus provides novel evidence that PAR-2 is localized in mucosal chief cells and facilitates gastric pepsin secretion in the rats, most probably by a direct mechanism...
  46. pmc The noradrenaline precursor L-threo-3,4-dihydroxyphenylserine exhibits antinociceptive activity via central alpha-adrenoceptors in the mouse
    A Kawabata
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kinki University, Higashi Osaka, Japan
    Br J Pharmacol 111:503-8. 1994
    ....
  47. ncbi request reprint Capsazepine inhibits thermal hyperalgesia but not nociception triggered by protease-activated receptor-2 in rats
    Naoyuki Kawao
    Department of Pathophysiology and Therapeutics, School of Pharmaceutical Sciences, Kinki University, Higashi Osaka, Japan
    Jpn J Pharmacol 89:184-7. 2002
    ..pl. SLIGRL-NH2 were attenuated by capsazepine. Our data imply that trans-activation of capsaicin receptors by PAR-2 might be involved in the PAR-2-triggered thermal hyperalgesia, but not nociception...
  48. doi request reprint The proteinase/proteinase-activated receptor-2/transient receptor potential vanilloid-1 cascade impacts pancreatic pain in mice
    Sachiyo Nishimura
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, Higashi Osaka, Japan
    Life Sci 87:643-50. 2010
    ..Given evidence for contribution of PAR2 to pancreatic pain, the present study aimed at clarifying the involvement of TRPV1 in processing of pancreatic pain by the proteinase/PAR2 pathway in mice...
  49. ncbi request reprint The potent inducible nitric oxide synthase inhibitor ONO-1714 inhibits neuronal NOS and exerts antinociception in rats
    Fumiko Sekiguchi
    Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashi Osaka, 577 8502, Japan
    Neurosci Lett 365:111-5. 2004
    ..t. L-NAME. Thus, ONO-1714 is considered a potent inhibitor of nNOS in addition to iNOS. The distinct relative antinociceptive activities of systemic and i.t. ONO-1714 are attributable to its possible poor blood-brain barrier permeability...
  50. doi request reprint Upregulation of Ca(v)3.2 T-type calcium channels targeted by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain
    Tomoko Takahashi
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, Higashi Osaka 577 8502, Japan
    Pain 150:183-91. 2010
    ..We thus propose that Ca(v)3.2 and CSE could be targets for the development of therapeutic drugs for the treatment of neuropathic pain...
  51. doi request reprint Hyperalgesia induced by spinal and peripheral hydrogen sulfide: evidence for involvement of Cav3.2 T-type calcium channels
    Yumi Maeda
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Pain 142:127-32. 2009
    ..2 T-type Ca2+ channels expressed in the primary afferents and/or spinal nociceptive neurons, leading to sensitization of nociceptive processing and hyperalgesia...
  52. ncbi request reprint Direct inhibition of endothelial nitric oxide synthase by hydrogen sulfide: contribution to dual modulation of vascular tension
    Satoko Kubo
    Division of Physiology and Pathophysiology, School of Pharmacy, Kinki University, 3 4 1 Kowakae, Higashi Osaka, Japan
    Toxicology 232:138-46. 2007
    ..Most interestingly, our data demonstrate direct inhibition of eNOS by NaHS, probably responsible for its contractile activity, being evidence for a novel function of H(2)S...
  53. ncbi request reprint Signal transduction for formation/release of interleukin-8 caused by a PAR2-activating peptide in human lung epithelial cells
    Kazumi Moriyuki
    Division of Physiology and Pathophysiology, School of Pharmacy, Kinki University, Higashi Osaka 577 8502, Japan
    Regul Pept 145:42-8. 2008
    ....
  54. ncbi request reprint Signal transduction for proteinase-activated receptor-2-triggered prostaglandin E2 formation in human lung epithelial cells
    Naoyuki Kawao
    Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, Higashi Osaka, Japan
    J Pharmacol Exp Ther 315:576-89. 2005
    ....
  55. doi request reprint Chelating luminal zinc mimics hydrogen sulfide-evoked colonic pain in mice: possible involvement of T-type calcium channels
    M Matsunami
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Neuroscience 181:257-64. 2011
    ..2 isoform. Hence, endogenous Zn(2+) is considered to play a critical role in modulating visceral pain...
  56. ncbi request reprint Roles of urokinase type plasminogen activator in a brain stab wound
    K Kataoka
    Department of Neurosurgery, Kinki University, School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, 589 8511, Osaka, Japan
    Brain Res 887:187-90. 2000
    ..Vasculatures in the wound proliferated in PAI-1 deficient mice. Our study shows that uPA affects BBB disruption. PA enhances angiogenesis after brain injury...
  57. ncbi request reprint [Pain information pathways from the periphery to the cerebral cortex]
    Ryotaro Kuroda
    Faculty of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Yakugaku Zasshi 123:533-46. 2003
    ..Based on the these findings, PAR-1 and PAR-2 are attracting interest as target molecules for new drug development...
  58. doi request reprint PAR2 triggers IL-8 release via MEK/ERK and PI3-kinase/Akt pathways in GI epithelial cells
    Yusuke Tanaka
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Biochem Biophys Res Commun 377:622-6. 2008
    ..Together, PAR2 triggers IL-8 release via two independent signaling pathways, MEK/ERK and PI3-kinase/Akt, suggesting a role of PAR2 as a pro-inflammatory receptor in the GI tract...
  59. ncbi request reprint [PAR (protease-activated receptor) as a novel target for development of gastric mucosal cytoprotective drugs]
    Atsufumi Kawabata
    Department of Pathophysiology and Therapeutics, School of Pharmaceutical Sciences, Kinki University, Higashi Osaka 577 8502, Japan
    Nihon Yakurigaku Zasshi 120:85P-87P. 2002
    ..PAR-2 would thus appear to be primarily protective in gastric mucosa, but may also have an aggressive property in certain conditions. Finally, functions of PARs other than PAR-2 in gastric mucosa are also discussed...
  60. ncbi request reprint The PAR-1-activating peptide attenuates carrageenan-induced hyperalgesia in rats
    Atsufumi Kawabata
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, 577 8502, Higashi Osaka, Japan
    Peptides 23:1181-3. 2002
    ..The thrombin-PAR-1 system might thus act to attenuate nociception during inflammatory hyperalgesia...
  61. ncbi request reprint Specific expression of spinal Fos after PAR-2 stimulation in mast cell-depleted rats
    Atsufumi Kawabata
    Department of Pathophysiology and Therapeutics, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Neuroreport 13:511-4. 2002
    ..Thus, specific expression of spinal Fos following peripheral PAR-2 activation is detectable in mast cell-depleted rats, suggesting activation of spinal nociceptive neurons, which is partially mediated by activation of PKC...
  62. ncbi request reprint [The G protein-coupled protease receptor PAR (protease-activated receptor) as a novel target for drug development]
    A Kawabata
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, 3-4-1 Kowakae, Higashi-Osaka 577-8502, Japan
    Yakugaku Zasshi 121:1-7. 2001
    ..The future perspective of studies on PARs is also discussed, focusing on the possibility of clinical application of PAR-targeted drugs...
  63. doi request reprint Rhodanese, but not cystathionine-gamma-lyase, is associated with dextran sulfate sodium-evoked colitis in mice: a sign of impaired colonic sulfide detoxification?
    Eiichi Taniguchi
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, Higashi Osaka 577 8502, Japan
    Toxicology 264:96-103. 2009
    ..The delayed enhancement of rhodanese activity in RBCs, a possible compensative event, might be available as a disease marker for IBD...
  64. ncbi request reprint Mechanisms for prostaglandin E2 formation caused by proteinase-activated receptor-1 activation in rat gastric mucosal epithelial cells
    Fumiko Sekiguchi
    Division of Physiology and Pathophysiology, School of Pharmacy, Kinki University, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Biochem Pharmacol 73:103-14. 2007
    ..In addition, our data also indicate involvement of COX-1, PKC and p38 MAPK in PAR1-triggered PGE(2) formation. PAR1, thus stimulates complex multiple signaling pathways responsible for PGE(2) formation in RGM1 cells...
  65. ncbi request reprint Distinct activity of peptide mimetic intracellular ligands (pepducins) for proteinase-activated receptor-1 in multiple cells/tissues
    Satoko Kubo
    Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Ann N Y Acad Sci 1091:445-59. 2006
    ....
  66. ncbi request reprint Hydrogen sulfide causes relaxation in mouse bronchial smooth muscle
    Satoko Kubo
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, Higashi Osaka, Japan
    J Pharmacol Sci 104:392-6. 2007
    ..Thus, NaHS evokes bronchodilation in mice, suggesting a possible role for H(2)S in the respiratory system...
  67. ncbi request reprint A protective role of hydrogen sulfide against oxidative stress in rat gastric mucosal epithelium
    Daiki Yonezawa
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Toxicology 241:11-8. 2007
    ..These results suggest that NaHS/H(2)S may protect gastric mucosal epithelial cells against oxidative stress through stimulation of MAP kinase pathways, a therapeutic dose range being very narrow...
  68. ncbi request reprint Evidence that PAR2-triggered prostaglandin E2 (PGE2) formation involves the ERK-cytosolic phospholipase A2-COX-1-microsomal PGE synthase-1 cascade in human lung epithelial cells
    Mami Nagataki
    Division of Physiology and Pathophysiology, Kinki University School of Pharmacy, Higashi Osaka, Japan
    Cell Biochem Funct 26:279-82. 2008
    ..PAR2 thus appears to trigger specific up-regulation of mPGES-1 that is dependent on prostanoids formed via the MEK/ERK/cPLA(2)/COX-1 pathway, being critical for PGE(2) formation...
  69. ncbi request reprint The PAR-1-activating peptide facilitates pepsinogen secretion in rats
    Naoyuki Kawao
    Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Peptides 24:1449-51. 2003
    ..In contrast, the control peptide FTLLR-NH(2), given in the same manner, had no such effect. Thus, PAR-1, like PAR-2, might function to facilitate pepsinogen secretion, suggesting a novel role of the thrombin-PAR-1-pathway in the stomach...
  70. doi request reprint Involvement of Src kinase in T-type calcium channel-dependent neuronal differentiation of NG108-15 cells by hydrogen sulfide
    Takeshi Tarui
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, Higashi Osaka, Japan
    J Neurochem 114:512-9. 2010
    ..Together, our data reveal that Src kinase participates in the T-type Ca(2+) channel-dependent neuronal differentiation caused by NaHS/H(2)S in NG108-15 cells...
  71. doi request reprint Opposite effects of two thiazolidinediones, ciglitazone and troglitazone, on proteinase-activated receptor-1-triggered prostaglandin E(2) release
    Kaori Takaoka
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Toxicology 268:40-5. 2010
    ..In conclusion, ciglitazone and troglitazone, exert opposite effects on the PAR1-triggered PGE(2) production and COX-2 upregulation by targeting molecules other than PPARgamma...
  72. ncbi request reprint Proteinase-activated receptor-2-triggered prostaglandin E(2) release, but not cyclooxygenase-2 upregulation, requires activation of the phosphatidylinositol 3-kinase/Akt / nuclear factor-kappaB pathway in human alveolar epithelial cells
    Kazumi Moriyuki
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, Japan
    J Pharmacol Sci 111:269-75. 2009
    ....
  73. doi request reprint Hydrogen sulfide evokes neurite outgrowth and expression of high-voltage-activated Ca2+ currents in NG108-15 cells: involvement of T-type Ca2+ channels
    Keita Nagasawa
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, Higashi Osaka, Japan
    J Neurochem 108:676-84. 2009
    ..2...
  74. ncbi request reprint Hydrogen sulfide inhibits activity of three isoforms of recombinant nitric oxide synthase
    Satoko Kubo
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Toxicology 241:92-7. 2007
    ..Our data thus demonstrate inhibition of three NOS isoforms by NaHS/H(2)S, and suggest involvement of interaction of NaHS/H(2)S with BH(4) in inhibition of nNOS and eNOS, but not iNOS...
  75. ncbi request reprint Effect of a potent iNOS inhibitor (ONO-1714) on acetaminophen-induced hepatotoxicity in the rat
    Yoshihisa Kamanaka
    Minase Research Institute, Ono Pharmaceutical Co Ltd, Osaka 618 8585, Japan
    Life Sci 74:793-802. 2003
    ....
  76. ncbi request reprint Suppression by protease-activated receptor-2 activation of gastric acid secretion in rats
    Hiroyuki Nishikawa
    Research and Development Center, Fuso Pharmaceutical Industries Ltd, 536 8523, Osaka, Japan
    Eur J Pharmacol 447:87-90. 2002
    ..These dual actions of PAR-2 would result in gastric mucosal cytoprotection...
  77. ncbi request reprint Effects of somatosensory cortical stimulation on expression of c-Fos in rat medullary dorsal horn in response to formalin-induced noxious stimulation
    Fusami Gojyo
    Department of Oral Anatomy and Neurobiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    J Neurosci Res 68:479-88. 2002
    ..These results suggest that activation of SII-medullary fibers suppress nociceptive information from the oro-facial regions...
  78. ncbi request reprint The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents
    Hiroyasu Ishikura
    Division of Endocrinology, Clinical Research Institute for Endocrine and Metabolic Diseases, National Hospital Organization, Kyoto Medical Center, 1 1 Fukakusa, Fushimiku 612 8555, Japan
    Life Sci 80:1999-2004. 2007
    ..These data suggest that camostat mesilate prevents and/or depresses pancreatitis-induced pain and/or referred hyperalgesia/allodynia, in which proteinases including trypsin would play a critical role...
  79. pmc Binding of a highly potent protease-activated receptor-2 (PAR2) activating peptide, [3H]2-furoyl-LIGRL-NH2, to human PAR2
    Toru Kanke
    Tokyo New Drug Research Laboratories, Kowa Company Limited, Higashimurayama, 27 Taylor Street, Tokyo 189 0022, Japan
    Br J Pharmacol 145:255-63. 2005
    ..7 These studies indicate that [(3)H]2-furoyl-LIGRL-NH(2) binds to human PAR2 at its ligand-binding site. The use of this radioligand will be valuable for characterising chemicals that interact to PAR2...
  80. ncbi request reprint Physiology and pathophysiology of proteinase-activated receptors (PARs): PAR-2 as a potential therapeutic target
    Toru Kanke
    Tokyo New Drug Research Laboratories, Kowa Company Limited, Tokyo, Japan
    J Pharmacol Sci 97:38-42. 2005
    ..Also, the PAR-2-gene-deficient mice and the potent and metabolically stable agonists are shown to be useful tools for evaluating the potency of PAR-2 as a therapeutic target...