Tatsuki Itoh

Summary

Affiliation: Kinki University
Country: Japan

Publications

  1. doi request reprint Neuroprotective effect of (-)-epigallocatechin-3-gallate in rats when administered pre- or post-traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka, 589 8511, Japan
    J Neural Transm 120:767-83. 2013
  2. doi request reprint Appearance of neural stem cells around the damaged area following traumatic brain injury in aged rats
    Tatsuki Itoh
    Department of Pathology, Faculty of Medicine, Kinki University, 377 2, Ohno Higashi, Osakasayama, Osaka, 589 8511, Japan
    J Neural Transm 120:361-74. 2013
  3. doi request reprint Increased apoptotic neuronal cell death and cognitive impairment at early phase after traumatic brain injury in aged rats
    Tatsuki Itoh
    Department of Pathology, Faculty of Medicine, Kinki University, 377 2 Ohno Higashi, Osakasayama, Osaka 589 8511, Japan
    Brain Struct Funct 218:209-20. 2013
  4. doi request reprint (-)-Epigallocatechin-3-gallate increases the number of neural stem cells around the damaged area after rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka, Japan
    J Neural Transm 119:877-90. 2012
  5. ncbi request reprint Effect of basic fibroblast growth factor on cultured rat neural stem cell in three-dimensional collagen gel
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, Osaka, Japan
    Neurol Res 27:429-32. 2005
  6. doi request reprint Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2, Ohno Higashi, Osakasayama, Osaka 589 8511, Japan
    Neurochem Res 35:348-55. 2010
  7. doi request reprint Exercise increases neural stem cell proliferation surrounding the area of damage following rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2, Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    J Neural Transm 118:193-202. 2011
  8. doi request reprint Exercise inhibits neuronal apoptosis and improves cerebral function following rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka, 589 8511, Japan
    J Neural Transm 118:1263-72. 2011
  9. doi request reprint (-)-Epigallocatechin-3-gallate protects against neuronal cell death and improves cerebral function after traumatic brain injury in rats
    Tatsuki Itoh
    Department of Pathology, Faculty of Medicine, Kinki University, 377 2, Ohno Higashi, Osakasayama City, Osaka, 589 8511, Japan
    Neuromolecular Med 13:300-9. 2011
  10. doi request reprint Neural stem cells and new neurons in the cerebral cortex of stroke-prone spontaneously hypertensive rats after stroke
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka, 589 8511, Japan
    J Mol Neurosci 41:55-65. 2010

Detail Information

Publications31

  1. doi request reprint Neuroprotective effect of (-)-epigallocatechin-3-gallate in rats when administered pre- or post-traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka, 589 8511, Japan
    J Neural Transm 120:767-83. 2013
    ..Importantly, continuous and post-TBI access to EGCG improved cerebral function following TBI. In summary, consumption of green tea may be an effective therapy for TBI patients...
  2. doi request reprint Appearance of neural stem cells around the damaged area following traumatic brain injury in aged rats
    Tatsuki Itoh
    Department of Pathology, Faculty of Medicine, Kinki University, 377 2, Ohno Higashi, Osakasayama, Osaka, 589 8511, Japan
    J Neural Transm 120:361-74. 2013
    ..These results indicate that, although there were fewer NSCs that have the potential to differentiate into neurons and glia, these NSCs escaped free radical-induced degeneration around the damaged area after TBI in the aged rat brain...
  3. doi request reprint Increased apoptotic neuronal cell death and cognitive impairment at early phase after traumatic brain injury in aged rats
    Tatsuki Itoh
    Department of Pathology, Faculty of Medicine, Kinki University, 377 2 Ohno Higashi, Osakasayama, Osaka 589 8511, Japan
    Brain Struct Funct 218:209-20. 2013
    ..05). These results indicate that following TBI, high levels of free radicals are produced in the aged rat brain, which induces neuronal degeneration and apoptotic cell death around the damaged area, resulting in cognitive impairment...
  4. doi request reprint (-)-Epigallocatechin-3-gallate increases the number of neural stem cells around the damaged area after rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka, Japan
    J Neural Transm 119:877-90. 2012
    ....
  5. ncbi request reprint Effect of basic fibroblast growth factor on cultured rat neural stem cell in three-dimensional collagen gel
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, Osaka, Japan
    Neurol Res 27:429-32. 2005
    ..The effect of growth factors on the three-dimensional culture of neural stem cells has not been reported. We studied the effect of basic fibroblast growth factor (bFGF) on cultured rat neural stem cells in a three-dimensional culture...
  6. doi request reprint Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2, Ohno Higashi, Osakasayama, Osaka 589 8511, Japan
    Neurochem Res 35:348-55. 2010
    ..In summary, edaravone treatment improved cerebral dysfunction following TBI, suggesting its potential as an effective clinical therapy...
  7. doi request reprint Exercise increases neural stem cell proliferation surrounding the area of damage following rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2, Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    J Neural Transm 118:193-202. 2011
    ..Exercise increases the proliferation of NSCs around the damaged area following TBI. Therefore, exercise therapy (rehabilitation) in the early phase following TBI is important for recuperation from cerebral dysfunction induced by TBI...
  8. doi request reprint Exercise inhibits neuronal apoptosis and improves cerebral function following rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka, 589 8511, Japan
    J Neural Transm 118:1263-72. 2011
    ..Therefore, exercise therapy (rehabilitation) in the early phase following TBI is important for recuperation from cerebral dysfunction...
  9. doi request reprint (-)-Epigallocatechin-3-gallate protects against neuronal cell death and improves cerebral function after traumatic brain injury in rats
    Tatsuki Itoh
    Department of Pathology, Faculty of Medicine, Kinki University, 377 2, Ohno Higashi, Osakasayama City, Osaka, 589 8511, Japan
    Neuromolecular Med 13:300-9. 2011
    ..In summary, consumption of green tea may be an effective therapy for TBI patients...
  10. doi request reprint Neural stem cells and new neurons in the cerebral cortex of stroke-prone spontaneously hypertensive rats after stroke
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osakasayama, Osaka, 589 8511, Japan
    J Mol Neurosci 41:55-65. 2010
    ..Immature cells and new neurons from the ipsilateral SVZ might migrate into the penumbra after cerebral stroke, and this is the first report of their observation after a spontaneous cerebral stroke...
  11. doi request reprint The novel free radical scavenger, edaravone, increases neural stem cell number around the area of damage following rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Neurotox Res 16:378-89. 2009
    ....
  12. ncbi request reprint Isolation of neural stem cells from damaged rat cerebral cortex after traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, Osaka, Japan
    Neuroreport 16:1687-91. 2005
    ..These results indicate that isolated and cultured neurospheres can differentiate into neurons and glia. An increase in nestin-positive cells around a cerebral cortical damaged area might contribute to neurogenesis and neuroplasticity...
  13. ncbi request reprint Cultured rat astrocytes give rise to neural stem cells
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, Osaka, Japan
    Neurochem Res 31:1381-7. 2006
    ..These results indicate that isolated neurospheres from brain cortex astrocytes can differentiate into neurons and glia and might contribute to neurogenesis and neuroplasticity...
  14. ncbi request reprint Immature and mature neurons coexist among glial scars after rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, Osaka, Japan
    Neurol Res 29:734-42. 2007
    ..However, the generation, differentiation and maturation of neural stem cells (NSCs) among glial scars after brain injury have not yet been reported...
  15. ncbi request reprint Neuroprotective effects of an extract from the inflamed skin of rabbits inoculated with vaccinia virus on glutamate-induced neurotoxicity in cultured neuronal cell line
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, Osaka, Japan
    Neurol Res 30:430-4. 2008
    ..However, the pharmacologic mechanisms of Rosemorgen and Neurotropin remain unclear...
  16. ncbi request reprint Improvement of cerebral function by anti-amyloid precursor protein antibody infusion after traumatic brain injury in rats
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osakasayama shi, Osaka, 589 8511, Japan
    Mol Cell Biochem 324:191-9. 2009
    ....
  17. doi request reprint The relationship between SDF-1alpha/CXCR4 and neural stem cells appearing in damaged area after traumatic brain injury in rats
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, Osaka, Japan
    Neurol Res 31:90-102. 2009
    ..In the present study, the temporal relationship between neural stem cells (NSCs) and SDF-1alpha/CXCR4 around a damaged area was investigated using a rat traumatic brain injury (TBI) model...
  18. doi request reprint Expression of amyloid precursor protein after rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, Okasayyama City, Osaka, Japan
    Neurol Res 31:103-9. 2009
    ..However, the chronologic changes in APP expression have not been evaluated after traumatic brain injury (TBI)...
  19. pmc Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma
    Masashi Yanae
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka, Japan
    J Exp Clin Cancer Res 30:74. 2011
    ..However, the molecular mechanism of apoptosis induction by statins is not well understood in glioblastoma. In the present study, we attempted to elucidate the mechanism by which statins induce apoptosis in C6 glioma cells...
  20. pmc Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway
    Yasuhiro Kidera
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi Osaka 577 8502, Japan
    J Exp Clin Cancer Res 29:127. 2010
    ..In the present study, we investigated whether statins inhibit tumor cell migration, invasion, adhesion, and metastasis in the B16BL6 mouse melanoma cell line...
  21. ncbi request reprint A preliminary study of single intraperitoneal administration of paclitaxel followed by sequential systemic chemotherapy with S-1 plus paclitaxel for advanced gastric cancer with peritoneal metastasis
    Motohiro Imano
    Kinki University Faculty of Medicine, Osaka, Japan
    Anticancer Res 32:4071-5. 2012
    ....
  22. doi request reprint Peritoneal metastatic lesions of gastric cancer exhibit low expression of human epidermal growth factor receptor 2
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Target Oncol 7:213-6. 2012
    ..Consequently, other therapeutic approaches for these patients must be developed...
  23. doi request reprint Phase II study of single intraperitoneal chemotherapy followed by systemic chemotherapy for gastric cancer with peritoneal metastasis
    Motohiro Imano
    Surgery, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    J Gastrointest Surg 16:2190-6. 2012
    ....
  24. doi request reprint Safety of intraperitoneal administration of paclitaxel after gastrectomy with en-bloc D2 lymph node dissection
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, Osaka Sayama, Osaka, Japan
    J Surg Oncol 105:43-7. 2012
    ....
  25. ncbi request reprint Osteopontin induced by macrophages contribute to metachronous liver metastases in colorectal cancer
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, Ohno Higashi Osaka Sayama, Osaka, Japan
    Am Surg 77:1515-20. 2011
    ..31, m-LV 28.2 ± 3.18, P < 0.05). These results suggest that the risk of metachronous liver metastasis could be well predicted by immunohistochemical staining of OPN in the central areas, and CD68 in the invasive margins of tumors...
  26. doi request reprint High expression of epithelial cellular adhesion molecule in peritoneal metastasis of gastric cancer
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, 377 2 Ohno Higashi Osaka Sayama, Osaka, Japan, 589 8511
    Target Oncol 8:231-5. 2013
    ..05). The intraperitoneally administrated EpCAM antibody might have a anti-cancer effect in PM lesions of GC. Additionally, it can be assumed that only GC cells which express a high level of EpCAM might metastasize to the peritoneum...
  27. ncbi request reprint Establishment of a novel model of peritoneal carcinomatosis of the peritoneal extension type
    Motohiro Imano
    Department of Surgery, Kinki University Faculty of Medicine, Osaka Sayama, Osaka, Japan
    Anticancer Res 33:1439-46. 2013
    ..We developed a novel animal model, suitable for testing treatments for PET...
  28. ncbi request reprint An immunohistochemical study of osteopontin in pigment gallstone formation
    Motohiro Imano
    Department of Surgery, Kinki University School of Medicine, Osaka, Japan
    Am Surg 76:91-5. 2010
    ..Our results indicate that Opn, an acidic glycoprotein from the gallbladder epithelium, seems to be involved in lithiasis. Opn from macrophages and/or the epithelium seems to help form the matrix protein...
  29. doi request reprint Increased osteopontin-positive macrophage expression in colorectal cancer stroma with synchronous liver metastasis
    Motohiro Imano
    Department of Surgery, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 6511, Japan
    World J Surg 34:1930-6. 2010
    ..The aim of the present study was to investigate differences in OPN-positive TAMs between cases of colorectal cancer with synchronous liver metastasis and those without liver metastasis...
  30. doi request reprint Immunohistochemical expression of osteopontin in gastric cancer
    Motohiro Imano
    Department of Surgery, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    J Gastrointest Surg 13:1577-82. 2009
    ..Thus, the aim of this study was to determine the relationship between the degree of OPN expression, the proliferative activity of cancer cells, and the clinicopathological findings for surgically resected gastric cancer...
  31. doi request reprint Macrophage inflammatory protein-1α induces osteoclast formation by activation of the MEK/ERK/c-Fos pathway and inhibition of the p38MAPK/IRF-3/IFN-β pathway
    Masanobu Tsubaki
    Division of Pharmacotherapy, Kinki University School of Pharmacy, Higashi Osaka, Osaka, Japan
    J Cell Biochem 111:1661-72. 2010
    ..These findings may be useful in the development of an OC inhibitor that targets intracellular signaling factors...