Kazuo Tsubota

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. pmc Tear lipid layer deficiency associated with incomplete blinking: a case report
    Motoko Kawashima
    MGD Clinic, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan
    BMC Ophthalmol 13:34. 2013
  2. doi request reprint The antiaging approach for the treatment of dry eye
    Kazuo Tsubota
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Cornea 31:S3-8. 2012
  3. pmc Neuroprotective response after photodynamic therapy: role of vascular endothelial growth factor
    Misa Suzuki
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Shinanomachi, Shinjuku ku, Tokyo, Japan
    J Neuroinflammation 8:176. 2011
  4. pmc Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina
    Toshihide Kurihara
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Diabetes 57:2191-8. 2008
  5. doi request reprint Prevention of ocular inflammation in endotoxin-induced uveitis with resveratrol by inhibiting oxidative damage and nuclear factor-kappaB activation
    Shunsuke Kubota
    Department ofOphthalmology, Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:3512-9. 2009
  6. pmc (Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Inaida Endowed Department of Anti Aging Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Pathol 173:1911-8. 2008
  7. doi request reprint Inhibition of choroidal neovascularization with an anti-inflammatory carotenoid astaxanthin
    Kanako Izumi-Nagai
    Laboratory of Retinal Cell Biology, Keio University of Medicne, Tokyo, Japan
    Invest Ophthalmol Vis Sci 49:1679-85. 2008
  8. doi request reprint The use of human mesenchymal stem cell-derived feeder cells for the cultivation of transplantable epithelial sheets
    Masahiro Omoto
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:2109-15. 2009
  9. doi request reprint Neuroprotective effect of an antioxidant, lutein, during retinal inflammation
    Mariko Sasaki
    Department of Ophthalmology, Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:1433-9. 2009
  10. ncbi request reprint Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:422-9. 2007

Collaborators

Detail Information

Publications70

  1. pmc Tear lipid layer deficiency associated with incomplete blinking: a case report
    Motoko Kawashima
    MGD Clinic, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan
    BMC Ophthalmol 13:34. 2013
    ..Unfortunately, the importance of blinking in meibomian gland dysfunction has been largely overlooked, and it is not known whether incomplete blinking causes tear lipid deficiency, even in the unobstructed meibomian glands...
  2. doi request reprint The antiaging approach for the treatment of dry eye
    Kazuo Tsubota
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Cornea 31:S3-8. 2012
    ..In this review, these 2 important aging theories, calorie restriction and free radical aging, are examined, and we discuss how to apply these theories to the prevention and treatment of dry eye...
  3. pmc Neuroprotective response after photodynamic therapy: role of vascular endothelial growth factor
    Misa Suzuki
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Shinanomachi, Shinjuku ku, Tokyo, Japan
    J Neuroinflammation 8:176. 2011
    ..Concern that PDT might induce VEGF and exacerbate the disease has led us to current practice of using anti-VEGF drugs with PDT simultaneously. However, the underlying molecular mechanisms of these therapies are not well understood...
  4. pmc Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina
    Toshihide Kurihara
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Diabetes 57:2191-8. 2008
    ..The aim of the present study was to show the relationship of the renin-angiotensin system (RAS) with the synaptic vesicle protein synaptophysin and neuronal activity in the diabetic retina...
  5. doi request reprint Prevention of ocular inflammation in endotoxin-induced uveitis with resveratrol by inhibiting oxidative damage and nuclear factor-kappaB activation
    Shunsuke Kubota
    Department ofOphthalmology, Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:3512-9. 2009
    ..Resveratrol is known as one of the antioxidant polyphenols contained in red wine and grape skin. The purpose of the present study was to investigate the role of resveratrol in ocular inflammation in endotoxin-induced uveitis (EIU)...
  6. pmc (Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Inaida Endowed Department of Anti Aging Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Pathol 173:1911-8. 2008
    ..These results indicate the significant contribution of RAPS to CNV pathogenesis...
  7. doi request reprint Inhibition of choroidal neovascularization with an anti-inflammatory carotenoid astaxanthin
    Kanako Izumi-Nagai
    Laboratory of Retinal Cell Biology, Keio University of Medicne, Tokyo, Japan
    Invest Ophthalmol Vis Sci 49:1679-85. 2008
    ..The purpose of the present study was to investigate the effect of AST on the development of experimental choroidal neovascularization (CNV) with underlying cellular and molecular mechanisms...
  8. doi request reprint The use of human mesenchymal stem cell-derived feeder cells for the cultivation of transplantable epithelial sheets
    Masahiro Omoto
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:2109-15. 2009
    ..To report the efficacy of human bone marrow-derived mesenchymal stem cells as a source of feeder cells for the cultivation of transplantable corneal epithelial cell sheets...
  9. doi request reprint Neuroprotective effect of an antioxidant, lutein, during retinal inflammation
    Mariko Sasaki
    Department of Ophthalmology, Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:1433-9. 2009
    ..The aim of this study was to investigate, with the use of a mouse endotoxin-induced uveitis (EIU) model, the neuroprotective effects of lutein against retinal neural damage caused by inflammation...
  10. ncbi request reprint Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:422-9. 2007
    ..The purpose of the present study was to investigate whether nonproteolytically activated prorenin plays a role in ischemia-induced retinal neovascularization...
  11. doi request reprint Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model
    Miyuki Kubota
    Department of Ophthalmology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Invest Ophthalmol Vis Sci 52:427-33. 2011
    ..To investigate the role of reactive oxygen species (ROS) as the prime initiators of the angiogenic response after alkali injury of the cornea and observe the effects of antioxidants in preventing angiogenesis...
  12. ncbi request reprint The implications of the upregulation of ICAM-1/VCAM-1 expression of corneal fibroblasts on the pathogenesis of allergic keratopathy
    Naoko Okada
    Department of Ophthalmology, Keio University, Shinanomachi, Tokyo, Japan
    Invest Ophthalmol Vis Sci 46:4512-8. 2005
    ..The present study investigated the expression of ICAM-1 and VCAM-1 on fibroblasts with interleukin (IL)-4 and/or tumor necrosis factor (TNF)-alpha stimulation and assessed the effect of eosinophil adhesion on fibroblast viability...
  13. doi request reprint Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2
    Hiroshi Mochimaru
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Invest Ophthalmol Vis Sci 49:2172-7. 2008
    ..To investigate whether the induction of cytotoxic T lymphocytes (CTLs) targeting VEGF receptor 2 inhibits corneal neovascularization caused by alkali injury...
  14. ncbi request reprint Early visual results with the 1CU accommodating intraocular lens
    Murat Dogru
    Department of Ophthalmology, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan
    J Cataract Refract Surg 31:895-902. 2005
    ..To prospectively assess the clinical outcome after implantation of the 1CU accommodating intraocular lens (IOL) and a foldable acrylic IOL (AcrySof, Alcon)...
  15. ncbi request reprint Suppression of diabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-kappaB pathway
    Norihiro Nagai
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:4342-50. 2007
    ..To investigate the involvement of the renin-angiotensin system (RAS) and the nuclear factor (NF)-kappaB pathway with diabetes-induced retinal inflammation...
  16. doi request reprint Corneal and conjunctival fibroblasts are major sources of eosinophil-recruiting chemokines
    Kazumi Fukagawa
    Department of Ophthalmology, Keio University, Tokyo, Japan
    Allergol Int 58:499-508. 2009
    ..Differential expression of chemokine genes were investigated in various types of ocular surface cells...
  17. doi request reprint Mechanism of visual sensations experienced during pars plana vitrectomy under retrobulbar anesthesia
    Eiko Sugisaka
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Ophthalmologica 224:103-8. 2010
    ..To investigate the visual sensations experienced by patients during vitrectomy under retrobulbar anesthesia...
  18. ncbi request reprint Eicosapentaenoic acid is anti-inflammatory in preventing choroidal neovascularization in mice
    Takashi Koto
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:4328-34. 2007
    ..To investigate the role of eicosapentaenoic acid (EPA), the major omega-3 polyunsaturated fatty acid (PUFA), in the development of choroidal neovascularization (CNV), together with underlying molecular mechanisms...
  19. ncbi request reprint Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, Tokyo, and Department of Ophthalmology, Kobe City General Hospital, Japan
    Invest Ophthalmol Vis Sci 47:2686-92. 2006
    ..The purpose of the present study was to elucidate the role of the receptor-dependent nonproteolytic activation of prorenin in ocular inflammation in endotoxin-induced uveitis (EIU)...
  20. doi request reprint Age-related dysfunction of the lacrimal gland and oxidative stress: evidence from the Cu,Zn-superoxide dismutase-1 (Sod1) knockout mice
    Takashi Kojima
    Department of Ocular Surface and Visual Optics, Keio University School of Medicine, Tokyo, Japan
    Am J Pathol 180:1879-96. 2012
    ..Our results suggest that Sod1(-/-) mice may be a good model system in which to study the mechanism of reactive oxygen species-mediated lacrimal gland alterations...
  21. doi request reprint The evaluation of the treatment response in obstructive meibomian gland disease by in vivo laser confocal microscopy
    Yukihiro Matsumoto
    Johnson and Johnson Department of Ocular Surface and Visual Optics, Keio University School of Medicine, Tokyo, Japan
    Graefes Arch Clin Exp Ophthalmol 247:821-9. 2009
    ....
  22. ncbi request reprint Suppression of choroidal neovascularization by inhibiting angiotensin-converting enzyme: minimal role of bradykinin
    Norihiro Nagai
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:2321-6. 2007
    ..The purpose of the present study was to investigate the role of bradykinin in the development of choroidal neovascularization (CNV), with or without ACE inhibition...
  23. doi request reprint Corneal and retinal effects of ultraviolet-B exposure in a soft contact lens mouse model
    Osama M A Ibrahim
    Departments of Johnson and Johnson Ocular Surface and Visual Optics and Ophthalmology, Keio University School of Medicine, Tokyo, Japan the Department of Ophthalmology, Tokyo Dental College School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 53:2403-13. 2012
    ..To investigate the lipid and DNA oxidative stress as well as corneal and retinal effects after ultraviolet B (UV-B) exposure in mice, with or without silicon hydrogel soft contact lenses (SCL)...
  24. doi request reprint The anti-oxidative role of ABCG2 in corneal epithelial cells
    Miyuki Kubota
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 51:5617-22. 2010
    ..The authors investigated whether ABCG2 functions in the homeostasis of corneal epithelial cells using abcg2 knockout (KO) mice and corneal epithelial cell lines...
  25. pmc (Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammation
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Diabetes 58:1625-33. 2009
    ..The aim of the present study was to define the association of the RAPS with diabetes-induced retinal inflammation...
  26. doi request reprint The role of oxidative stress and inflammation in conjunctivochalasis
    Samantha K Ward
    Keio University School of Medicine, Johnson and Johnson Ocular Surface and Visual Optics Department, Tokyo, Japan
    Invest Ophthalmol Vis Sci 51:1994-2002. 2010
    ..Increased tear inflammation seemed to coexist with loss of conjunctival epithelial cohesiveness and increased collagenolytic activity, which may explain the conjunctival laxity observed in patients with conjunctivochalasis...
  27. doi request reprint Management of evaporative dry eye in ectrodactyly-ectodermal dysplasia-clefting syndrome
    Yu Ota
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Optom Vis Sci 85:E795-801. 2008
    ..The purpose of this study is to report the features of dry eye and ocular surface disease in an unusual case of ectrodactyly-ectodermal dysplasia-clefting (EEC) syndrome...
  28. doi request reprint Presence and physiologic function of the renin-angiotensin system in mouse lacrimal gland
    Saori Yaguchi
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 53:5416-25. 2012
    ..To investigate the expression, localization, and physiologic function of renin-angiotensin system (RAS) components in the mouse lacrimal gland...
  29. ncbi request reprint Proliferation and differentiation of transplantable rabbit epithelial sheets engineered with or without an amniotic membrane carrier
    Kazunari Higa
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    Invest Ophthalmol Vis Sci 48:597-604. 2007
    ....
  30. pmc Evaluation of lipid oxidative stress status and inflammation in atopic ocular surface disease
    Tais H Wakamatsu
    Johnson and Johnson Ocular Surface and Visual Optics Department, Keio University School of Medicine, and Department of Ophthalmology, Kitasato Institute Hospital, Tokyo, Japan
    Mol Vis 16:2465-75. 2010
    ..The purpose of this study was to evaluate the ocular surface lipid oxidative stress status and inflammation in atopic keratoconjunctivitis (AKC) patients and normal subjects...
  31. ncbi request reprint The impact of nasal conjunctivochalasis on tear functions and ocular surface findings
    Yan Wang
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Ophthalmol 144:930-937. 2007
    ..To investigate the effect of grade 3 nasal conjunctivochalasis (NCCh) on the tear film inflammation, ocular surface findings, and tear function findings...
  32. doi request reprint Induction of corneal epithelium-like cells from cynomolgus monkey embryonic stem cells and their experimental transplantation to damaged cornea
    Yuta Kumagai
    Department of Ophthalmology, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
    Cornea 29:432-8. 2010
    ....
  33. doi request reprint Topography-guided conductive keratoplasty: treatment for advanced keratoconus
    Naoko Kato
    Department of Ophthalmology, School of Medicine, Keio University, Tokyo, Japan
    Am J Ophthalmol 150:481-489.e1. 2010
    ..To evaluate the use of topography-guided conductive keratoplasty in eyes with keratoconus...
  34. doi request reprint Evaluation of lipid oxidative stress status in Sjögren syndrome patients
    Tais H Wakamatsu
    Johnson and Johnson Ocular Surface and Visual Optics Department, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 54:201-10. 2013
    ..We evaluated the levels of lipid oxidative stress markers and inflammatory cells from tears and conjunctiva of patients with Sjögren syndrome (SS) and normal subjects...
  35. ncbi request reprint Five-year outcome of LASIK for myopia
    Naoko Kato
    Minamiaoyama Eye Clinic, Tokyo, Japan Department of Ophthalmology, School of Medicine, Keio University, Tokyo, Japan
    Ophthalmology 115:839-844.e2. 2008
    ..To investigate the efficacy and safety of LASIK over a 5-year postoperative period...
  36. ncbi request reprint Ocular surface and MUC5AC alterations in atopic patients with corneal shield ulcers
    Murat Dogru
    Department of Ophthalmology, Keio University School of Medicine, Shinanomachi, Tokyo
    Curr Eye Res 30:897-908. 2005
    ..To describe MUC5AC alterations and the ocular surface disorder in atopic patients with or without corneal ulcers...
  37. pmc Greater growth potential of p63-positive epithelial cell clusters maintained in human limbal epithelial sheets
    Tetsuya Kawakita
    Department of Ophthalmology, Keio University School of Medicine, Keio, Japan
    Invest Ophthalmol Vis Sci 50:4611-7. 2009
    ..To determine the growth potential of p63-positive cell clusters maintained in human limbal epithelial sheets...
  38. pmc Evaluation of conjunctival inflammatory status by confocal scanning laser microscopy and conjunctival brush cytology in patients with atopic keratoconjunctivitis (AKC)
    Tais Hitomi Wakamatsu
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Mol Vis 15:1611-9. 2009
    ..To elucidate the status of the conjunctival inflammation in atopic keratoconjunctivitis (AKC) using laser scanning confocal microscopy and compare the relevant findings with conjunctival brush cytology in a prospective controlled study...
  39. doi request reprint Evaluation of tear stability after surgery for conjunctivochalasis
    Shuya Hara
    Department of Ophthalmology, Social Insurance Chukyo Hospital, Aichi, Japan
    Optom Vis Sci 88:1112-8. 2011
    ..To evaluate the efficacy of surgical treatment for conjunctivochalasis using the Tear Film Stability Analysis System...
  40. ncbi request reprint Conjunctival in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis
    Yiqian Hu
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Mol Vis 13:1379-89. 2007
    ..To elucidate the morphological alterations of the conjunctiva in atopic keratoconjunctivitis (AKC) using the new generation Heidelberg Retina Tomograph II (HRT II)/Rostock Cornea Module confocal microscope in a prospective controlled study...
  41. doi request reprint Functional corneal endothelium derived from corneal stroma stem cells of neural crest origin by retinoic acid and Wnt/β-catenin signaling
    Shin Hatou
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Stem Cells Dev 22:828-39. 2013
    ..This protocol enables efficient production of corneal endothelium from corneal stromal stem cells by direct induction, which may lead to a novel stem cell therapy for corneal endothelial dysfunction...
  42. doi request reprint Disruption of cell-cell junctions and induction of pathological cytokines in the retinal pigment epithelium of light-exposed mice
    Toshio Narimatsu
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Invest Ophthalmol Vis Sci 54:4555-62. 2013
    ..To elucidate the influences of light exposure on the retinal pigment epithelium (RPE) in vivo that may be involved in the pathogenesis of AMD...
  43. pmc Resveratrol prevents light-induced retinal degeneration via suppressing activator protein-1 activation
    Shunsuke Kubota
    Laboratories of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Am J Pathol 177:1725-31. 2010
    ..Our data suggest the potential use of resveratrol as a therapeutic agent to prevent retinal degeneration related to light damage...
  44. doi request reprint The efficacy, sensitivity, and specificity of in vivo laser confocal microscopy in the diagnosis of meibomian gland dysfunction
    Osama M A Ibrahim
    Johnson and Johnson Ocular Surface and Visual Optics Department, Keio University School of Medicine, Tokyo, Japan
    Ophthalmology 117:665-72. 2010
    ....
  45. pmc Transcriptional factors associated with epithelial-mesenchymal transition in choroidal neovascularization
    Manabu Hirasawa
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Mol Vis 17:1222-30. 2011
    ..To investigate the transcriptional factors associated with epithelial-mesenchymal transition (EMT) in choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD)...
  46. ncbi request reprint Role of heat shock protein 47, a collagen-binding chaperone, in lacrimal gland pathology in patients with cGVHD
    Yoko Ogawa
    Department of Ophthalmology, Keio University, School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:1079-86. 2007
    ..In this study, the role of HSP47 in the pathogenesis of lacrimal gland of patients with cGVHD was investigated...
  47. ncbi request reprint Long-standing bullous keratopathy is associated with peripheral conjunctivalization and limbal deficiency
    Yuichi Uchino
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    Ophthalmology 113:1098-101. 2006
    ..To investigate whether peripheral corneal neovascularization in bullous keratopathy (BK) is due to conjunctivalization, a sign of limbal stem cell deficiency...
  48. pmc Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation
    Yoko Ozawa
    Department of Ophthalmology, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Biol Chem 283:24561-70. 2008
    ..These findings suggest SOCS3 as a potential therapeutic target molecule for protecting photoreceptor cell function during inflammation...
  49. doi request reprint Effect of spherical aberration on visual function under photopic and mesopic conditions after cataract surgery
    Takefumi Yamaguchi
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    J Cataract Refract Surg 35:57-63. 2009
    ..To evaluate the effect of spherical aberration on visual function under natural pupil conditions after cataract surgery...
  50. doi request reprint Corneal in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis
    Yiqian Hu
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Ophthalmology 115:2004-12. 2008
    ..To elucidate the morphologic alterations of the cornea in atopic keratoconjunctivitis (AKC) using confocal microscopy (Heidelberg Retina Tomograph II-Rostock Cornea Module: HRT-II RCM)...
  51. ncbi request reprint Neuroprotective effects of angiotensin II type 1 receptor (AT1R) blocker, telmisartan, via modulating AT1R and AT2R signaling in retinal inflammation
    Toshihide Kurihara
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 47:5545-52. 2006
    ..To investigate the retinal neural damage that occurs during inflammation and the therapeutic effects of the angiotensin II type 1 receptor (AT1R) blocker, telmisartan, using a model of endotoxin-induced uveitis (EIU)...
  52. ncbi request reprint The impact of the onset time of atopic keratoconjunctivitis on the tear function and ocular surface findings
    Tatsuya Onguchi
    Department of Ophthalmology, Tokyo Dental College, Ichikawa General Hospital, 5 11 13 Sugano, Ichikawa, Chiba 272 8513, Japan
    Am J Ophthalmol 141:569-71. 2006
    ..To investigate the tear and ocular surface findings between controls, children, and adults with atopic keratoconjunctivitis (AKC)...
  53. pmc Oxidative stress induced inflammation initiates functional decline of tear production
    Yuichi Uchino
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 7:e45805. 2012
    ..These findings strongly suggest that oxidative stress can be a causative factor for the development of dry eye disease...
  54. doi request reprint Biological role of lutein in the light-induced retinal degeneration
    Mariko Sasaki
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Nutr Biochem 23:423-9. 2012
    ..Lutein reduced light-induced oxidative stress in the retina, which might contribute to promote DNA repair. The lutein-supplemented diet attenuated light-induced visual impairment by protecting the photoreceptor cells' DNA...
  55. pmc Accumulation of secretory vesicles in the lacrimal gland epithelia is related to non-Sjögren's type dry eye in visual display terminal users
    Mizuka Kamoi
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 7:e43688. 2012
    ..The duration of VDT use was significantly longer in the VDT group than in the other groups. These findings suggest that excessive SV accumulation in the acinar epithelia may contribute to the reduced tear secretion in VDT users...
  56. ncbi request reprint Experience with the Artisan phakic intraocular lens in Asian eyes
    Naoko Asano-Kato
    Department of Ophthalmology, Tokyo Dental College, Chiba 272 8513, Japan
    J Cataract Refract Surg 31:910-5. 2005
    ..To investigate the efficacy and safety of implantation of an iris-claw phakic intraocular lens (PIOL), Artisan Myopia, in Asian eyes...
  57. ncbi request reprint Angiotensin II type 1 receptor-mediated inflammation is required for choroidal neovascularization
    Norihiro Nagai
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arterioscler Thromb Vasc Biol 26:2252-9. 2006
    ..The aim of the current study was to determine the involvement of the renin-angiotensin system (RAS) with the development of CNV, using human surgical samples and the murine model of laser-induced CNV...
  58. ncbi request reprint Efficacy of a new warm moist air device on tear functions of patients with simple meibomian gland dysfunction
    Yukihiro Matsumoto
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    Cornea 25:644-50. 2006
    ..To evaluate the safety and efficacy of an original warm moist air device on tear functions and ocular surface of patients with simple meibomian gland dysfunction (MGD)...
  59. ncbi request reprint Amniotic membrane immobilized poly(vinyl alcohol) hybrid polymer as an artificial cornea scaffold that supports a stratified and differentiated corneal epithelium
    Yuichi Uchino
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    J Biomed Mater Res B Appl Biomater 81:201-6. 2007
    ..Corneal epithelialization on PVA-AM in rabbit corneas improved over PVA-COL, suggesting the possibility of using PVA-AM as a biocompatible hybrid material for keratoprosthesis...
  60. doi request reprint Fate of corneal epithelial cells separated from limbus in vivo
    Tetsuya Kawakita
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    Invest Ophthalmol Vis Sci 52:8132-7. 2011
    ..To characterize corneal epithelial cells separated from limbus in vivo by transplantation of a stainless steel ring with or without creating a defect inside the ring...
  61. doi request reprint Conjunctival in vivo confocal scanning laser microscopy in patients with Sjögren syndrome
    Tais Hitomi Wakamatsu
    Johnson and Johnson Department of Ocular Surface and Visual Optics, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 51:144-50. 2010
    ....
  62. doi request reprint Involvement of hyaluronan and its receptor CD44 with choroidal neovascularization
    Hiroshi Mochimaru
    Department of Ophthalmology, Laboratory of Retinal Cell Biology, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:4410-5. 2009
    ..The purpose of the present study was to clarify a role of HA and CD44 in the development of choroidal neovascularization (CNV)...
  63. pmc Retinal dysfunction and progressive retinal cell death in SOD1-deficient mice
    Kouhei Hashizume
    Department of Ophthalmology, Inaida Laboratory, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Am J Pathol 172:1325-31. 2008
    ..Our results indicate that Sod1(-/-) mice may be a good model system in which to study the mechanism of reactive oxygen species-mediated retinal degeneration...
  64. doi request reprint The effects of 2 week senofilcon-A silicone hydrogel contact lens daily wear on tear functions and ocular surface health status
    Murat Dogru
    Keio University School of Medicine, Johnson and Johnson Department of Ocular Surface and Visual Optics, Shinanomachi, Shinjuku ku, Tokyo, Japan
    Cont Lens Anterior Eye 34:77-82. 2011
    ..To prospectively investigate the effects of 2 week senofilcon A contact lens (CL) daily wear on the functional visual acuity (VA), ocular surface and tear film...
  65. doi request reprint Clusterin promotes corneal epithelial cell growth through upregulation of hepatocyte growth factor by mesenchymal cells in vitro
    Naoko Okada
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 52:2905-10. 2011
    ..Although the cornea expresses high levels of clusterin (CLU), the role of CLU in the cornea is poorly understood. This study was performed to investigate the possible role of CLU in corneal epithelial homeostasis...
  66. ncbi request reprint Macular pigment lutein is antiinflammatory in preventing choroidal neovascularization
    Kanako Izumi-Nagai
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arterioscler Thromb Vasc Biol 27:2555-62. 2007
    ..The aim of the current study was to investigate the effect of lutein supplementation on the development of the murine model of laser-induced CNV together with underlying molecular mechanisms...
  67. doi request reprint Retinal ganglion cell loss in superoxide dismutase 1 deficiency
    Kenya Yuki
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 52:4143-50. 2011
    ..To investigate the influence of deficiency in superoxide dismutase (SOD) 1, a major antioxidative enzyme, on retinal ganglion cells (RGCs)...
  68. ncbi request reprint New grading system for the evaluation of chronic ocular manifestations in patients with Stevens-Johnson syndrome
    Chie Sotozono
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Ophthalmology 114:1294-302. 2007
    ..To evaluate and grade the extent and severity of chronic ocular manifestations in Stevens-Johnson syndrome (SJS)...
  69. doi request reprint Effect of age on changes in anterior chamber depth and volume after laser in situ keratomileusis
    Ryo Nishimura
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    J Cataract Refract Surg 35:1868-72. 2009
    ..To evaluate the effect of age on anterior chamber depth (ACD) and anterior chamber volume (ACV) after laser in situ keratomileusis (LASIK) for myopia...
  70. ncbi request reprint Comparison of deep lamellar keratoplasty and penetrating keratoplasty for lattice and macular corneal dystrophies
    Motoko Kawashima
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    Am J Ophthalmol 142:304-9. 2006
    ..To compare the therapeutic outcomes after deep lamellar keratoplasty (DLKP) and penetrating keratoplasty (PKP) in patients with lattice corneal dystrophy (LCD) and macular corneal dystrophy (MCD)...