T Takahashi

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. ncbi request reprint A novel compound heterozygous dysferlin mutation in Miyoshi myopathy siblings responding to dantrolene
    H Hattori
    Department of Neurology, Keio University School of Medicine, Tokyo, Japan
    Eur J Neurol 14:1288-91. 2007
  2. ncbi request reprint A561C polymorphism of E-selectin is associated with ischemic cerebrovascular disease in the Japanese population without diabetes mellitus and hypercholesterolemia
    Hidenori Hattori
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Tokyo 160 8582, Japan
    Brain Res 1108:221-3. 2006
  3. ncbi request reprint G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke
    Hidenori Hattori
    Department of Neurology, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    Brain Res 1121:246-9. 2006
  4. ncbi request reprint Inflammatory myopathy with anti-Golgi antibody and anti-SS-A/Ro antibody
    Hidenori Hattori
    Department of Neurology, Keio University School of Medicine, Tokyo
    Intern Med 46:1927-30. 2007
  5. ncbi request reprint Astrocytic damage is far more severe than demyelination in NMO: a clinical CSF biomarker study
    R Takano
    Department of Neurology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    Neurology 75:208-16. 2010
  6. ncbi request reprint Classification and antimicrobial susceptibilities of enterococcus species isolated from apparently healthy food-producing animals in Japan
    A Kojima
    National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, Kokubunji, Tokyo, Japan
    Zoonoses Public Health 57:137-41. 2010
  7. ncbi request reprint Effect of 3 mg melatonin on jet lag syndrome in an 8-h eastward flight
    T Takahashi
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Psychiatry Clin Neurosci 54:377-8. 2000
  8. ncbi request reprint Serovars of Erysipelothrix strains isolated from pigs affected with erysipelas in Japan
    T Takahashi
    National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, Tokyo, Japan
    J Vet Med Sci 58:587-9. 1996
  9. ncbi request reprint Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis
    T Misu
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Brain 130:1224-34. 2007
  10. ncbi request reprint Search for novel gene markers of traumatic brain injury by time differential microarray analysis
    Y Ishikawa
    Gene Analysis Center, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
    Acta Neurochir Suppl 96:163-7. 2006

Collaborators

Detail Information

Publications129 found, 100 shown here

  1. ncbi request reprint A novel compound heterozygous dysferlin mutation in Miyoshi myopathy siblings responding to dantrolene
    H Hattori
    Department of Neurology, Keio University School of Medicine, Tokyo, Japan
    Eur J Neurol 14:1288-91. 2007
    ..We report a novel pair of heterozygous mutations in the 3'-splicing site of exon 26 and the translation site of exon 28 of the dysferlin gene in two siblings, and effective treatment of their MM with dantrolene...
  2. ncbi request reprint A561C polymorphism of E-selectin is associated with ischemic cerebrovascular disease in the Japanese population without diabetes mellitus and hypercholesterolemia
    Hidenori Hattori
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Tokyo 160 8582, Japan
    Brain Res 1108:221-3. 2006
    ..7% vs. 5.8% (P=0.04). Our results show that E-selectin gene polymorphisms represent an increased risk for ischemic CVD in the Japanese population without diabetes mellitus and hypercholesterolemia...
  3. ncbi request reprint G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke
    Hidenori Hattori
    Department of Neurology, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    Brain Res 1121:246-9. 2006
    ..48). The C allele was not significantly different between the patients and controls (C versus G, p=0.91). Our results show that the OLR1 gene polymorphism has little effect on an increased risk for ischemic CVD in the Japanese population...
  4. ncbi request reprint Inflammatory myopathy with anti-Golgi antibody and anti-SS-A/Ro antibody
    Hidenori Hattori
    Department of Neurology, Keio University School of Medicine, Tokyo
    Intern Med 46:1927-30. 2007
    ..This report suggests that there is a new categorized subgroup of inflammatory myopathy with these specific antibodies and the pattern of autoantibody in these patients indicates the specific clinical course and treatment strategy...
  5. ncbi request reprint Astrocytic damage is far more severe than demyelination in NMO: a clinical CSF biomarker study
    R Takano
    Department of Neurology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    Neurology 75:208-16. 2010
    ..However, the clinicopathologic significance of astrocytic damage and its relation with demyelination are unknown...
  6. ncbi request reprint Classification and antimicrobial susceptibilities of enterococcus species isolated from apparently healthy food-producing animals in Japan
    A Kojima
    National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, Kokubunji, Tokyo, Japan
    Zoonoses Public Health 57:137-41. 2010
    ..hirae. Isolates from cattle were more susceptible to the antimicrobials studied than those from pigs and broilers. VanA- or VanB-type vancomycin-resistant enterococci have not been found since the ban of avoparcin use 5 years ago...
  7. ncbi request reprint Effect of 3 mg melatonin on jet lag syndrome in an 8-h eastward flight
    T Takahashi
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Psychiatry Clin Neurosci 54:377-8. 2000
    ..Melatonin accelerated the rate of the re-entrainment of the circadian melatonin rhythm. Melatonin was useful to jet travel from Tokyo to Los Angeles...
  8. ncbi request reprint Serovars of Erysipelothrix strains isolated from pigs affected with erysipelas in Japan
    T Takahashi
    National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, Tokyo, Japan
    J Vet Med Sci 58:587-9. 1996
    ..8%) to serovar 5, 11 (1.1%) to serovar 21, and the remaining 26 to serovars 4, 8, 11, 12, 15, 17, or 19. Only 5 (0.5%) strains isolated from the cases of erysipelas belonged to Erysipelothrix tonsillarum and represented serovars 7 or 23...
  9. ncbi request reprint Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis
    T Misu
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Brain 130:1224-34. 2007
    ....
  10. ncbi request reprint Search for novel gene markers of traumatic brain injury by time differential microarray analysis
    Y Ishikawa
    Gene Analysis Center, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
    Acta Neurochir Suppl 96:163-7. 2006
    ..These results may help elucidate the mechanisms of neuronal cell death after TBI and the neuroprotective effects of CsA after TBI...
  11. doi request reprint Occurrence of acute large and edematous callosal lesions in neuromyelitis optica
    M Nakamura
    Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Mult Scler 15:695-700. 2009
    ..The corpus callosum is commonly involved in multiple sclerosis (MS), but the characteristics of callosal lesions in neuromyelitis optica (NMO) are unknown.ObjectiveTo reveal the features of callosal lesions in NMO in comparison to MS...
  12. ncbi request reprint Effect of food on the bioavailability of cyclandelate from commercial capsules
    N Kaniwa
    Division of Drugs, National Institute of Hygienic Sciences, Tokyo, Japan
    Clin Pharmacol Ther 49:641-7. 1991
    ..This suggests that the absorption of cyclandelate was incomplete in fasting subjects, even from the capsule with the highest bioavailability. Bioinequivalence between the two capsules remained after postprandial drug administration...
  13. ncbi request reprint Neuromyelitis optica preceded by hyperCKemia episode
    N Suzuki
    Department of Neurology, Tohoku University School of Medicine, Aoba ku, Sendai 980 8574, Japan
    Neurology 74:1543-5. 2010
    ..AQP4 is the major water channel in the CNS, but it is also expressed in fast-twitch skeletal muscle fibers. However, muscle diseases have not been described in NMO...
  14. ncbi request reprint Drug resistance and random amplified polymorphic DNA analysis of Photobacterium damselae ssp. piscicida isolates from cultured Seriola (yellowtail, amberjack and kingfish) in Japan
    M Kawanishi
    National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, Kokubunji, Tokyo, Japan
    Lett Appl Microbiol 42:648-53. 2006
    ..To investigate the antimicrobial susceptibility and genetic characteristics of Photobacterium damselae ssp. piscicida isolates obtained from cultured Seriola in Japan...
  15. ncbi request reprint Dysferlin mutations in Japanese Miyoshi myopathy: relationship to phenotype
    T Takahashi
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Neurology 60:1799-804. 2003
    ..To study dysferlin gene mutations and genotype-phenotype correlations in Japanese patients with Miyoshi myopathy (MM)...
  16. ncbi request reprint Role of angiotensin II in activation of the JAK/STAT pathway induced by acute pressure overload in the rat heart
    J Pan
    Cardiopulmonary Division, Keio University, Tokyo, Japan
    Circ Res 81:611-7. 1997
    ..Both angiotensin II-dependent and -independent pathways take part in activating the JAK/STAT pathway in the pressure-overloaded rat heart...
  17. doi request reprint Marked increase in cerebrospinal fluid glial fibrillar acidic protein in neuromyelitis optica: an astrocytic damage marker
    T Misu
    Department of Neurology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    J Neurol Neurosurg Psychiatry 80:575-7. 2009
    ..Recent studies have revealed that loss of aquaporin 4 and glial fibrillar acidic protein (GFAP) is a prominent feature of NMO lesions, suggesting astrocytic impairment...
  18. ncbi request reprint Induction of bronchial hyperresponsiveness by Bordetella bronchiseptica infection in dogs
    H Nishikata
    Showa University, School of Medicine, Tokyo, Japan
    Ann Allergy 62:51-8. 1989
    ..Thus, it is speculated that airway epithelial damage and effects on ciliostatic function induced by the organism are primarily involved in the pathogenesis...
  19. ncbi request reprint Anatomical major resection versus nonanatomical limited resection for liver metastases from colorectal carcinoma
    N Kokudo
    Department of Surgery, Cancer Institute Hospital, Tokyo, Japan
    Am J Surg 181:153-9. 2001
    ..The purpose of the present study was to determine whether selection of surgical procedures for liver resection is associated with the pattern of tumor recurrence or patient survival...
  20. ncbi request reprint Intractable hiccup and nausea in neuromyelitis optica with anti-aquaporin-4 antibody: a herald of acute exacerbations
    T Takahashi
    Department of Neurology, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    J Neurol Neurosurg Psychiatry 79:1075-8. 2008
    ..Recent studies have strongly suggested that the pathogenesis of NMO is closely associated with anti-aquaporin-4 (AQP4) antibody. However, clinical implications of IHN and the relationship with anti-AQP4 antibody remain unknown...
  21. ncbi request reprint A national surveillance of Shiga toxin-producing Escherichia coli in food-producing animals in Japan
    M Kijima-Tanaka
    National Veterinary Assay Laboratory, Tokyo, 185 8511, Japan
    J Vet Med B Infect Dis Vet Public Health 52:230-7. 2005
    ..This first national study of STEC in the Japanese veterinary field should aid our understanding of Japan's STEC status...
  22. ncbi request reprint Serovar, pathogenicity and antimicrobial susceptibility of erysipelothrix rhusiopathiae isolates from farmed wild boars (Sus scrofa) affected with septicemic erysipelas in Japan
    K Yamamoto
    National Veterinary Assay Laboratory, Tokyo, 185 8511, Japan
    Res Vet Sci 67:301-3. 1999
    ..All of the isolates were resistant to oxytetracycline and/or dihydrostreptomycin. These observations suggest that E. rhusiopathiae strains isolated from wild boars may have aetiological significance in swine erysipelas...
  23. ncbi request reprint Taxonomic evidence that serovar 7 of Erysipelothrix strains isolated from dogs with endocarditis are Erysipelothrix tonsillarum
    T Takahasi
    National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, Tokyo, Japan
    J Vet Med B Infect Dis Vet Public Health 47:311-3. 2000
    ..tonsillarum. These results strongly indicate that some strains of genomic E. tonsillarum are a canine pathogen...
  24. ncbi request reprint Plasma total homocysteine levels are associated with advanced leukoaraiosis but not with asymptomatic microbleeds on T2*-weighted MRI in patients with stroke
    H Naka
    Department of Neurology, Suiseikai Kajikawa Hospital, Showamachi, Hiroshima, Japan
    Eur J Neurol 13:261-5. 2006
    ..330; 95% CI, 1.130-1.565] but not with the presence of microbleeds. Elevated tHcy level appears to be associated with ischemic small-artery disease rather than with bleeding-prone small-artery disease...
  25. doi request reprint Clinical significance of serum retinol binding protein-4 levels in patients with systemic sclerosis
    T Toyama
    Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    J Eur Acad Dermatol Venereol 27:337-44. 2013
    ..Retinol binding protein-4 (RBP-4) is a member of adipocytokines, which is potentially associated with fibrosis, vasodilation, and angiogenesis in addition to insulin resistance...
  26. ncbi request reprint Antimicrobial susceptibilities of Erysipelothrix rhusiopathiae isolated from pigs with swine erysipelas in Japan, 1988-1998
    K Yamamoto
    National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1 15 1, Tokura, Kokubunji, Tokyo, 185 8511, Japan
    J Vet Med B Infect Dis Vet Public Health 48:115-26. 2001
    ..It was suggested that the strains resistant to dihydrostreptomycin and oxytetracycline were distributed over almost all districts of Japan...
  27. ncbi request reprint Influence of antibiotics used as feed additives on the immune effect of erysipelas live vaccine in swine
    K Yamamoto
    National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, Tokyo, Japan
    J Vet Med B Infect Dis Vet Public Health 47:453-60. 2000
    ..Therefore, the present results suggest that these selected antibiotics would not interfere with the immune effect of the vaccine if given at the usual concentrations used for feed additives...
  28. ncbi request reprint Pain in neuromyelitis optica and its effect on quality of life: a cross-sectional study
    Y Kanamori
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Neurology 77:652-8. 2011
    ..To assess the features of pain and its impact on the health-related quality of life (HRQOL) in neuromyelitis optica (NMO)...
  29. ncbi request reprint Efficacy and safety of modified rituximab-ESHAP therapy for relapsed/refractory B-cell lymphoma
    K Ueda
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Chemother 22:54-7. 2010
    ..Our study indicates that modified R-ESHAP is an effective and safe salvage regimen for relapsed/refractory FL, however, its efficacy for relapsed DLBCL is limited...
  30. ncbi request reprint Plasma brain natriuretic peptide is associated with hepatic veno-occlusive disease and early mortality after allogeneic hematopoietic stem cell transplantation
    K Kataoka
    Department of Hematology and Oncology, Cell Therapy and Transplantation Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Bone Marrow Transplant 45:1631-7. 2010
    ..In multivariate analysis, BNP elevation before day 7 significantly predicted 100-day survival (hazard ratio 5.3; 95% CI: 1.1-24.3; P=0.03). These findings suggest that plasma BNP may serve as a diagnostic and prognostic marker of VOD...
  31. ncbi request reprint Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression
    K Kumano
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Blood 98:3283-9. 2001
    ..These results indicate that GATA-2 activity is necessary for the Notch signaling in hematopoietic cells...
  32. doi request reprint Clinical utility of preoperative evaluation of bronchial arteries by three-dimensional computed tomographic angiography for esophageal cancer surgery
    T Wada
    Department of Surgery, School of Medicine, Keio University, Tokyo, Japan
    Dis Esophagus 26:616-22. 2013
    ..3D-CTA clearly revealed BA anatomy, contributing to BA preservation and safe and precise lymphadenectomy in esophageal cancer surgery. 3D-CTA of BAs is useful for preoperative evaluation in esophageal cancer surgery. ..
  33. ncbi request reprint Blood-brain barrier disruption is more severe in neuromyelitis optica than in multiple sclerosis and correlates with clinical disability
    Y Tomizawa
    Department of Neurology, Clinical Research Centre, Juntendo University Graduate School of Medicine, Tokyo, Japan
    J Int Med Res 40:1483-91. 2012
    ....
  34. doi request reprint Effect of cooking loss in the assessment of vitamin intake for epidemiological data in Japan
    M Kobayashi
    Department of Food Science, Faculty of Home Economics, Otsuma Women s University, Tokyo, Japan
    Eur J Clin Nutr 65:546-52. 2011
    ..However, because few published food values have considered cooking effect, allowing for cooking loss in the assessment of vitamin intake in Japan has been difficult...
  35. doi request reprint Intensive glucose control after allogeneic hematopoietic stem cell transplantation: a retrospective matched-cohort study
    S Fuji
    Department of Hematology and Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
    Bone Marrow Transplant 44:105-11. 2009
    ..36) and the elevation of C-reactive protein (18 vs 38%, P=0.13). This study suggests that IGC has may have a beneficial effect after HSCT. IGC should be evaluated further in a large prospective, randomized study...
  36. ncbi request reprint Identification of the tetracycline resistance gene, tet(M), in Erysipelothrix rhusiopathiae
    K Yamamoto
    National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1 15 1, Tokura, Kokubunji, Tokyo, 185 8511, Japan
    J Vet Med B Infect Dis Vet Public Health 48:293-301. 2001
    ..The specific amplified DNA fragment was obtained from all 114 tetracycline-resistant strains. It was suggested that the tet(M) gene was widely present in the field isolates of E. rhusiopathiae resistant to tetracycline...
  37. ncbi request reprint Serological and pathogenic characterization of Erysipelothrix rhusiopathiae isolates from tonsils of slaughter pigs in Indonesia
    T Takahashi
    National Veterinary Assay Laboratory, Tokyo, Japan
    Vet Microbiol 21:165-75. 1989
    ..A tendency to be refractory to the bacterin-induced immunity was observed in some isolates of various serotypes, but this characteristic was not consistent...
  38. ncbi request reprint Interleukin-1 beta decreases sensitivity of guinea-pig airway to potassium chloride and isoproterenol by an epithelium-dependent mechanism
    M Munakata
    First Department of Medicine, School of Medicine, Hokkaido University, Sapporo, Japan
    Respirology 1:61-7. 1996
    ..These results suggest that IL-1 beta decreases the sensitivity of airway strips to KCl and ISO, possibly by stimulating prostaglandin production from the airway epithelium [corrected]...
  39. ncbi request reprint 3'-Deamino-3'-morpholino-13-deoxo-10-hydroxycarminomycin conquers multidrug resistance by rapid influx following higher frequency of formation of DNA single- and double-strand breaks
    N Horichi
    Pharmacology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 50:4698-701. 1990
    ..It is concluded that MX2 conquers multidrug resistance by rapid influx following a higher frequency of formation of DNA single- and double-strand breaks in K562/ADM cells...
  40. ncbi request reprint Expression of c-kit and kit ligand in human colon carcinoma cells
    M Toyota
    Department of Internal Medicine, Section 1, School of Medicine, Sapporo Medical University, Japan
    Tumour Biol 14:295-302. 1993
    ..These data suggest that c-kit and KL may play an important role as an autocrine loop in the proliferation of some colon carcinoma cells...
  41. ncbi request reprint Distal myopathy with rimmed vacuoles is allelic to hereditary inclusion body myopathy
    I Nishino
    Department of Neuromuscular Research, National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Neurology 59:1689-93. 2002
    ..Recently, HIBM was shown to be associated with the mutations in the gene encoding the bifunctional enzyme, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE)...
  42. doi request reprint Outcome and treatment of late-onset noninfectious pulmonary complications after allogeneic haematopoietic SCT
    K Ueda
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Bone Marrow Transplant 45:1719-27. 2010
    ..054 for short-term response, and 0.016 for final outcome). Our study indicates that LONIPCs reduce OS, and early intervention with systemic corticosteroids may be effective...
  43. ncbi request reprint Acute parvovirus B19 infection during anti-retroviral therapy
    H Taguchi
    Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Infect Chemother 7:110-2. 2001
    ..More than likely, highly active anti-retroviral therapy (HAART), including a protease inhibitor, played a role in clearing the virus...
  44. ncbi request reprint Recovery of Valpha24+ NKT cells after hematopoietic stem cell transplantation
    K Haraguchi
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Bone Marrow Transplant 34:595-602. 2004
    ..Our results raise the possibility that the number of Valpha24+ NKT cells could be related to the development of GVHD...
  45. ncbi request reprint IgG-mediated histamine release from canine mastocytoma-derived cells
    T Takahashi
    Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Int Arch Allergy Immunol 125:228-35. 2001
    ..Further research is required to clarify the pathophysiological significance of constitutive expression of IgG receptors in neoplastic (canine) mast cells...
  46. ncbi request reprint Sleep architectures of obstructive sleep apnea syndrome in the young child
    W Yamadera
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Psychiatry Clin Neurosci 54:330-1. 2000
    ..Sleep fragmentation in child-OSAS was not so remarkable. The quantity of slow wave sleep in child-OSAS was similar to that of primary snoring in the child. Both profiles of sleep architectures showed nearly the same pattern...
  47. pmc Potential responders to FOLFOX therapy for colorectal cancer by Random Forests analysis
    S Tsuji
    Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan
    Br J Cancer 106:126-32. 2012
    ..Molecular characterisation using gene-expression profiling will undoubtedly improve the prediction of treatment responses, and ultimately, the clinical outcome of cancer patients...
  48. doi request reprint Differential prognostic impact of pretransplant comorbidity on transplant outcomes by disease status and time from transplant: a single Japanese transplant centre study
    K Kataoka
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Bone Marrow Transplant 45:513-20. 2010
    ..Within patients who survived without relapse >1 year after HSCT, the HCT-CI did not predict OS (P=0.59) or NRM (P=0.31). These findings can be useful to determine the role of pretransplant comorbidity in allogeneic HSCT...
  49. pmc Familial leptomeningeal amyloidosis with a transthyretin variant Asp18Gly representing repeated subarachnoid haemorrhages with superficial siderosis
    K Jin
    Department of Neurology, Kohnan Hospital, 4 20 1, Nagamachi minami, Taihaku ku, Sendai 982 8523, Japan
    J Neurol Neurosurg Psychiatry 75:1463-6. 2004
    ..To report the clinical features of two Japanese brothers with familial leptomeningeal amyloidosis, showing a causative gene abnormality of a transthyretin (TTR) variant Asp18Gly, previously reported only in a Hungarian family...
  50. ncbi request reprint Autoimmunity against the second extracellular loop of beta(1)-adrenergic receptors induces beta-adrenergic receptor desensitization and myocardial hypertrophy in vivo
    M Iwata
    Cardiology Division, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Circ Res 88:578-86. 2001
    ..Sustained sympathomimetic-like actions of autoantibodies against the domain may be partly responsible for these changes...
  51. doi request reprint Serum glycated albumin: Potential use as an index of glycemic control in diabetic dogs
    T Sako
    Department of Veterinary Nursing, Nippon Veterinary and Life Science University, Musashino, Tokyo, 180 8602, Japan
    Vet Res Commun 33:473-9. 2009
    ..Furthermore, serum GA% can reflect long-term changes (almost 1-3 weeks) in blood glucose concentration and the effect of injected insulin in diabetic dogs...
  52. ncbi request reprint [The effect of leukotriene C4/D4 receptor antagonist (ONO-1078) and thromboxane A2 synthetase inhibitor (OKY-046) on airway hyperresponsiveness induced by ozone exposure in guinea pigs]
    A Okazawa
    First Department of Internal Medicine, School of Medicine, Showa University, Tokyo, Japan
    Nihon Kyobu Shikkan Gakkai Zasshi 28:293-9. 1990
    ..These results suggest that leukotriene and thromboxane play an important role in the development of airway hyperresponsiveness induced by ozone exposure in guinea pigs...
  53. ncbi request reprint Localization of initial lymph node metastasis from carcinoma of the thoracic esophagus
    T Matsubara
    Department of Surgery, Cancer Institute Hospital, Kami Ikebukuro, Toshima ku, Tokyo, Japan
    Cancer 89:1869-73. 2000
    ..However, it is possible that the disease may be localized in the earlier phases of lymphatic metastasis. The distribution of involved lesions in the initial phase of lymph node metastasis has not been thoroughly investigated yet...
  54. pmc Enhancement of goblet cell hyperplasia and airway hyperresponsiveness by salbutamol in a rat model of atopic asthma
    A Kamachi
    First Department of Medicine, School of Medicine, Hokkaido University, Sapporo, Japan
    Thorax 56:19-24. 2001
    ..The aim of this study was to examine the effect of a beta(2) agonist on the development of GCH induced by the immune response...
  55. ncbi request reprint [A case of potassium-sensitive periodic paralysis with cardiac dysrhythmia controlled with imipramine and acetazolamide]
    T Endo
    Department of Neurology, Neurosurgery, Tohoku University School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574, Japan
    No To Shinkei 53:373-6. 2001
    ..We also discussed the efficacy of the exercise test. It enabled us to confirm the diagnosis of periodic paralysis safely and easily by recording the change of compound muscle action potential amplitudes...
  56. ncbi request reprint Proliferative behavior of the murine cerebral wall in tissue culture: cell cycle kinetics and checkpoints
    T Takahashi
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA
    Exp Neurol 156:407-17. 1999
    ..0 in vivo. The embryonic murine cerebral explant, cultured in minimum essential medium, should be favorable for studies of cycle modulatory actions of cell external influences such as growth factors or neurotransmitters...
  57. ncbi request reprint Sequence of neuron origin and neocortical laminar fate: relation to cell cycle of origin in the developing murine cerebral wall
    T Takahashi
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 19:10357-71. 1999
    ..We infer from these findings that cell cycle is a neuronogenetic counting mechanism and that this counting mechanism is integral to subsequent processes that determine cortical laminar fate...
  58. pmc Cardiomyocytes can be generated from marrow stromal cells in vitro
    S Makino
    Cardiopulmonary Division, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Invest 103:697-705. 1999
    ..These cells expressed Nkx2.5/Csx, GATA4, TEF-1, and MEF-2C mRNA before 5-azacytidine treatment and expressed MEF-2A and MEF-2D after treatment. This new cell line provides a powerful model for the study of cardiomyocyte differentiation...
  59. ncbi request reprint 1173C>T polymorphism in VKORC1 modulates the required warfarin dose
    K Kosaki
    Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Tokyo, Shinjuku ku, 160 8582, Japan
    Pediatr Cardiol 27:685-8. 2006
    ....
  60. pmc Characterisation of a vindesine-resistant human small-cell lung cancer cell line
    S Ohta
    Pharmacology Division of National Cancer Center Research Institute, Tokyo, Japan
    Br J Cancer 68:74-9. 1993
    ..In H69/VDS cells, however, verapamil increased the amount of total tubulin to the level of parental cells, but decreased the amount of polymerised tubulin. Modulation of tubulin may play a role in the resistance to vindesine...
  61. ncbi request reprint Combinations of the presence or absence of cerebral microbleeds and advanced white matter hyperintensity as predictors of subsequent stroke types
    H Naka
    Department of Neurology, Suiseikai Kajikawa Hospital, Hiroshima, Japan
    AJNR Am J Neuroradiol 27:830-5. 2006
    ..This study was performed to determine whether combinations of the presence or absence of microbleeds and advanced WMH are risk factors for subsequent recurrent stroke types...
  62. ncbi request reprint Cytotoxicity of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines
    W Maruyama
    Department of Neurology, Nagoya University School of Medicine, Japan
    Adv Neurol 60:224-30. 1993
    ....
  63. ncbi request reprint Effect of cyclophosphamide on serum cyclosporine levels at the conditioning of hematopoietic stem cell transplantation
    F Nagamura
    Department of Hematology Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Bone Marrow Transplant 32:1051-8. 2003
    ..The mechanism of this effect is not clear, but it may be due to the autoinduction of CY...
  64. ncbi request reprint Two special types of breast cancer presenting as progressive disease after neoadjuvant chemotherapy with docetaxel plus doxorubicin
    T Takahashi
    Breasr Surgery Division, National Cancer Hospital, Tokyo, Japan
    Breast Cancer 8:234-7. 2001
    ..There were 4 cases of IBC and one case of SCC of the breast who received neoadjuvant chemotherapy in this series. Our observations suggest that this regimen might not be effective for these types of breast cancer...
  65. ncbi request reprint Nested polymerase chain reaction for assessing the clinical course of tuberculous meningitis
    T Takahashi
    Division of Neurology, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
    Neurology 64:1789-93. 2005
    ..During anti-tuberculosis treatments, N-PCR results converted from positive to negative, correlating with the improvement of the patient's clinical condition...
  66. ncbi request reprint Mutation in the caveolin-3 gene causes a peculiar form of distal myopathy
    M Tateyama
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Neurology 58:323-5. 2002
    ..This patient further demonstrated possible clinical heterogeneity of myopathies with mutations in the caveolin-3 gene...
  67. ncbi request reprint Proliferative activity of intrahepatic colorectal metastases after preoperative hemihepatic portal vein embolization
    N Kokudo
    Department of Surgery, Cancer Institute Hospital, Tokyo, Japan
    Hepatology 34:267-72. 2001
    ..004). We conclude that PVE increases tumor growth and probably is associated with enhanced recurrence of disease. Although PVE is effective in extending indications for surgery, patient selection for PVE should be cautious...
  68. ncbi request reprint Lactobacillus casei acquires the binding activity to fibronectin by the expression of the fibronectin binding domain of Streptococcus pyogenes on the cell surface
    A Kushiro
    Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan
    J Mol Microbiol Biotechnol 3:563-71. 2001
    ..This L. casei also shows binding affinity to fibrinogen, indicating that fibronectin binding domain is involved in the binding to fibrinogen as well...
  69. ncbi request reprint Significance of lymphocytosis in bronchoalveolar lavage in suspected ocular sarcoidosis
    T Takahashi
    Fourth Dept of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Eur Respir J 18:515-21. 2001
    ..It should be kept in mind that a diagnostic group of patients with sarcoidosis who manifest ocular involvement and lymphocytosis in bronchoalveolar lavage exists...
  70. ncbi request reprint Allele frequency of HLA-B39 in the Japanese population and identification of a novel B39 allele, B*3923
    T Akesaka
    Japanese Red Cross Central Blood Center, Tokyo, Japan
    Tissue Antigens 57:169-72. 2001
    ..The frequency of B*3923 was estimated to be 0.4% in B39 alleles of the Japanese population. B*3923 was found in samples from four Japanese individuals, all of whom have DRB1*1406...
  71. ncbi request reprint No genetic association between alpha-2 macroglobulin I1000V polymorphism and Japanese sporadic Alzheimer's disease
    N Shibata
    Department of Psychiatry, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, 113 8421, Tokyo, Japan
    Neurosci Lett 290:154-6. 2000
    ..8% in the control and AD groups, respectively. Our results failed to demonstrate an association between this polymorphism and Japanese sporadic AD, and the A2M I1000V mutation does not seem to be a risk factor per se for sporadic AD...
  72. ncbi request reprint The ACE gene polymorphism and cough threshold for capsaicin after cilazapril usage
    T Takahashi
    First Department of Medicine, School of Medicine, Hokkaido University, Sapporo, Japan
    Respir Med 95:130-5. 2001
    ..These findings provide further evidence of a link between ACEI-induced cough and I/D polymorphism of the ACE gene and suggest that ACEIs induce cough by modulating the tissue level of bradykinin...
  73. ncbi request reprint Altered extracellular matrix component gene expression in murine polycystic kidney
    I Ebihara
    Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Ren Physiol Biochem 18:73-80. 1995
    ..These data suggest that changes in the expression of basement membrane components and interstitial collagens are associated with the development of polycystic kidney disease...
  74. ncbi request reprint Spontaneous pneumomediastinum complicating pneumonia in children infected with the 2009 pandemic influenza A (H1N1) virus
    M Hasegawa
    Department of General Paediatrics, Nihon University Nerima Hikarigaoka Hospital, Nihon University School of Medicine, Tokyo, Japan
    Clin Microbiol Infect 16:195-9. 2010
    ..The presented patients illustrate the specific clinical and radiological signs associated with SPM complicating pneumonia in children infected with A(H1N1)v...
  75. pmc Detection of antibodies to Erysipelothrix in stray dogs in Japan
    Y Shimazaki
    National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, Kokubunji, Tokyo, Japan
    Acta Vet Scand 46:159-61. 2005
  76. ncbi request reprint Detection of Toxoplasma gondii by polymerase chain reaction in cerebrospinal fluid from human immunodeficiency virus-1-infected Japanese patients with focal neurological signs
    M Goto
    Division of Infectious Diseases, Advanced Clinical Research Centre, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Int Med Res 32:665-70. 2004
    ..7%, respectively. These results suggest that PCR might be a clinically useful technique for detecting T. gondii DNA in patients infected with HIV showing focal neurological signs. Improvements in sensitivity are needed, however...
  77. ncbi request reprint Drug resistance and pulsed-field gel electrophoresis patterns of Lactococcus garvieae isolates from cultured Seriola (yellowtail, amberjack and kingfish) in Japan
    M Kawanishi
    National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, Tokyo, Japan
    Lett Appl Microbiol 40:322-8. 2005
    ..To investigate the existing antimicrobial susceptibility and genetic characteristics of Lactococcus garvieae isolates from cultured Seriola in Japan...
  78. ncbi request reprint Efficacy of budesonide Turbuhaler compared with that of beclomethasone dipropionate pMDI in Japanese patients with moderately persistent asthma
    T Miyamoto
    National Sagamihara Hospital, Sagamihara, Showa University, Tokyo, Japan
    Respirology 6:27-35. 2001
    ..Without that information, comparative studies are usually inconclusive...
  79. ncbi request reprint Validity and reproducibility of a self-administered food-frequency questionnaire to assess isoflavone intake in a japanese population in comparison with dietary records and blood and urine isoflavones
    S Yamamoto
    National Cancer Center Research Institute, Tokyo and Kashiwa, Japan Tokyo University of Agriculture, Tokyo, Japan
    J Nutr 131:2741-7. 2001
    ..The original FFQ and the shorter versions have sufficient validity and reproducibility to be used in epidemiologic studies...
  80. ncbi request reprint High speed digital circuits for medical communication; the MINCS-UH project
    T Kiuchi
    University Hospital Medical Information Network Center, Hospital Computer Center, University of Tokyo Hospital, Tokyo, Japan
    Methods Inf Med 39:353-5. 2000
    ..High-quality motion images, and security protection mechanisms are essential for use in clinical medicine...
  81. ncbi request reprint Risk factors for development of postoperative hypertension
    R Nishigaki
    Department of Pharmacy, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan
    Methods Find Exp Clin Pharmacol 23:203-7. 2001
    ..05 for every 1 year increase in age and 0.82 for every 1 kg/m2 increase in BMI. These findings may have important clinical implications for the prevention of postoperative hypertension...
  82. ncbi request reprint Visual event-related potentials in progressive supranuclear palsy, corticobasal degeneration, striatonigral degeneration, and Parkinson's disease
    L Wang
    Department of Neurology, Yokohama City University School of Medicine, Yokohama, Japan
    J Neurol 247:356-63. 2000
    ..Simultaneous measurement of P300 and RT may yield useful supplementary information in facilitating diagnosis of parkinsonian syndromes in addition to clinical criteria...
  83. ncbi request reprint Morphology and properties of Asian and Caucasian hair
    T Takahashi
    Hair Care Research Laboratories, Kao Corporation, 1 3, Bunka 2, Sumida ku, Tokyo, 131 8501, Japan
    J Cosmet Sci 57:327-38. 2006
    ..It was proven that the cuticles of Asian hair are more easily peeled off than Caucasian hair cuticles during daily grooming. This can be attributed to the difference in how stress is absorbed...
  84. pmc Clinical and MRI features of Japanese patients with multiple sclerosis positive for NMO-IgG
    I Nakashima
    Department of Neurology, Tohoku University School of Medicine, Sendai 980 8574, Japan
    J Neurol Neurosurg Psychiatry 77:1073-5. 2006
    ..This newly discovered serum autoantibody was markedly associated with longitudinally extensive spinal cord lesions and with complete blindness, suggesting severe optic-spinal disease...
  85. ncbi request reprint Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene
    H Date
    Department of Neurology, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951, Japan
    Nat Genet 29:184-8. 2001
    ..We have called its product aprataxin; the gene symbol is APTX. Although many HIT proteins have been identified, aprataxin is the first to be linked to a distinct phenotype...
  86. ncbi request reprint Population-based mapping of pulmonary adenoma susceptibility 1 locus
    T A Dragani
    National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 60:5017-20. 2000
    ..001) and survival rate (log rank = 0.0014), confirming the mapping of PAS1 and pointing to the role of this locus in human lung cancer...
  87. ncbi request reprint Regression of an unresectable pancreatic tumor following nonmyeloablative allogeneic peripheral-blood stem-cell transplantation
    Y Omuro
    Department of Chemotherapy, Tokyo Metropolitan Komagome Hospital, Hokomagome, Bunkyo ku, Tokyo, Japan
    Bone Marrow Transplant 31:943-5. 2003
    ..The observed clinical course may suggest a graft-versus-tumor effect on the pancreatic tumor following allogeneic stem-cell transplantation...
  88. ncbi request reprint Early expression of human J chain and mu chain gene in the fetal liver
    T Iwase
    Department of Pathology, Nihon University School of Dentistry, Tokyo, Japan
    Cell Struct Funct 18:297-302. 1993
    ..Therefore, our results imply that J chain is the first immunoglobulin-related polypeptide expressed during the embryogenesis and differentiation of B cells in the fetal liver...
  89. ncbi request reprint Health and welfare data on optical memory cards in Isehara city
    Y Sakashita
    Tokai University, School of Medicine, Kanagawa, Japan
    Med Inform (Lond) 21:69-79. 1996
    ..It has been a good experience for us, because the optical memory card system needs co-operation among citizens, medical association and local government, and the experience will help us to expand the system in the future...
  90. pmc Evidence for linkage of human primary systemic carnitine deficiency with D5S436: a novel gene locus on chromosome 5q
    Y Shoji
    Department of Pediatrics, Akita University School of Medicine, Akita, Japan
    Am J Hum Genet 63:101-8. 1998
    ..This region was syntenic with the jvs locus, which is responsible for murine SCD. Phylogenic conversion of the SCD locus strongly suggests involvement of a single gene, in human SCD...
  91. ncbi request reprint Identification of a novel HLA-B46 allele, B*4602, in Japanese
    T Akesaka
    Japanese Red Cross Central Blood Center, Hoshi University, Tokyo
    Tissue Antigens 55:460-2. 2000
    ..The gene frequency of B*4602 in the Japanese population is extremely low. The presumed haplotype of B*4602 was HLA-A2-Cw1-B*4602-DRB1*09. This is the first report of polymorphism of the B46 antigen...
  92. ncbi request reprint Ala/Thr60 variant of the Leydig insulin-like hormone is not associated with cryptorchidism in the Japanese population
    I Takahashi
    Department of Pediatrics, Akita University School of Medicine, Akita, Japan
    Pediatr Int 43:256-8. 2001
    ..Recently, the absence of the Insl3 gene has been reported to result in bilateral cryptorchidism in male mice and it has been suggested that mutations of the INSL3 gene may cause cryptorchidism in humans...
  93. pmc NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses
    T S Doi
    Laboratory of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Exp Med 185:953-61. 1997
    ..The results indicate that RelA plays a critical role in production of specific Ig isotypes and also in signal transduction pathways for lymphocyte proliferation...
  94. ncbi request reprint Suppression of autoimmune disease and of massive lymphadenopathy in MRL/Mp-lpr/lpr mice lacking tyrosine kinase Fyn (p59fyn)
    T Takahashi
    Department of Molecular Immunology, Center for Basic Research, The Kitasato Institute, Tokyo, Japan
    J Immunol 159:2532-41. 1997
    ..Fyn provides a signal for both the expansion of autoreactive T cells and the production of IgG3 anti-DNA autoantibody by B cells. Thus, manipulation of Fyn may improve systemic autoimmune disease in humans...
  95. ncbi request reprint [An epidemiological study of penicillin-resistant Streptococcus pneumoniae in Japan]
    M Konno
    Teikyo University, School of Medicine
    Kansenshogaku Zasshi 68:1338-51. 1994
    ..Most of the Pcr strains were simultaneously resistant to macrolides and minocycline. Further more, isolation frequencies of Pcr S. pneumoniae in west Japan, were relatively high compared with those of east Japan...
  96. ncbi request reprint A novel allelic variant of serum amyloid A, SAA1 gamma: genomic evidence, evolution, frequency, and implication as a risk factor for reactive systemic AA-amyloidosis
    S Baba
    Department of Pathology, Hamamatsu University School of Medicine, Shizuoka, Japan
    Hum Mol Genet 4:1083-7. 1995
    ..012) with an increased frequency of gamma/gamma-homozygotes in the AA-amyloid group (0.60 vs. 0.18). Thus our findings indicate that this novel allelic variant may be an important risk factor for the development of AA-amyloidosis...
  97. pmc Genotyping of congenital adrenal hyperplasia due to 21-hydroxylase deficiency presenting as male infertility: case report and literature review
    Y Sugino
    Department of Urology, Kyoto University, Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, 606 8507, Japan
    J Assist Reprod Genet 23:377-80. 2006
    ..It is important to investigate genotyping and to classify patients on the basis of genotypic information in order to arrive at better treatment strategies for male infertility; especially in counseling of TESE-ICSI...
  98. ncbi request reprint Isolation and sequencing of a cDNA clone encoding the 85 kDa human lysosomal sialoglycoprotein (hLGP85) in human metastatic pancreas islet tumor cells
    H Fujita
    Division of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Fukuoka, Japan
    Biochem Biophys Res Commun 184:604-11. 1992
    ..The protein contained the short cytoplasmic tail at the COOH-terminus which does not form the glycine-tyrosine sequence (GY motif), the so-called lysosomal targetting signal...
  99. ncbi request reprint Identification of a missense mutation (S436R) in the acid sphingomyelinase gene from a Japanese patient with type B Niemann-Pick disease
    T Takahashi
    Mount Sinai School of Medicine, New York, New York 10029
    Hum Mutat 1:70-1. 1992
  100. ncbi request reprint CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells
    H Nagai
    Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Oncogene 26:4025-31. 2007
    ..Although the physiological role of the interaction between CLCP1 and SEMA4B remains to be investigated, this novel gene may become a target of therapy to inhibit metastasis of lung cancers...
  101. ncbi request reprint Isolation of cDNA encoding the human liver phosphorylase kinase alpha subunit (PHKA2) and identification of a missense mutation of the PHKA2 gene in a family with liver phosphorylase kinase deficiency
    H Hirono
    Department of Pediatrics, Akita University School of Medicine, Japan
    Biochem Mol Biol Int 36:505-11. 1995
    ..We identified a missense mutation, a valine substitution for glycine at amino acid 193, in the PHKA2 gene of a family with XLG...