Shigeaki Suzuki

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. doi request reprint Myopathy associated with antibodies to signal recognition particle: disease progression and neurological outcome
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arch Neurol 69:728-32. 2012
  2. pmc Quality of life in purely ocular myasthenia in Japan
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    BMC Neurol 14:142. 2014
  3. pmc Three types of striational antibodies in myasthenia gravis
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Autoimmune Dis 2011:740583. 2011
  4. doi request reprint Overlooked non-motor symptoms in myasthenia gravis
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, Tokyo, Japan
    J Neurol Neurosurg Psychiatry 84:989-94. 2013
  5. doi request reprint Clinical and immunological predictors of prognosis for Japanese patients with thymoma-associated myasthenia gravis
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, Tokyo, Japan
    J Neuroimmunol 258:61-6. 2013
  6. ncbi request reprint Autoimmunity to endoplasmic reticulum chaperone GRP94 in myasthenia gravis
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Neuroimmunol 237:87-92. 2011
  7. doi request reprint Anti-signal recognition particle myopathy in the first decade of life
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, Tokyo, Japan
    Pediatr Neurol 45:114-6. 2011
  8. doi request reprint Autoimmune targets of heart and skeletal muscles in myasthenia gravis
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arch Neurol 66:1334-8. 2009
  9. ncbi request reprint Classification of myasthenia gravis based on autoantibody status
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Tokyo 160 8582, Japan
    Arch Neurol 64:1121-4. 2007
  10. ncbi request reprint Novel autoantibodies to a voltage-gated potassium channel Kv1.4 in a severe form of myasthenia gravis
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Tokyo 160 8582, Japan
    J Neuroimmunol 170:141-9. 2005

Collaborators

Detail Information

Publications46

  1. doi request reprint Myopathy associated with antibodies to signal recognition particle: disease progression and neurological outcome
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arch Neurol 69:728-32. 2012
    ..To characterize the clinical course of myopathy associated with antibodies to signal recognition particle (SRP), or anti-SRP myopathy...
  2. pmc Quality of life in purely ocular myasthenia in Japan
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    BMC Neurol 14:142. 2014
    ..However, the therapeutic outcomes concerning the quality-of-life (QOL) of patients with ocular myasthenia are not yet fully understood...
  3. pmc Three types of striational antibodies in myasthenia gravis
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Autoimmune Dis 2011:740583. 2011
    ..Detection of striational antibodies provides more specific and useful clinical information in MG patients...
  4. doi request reprint Overlooked non-motor symptoms in myasthenia gravis
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, Tokyo, Japan
    J Neurol Neurosurg Psychiatry 84:989-94. 2013
    ..Early diagnosis is important, since non-motor symptoms can be treatable. A complete understanding of non-motor symptoms is necessary for the management of patients with thymoma-associated MG. ..
  5. doi request reprint Clinical and immunological predictors of prognosis for Japanese patients with thymoma-associated myasthenia gravis
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, Tokyo, Japan
    J Neuroimmunol 258:61-6. 2013
    ..Multivariate analyses showed that anti-Kv1.4 antibody was the only independent factor associated with MG relapse. Anti-Kv1.4 antibody is a useful predictor of the prognosis of thymoma-associated MG...
  6. ncbi request reprint Autoimmunity to endoplasmic reticulum chaperone GRP94 in myasthenia gravis
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Neuroimmunol 237:87-92. 2011
    ..001). Autoimmunity to ER chaperone GRP94 is associated with a subset of MG patients who have additional autoimmune diseases...
  7. doi request reprint Anti-signal recognition particle myopathy in the first decade of life
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, Tokyo, Japan
    Pediatr Neurol 45:114-6. 2011
    ..Anti-signal recognition particle myopathy can occur in the first decade of life and should be included in the differential diagnosis for children with progressive limb girdle muscle weakness and high creatine kinase levels...
  8. doi request reprint Autoimmune targets of heart and skeletal muscles in myasthenia gravis
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arch Neurol 66:1334-8. 2009
    ..To investigate the clinical, histological, and immunological features of patients with myasthenia gravis (MG) who also developed myocarditis and/or myositis...
  9. ncbi request reprint Classification of myasthenia gravis based on autoantibody status
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Tokyo 160 8582, Japan
    Arch Neurol 64:1121-4. 2007
    ..To investigate the autoantibody status of patients with myasthenia gravis (MG) and to evaluate its usefulness for disease classification...
  10. ncbi request reprint Novel autoantibodies to a voltage-gated potassium channel Kv1.4 in a severe form of myasthenia gravis
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Tokyo 160 8582, Japan
    J Neuroimmunol 170:141-9. 2005
    ..These findings suggest that anti-Kv1.4 antibody is a novel autoantibody associated with a severe MG subset and thymoma...
  11. ncbi request reprint Blockade of interleukin-6 signaling aggravates ischemic cerebral damage in mice: possible involvement of Stat3 activation in the protection of neurons
    Toru Yamashita
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    J Neurochem 94:459-68. 2005
    ..These results suggest that endogenous IL-6 plays a critical role in preventing damaged neurons from undergoing apoptosis in the acute phase of cerebral ischemia and that its role may be mediated by Stat3 activation...
  12. ncbi request reprint Myelitis associated with human herpes virus 6 (HHV-6) after allogeneic cord blood transplantation
    Takehiko Mori
    Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Scand J Infect Dis 39:276-8. 2007
    ..We here report 2 patients who developed HHV-6-associated myelitis soon after allogeneic cord blood transplantation...
  13. ncbi request reprint [A case of Good syndrome accompanied by myasthenia gravis: immunological evaluations]
    Yumiko Katsuki
    Department of Neurology, Keio University School of Medicine
    Nihon Rinsho Meneki Gakkai Kaishi 29:102-6. 2006
    ..We failed to detect IgG autoantibodies reactive with B cells in his serum. Patients with Good syndrome represent imbalance of immune responses, leading to both immunodeficiency and autoimmunity...
  14. doi request reprint The MG-QOL15 Japanese version: validation and associations with clinical factors
    Masayuki Masuda
    Department of Neurology, Tokyo Medical University, Tokyo, Japan
    Muscle Nerve 46:166-73. 2012
    ..Our study aim was to produce a Japanese translation of the 15-item Myasthenia Gravis Quality-of-Life Scale (MG-QOL15), assess its reliability and validity, and examine clinical factors affecting self-perceived QOL in MG...
  15. doi request reprint Clinical and immunological differences between early and late-onset myasthenia gravis in Japan
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, Tokyo, Japan
    J Neuroimmunol 230:148-52. 2011
    ..HLA-DRB1 genotyping failed to detect statistical differences in specific alleles between each group and healthy controls. The immunological profiles in late-onset MG were different from early-onset in Japan...
  16. doi request reprint Identification of biomarkers associated with migraine with aura
    Eiichiro Nagata
    Department of Neurology, Tokai University School of Medicine, 143 Shimo Kasuya, Isehara, Kanagawa 259 1193, Japan
    Neurosci Res 64:104-10. 2009
    ..Thus, alpha-fodrin might play an important role in the pathophysiology of migraine, possibly serving as a migraine biomarker...
  17. ncbi request reprint Initial predictors of development of pure red cell aplasia in myasthenia gravis after thymectomy
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Clin Neurol Neurosurg 106:16-8. 2003
    ..Japanese MG patients with these characteristics at presentation were at significant risk for the development of PRCA after thymectomy...
  18. doi request reprint Two-year treatment with cyclosporine microemulsion for responder myasthenia gravis patients
    Yuriko Nagane
    Department of Neurology, Hanamaki General Hospital, Hanamaki, Japan
    Eur Neurol 64:186-90. 2010
    ..Cyclosporine (CsA) microemulsion pre-concentrate (MEPC) is a potential steroid-sparing agent for myasthenia gravis (MG) patients; however, there is a paucity of information on the long-term use of CsA MEPC in these patients...
  19. doi request reprint Factors associated with response to calcineurin inhibitors in myasthenia gravis
    Yuriko Nagane
    Department of Neurology, Hanamaki General Hospital, 4 28 Kajoh chou, Hanamaki 025 0075, Japan
    Muscle Nerve 41:212-8. 2010
    ..4, was associated with response (OR = 9.01, P = 0.04) and showed a correlation with the presence of thymoma (P < 0.01). In MG, the early stages of disease and thymoma-associated MG are responsive to treatment with CNIs...
  20. ncbi request reprint Inflammatory myopathy with anti-Golgi antibody and anti-SS-A/Ro antibody
    Hidenori Hattori
    Department of Neurology, Keio University School of Medicine, Tokyo
    Intern Med 46:1927-30. 2007
    ..This report suggests that there is a new categorized subgroup of inflammatory myopathy with these specific antibodies and the pattern of autoantibody in these patients indicates the specific clinical course and treatment strategy...
  21. ncbi request reprint Antigen-specific T-cell activation in hyperplastic thymus in myasthenia gravis
    Kimiaki Utsugisawa
    Department of Neurology, Hanamaki General Hospital, Kajoh chou 4 28, Hanamaki 025 0075, Japan
    Muscle Nerve 36:100-3. 2007
    ....
  22. doi request reprint Topical naphazoline in the treatment of myasthenic blepharoptosis
    Yuriko Nagane
    Department of Neurology, Hanamaki General Hospital, 4 28 Kajoh chou, Hanamaki 025 0075, Japan
    Muscle Nerve 44:41-4. 2011
    ..We examined the efficacy of topical naphazoline in the treatment of myasthenic blepharoptosis...
  23. ncbi request reprint Clinical and laboratory features of in-patients with multiple sclerosis in a University Hospital in Tokyo from 1988-2002
    Kortaro Tanaka
    Department of Neurology, School of Medicine, Keio University, Shinanomachi, Tokyo
    Intern Med 44:560-6. 2005
    ..The aim of this study was to analyze the clinical and laboratory features of each subtype of multiple sclerosis (MS) (relapsing-remitting, primary progressive, and secondary progressive) in the Tokyo metropolitan area...
  24. doi request reprint Early aggressive treatment strategy against myasthenia gravis
    Yuriko Nagane
    Department of Neurology, Hanamaki General Hospital, 4 28 Kajoh chou, Hanamaki, Japan
    Eur Neurol 65:16-22. 2011
    ..We examined the merits of the EAT strategy...
  25. pmc Factors associated with depressive state in patients with myasthenia gravis: a multicentre cross-sectional study
    Yasushi Suzuki
    Department of Neurology, Sendai Medical Center, Sendai, Japan
    BMJ Open 1:e000313. 2011
    ..Unchanged status despite treatment and early disease stage are also significant background factors for depressive state, along with disease severity...
  26. ncbi request reprint Ambivalent aspects of interleukin-6 in cerebral ischemia: inflammatory versus neurotrophic aspects
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Cereb Blood Flow Metab 29:464-79. 2009
    ..Taken together, the information suggests that IL-6 plays a double role in cerebral ischemia, as an inflammatory mediator during the acute phase and as a neurotrophic mediator between the subacute and prolonged phases...
  27. ncbi request reprint [New clinical entity of myasthenia gravis with autoimmune targets of heart and skeletal muscles]
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine
    Rinsho Shinkeigaku 52:1312-4. 2012
    ..Heart and skeletal muscles are autoimmune targets in some MG patients. This autoimmunity has a broad clinical spectrum with anti-striational autoantibodies...
  28. ncbi request reprint [Recent concept of limbic encephalitis: progress in anti-NMDA receptor encephalitis]
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine
    Nihon Rinsho Meneki Gakkai Kaishi 36:86-94. 2013
    ..This review focuses in the recent concept of limbic encephalitis and clinical characteristics of anti-NMDA receptor encephalitis...
  29. ncbi request reprint [Non-motor symptoms in myasthenia gravis: attributed to T-cell clones from thymoma]
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, Japan
    Brain Nerve 65:477-83. 2013
    ..Non-motor symptoms affect many target organs and result in a broad disease spectrum, ranging from the impairment of quality of life to lethal conditions...
  30. ncbi request reprint T helper type 2-biased natural killer cell phenotype in patients with pemphigus vulgaris
    Hayato Takahashi
    Department of Dermatology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Invest Dermatol 127:324-30. 2007
    ..Together these findings suggest that NK cells contribute to a T helper type 2-biased immune response in PV patients through impaired IL-12 signaling and an upregulation of IL-10 and IL-5...
  31. pmc Headache associated with myasthenia gravis: the impact of mild ocular symptoms
    Yoshinori Nishimoto
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Autoimmune Dis 2011:840364. 2011
    ..Our results suggest that treatment of chronic headache should be required to improve the quality of life in MG patients...
  32. ncbi request reprint [Anti-SRP myopathy: different entity from myositis]
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine
    Rinsho Shinkeigaku 52:1148-50. 2012
    ..A subset of patients with anti-SRP myopathy can show a chronic progressive form associated with severe clinical deficits...
  33. doi request reprint Intracranial transplantation of monocyte-derived multipotential cells enhances recovery after ischemic stroke in rats
    Hidenori Hattori
    Department of Neurology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Neurosci Res 90:479-88. 2012
    ..These findings provide evidence that the intracranial delivery of MOMCs enhances functional recovery by promoting neovascularization in a rat model for ischemic stroke...
  34. ncbi request reprint [Autoantibodies in thymoma-associated myasthenia gravis and their clinical significance]
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, Tokyo, Japan
    Brain Nerve 63:705-12. 2011
    ..4 antibody. In addition, the anti-Kv1.4 antibody is a useful marker to check the response to calcineurin inhibitors. In summary, the detection of striational antibodies provides more specific clinical information in MG patients...
  35. ncbi request reprint Altered levels of serotonin in lymphoblasts derived from migraine patients
    Eiichiro Nagata
    Department of Neurology, Saitama City Hospital, 2560 Mimuro, Saitama City, Japan
    Neurosci Res 57:179-83. 2007
    ..These findings suggest that lymphoblasts in MwA patients have altered levels of serotonin metabolism. Moreover, we propose that this lymphoblast cell system could serve as a novel modality for migraine research...
  36. ncbi request reprint Differential diagnosis between intracranial dissemination of spinal cord astrocytoma and paraneoplastic limbic encephalitis
    Morinobu Seki
    Department of Neurology, School of Medicine, Keio University, Japan
    Intern Med 51:321-4. 2012
    ..The differential diagnosis between intracranial dissemination of spinal cord astrocytoma and paraneoplastic limbic encephalitis may be sometimes difficult...
  37. ncbi request reprint [Anti-SRP myopathy]
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine
    Rinsho Shinkeigaku 51:961-3. 2011
    ..Some patients with anti-SRP myopathy show chronic progression indistinguishable from muscular dystrophy...
  38. ncbi request reprint [Myositis-specific autoantibodies and their clinical significance]
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Brain Nerve 63:1197-203. 2011
    ..This review reports recent progress in myositis-specific autoantigens, particularly their clinical significance...
  39. ncbi request reprint Risk factors for developing human herpesvirus 6 (HHV-6) reactivation after allogeneic hematopoietic stem cell transplantation and its association with central nervous system disorders
    Akiko Yamane
    Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Biol Blood Marrow Transplant 13:100-6. 2007
    ..Thus, together with the assessment of risk factors, monitoring of HHV-6 DNAemia could be a useful asset in diagnosing HHV-6-associated CNS disorders...
  40. ncbi request reprint Activation of cytokine signaling through leukemia inhibitory factor receptor (LIFR)/gp130 attenuates ischemic brain injury in rats
    Shigeaki Suzuki
    Department of Neurology, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    J Cereb Blood Flow Metab 25:685-93. 2005
    ..Early induction of phosphorylated Stat3 was significantly detected on the ischemic side in the high-LIF group after LIF injection. Exogenous LIF attenuates ischemic brain injury by activating cytokine signaling through LIFR/gp130...
  41. ncbi request reprint [A case of systemic lupus erythematosus predominantly presenting with myositis at onset]
    Yoshinori Endo
    Department of Neurology, Faculty of Medical Sciences, University of Fukui, Japan
    Rinsho Shinkeigaku 53:634-7. 2013
    ..The present case suggests that patients who predominantly present with myositis accompanied by nephritis and autoantibodies should be considered as SLE with myositis. ..
  42. ncbi request reprint [Limbic encephalitis up to date]
    Morinobu Seki
    Department of Neurology, Keio University School of Medicine
    Nihon Rinsho 69:442-7. 2011
    ..While, LE with antibodies against cell-membrane antigens, including NMDAR, AMPAR, GABA(B)R, VGKC, tend to respond better to antitumor therapy and immunotherapy...
  43. ncbi request reprint [Lambert-Eaton myasthenic syndrome (LEMS)]
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Brain Nerve 62:419-26. 2010
    ..The efficacy of 3,4-diaminopyridine for the treatment of LEMS has also been established. Patients with LEMS require the immunotherapies such as plasma exchange and the administration of high doses of immunoglobulin and prednisolone...
  44. doi request reprint Surgical treatment of severe blepharoptosis and facial palsy caused by oculopharyngodistal myopathy
    Yusuke Shimizu
    Department of Plastic and Reconstructive Surgery, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    J Plast Reconstr Aesthet Surg 66:e277-80. 2013
    ..The condition was successfully treated by simple surgical intervention. ..
  45. ncbi request reprint Upregulation of oligodendrocyte progenitor cells associated with restoration of mature oligodendrocytes and myelination in peri-infarct area in the rat brain
    Kortaro Tanaka
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Brain Res 989:172-9. 2003
    ..These findings suggest that the upregulation of OPCs may contribute to replenishment of OLGs and resultant remyelination in the peri-infarct area after ischemic insult...
  46. ncbi request reprint Autoreactive T cells to the P3A+ isoform of AChR alpha subunit in myasthenia gravis
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Neuroimmunol 137:177-86. 2003
    ..These autoreactive T cells may be involved in the pathogenic process in a subset of MG patients...