Hidekazu Suzuki

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. ncbi request reprint [Ghrelin - a novel appetite-stimulating hormone which also affects gastrointestinal functions]
    Hidekazu Suzuki
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Korean J Gastroenterol 48:82-8. 2006
  2. ncbi request reprint Overview: Helicobacter pylori and extragastric disease
    Hidekazu Suzuki
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Int J Hematol 84:291-300. 2006
  3. pmc Helicobacter pylori infection modifies gastric and plasma ghrelin dynamics in Mongolian gerbils
    H Suzuki
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Gut 53:187-94. 2004
  4. ncbi request reprint Current consensus on the diagnosis and treatment of H. pylori-associated gastroduodenal disease
    Hidekazu Suzuki
    Department of Internal Medicine, School of Medicine Keio University, Tokyo, Japan
    Keio J Med 52:163-73. 2003
  5. ncbi request reprint Rabeprazole treatment attenuated Helicobacter pylori-associated gastric mucosal lesion formation in Mongolian gerbils
    Hidekazu Suzuki
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Gastroenterol Hepatol 18:787-95. 2003
  6. ncbi request reprint No difference in the level of gastric mucosal cell apoptosis and proliferation in Helicobacter pylori-colonized p53 heterozygous knockout mice
    H Suzuki
    Department of Internal Medicine, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    Aliment Pharmacol Ther 16:158-66. 2002
  7. doi request reprint Helicobacter pylori and microcirculation
    Hidekazu Suzuki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Microcirculation 16:547-58. 2009
  8. doi request reprint Helicobacter pylori eradication therapy
    Hidekazu Suzuki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Future Microbiol 5:639-48. 2010
  9. doi request reprint Acotiamide (Z-338) as a possible candidate for the treatment of functional dyspepsia
    H Suzuki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Neurogastroenterol Motil 22:595-9. 2010
  10. ncbi request reprint Improvement of gastrointestinal quality of life scores in cases of Helicobacter pylori-positive functional dyspepsia after successful eradication therapy
    Hidekazu Suzuki
    Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Gastroenterol Hepatol 20:1652-60. 2005

Collaborators

Detail Information

Publications154 found, 100 shown here

  1. ncbi request reprint [Ghrelin - a novel appetite-stimulating hormone which also affects gastrointestinal functions]
    Hidekazu Suzuki
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Korean J Gastroenterol 48:82-8. 2006
    ..Increased plasma ghrelin level has been reported in patients with upper gastrointestinal (GI) disease or in their disease animal model, suggesting its important role in the pathogenesis of upper GI disease...
  2. ncbi request reprint Overview: Helicobacter pylori and extragastric disease
    Hidekazu Suzuki
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Int J Hematol 84:291-300. 2006
    ..In summary, the association between H pylori infection and other extragut diseases is still controversial but worthy of further investigation...
  3. pmc Helicobacter pylori infection modifies gastric and plasma ghrelin dynamics in Mongolian gerbils
    H Suzuki
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Gut 53:187-94. 2004
    ..The present study was designed to investigate plasma and gastric ghrelin levels in Mongolian gerbils with H pylori colonisation of the gastric mucosa...
  4. ncbi request reprint Current consensus on the diagnosis and treatment of H. pylori-associated gastroduodenal disease
    Hidekazu Suzuki
    Department of Internal Medicine, School of Medicine Keio University, Tokyo, Japan
    Keio J Med 52:163-73. 2003
    ..g., chronic atrophic gastritis, gastric MALT lymphoma, gastric cancer, non-ulcer dyspepsia, chronic urticaria, idiopathic thrombocytopenic purpura (ITP)), further basic and clinical investigation is required...
  5. ncbi request reprint Rabeprazole treatment attenuated Helicobacter pylori-associated gastric mucosal lesion formation in Mongolian gerbils
    Hidekazu Suzuki
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Gastroenterol Hepatol 18:787-95. 2003
    ..In the present study, we investigated the effect of RPZ on H. pylori-associated gastric mucosal lesion formation...
  6. ncbi request reprint No difference in the level of gastric mucosal cell apoptosis and proliferation in Helicobacter pylori-colonized p53 heterozygous knockout mice
    H Suzuki
    Department of Internal Medicine, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    Aliment Pharmacol Ther 16:158-66. 2002
    ..p53 is a well-known tumour suppressor gene, mutation of which is also known to be involved in gastric cancer formation...
  7. doi request reprint Helicobacter pylori and microcirculation
    Hidekazu Suzuki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Microcirculation 16:547-58. 2009
    ....
  8. doi request reprint Helicobacter pylori eradication therapy
    Hidekazu Suzuki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Future Microbiol 5:639-48. 2010
    ..The alternative candidates for third-line therapy are quinolones, tetracycline, rifabutin and furazolidone; high-dose PPI/amoxicillin therapy might also be promising...
  9. doi request reprint Acotiamide (Z-338) as a possible candidate for the treatment of functional dyspepsia
    H Suzuki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Neurogastroenterol Motil 22:595-9. 2010
    ..Although a phase III study is on going, acotiamide is now expected as a novel treatment option for FD...
  10. ncbi request reprint Improvement of gastrointestinal quality of life scores in cases of Helicobacter pylori-positive functional dyspepsia after successful eradication therapy
    Hidekazu Suzuki
    Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Gastroenterol Hepatol 20:1652-60. 2005
    ..Conclusion: Successful H. pylori eradication improved the QOL of patients with FD, in particular H. pylori-positive patients with ulcer-like FD or dysmotility-like FD...
  11. ncbi request reprint Gastric mucosal response to Helicobacter pylori
    Hidekazu Suzuki
    Department of Internal Medicine and Center for Integrated Medical Research, School of Medicine, Keio University, Tokyo, Japan
    Keio J Med 51:40-4. 2002
    ..In the long-term colonization of H. pylori, gastric mucosal cell turnover would be modified due to persistent inflammation and then such deregulation of cell turnover might link to the precancerous lesion formation...
  12. doi request reprint Can Helicobacter pylori-associated dyspepsia be categorized as functional dyspepsia?
    Hidekazu Suzuki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Japan
    J Gastroenterol Hepatol 26:42-5. 2011
    ..Especially in Asia, H. pylori should not be overlooked when considering the pathophysiology of FD. H. pylori-associated dyspepsia might be dealt as a different disease entity from FD...
  13. ncbi request reprint Lansoprazole promotes gastric mucosal cell proliferation and migration by activating p44/p42 mitogen-activated protein kinase
    Hidekazu Suzuki
    Department of Internal Medicine and Center for the Integrated Medical Research, School of Medicine, Keio University, Tokyo, Japan
    Wound Repair Regen 12:93-9. 2004
    ..Furthermore, the mechanism by which cell proliferation and migration is promoted by LPZ may involve the activation of p44/p42 MAPK...
  14. ncbi request reprint Novel effects other than antisecretory action and off-label use of proton pump inhibitors
    Hidekazu Suzuki
    Keio University School of Medicine, Department of Internal Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    Expert Opin Pharmacother 6:59-67. 2005
    ..This article reviews the novel pharmacological action other than acid secretion and the diverse clinical usage of PPIs, in order to seek possible extensions of the use of this unique agent...
  15. ncbi request reprint Plasma ghrelin concentration correlates with the levels of serum pepsinogen I and pepsinogen I/II ratio--a possible novel and non-invasive marker for gastric atrophy
    Hidekazu Suzuki
    Department of Internal Medicine, School of Medicine Keio University, Tokyo, Japan
    Hepatogastroenterology 51:1249-54. 2004
    ..The present study was designed to investigate the correlation between the plasma ghrelin levels and the extent of gastric mucosal atrophy in patients with chronic gastritis caused by H. pylori infection...
  16. ncbi request reprint Effect of dietary anti-Helicobacter pylori-urease immunoglobulin Y on Helicobacter pylori infection
    H Suzuki
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Aliment Pharmacol Ther 20:185-92. 2004
    ..Furthermore, anti-HpU IgY combined with antacids appears to ameliorate gastric inflammation. These encouraging results may represent a novel approach to the management of H. pylori-associated gastroduodenal disease...
  17. pmc Japanese herbal medicine in functional gastrointestinal disorders
    H Suzuki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Neurogastroenterol Motil 21:688-96. 2009
    ..This updated summary of JHM in the field of gastrointestinal disorders illustrates the potential for herbal medication to serve a valuable role in the management of patients with functional gastrointestinal disorders...
  18. ncbi request reprint Down-regulation of a morphogen (sonic hedgehog) gradient in the gastric epithelium of Helicobacter pylori-infected Mongolian gerbils
    Hidekazu Suzuki
    Department of Internal Medicine, Keio University School of Medicine, Shinanomachi, Tokyo, Japan
    J Pathol 206:186-97. 2005
    ..pylori-associated gastritis. These data show for the first time that H. pylori infection leads to down-regulation of the expression of a morphogen with an established role (Shh) in gastric epithelial differentiation...
  19. pmc Efficacy of sitafloxacin-based rescue therapy for Helicobacter pylori after failures of first- and second-line therapies
    Juntaro Matsuzaki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Antimicrob Agents Chemother 56:1643-5. 2012
    ..The position of the gyrA mutation (N87 or D91) was determined to be a better marker than MIC levels for predicting outcomes of sitafloxacin-based treatment...
  20. ncbi request reprint Long-term strict monitoring of plasma ghrelin and other serological markers of gastric diseases after Helicobacter pylori eradication
    Tatsuhiro Masaoka
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Hepatogastroenterology 52:1-4. 2005
    ..pylori eradication therapy, the observations suggesting that reduction of plasma ghrelin levels cannot be achieved merely by H. pylori eradication, without resolution of the gastric atrophy...
  21. ncbi request reprint Suppressed apoptosis in the inflamed gastric mucosa of Helicobacter pylori-colonized iNOS-knockout mice
    Masaharu Miyazawa
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Free Radic Biol Med 34:1621-30. 2003
    ..pylori-colonized gastric mucosa. Thus, the present study was designed to examine gastric leukocyte activation and epithelial cell apoptosis in the gastric mucosa following H. pylori inoculation in iNOS-knockout mice...
  22. doi request reprint Past rifampicin dosing determines rifabutin resistance of Helicobacter pylori
    Shoji Suzuki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Digestion 79:1-4. 2009
    ....
  23. doi request reprint Contribution of efflux pumps to clarithromycin resistance in Helicobacter pylori
    Kenro Hirata
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Gastroenterol Hepatol 25:S75-9. 2010
    ..At least four gene clusters have been identified as efflux pump systems in H. pylori and the present study was designed to investigate their role in the CLR resistance of clinical isolates of H. pylori...
  24. doi request reprint Gatifloxacin-based triple therapy as a third-line regimen for Helicobacter pylori eradication
    Toshihiro Nishizawa
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Gastroenterol Hepatol 23:S167-70. 2008
    ..pylori) eradication, according to the assessment of the susceptibility to GAT and gyrA mutation...
  25. doi request reprint Clinical results of observation of the upper gastrointestinal tract by transgastrostomic endoscopy using an ultrathin endoscope
    Hiroyuki Imaeda
    Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan
    J Gastroenterol Hepatol 25:1850-4. 2010
    ..The aim of this study was to evaluate results for the upper gastrointestinal tract by transgastrostomic endoscopy using an ultrathin endoscope...
  26. ncbi request reprint Enhanced ghrelin secretion in rats with cysteamine-induced duodenal ulcers
    Seiichiro Fukuhara
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Am J Physiol Gastrointest Liver Physiol 289:G138-45. 2005
    ..In conclusion, an increase in the plasma ghrelin level precedes the formation of duodenal ulcers in rats treated with cysteamine...
  27. pmc Overexpression of miR-142-5p and miR-155 in gastric mucosa-associated lymphoid tissue (MALT) lymphoma resistant to Helicobacter pylori eradication
    Yoshimasa Saito
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Shinjuku ku, Tokyo, Japan
    PLoS ONE 7:e47396. 2012
    ..These miRNAs might have potential application as therapeutic targets and novel biomarkers for gastric MALT lymphoma...
  28. doi request reprint FecA1, a bacterial iron transporter, determines the survival of Helicobacter pylori in the stomach
    Hitoshi Tsugawa
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Free Radic Biol Med 52:1003-10. 2012
    ..pylori through Fe(2+) supply to SodB, suggesting that FecA1 may be a possible target for the development of a novel bactericidal drug...
  29. ncbi request reprint Enhanced ghrelin expression and subsequent acid secretion in mice with genetic H(2)-receptor knockout
    Mamoru Arakawa
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Gastroenterol 42:711-8. 2007
    ..The present study was designed to clarify the dynamics of ghrelin in H(2) receptor (H(2)R)-null mice by genetic H(2)R knockout...
  30. pmc Rapid detection of point mutations conferring resistance to fluoroquinolone in gyrA of Helicobacter pylori by allele-specific PCR
    Toshihiro Nishizawa
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Clin Microbiol 45:303-5. 2007
    ..Moreover, genotyping by AS-PCR took less than 3 to 4 h. The AS-PCR method for the detection of gyrA mutations in H. pylori is useful for easy identification of fluoroquinolone-resistant strains of H. pylori...
  31. ncbi request reprint Ammonia aggravates stress-induced gastric mucosal oxidative injury through the cancellation of cytoprotective heat shock protein 70
    Shoichi Nagahashi
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Free Radic Biol Med 33:1073-81. 2002
    ..This injury may be associated with the enhanced production of oxygen free radicals from accumulated neutrophils under the NH(3)-mediated cancellation of gastric mucosal cytoprotective HSP70...
  32. ncbi request reprint Effect of dietary anti-urease immunoglobulin Y on Helicobacter pylori infection in Mongolian gerbils
    Sachiko Nomura
    Center for Integrated Medical Research, Keio University School of Medicine, Tokyo, Japan
    Helicobacter 10:43-52. 2005
    ..The present study was designed to investigate the effect of anti-urease IgY on H. pylori infection in Mongolian gerbils...
  33. doi request reprint Dysfunctional gastric emptying with down-regulation of muscle-specific microRNAs in Helicobacter pylori-infected mice
    Yoshimasa Saito
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Gastroenterology 140:189-98. 2011
    ..Little is known about the pathogenic mechanisms of functional dyspepsia. We investigated the role of microRNAs (miRNAs) in gastric motility disorders associated with Helicobacter pylori infection...
  34. doi request reprint Autofluorescence videoendoscopy system using the SAFE-3000 for assessing superficial gastric neoplasia
    Hiroyuki Imaeda
    Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan
    J Gastroenterol Hepatol 25:706-11. 2010
    ....
  35. doi request reprint The tumor suppressor microRNA-29c is downregulated and restored by celecoxib in human gastric cancer cells
    Yoshimasa Saito
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Int J Cancer 132:1751-60. 2013
    ..Selective COX-2 inhibitors may have clinical promise for the treatment of gastric cancer via restoration of miR-29c...
  36. ncbi request reprint Investigation of the possibility of human-beta defensin 2 (hBD2) as a molecular marker of gastric mucosal inflammation
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba Hospital, Chiba, Japan
    Hepatogastroenterology 52:1320-4. 2005
    ..The present study was conducted to evaluate the possibility of hBD2 as a molecular marker of gastric mucosal inflammation...
  37. doi request reprint Etiological difference between ultrashort- and short-segment Barrett's esophagus
    Juntaro Matsuzaki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Gastroenterol 46:332-8. 2011
    ..While both LSBE and SSBE are thought to be induced by gastroesophageal reflux, the etiology of USBE is still unclear...
  38. ncbi request reprint Perforin and granzyme B of cytotoxic T lymphocyte mediate apoptosis irrespective of Helicobacter pylori infection: possible act as a trigger of peptic ulcer formation
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba Hospital, Ichikawa General Hospital, Chiba, Japan
    Hepatogastroenterology 50:1774-9. 2003
    ..We designed a clinical study to examine whether cytotoxic T lymphocyte-mediated apoptosis associated with peptic ulcer formation may occur via either or both of these two pathways...
  39. ncbi request reprint A new eradication resistance index as a predictor of metronidazole-containing second-line treatment of Helicobacter pylori
    Toshihiro Nishizawa
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Digestion 76:215-20. 2007
    ..It is helpful in clinical practice to predict the effects of eradication therapy on Helicobacter pylori...
  40. ncbi request reprint Usefulness of proton pump inhibitor (PPI) maintenance therapy for patients with H. pylori-negative recurrent peptic ulcer after eradication therapy for H. pylori: pathophysiological characteristics of H. pylori-negative recurrent ulcer scars and beyond ac
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba Hospital, Chiba, Japan
    Hepatogastroenterology 51:338-42. 2004
    ....
  41. doi request reprint Early Helicobacter pylori eradication restores sonic hedgehog expression in the gastric mucosa of Mongolian gerbils
    Toshihiro Nishizawa
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Digestion 79:99-108. 2009
    ..Sonic hedgehog (Shh) is a morphogen involved in the homeostasis of the gastric fundic glands. Alterations of gastric mucosal Shh expression after eradication of Helicobacter pylori were examined...
  42. ncbi request reprint Enhanced plasma ghrelin levels in Helicobacter pylori-colonized, interleukin-1-receptor type 1-homozygous knockout (IL-1R1-/-) mice
    Yuka Abiko
    Department of Internal Medicine, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    World J Gastroenterol 11:4148-53. 2005
    ..On the other hand, H pylori infection evokes the release of gastric IL-1beta. The present study was designed to investigate the involvement of the gastric IL-1 signal in the ghrelin dynamics in H pylori-colonized mice...
  43. pmc Helicobacter pylori resistance to rifabutin in the last 7 years
    Toshihiro Nishizawa
    Division of Gastroenterology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan
    Antimicrob Agents Chemother 55:5374-5. 2011
    ..The only rifabutin-resistant strain detected showed a point mutation in the rpoB gene and was isolated from a patient with a history of rifampin treatment for pulmonary tuberculosis...
  44. ncbi request reprint Attenuated apoptosis in H. pylori-colonized gastric mucosa of Mongolian gerbils in comparison with mice
    Hidekazu Suzuki
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Dig Dis Sci 47:90-9. 2002
    ..In conclusion, the SS1-induced increase in gastric mucosal apoptosis observed in mice was attenuated significantly in Mongolian gerbils, suggesting the causative role for the higher incidence of gastric carcinogenesis in this animal...
  45. pmc Enhancement of amoxicillin resistance after unsuccessful Helicobacter pylori eradication
    Toshihiro Nishizawa
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Antimicrob Agents Chemother 55:3012-4. 2011
    ..Unsuccessful eradication regimens significantly increase resistance to not only clarithromycin (CLR) and metronidazole (MNZ) but also AMX...
  46. doi request reprint Two amino acids mutation of ferric uptake regulator determines Helicobacter pylori resistance to metronidazole
    Hitoshi Tsugawa
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Antioxid Redox Signal 14:15-23. 2011
    ..Our approach demonstrated that SodB expression is derepressed by mutant-type Fur, which is associated with the development of Mtz resistance...
  47. doi request reprint Decreased levels of adiponectin in obese patients with gastroesophageal reflux evaluated by videoesophagography: possible relationship between gastroesophageal reflux and metabolic syndrome
    Eisuke Iwasaki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medcine, Shinjuku ku, Tokyo, Japan
    J Gastroenterol Hepatol 23:S216-21. 2008
    ..The present study was designed to investigate the effect of metabolic disorders including obesity on the levels of functional gastroesophageal reflux by videoesophagography...
  48. ncbi request reprint Antibiotics directly induce apoptosis in B cell lymphoma cells derived from BALB/c mice
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba Hospital, Chiba 261 8502, Japan
    Anticancer Res 24:3723-30. 2004
    ..The present study was undertaken to examine the possibility and mechanism of direct induction of apoptosis of the tumor cells by the antibiotics used for bacterial eradication therapy...
  49. pmc Helicobacter pylori: present status and future prospects in Japan
    Hidekazu Suzuki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Gastroenterol 42:1-15. 2007
    ..We should consider such provocative scientific ideas as bridges to the future disease control...
  50. doi request reprint Reduced ghrelin production induced anorexia after rat gastric ischemia and reperfusion
    Sachiko Mogami
    Div of Gastroenterology and Hepatology, Dept of Internal Medicine, Keio Univ School of Medicine, Tokyo, Japan
    Am J Physiol Gastrointest Liver Physiol 302:G359-64. 2012
    ..The decrease in the plasma ghrelin levels may have been responsible for the decreased food intake after gastric I/R...
  51. doi request reprint Partial regression of duodenal lesions of intestinal follicular lymphoma after antibiotic treatment
    Tomonori Yaguchi
    Center for Diagnostic and Therapeutic Endoscopy, Keio University, Tokyo, Japan
    Dig Endosc 22:316-8. 2010
    ..Endoscopy 4 months later showed regression of FL, and there was no evidence of recurrence during 3 years of follow up. The partial regression of duodenal lesions of intestinal FL may be due to the effect of antibiotic treatment...
  52. ncbi request reprint Analysis of the differences in structural chromosomal aberrations of the gastric mucosa between H. pylori positive and negative gastric cancer patients: involvement of H. pylori in the onset of gastric cancer and examination of the mechanism in gastric ca
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba 261 8502, Japan
    Oncol Rep 16:1333-42. 2006
    ..These results suggest the possibility that Hp eradication does not affect chromosomal structures and Hp is involved in gastric carcinogenesis as an additive environmental factor rather than as a factor acting at the gene level...
  53. doi request reprint Total sagittal spinal alignment in patients with lumbar canal stenosis accompanied by intermittent claudication
    Hidekazu Suzuki
    Department of Orthopedic Surgery, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo, Japan
    Spine (Phila Pa 1976) 35:E344-6. 2010
    ..Cross-sectional study of total sagittal spinal alignment in lumbar spinal canal stenosis (LCS) patients with and without intermittent claudication...
  54. ncbi request reprint Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes
    Tatsuhiro Masaoka
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    FEBS Lett 541:64-8. 2003
    ..Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream...
  55. pmc Improvement of reflux symptom related quality of life after Helicobacter pylori eradication therapy
    Kenro Hirata
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Clin Biochem Nutr 52:172-8. 2013
    ..In conclusion, improved GERD-related QOL and reflux symptoms were noted 1 year after H. pylori eradication therapy. In addition, the degree of improvement was more marked in cases with severe reflux symptoms...
  56. doi request reprint Enhanced gastric ghrelin production and secretion in rats with gastric outlet obstruction
    Eisuke Iwasaki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Dig Dis Sci 57:858-64. 2012
    ....
  57. doi request reprint Novel technique of endoscopic submucosal dissection using an external grasping forceps for superficial gastric neoplasia
    Hiroyuki Imaeda
    Center for Diagnostic and Therapeutic Endoscopy, Keio University Hospital, Shinjuku ku, Tokyo, Japan
    Dig Endosc 21:122-7. 2009
    ..Bleeding after ESD occurred in 10 patients (3.8%) and perforation occurred in one patient (0.4%). The endoscopic submucosal dissection using an external grasping forceps for superficial gastric neoplasia is efficacious and safe...
  58. doi request reprint Enhanced bacterial efflux system is the first step to the development of metronidazole resistance in Helicobacter pylori
    Hitoshi Tsugawa
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 404:656-60. 2011
    ..Our finding suggests that overexpression of hefA may be the initial step in the acquisition of Mtz resistance in H. pylori...
  59. ncbi request reprint Helicobacter pylori eradication restored sonic hedgehog expression in the stomach
    Toshihiro Nishizawa
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Hepatogastroenterology 54:697-700. 2007
    ..Shh expression is reportedly to be reduced in Helicobacterpylori-associated gastritis. The aim of this study was to assess the restoration of Shh expression after H. pylori eradication...
  60. ncbi request reprint Analysis of Toll-like receptor 2, 4, 6 and 9 genome DNA mutations in patients with tractable and intractable gastric mucosal diseases
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba Hospital, Chiba 261 8502, Japan
    Int J Mol Med 17:53-8. 2006
    ..These data suggest that mutations of the TLR 2, 4, 6 and 9 genome DNA may not be involved in the recurrence, delayed healing or intractability of gastritis and gastric ulcers...
  61. doi request reprint Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells
    Hitoshi Tsugawa
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Cell Host Microbe 12:764-77. 2012
    ..These findings provide a molecular link between H. pylori and gastric carcinogenesis through the specific accumulation of CagA in gastric cancer stem-like cells...
  62. doi request reprint Development of a novel microRNA promoter microarray for ChIP-on-chip assay to identify epigenetically regulated microRNAs
    Yoshimasa Saito
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 426:33-7. 2012
    ..One of these miRNAs, miR-9, is downregulated in gastric cancer tissues and is activated by chromatin-modifying drugs, suggesting that it may be a potential target for epigenetic therapy of gastric cancer...
  63. ncbi request reprint Persistent oxidative stress in the corpus mucosa is evoked by long-term treatment of H. pylori-infected patients with proton pump inhibitors
    Masayuki Suzuki
    Division of Gastroenterology, National Hospital Organization Tokyo Medical Center, Meguro ku, Tokyo, Japan
    Hepatogastroenterology 55:138-41. 2008
    ..To examine the influence of long-term treatment of H. pylori-infected patients with proton pump inhibitors (PPI) on the toxic oxidant production in the stomach...
  64. ncbi request reprint [Stomach disease and ghrelin]
    Hidekazu Suzuki
    Department of Internal Medicine, School of Medicine, Keio University
    Nihon Rinsho 62:399-405. 2004
  65. ncbi request reprint Recurrent peptic ulcers in patients following successful Helicobacter pylori eradication: a multicenter study of 4940 patients
    Hiroto Miwa
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Helicobacter 9:9-16. 2004
    ..The aim of this study is to describe the recurrence rate and specific features of peptic ulcers after cure of H. pylori infection...
  66. doi request reprint Homology model of the DNA gyrase enzyme of Helicobacter pylori, a target of quinolone-based eradication therapy
    Juntaro Matsuzaki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Gastroenterol Hepatol 25:S7-10. 2010
    ..Quinolone resistance of H. pylori is caused by a point mutation of the DNA gyrase subunit A (GyrA) protein, especially on amino acids 87 and 91. The aim of this study is to surmise the structure of H. pylori GryA...
  67. ncbi request reprint [Effect of proton pump inhibitors (PPIs) on wound healing of gastric mucosal cell injury]
    Tatsuhiro Masaoka
    Department of Internal Medicine, Keio University School of Medicine
    Nihon Rinsho 62:556-60. 2004
    ..While the addition of MEK inhibitor significantly attenuated the cell restitution rate in the LPZ groups, suggesting that mechanism of cell proliferation and migration promoted by LPZ might involve the activation of p44/p42 MAPK...
  68. ncbi request reprint Mutation of luxS affects motility and infectivity of Helicobacter pylori in gastric mucosa of a Mongolian gerbil model
    Takako Osaki
    Department of Infectious Diseases, Kyorin University School of Medicine, Shinkawa, Mitaka, Tokyo, Japan
    J Med Microbiol 55:1477-85. 2006
    ..Gastric inflammation and increased antibody titre for H. pylori were observed in TK1402-infected gerbils only...
  69. ncbi request reprint Expression of Musashi-1 in the rat stomach and changes during mucosal injury and restitution
    Hiroshi Nagata
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    FEBS Lett 580:27-33. 2006
    ..We conclude that a subpopulation of parietal cells acts as a source of Musashi-1, which contributes to rapid re-epithelization by restoration of stem cells and regulation of cell differentiation...
  70. doi request reprint Caudal regression and tracheoesophageal malformation induced by adriamycin: a novel chick model of VATER association
    Yoko Naito
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
    Pediatr Res 65:607-12. 2009
    ....
  71. pmc Helicobacter pylori eradication shifts monocyte Fcgamma receptor balance toward inhibitory FcgammaRIIB in immune thrombocytopenic purpura patients
    Atsuko Asahi
    Division of Rheumatology, Department of Internal Medicine, and Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    J Clin Invest 118:2939-49. 2008
    ..Our findings strongly suggest that the recovery in platelet numbers observed in ITP patients after H. pylori eradication is mediated through a change in FcgammaR balance toward the inhibitory FcgammaRIIB...
  72. ncbi request reprint [Pathogenesis of gastric mucosal microcirculatory damage]
    Hidekazu Suzuki
    Department of Internal Medicine, School of Medicine, Keio University
    Nihon Rinsho 60:166-72. 2002
  73. ncbi request reprint Treatment with a proton pump inhibitor promotes corpus gastritis in patients with Helicobacter pylori-infected antrum-predominant gastritis
    M Suzuki
    Division of Gastroenterology, National Tokyo Medical Center, Tokyo, Japan
    Aliment Pharmacol Ther 16:159-65. 2002
    ..Proton pump inhibitors have been reported to modify the level of Helicobacter pylori gastritis...
  74. ncbi request reprint Limited capability of regional lymph nodes to eradicate metastatic cancer cells
    Hiroshi Nagata
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Cancer Res 64:8239-48. 2004
    ..Deterioration of cytokine induction may be responsible for subsequent cancer proliferation...
  75. doi request reprint Preventative effect of exercise against falls in the elderly: a randomized controlled trial
    J Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Osteoporos Int 20:1233-40. 2009
    ..The present study showed the beneficial effect of the exercise program aimed at improving flexibility, body balance, muscle power, and walking ability in preventing falls in the elderly...
  76. pmc Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus
    M Amagai
    Department of Dermatology, and Department of Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Clin Invest 105:625-31. 2000
    ..This model will be valuable for developing novel therapeutic strategies. Furthermore, our approach can be applied broadly for the development of various autoimmune disease models...
  77. ncbi request reprint Primary natural killer cell lymphoma of the lacrimal sac
    T Mori
    Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Ann Hematol 80:607-10. 2001
    ..However, shortly after completion of chemoradiotherapy, the lymphoma relapsed with rapid systemic dissemination. The disease was refractory to chemotherapy, and the patient eventually succumbed due to sepsis...
  78. ncbi request reprint In vivo identification of parasinus macrophages in the mesenteric lymph node
    H Nagata
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Clin Hemorheol Microcirc 23:345-8. 2000
    ..Morphology of these phagocytes in cell suspension was consistent with macrophages. In conclusion, we successfully visualized parasinus macrophages in vivo, which incorporated foreign bodies and migrated within the marginal sinus...
  79. ncbi request reprint Ethanol intake preceding Helicobacter pylori inoculation promotes gastric mucosal inflammation in Mongolian gerbils
    H Suzuki
    Department of Internal Medicine and School of Medicine, Keio University, Tokyo, Japan
    J Gastroenterol Hepatol 14:1062-9. 1999
    ..pylori infection remains unknown. The aim of the present study is to investigate the effect of ethanol treatment prior to H. pylori inoculation on associated gastric mucosal injury...
  80. ncbi request reprint Enhanced DNA fragmentation in the thymus of spontaneously hypertensive rats
    H Suzuki
    Department of Bioengineering and Institute for Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Am J Physiol 276:H2135-40. 1999
    ..Thus increased DNA fragmentation represents one of the mechanisms associated with thymic atrophy, a feature that reflects immune suppression in SHR...
  81. ncbi request reprint Helicobacter pylori eradication treatment modulates epithelial cell proliferation and tissue content of hepatocyte growth factor in the gastric mucosa
    M Suzuki
    Division of Gastroenterology and Clinical Research Institute, National Hospital Organization Tokyo Medical Center, Tokyo, Japan
    Aliment Pharmacol Ther 20:158-64. 2004
    ..Precancerous lesions such as intestinal metaplasia, enhanced proliferation of epithelial cells and elevated level of growth factors have been postulated to play a role...
  82. ncbi request reprint Polaprezinc attenuates the Helicobacter pylori-induced gastric mucosal leucocyte activation in Mongolian gerbils--a study using intravital videomicroscopy
    H Suzuki
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Aliment Pharmacol Ther 15:715-25. 2001
    ..CONCLUSION: Polaprezinc inhibited H. pylori-associated gastric mucosal oxidative inflammation, including initial micro-vascular leucocyte activation, in Mongolian gerbils...
  83. ncbi request reprint Significant role of ceramide pathway in experimental gastric ulcer formation in rats
    Keita Uehara
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Pharmacol Exp Ther 305:232-9. 2003
    ..However, after the increase in ceramide levels, the NF-kappaB and apoptosis pathways may be separately involved in ulcer formation...
  84. ncbi request reprint [Eradication therapy for the improvement of quality of life in cases of Helicobacter pylori-positive functional dyspepsia]
    Tatsuhiro Masaoka
    Department of Emergency Medicine, School of Medicine, Keio University
    Nihon Rinsho 63:474-7. 2005
  85. ncbi request reprint Proton pump inhibitor modifies inflammatory reaction in human gastric mucosa infected by Helicobacter pylori
    M Suzuki
    Division of Gastroenterology, National Tokyo Medical Center, Meguro ku, Tokyo, Japan
    Aliment Pharmacol Ther 16:229-34. 2002
    ..To examine whether proton pump inhibitors modify the production of oxygen-derived free radicals and related cytokines in the human gastric mucosa infected with H. pylori...
  86. ncbi request reprint Bile acids are able to reduce blood pressure by attenuating the vascular reactivity in spontaneously hypertensive rats
    T Tominaga
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Life Sci 42:1861-8. 1988
    ..These results in vivo and in vitro studies strongly suggest that bile acids act directly on the vascular beds and attenuate vascular response to norepinephrine...
  87. ncbi request reprint Physiological studies of stress responses in the hypothalamus of vasopressin-enhanced green fluorescent protein transgenic rat
    M Shibata
    Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Neuroendocrinol 19:285-92. 2007
    ..p. administration of LPS. Our results indicate that AVP-eGFP transgenic rats are useful animal model to study dynamic changes of AVP expression in the hypothalamus under stressful conditions...
  88. ncbi request reprint Alcohol dehydrogenase activities in the human gastric mucosa: effects of Helicobacter pylori infection, sex, age, and the part of the stomach
    M Matsumoto
    Department of Internal Medicine, School of Medicine, Keio University, Japan
    Alcohol Clin Exp Res 25:29S-34S. 2001
    ..In this study, these unsettled issues were reexamined...
  89. ncbi request reprint Therapeutic strategies for functional dyspepsia and the introduction of the Rome III classification
    Hidekazu Suzuki
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Tokyo, 160 8582, Japan
    J Gastroenterol 41:513-23. 2006
    ..These new criteria are of value in clinical practice, for epidemiological, pathophysiological, and clinical research, and for the development of new therapeutic strategies...
  90. ncbi request reprint [Peptic ulcer disease complicated with liver cirrhosis]
    Hidekazu Suzuki
    Department of Internal Medicine, Keio University School of Medicine
    Nihon Rinsho 62:532-40. 2004
    ..It is important that degradation of a gastric mucosal defense by liver cirrhosis itself, gastric mucosal atrophy might greatly affect the ulcerogenic mechanism in the stomach...
  91. ncbi request reprint Comparison of early and late start of antihypertensive agents and baroreceptor reflexes
    K Kumagai
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Hypertension 27:209-18. 1996
    ....
  92. ncbi request reprint 13C-ethanol breath test reveals impaired alcohol metabolism in patients with Helicobacter pylori infection
    M Suzuki
    Division of Gastroenterology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan
    Aliment Pharmacol Ther 20:109-15. 2004
    ..However, the role of H. pylori infection in the metabolism of ingested ethanol has not been fully elucidated...
  93. ncbi request reprint High prevalence rate of Helicobacter pylori resistance to clarithromycin during long-term multiple antibiotic therapy for chronic respiratory disease caused by non-tuberculous mycobacteria
    F Kaneko
    National Minami Yokohama Hospital, Tokyo, Japan
    Aliment Pharmacol Ther 20:62-7. 2004
    ..Helicobacter pylori resistance to clarithromycin, probably due to the frequent use of this antibiotic for the treatment of other diseases, is the greatest obstacle against its eradication...
  94. ncbi request reprint Increased intracellular Ca2+ is not coinherited with an inferred major gene locus for hypertension (ht) in the spontaneously hypertensive rat
    Y Ohno
    Department of Internal Medicine, Keio University, Tokyo, Japan
    Am J Hypertens 10:282-8. 1997
    ..Increased [Ca2+]i in platelets was not coinherited with ht and was considered to be a minor inheritable hypertensive trait discriminated from ht. Therefore, [Ca2+]i in platelets is an inadequate marker for searching ht...
  95. ncbi request reprint Renal damage and salt-dependent hypertension in aged transgenic mice overexpressing endothelin-1
    T Shindo
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Mol Med (Berl) 80:105-16. 2002
    ..It thus appears that mild, chronic overproduction of ET-1 does not primarily cause hypertension but triggers damaging changes in the kidney which lead to the susceptibility to salt-induced hypertension...
  96. doi request reprint Delayed gastric emptying and disruption of the interstitial cells of Cajal network after gastric ischaemia and reperfusion
    S Suzuki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Neurogastroenterol Motil 22:585-93, e126. 2010
    ..The present study was designed to investigate the alterations in gastric emptying, the ICC and enteric nerves that regulate smooth muscle function in response to gastric I/R...
  97. doi request reprint Gallstones increase the prevalence of Barrett's esophagus
    Juntaro Matsuzaki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Gastroenterol 45:171-8. 2010
    ....
  98. ncbi request reprint [Lifestyle-related diseases and H. pylori]
    Hidekazu Suzuki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine
    Nihon Rinsho 67:2366-71. 2009
    ..pylori infection are still controversial, H. pylori infection may increase the risk for cardiovascular and cerebrovascular diseases, especially when CagA+ cytotoxic strains of H. pylori are present...
  99. doi request reprint Helicobacter pylori and gastric cancer
    Hidekazu Suzuki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    Gastric Cancer 12:79-87. 2009
    ..At present, clinicians and researchers in the field emphasize the strong need for H. pylori eradication from the human stomach...
  100. ncbi request reprint Pathophysiological role of human beta-defensins 2 in gastric mucosa
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba Hospital, Chiba 261 8502, Japan
    Int J Mol Med 14:1023-7. 2004
    ....
  101. ncbi request reprint Retinoic acid formation from retinol in the human gastric mucosa: role of class IV alcohol dehydrogenase and its relevance to morphological changes
    Michinaga Matsumoto
    Dept of Internal Medicine, School of Medicine, Keio Univ, 35 Shinanomachi, Shinjukuku, Tokyo 160 8582, Japan
    Am J Physiol Gastrointest Liver Physiol 289:G429-33. 2005
    ..In that retinoic acid is a key molecule for maintaining normal morphology, the reduction of class IV ADH activity may be involved in the pathogenesis of these morphological changes in the human gastric mucosa...