Affiliation: Keio University
- Soga T, Sugimoto M, Honma M, Mori M, Igarashi K, Kashikura K, et al. Serum metabolomics reveals ?-glutamyl dipeptides as biomarkers for discrimination among different forms of liver disease. J Hepatol. 2011;55:896-905 pubmed publisher..Glutamyl dipeptides are novel biomarkers for liver diseases, and varying levels of individual or groups of these peptides have the power to discriminate among different forms of hepatic disease. ..
- Soga T. Cancer metabolism: key players in metabolic reprogramming. Cancer Sci. 2013;104:275-81 pubmed publisher..This paper reviews recent findings related to key transcription factors and enzymes that play an important role in the regulation of cancer metabolism. ..
- Itoi T, Sugimoto M, Umeda J, Sofuni A, Tsuchiya T, Tsuji S, et al. Serum Metabolomic Profiles for Human Pancreatic Cancer Discrimination. Int J Mol Sci. 2017;18: pubmed publisher..Changes in metabolomic profiles might be used to screen for malignant cancers as well as to differentiate between PC and other malignant diseases. ..
- Asai Y, Itoi T, Sugimoto M, Sofuni A, Tsuchiya T, Tanaka R, et al. Elevated Polyamines in Saliva of Pancreatic Cancer. Cancers (Basel). 2018;10: pubmed publisher..These data show the potential of saliva as a source for tests screening for PC. ..
- Soga T, Igarashi K, Ito C, Mizobuchi K, Zimmermann H, Tomita M. Metabolomic profiling of anionic metabolites by capillary electrophoresis mass spectrometry. Anal Chem. 2009;81:6165-74 pubmed publisher..8 and 24 fmol) at a signal-to-noise ratio of 3. This method is quantitative, sensitive, and robust, and its utility was demonstrated by the analysis of the metabolites in the central metabolic pathways extracted from mouse liver...
- Satoh K, Yachida S, Sugimoto M, Oshima M, Nakagawa T, Akamoto S, et al. Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC. Proc Natl Acad Sci U S A. 2017;114:E7697-E7706 pubmed publisher..Moreover, inhibition of MYC target pyrimidine synthesis genes such as CAD, UMPS, and CTPS blocked cell growth, and thus are potential targets for colorectal cancer therapy. ..