Akira Shimada

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. ncbi request reprint Detection of GAD-reactive CD4+ cells in so-called "type 1B" diabetes
    Akira Shimada
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Ann N Y Acad Sci 1005:378-86. 2003
  2. ncbi request reprint GAD-reactive T cells were mainly detected in autoimmune-related type 1 diabetic patients with HLA DR9
    Arata Itoh
    Department of Internal Medicine, Keio Univ School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Ann N Y Acad Sci 1037:33-40. 2004
  3. doi request reprint FOXP3/Scurfin gene polymorphism is associated with adult onset type 1 diabetes in Japanese, especially in women and slowly progressive-type patients
    Kyoko Iwase
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Autoimmunity 42:159-67. 2009
  4. ncbi request reprint Frequency of CTLA-4 gene CT60 polymorphism may not be affected by vitamin D receptor gene Bsm I polymorphism or HLA DR9 in autoimmune-related type 1 diabetes in the Japanese
    Yasuhiko Kanazawa
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Ann N Y Acad Sci 1079:251-6. 2006
  5. ncbi request reprint CXCL10 DNA vaccination prevents spontaneous diabetes through enhanced beta cell proliferation in NOD mice
    Toshikatsu Shigihara
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Immunol 175:8401-8. 2005
  6. ncbi request reprint Evidence for association between vitamin D receptor BsmI polymorphism and type 1 diabetes in Japanese
    Akira Shimada
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Autoimmun 30:207-11. 2008
  7. ncbi request reprint Effects of pretreatment with low-dose metformin on metabolic parameters and weight gain by pioglitazone in Japanese patients with type 2 diabetes
    Toshihide Kawai
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Intern Med 47:1181-8. 2008
  8. ncbi request reprint Multicenter prevention trial of slowly progressive type 1 diabetes with small dose of insulin (the Tokyo study): preliminary report
    Taro Maruyama
    Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama, Japan
    Ann N Y Acad Sci 1005:362-9. 2003
  9. ncbi request reprint T-cell function in anti-GAD65(+)diabetes with residual beta-cell function
    Ryuji Suzuki
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Autoimmun 20:83-90. 2003
  10. doi request reprint Induction of anti-whole GAD65 reactivity in vivo results in disease suppression in type 1 diabetes
    Yasuhiko Kanazawa
    Department of Internal Medicine, Keio University School of Medicine, Shimanomachi Shinjuku ku, Tokyo, Japan
    J Autoimmun 32:104-9. 2009

Detail Information

Publications79

  1. ncbi request reprint Detection of GAD-reactive CD4+ cells in so-called "type 1B" diabetes
    Akira Shimada
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Ann N Y Acad Sci 1005:378-86. 2003
    ..In this study, we tried to demonstrate the existence of islet-associated antigen-specific T cells in type 1 diabetes without islet-associated autoantibody...
  2. ncbi request reprint GAD-reactive T cells were mainly detected in autoimmune-related type 1 diabetic patients with HLA DR9
    Arata Itoh
    Department of Internal Medicine, Keio Univ School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Ann N Y Acad Sci 1037:33-40. 2004
    ..There was an association between T cell reactivity against GAD and HLA DR9 in Japanese type 1 diabetes...
  3. doi request reprint FOXP3/Scurfin gene polymorphism is associated with adult onset type 1 diabetes in Japanese, especially in women and slowly progressive-type patients
    Kyoko Iwase
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Autoimmunity 42:159-67. 2009
    ..The FOXP3/Scurfin gene is known to be a master gene of Tregs. Therefore, we tried to analyze the relation between the gene polymorphism and adult onset type 1 diabetes and its subtype in the Japanese population...
  4. ncbi request reprint Frequency of CTLA-4 gene CT60 polymorphism may not be affected by vitamin D receptor gene Bsm I polymorphism or HLA DR9 in autoimmune-related type 1 diabetes in the Japanese
    Yasuhiko Kanazawa
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Ann N Y Acad Sci 1079:251-6. 2006
    ..The frequency of the CT60 GG genotype did not appear to be affected by either the VDR gene Bsm I large B polymorphism or HLA DR9...
  5. ncbi request reprint CXCL10 DNA vaccination prevents spontaneous diabetes through enhanced beta cell proliferation in NOD mice
    Toshikatsu Shigihara
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Immunol 175:8401-8. 2005
    ..Therefore, CXCL10 neutralization is suggested to be useful for maintaining beta cell mass at any stage of autoimmune diabetes...
  6. ncbi request reprint Evidence for association between vitamin D receptor BsmI polymorphism and type 1 diabetes in Japanese
    Akira Shimada
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Autoimmun 30:207-11. 2008
    ..Based upon these results, we propose that it may be worthwhile to focus on subjects with the BB genotype of this gene polymorphism as having high risk for type 1 diabetes...
  7. ncbi request reprint Effects of pretreatment with low-dose metformin on metabolic parameters and weight gain by pioglitazone in Japanese patients with type 2 diabetes
    Toshihide Kawai
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Intern Med 47:1181-8. 2008
    ..We investigated whether or not "low dose" metformin could prevent weight gain induced by pioglitazone...
  8. ncbi request reprint Multicenter prevention trial of slowly progressive type 1 diabetes with small dose of insulin (the Tokyo study): preliminary report
    Taro Maruyama
    Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama, Japan
    Ann N Y Acad Sci 1005:362-9. 2003
    ..We recommend avoiding SU treatment and instead administering insulin to NIDDM patients with high GADA titer...
  9. ncbi request reprint T-cell function in anti-GAD65(+)diabetes with residual beta-cell function
    Ryuji Suzuki
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Autoimmun 20:83-90. 2003
    ....
  10. doi request reprint Induction of anti-whole GAD65 reactivity in vivo results in disease suppression in type 1 diabetes
    Yasuhiko Kanazawa
    Department of Internal Medicine, Keio University School of Medicine, Shimanomachi Shinjuku ku, Tokyo, Japan
    J Autoimmun 32:104-9. 2009
    ..Based upon these results, we propose that anti-whole GAD65-reactive T cells have the ability to regulate the development of type 1 diabetes...
  11. ncbi request reprint Relationship between beta cell mass of NOD donors and diabetes development of NOD-scid recipients in adoptive transfer system
    Satoru Yamada
    Department of Internal Medicine, Kitasato Institute Hospital, Tokyo, Japan
    Ann N Y Acad Sci 1005:211-4. 2003
    ..To clarify how the beta cell mass is reduced, we performed adoptive transfer experiments and examined the relationship between the pancreatic status of NOD donors and the time taken to transfer diabetes into NOD-scid recipients...
  12. ncbi request reprint Relation between development of nephropathy and the p22phox C242T and receptor for advanced glycation end product G1704T gene polymorphisms in type 2 diabetic patients
    Seiko Matsunaga-Irie
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Diabetes Care 27:303-7. 2004
    ..We studied the relation between the genotypes of the NADPH p22phox C242T and RAGE G1704T polymorphisms and the development of diabetic nephropathy in type 2 diabetic patients...
  13. ncbi request reprint Thiazolidinediones may not reduce diabetes incidence in type 1 diabetes
    Toshikatsu Shigihara
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Ann N Y Acad Sci 1079:365-8. 2006
    ..Therefore, further research should take place before the application of thiazolidinediones to human slowly progressive insulin-dependent diabetes mellitus (SPIDDM) patients...
  14. ncbi request reprint CXC chemokine ligand 10 neutralization suppresses the occurrence of diabetes in nonobese diabetic mice through enhanced beta cell proliferation without affecting insulitis
    Jiro Morimoto
    Division of Endocrinology, School of Medicine, Keio University, Tokyo, Japan
    J Immunol 173:7017-24. 2004
    ..Thus, CXCL10 neutralization can be a new therapeutic target for beta cell survival, not only during the early stage of type 1 diabetes, but also after islet transplantation...
  15. ncbi request reprint Significance of serum CXCL10/IP-10 level in type 1 diabetes
    Toshikatsu Shigihara
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Tokyo 160 8582, Japan
    J Autoimmun 26:66-71. 2006
    ..These results suggest that serum CXCL10 level may reflect accumulation of Th1 lymphocytes in pancreatic LN, and measurement of serum CXCL10 level may be useful to assess the pathophysiology of the disease course in type 1 diabetes...
  16. ncbi request reprint Risk for future diabetes among individuals with high-normal glycemia at 40 years of age
    Yusuke Kabeya
    Department of Internal Medicine, Saiseikai Central Hospital, Japan
    Intern Med 51:2703-8. 2012
    ..The present study investigated the risk for future diabetes among individuals with high-normal glycemia (fasting plasma glucose (FPG) of 100-109 mg/dL) in an early middle-aged population...
  17. ncbi request reprint Effect of combination therapy of a rapid-acting insulin secretagogue (glinide) with premixed insulin in type 2 diabetes mellitus
    Satoru Yamada
    Department of Internal Medicine, Kitasato Institute Hospital, Tokyo
    Intern Med 46:1893-7. 2007
    ..To examine this, we added glinide once a day to twice daily injections of premixed insulin...
  18. ncbi request reprint Insulin-like growth factor-1 (IGF-1)-derived peptide protects against diabetes in NOD mice
    Keiichi Kodama
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Autoimmunity 37:481-7. 2004
    ..It was suggested that IGF-1 peptide 50-70 immunization can be used as a tool for prevention of type 1 diabetes...
  19. ncbi request reprint Two cases of "fulminant" type 1 diabetes suggesting involvement of autoimmunity
    Yoshinori Nakagawa
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Ann N Y Acad Sci 1005:359-61. 2003
    ..Here, we report two cases of fulminant type 1 diabetes in which these markers were detected and in which the involvement of islet-associated autoimmunity is suggested...
  20. ncbi request reprint NKT cell frequency in Japanese type 1 diabetes
    Yoichi Oikawa
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Ann N Y Acad Sci 1005:230-2. 2003
    ..Here, we combined the data of NKT cell frequency in Ab+ and Ab- "classic" type 1 diabetic patients and then analyzed the relationship between NKT cell frequency and disease activity...
  21. ncbi request reprint Association between beta cell function and future glycemic control in patients with type 2 diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 60:517-23. 2013
    ..Multivariate analyses showed consistent results (OR 1.23, 95%CI 1.03-1.48, P = 0.021). In conclusion, preserved beta cell function at baseline was associated with better glycemic control thereafter in patients with type 2 diabetes...
  22. doi request reprint Pioglitazone may accelerate disease course of slowly progressive type 1 diabetes
    Akira Shimada
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Diabetes Metab Res Rev 27:951-3. 2011
    ..However, the rate of progression to SPIDDM with the use of insulin-sensitizing agents is unknown. The aim of this study was to determine the effect of insulin-sensitizing agents on SPIDDM patients...
  23. ncbi request reprint Hyperplastic islets observed in "reversed" NOD mice treated without hematopoietic cells
    Yoshiaki Okubo
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo 160 8582, Japan
    Diabetes Res Clin Pract 79:18-23. 2008
    ....
  24. ncbi request reprint Beta cell dysfunction and its clinical significance in gestational diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Endocr J 57:973-80. 2010
    ..The level of beta cell dysfunction in GDM was associated with the severity of glucose intolerance and total insulin dosage required. These findings underpin clinical significance of beta cell dysfunction in GDM...
  25. ncbi request reprint Assessment of beta cell mass and oxidative peritoneal exudate cells in murine type 1 diabetes using adoptive transfer system
    Satoru Yamada
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Autoimmunity 36:63-70. 2003
    ..These results suggest that a marked reduction of beta cell mass occurs at the very late prediabetic stage, and assessment of the proportion of oxidative PEC is useful to evaluate disease activity in type 1 diabetes...
  26. pmc CXC chemokine ligand 10 DNA vaccination plus Complete Freund's Adjuvant reverses hyperglycemia in non-obese diabetic mice
    Yoichi Oikawa
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Rev Diabet Stud 7:209-24. 2010
    ..In the present study, we aimed to examine whether anti-CXCL10 plus CFA treatment can effectively reverse autoimmune diabetes development...
  27. ncbi request reprint Expression levels of CXC chemokine receptors 3 are associated with clinical phenotype of type 1 diabetes
    Satoru Yamada
    Department of Internal Medicine, Kitasato Institute Hospital, 5 9 1 Shirokane, Minato ku, Tokyo 108 8642, Japan
    Ann N Y Acad Sci 1079:186-9. 2006
    ..CXCR3 expression level is associated with the onset pattern of type 1 diabetes. Further studies are needed to clarify the role of chemokines in type 1 diabetes...
  28. ncbi request reprint Associations of insulin resistance and glycemic control with the risk of kidney stones
    Yusuke Kabeya
    Department of Internal Medicine, Saiseikai Central Hospital, Japan
    Intern Med 51:699-705. 2012
    ..The associations of insulin resistance and glycemic control with the risk of kidney stones were explored...
  29. doi request reprint Effects of olmesartan medoxomil, an angiotensin II type 1 receptor antagonist, on plasma concentration of B-type natriuretic peptide, in hypertensive patients with type 2 diabetes mellitus: a preliminary, observational, open-label study
    Toshihide Kawai
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Clin Drug Investig 31:237-45. 2011
    ..The objective of this study was to determine the effects of olmesartan medoxomil, a novel ARB, on the plasma level of BNP in hypertensive patients with type 2 diabetes...
  30. pmc Factors Associated with the Decline of Kidney Function Differ among eGFR Strata in Subjects with Type 2 Diabetes Mellitus
    Shu Meguro
    Nephrology, Endocrinology and Metabolism Division, Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Int J Endocrinol 2012:687867. 2012
    ....
  31. ncbi request reprint Proatherogenic effect of interleukin-18 is exerted with high-fat diet, but not with normal diet in spontaneously hyperlipidemic mice
    Takatoshi Imai
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 18:1090-101. 2011
    ..The purpose of this study was to reveal the effect of increased serum IL-18 within its physiological fluctuations on atherosclerosis development under different conditions of dietary fat content...
  32. doi request reprint Effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy in patients with type 2 diabetes, in relation to suppression of N(ɛ)-carboxymethyl lysine
    Toshihide Kawai
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Diabetes Complications 24:424-32. 2010
    ..We investigated the efficacy of epalrestat, an aldose reductase inhibitor, for diabetic peripheral neuropathy in Japanese patients with type 2 diabetes...
  33. ncbi request reprint Stromal cell-derived factor-1 chemokine gene polymorphism is not associated with onset age of Japanese type 1 diabetes
    Toshikatsu Shigihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Ann N Y Acad Sci 1005:328-31. 2003
    ..The SDF-1 gene polymorphism was not associated with onset age (or onset pattern) of type 1 diabetes in Japanese. Further study is necessary to conclude whether SDF-1 gene polymorphism affects the onset age in type 1 diabetes in general...
  34. ncbi request reprint Systemic administration of IL-18 promotes diabetes development in young nonobese diabetic mice
    Yoichi Oikawa
    Department of Internal Medicine, Keio University School of Medicine, Department of Internal Medicine, Tokyo Denryoku Hospital, Japan
    J Immunol 171:5865-75. 2003
    ....
  35. ncbi request reprint Determinants of an optimal response to pioglitazone in terms of HDL-cholesterol
    Yusuke Kabeya
    Department of Internal Medicine, Saiseikai Central Hospital, Japan
    Intern Med 50:825-31. 2011
    ..In the present study, the characteristics of lipid responders were investigated...
  36. ncbi request reprint Effect of obesity on declining beta cell function after diagnosis of type 2 diabetes: a possible link suggested by cross-sectional analysis
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 59:187-95. 2012
    ..Treatment of obesity may be an important strategy to preserve beta cell function in patients with type 2 diabetes...
  37. pmc GAD65 autoantibody responses in Japanese latent autoimmune diabetes in adult patients
    Taro Maruyama
    Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama, Japan
    Diabetes Care 31:1602-7. 2008
    ..To determine whether development of insulin requirement in patients with latent autoimmune diabetes in adults (LADA) is accompanied with the emergence of a type 1 diabetes-like autoimmune response...
  38. ncbi request reprint Vitamin D receptor gene polymorphism affects onset pattern of type 1 diabetes
    Yoshiko Motohashi
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Endocrinol Metab 88:3137-40. 2003
    ..Assessment of this VDR gene polymorphism may contribute to prediction of the onset pattern in individuals with a high risk of type 1 diabetes...
  39. ncbi request reprint High frequency of valpha24(+) vbeta11(+) T-cells observed in type 1 diabetes
    Yoichi Oikawa
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Diabetes Care 25:1818-23. 2002
    ..In this study, we measured the frequency of peripheral Valpha24(+) Vbeta11(+) T-cells, which include human NKT cells, in Japanese diabetic patients...
  40. ncbi request reprint Postprandial serum C-peptide to plasma glucose ratio as a predictor of subsequent insulin treatment in patients with type 2 diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Endocr J 58:315-22. 2011
    ..Our study indicates that among CPR measurements, postprandial CPR index is the best predictive marker for future insulin therapy...
  41. doi request reprint Effect on the atherogenic marker plasminogen activator inhibitor type-1 of addition of the ACE inhibitor imidapril to angiotensin II type 1 receptor antagonist therapy in hypertensive patients with abnormal glucose metabolism: a prospective cohort study i
    Ken Yajima
    Department of Internal Medicine, Federation of National Public Service Personnel Mutual Aid Associations, Tachikawa Hospital, 4 2 22 Nishikicho, Tachikawa, Tokyo 190 8531, Japan
    Clin Drug Investig 29:811-9. 2009
    ..The objective of this study was to determine whether the ACE inhibitor imidapril reduces PAI-1 levels in hypertensive patients already being treated with an ARB...
  42. ncbi request reprint Nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) P22 Phox C242T gene polymorphism in type 1 diabetes
    Seiko Matsunaga
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Ann N Y Acad Sci 1005:324-7. 2003
    ..In conclusion, the p22 phox C242T gene polymorphism did not affect the susceptibility to and clinical course of Japanese type 1 diabetes...
  43. doi request reprint A mimic of viral double-stranded RNA triggers fulminant type 1 diabetes-like syndrome in regulatory T cell-deficient autoimmune diabetic mouse
    Ai Tada
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Immunol 187:4947-53. 2011
    ..We conclude that an FT1D-like phenotype can be induced in the background of autoimmune diabetes by a mimic of viral dsRNA, and this model is useful for understanding human FT1D...
  44. ncbi request reprint Anti-insulin-like growth factor-1 autoantibodies in type 1 diabetes
    Taro Maruyama
    Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama, 336 0002, Japan
    Ann N Y Acad Sci 958:267-70. 2002
    ..Further study is necessary to clarify whether anti-IGF-1 autoantibodies are existent in human type 1 diabetes and to determine the significance of IGF-1 in the pathogensesis of type 1 diabetes...
  45. doi request reprint Eradication of Helicobactor pylori may trigger onset of type 1 diabetes: a case report
    Ai Tada
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Ann N Y Acad Sci 1150:208-9. 2008
    ..Although further investigation is needed to understand the pathophysiology of T1D, we would like to emphasize that clinicians should consider the risk of its development after eradication of Helicobactor pylori...
  46. ncbi request reprint Efficacy of pitavastatin, a new HMG-CoA reductase inhibitor, on lipid and glucose metabolism in patients with type 2 diabetes
    Toshihide Kawai
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Diabetes Care 28:2980-1. 2005
  47. ncbi request reprint Pancreatic beta-cell function and fetal growth in gestational impaired glucose tolerance
    Kei Miyakoshi
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Acta Obstet Gynecol Scand 89:769-75. 2010
    ..To investigate the metabolic phenotype and pregnancy outcomes of gestational impaired glucose tolerance (IGT) defined by isolated hyperglycemia during an oral glucose tolerance test (OGTT)...
  48. ncbi request reprint Hypertensive disorders in Japanese women with gestational glucose intolerance
    Kei Miyakoshi
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Diabetes Res Clin Pract 64:201-5. 2004
    ..2% or 4.1%, respectively, compared to those with normal glucose tolerance). Japanese women with gestational glucose intolerance therefore have an increased risk of developing GH...
  49. ncbi request reprint Slowly progressive type 1 diabetes treated with metformin for five years after onset
    Takumi Hirata
    Department of Internal Medicine, Saitama Social Insurance Hospital, Japan
    Intern Med 52:2635-7. 2013
    ..Although one case is insufficient to draw firm conclusions, this report suggests that metformin is a therapeutic choice for SPIDDM when the insulin secretion capacity is maintained. ..
  50. pmc The Role of the CXCL10/CXCR3 System in Type 1 Diabetes
    Akira Shimada
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Rev Diabet Stud 6:81-4. 2009
    ..Thus, understanding the CXCL10/CXCR3 system may be important for finding a cure. In this short review, we discuss the role of the CXCL10/CXCR3 system in type 1 diabetes and propose relevant treatment options...
  51. ncbi request reprint Age-associated difference in gene expression of paediatric acute myelomonocytic lineage leukaemia (FAB M4 and M5 subtypes) and its correlation with prognosis
    Aoi Jo
    Genetics Division, National Cancer Centre Research Institute, Tokyo, Japan
    Br J Haematol 144:917-29. 2009
    ....
  52. ncbi request reprint Insulin intervention to preserve beta cells in slowly progressive insulin-dependent (type 1) diabetes mellitus
    Tetsuro Kobayashi
    Department of Endocrinology and Metabolism, Toranomon Hospital, Okinaka Memorial Institute for Medical Research, Tokyo, 105 8470, Japan
    Ann N Y Acad Sci 958:117-30. 2002
    ..Insulin intervention to preserve beta cell dysfunction in SPIDDM is effective and safe in patients with preserved beta cell function and high GADAb titers at the initiation of insulin...
  53. pmc Improved Monitoring of the Hyperglycemic State in Type 1 Diabetes Patients by Use of the Glycoalbumin/HbA1c Ratio
    Takatoshi Imai
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Rev Diabet Stud 4:44-8. 2007
    ..However, in type 1 diabetic patients, we often find an even higher GA/HbA1c ratio of nearly 3.5. Therefore, this study was performed to examine the significance of a higher GA/HbA1c ratio...
  54. doi request reprint Long-term parvovirus B19 infections with genetic drift after cord blood transplantation complicated by persistent CD4+ lymphocytopenia
    Michio Suzuki
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya Gunma Prefectural Institute of Public Health and Environmental Sciences, Gunma Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan
    J Pediatr Hematol Oncol 36:e65-8. 2014
    ..The resulting changes of the nonstructural 1 structure may have altered antigenicity of the virus and could play a role in the pathogenesis of persistent infection under immunocompromised conditions...
  55. doi request reprint Histopathological characteristics of stenosing flexor tenosynovitis in diabetic patients and possible associations with diabetes-related variables
    Makoto Kameyama
    Department of Orthopaedic Surgery, Saiseikai Central Hospital, Tokyo, Japan
    J Hand Surg Am 38:1331-9. 2013
    ..To compare the histopathological findings of stenosing flexor tenosynovitis (SFTS) in diabetic patients with those in nondiabetic patients and to analyze the predominant characteristics of SFTS in diabetic patients by statistical methods...
  56. ncbi request reprint Correlation between serum resistin level and adiposity in obese individuals
    Koichiro Azuma
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Obes Res 11:997-1001. 2003
    ..The aim of our study was to examine the relationship of serum resistin level to body composition, insulin resistance, and related obesity phenotypes in humans...
  57. ncbi request reprint Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies
    Yuyan Chen
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Genes Chromosomes Cancer 45:583-91. 2006
    ..Our data suggest that mutations of PTPN11 as well as RAS play a role in the pathogenesis of not only myeloid hematological malignancies but also a subset of RMS malignancies...
  58. ncbi request reprint Seroconversion of GAD antibody in unclassified diabetes with long duration of disease
    Toshikatsu Shigihara
    Diabetes Care 27:1836-7. 2004
  59. ncbi request reprint Fulminant type 1 diabetes: a nationwide survey in Japan
    Akihisa Imagawa
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Diabetes Care 26:2345-52. 2003
    ..To describe the clinical and immunologic characteristics of fulminant type 1 diabetes, a novel subtype of type 1 diabetes, we conducted a nationwide survey...
  60. ncbi request reprint The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multicenter collaborative study in Japan
    Hiroshi Ikegami
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka 565 0871, Japan
    J Clin Endocrinol Metab 91:1087-92. 2006
    ..The low incidence of type 1 diabetes in Asian countries, however, makes it difficult to perform large-scale studies in Asia...
  61. ncbi request reprint Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): association between a promoter polymorphism and type 1 diabetes in Asian populations
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan
    Am J Med Genet A 140:586-93. 2006
    ..In conclusion, the type 1 diabetes association with PTPN22 is confirmed, but it cannot be attributed solely to the +1858C > T variant. The promoter -1123G > C SNP is a more likely causative variant in PTPN22...
  62. ncbi request reprint T cell immunity to glutamic acid decarboxylase in fulminant type 1 diabetes without significant elevation of serum amylase
    Kanemi Aoki
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba, Yokohama, Kanagawa, Japan 227 8501
    Ann N Y Acad Sci 1079:181-5. 2006
    ....
  63. ncbi request reprint High titer of autoantibodies to GAD identifies a specific phenotype of adult-onset autoimmune diabetes: response to Buzzetti et al
    Tetsuro Kobayashi
    Diabetes Care 30:e126; author reply e127. 2007
  64. doi request reprint Insulin intervention in slowly progressive insulin-dependent (type 1) diabetes mellitus
    Taro Maruyama
    Third Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, Japan
    J Clin Endocrinol Metab 93:2115-21. 2008
    ....
  65. doi request reprint Nationwide survey to compare the prevalence of transient elevation of liver transaminase during treatment of diabetic ketosis or ketoacidosis in new-onset acute and fulminant type 1 diabetes mellitus
    Hiroko Takaike
    Diabetes Center, Tokyo Women s Medical University, Japan
    Ann Med 40:395-400. 2008
    ..The aim of the present study was to assess the cause and prevalence of the elevation of liver transaminase levels in fulminant and acute-onset type 1 diabetic patients experiencing diabetic ketosis or ketoacidosis...
  66. ncbi request reprint Insulin gene/IDDM2 locus in Japanese type 1 diabetes: contribution of class I alleles and influence of class I subdivision in susceptibility to type 1 diabetes
    Takuya Awata
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
    J Clin Endocrinol Metab 92:1791-5. 2007
    ..It is suggested that insulin autoimmunity plays an important role in the development of type 1 diabetes in humans. However, the association between insulin gene (INS) region (IDDM2) and type 1 diabetes has been uncertain in Asians...
  67. ncbi request reprint Immunopathological and genetic features in slowly progressive insulin-dependent diabetes mellitus and latent autoimmune diabetes in adults
    Tetsuro Kobayashi
    Third Department of Internal Medicine, School of Medicine, University of Yamanashi, Tamaho, Yamanashi 409 3898, Japan
    Ann N Y Acad Sci 1079:60-6. 2006
    ....
  68. ncbi request reprint Incidence and underlying etiologies of bronchial secretion in terminally ill cancer patients: a multicenter, prospective, observational study
    Tatsuya Morita
    Seirei Hospice, Seirei Mikatabara Hospital, Hamamatsu, Shizuoka, Japan
    J Pain Symptom Manage 27:533-9. 2004
    ..Etiology-based classification of bronchial secretion is useful to identify the most suitable palliative treatments and to clarify treatment efficacy in each specific pathophysiology...
  69. ncbi request reprint Omenn syndrome--review of several phenotypes of Omenn syndrome and RAG1/RAG2 mutations in Japan
    Masahiko Kato
    Department of Allergy and Immunology, Gunma Children s Medical Center, Hokkitsu, Gunma, Japan gcmc pref gunma jp
    Allergol Int 55:115-9. 2006
    ..In this review, we will focus on the variation of several phenotypes of OS...
  70. ncbi request reprint AML1 mutation and FLT3-internal tandem duplication in leukemia transformed from myelodysplastic syndrome
    Akira Shimada
    J Pediatr Hematol Oncol 29:666-7. 2007
  71. ncbi request reprint GAD antibody in mitochondrial diabetes associated with tRNA(UUR) mutation at position 3271
    Yoshihiko Suzuki
    Diabetes Care 25:1097-8. 2002
  72. ncbi request reprint Detection of ATM gene mutation in human glioma cell line M059J by a rapid frameshift/stop codon assay in yeast
    Rika Tsuchida
    Department of Pediatrics and Developmental Biology, Postgraduate Medical School, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Radiat Res 158:195-201. 2002
    ..Thus the radiosensitive phenotype of M059J cells appears to be due to a defect in PRKDC and a truncating ATM mutation...
  73. ncbi request reprint A case of fulminant type 1 diabetes with strong evidence of autoimmunity
    Akira Shimada
    Diabetes Care 25:1482-3. 2002
  74. ncbi request reprint [Rhabdomyolysis in the diabetic state]
    Satoru Yamada
    Department of Internal Medicine, Kitasato Institute Hospital
    Nihon Rinsho 60:443-8. 2002
  75. ncbi request reprint KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study Group
    Akira Shimada
    Department of Hematology Oncology, Gunma Children s Medical Center, 779 Shimohakoda, Kitatachibana, Gunma 377 8577, Japan
    Blood 107:1806-9. 2006
    ..0% versus 2.7%, P < .001). Furthermore, FLT3 internal tandem duplication was found in only 2 (4.3%) patients. These results suggested that KIT mutations are strongly associated with a poor prognosis in pediatric t(8;21) AML...
  76. ncbi request reprint Evaluation of the diagnostic accuracy of the stop codon (SC) assay for identifying protein-truncating mutations in the BRCA1and BRCA2genes in familial breast cancer
    Masato Sakayori
    Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Hum Genet 48:130-7. 2003
    ....
  77. ncbi request reprint [Chronic kidney diseases and other diseases: 6. Obesity]
    Toshihide Kawai
    Nihon Naika Gakkai Zasshi 96:916-21. 2007
  78. ncbi request reprint T-cell-mediated autoimmunity may be involved in fulminant type 1 diabetes
    Akira Shimada
    Diabetes Care 25:635-6. 2002
  79. ncbi request reprint Artificial hydration therapy, laboratory findings, and fluid balance in terminally ill patients with abdominal malignancies
    Tatsuya Morita
    Department of Palliative and Supportive Care, Palliative Care Team and Seirei Hospice, Seirei Mikatahara General Hospital, Hamamatsu, Japan
    J Pain Symptom Manage 31:130-9. 2006
    ..Calculated fluid balance is not an appropriate alternative to direct monitoring of patient symptoms. More studies are needed to determine the clinical efficacy of artificial hydration for terminally ill cancer patients...