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Genomes and Genes | Akira ShimadaSummaryAffiliation: Keio University Country: Japan Publications
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Publications
Detection of GAD-reactive CD4+ cells in so-called "type 1B" diabetesAkira Shimada
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Ann N Y Acad Sci 1005:378-86. 2003..In this study, we tried to demonstrate the existence of islet-associated antigen-specific T cells in type 1 diabetes without islet-associated autoantibody...- GAD-reactive T cells were mainly detected in autoimmune-related type 1 diabetic patients with HLA DR9Arata Itoh
Department of Internal Medicine, Keio Univ. School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Ann N Y Acad Sci 1037:33-40. 2004..There was an association between T cell reactivity against GAD and HLA DR9 in Japanese type 1 diabetes... 
FOXP3/Scurfin gene polymorphism is associated with adult onset type 1 diabetes in Japanese, especially in women and slowly progressive-type patientsKyoko Iwase
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Autoimmunity 42:159-67. 2009..The FOXP3/Scurfin gene is known to be a master gene of Tregs. Therefore, we tried to analyze the relation between the gene polymorphism and adult onset type 1 diabetes and its subtype in the Japanese population...- Frequency of CTLA-4 gene CT60 polymorphism may not be affected by vitamin D receptor gene Bsm I polymorphism or HLA DR9 in autoimmune-related type 1 diabetes in the JapaneseYasuhiko Kanazawa
Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Ann N Y Acad Sci 1079:251-6. 2006..The frequency of the CT60 GG genotype did not appear to be affected by either the VDR gene Bsm I large B polymorphism or HLA DR9... - Evidence for association between vitamin D receptor BsmI polymorphism and type 1 diabetes in JapaneseAkira Shimada
Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
J Autoimmun 30:207-11. 2008..Based upon these results, we propose that it may be worthwhile to focus on subjects with the BB genotype of this gene polymorphism as having high risk for type 1 diabetes... - CXCL10 DNA vaccination prevents spontaneous diabetes through enhanced beta cell proliferation in NOD miceToshikatsu Shigihara
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
J Immunol 175:8401-8. 2005..Therefore, CXCL10 neutralization is suggested to be useful for maintaining beta cell mass at any stage of autoimmune diabetes... - Effects of pretreatment with low-dose metformin on metabolic parameters and weight gain by pioglitazone in Japanese patients with type 2 diabetesToshihide Kawai
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
Intern Med 47:1181-8. 2008..We investigated whether or not "low dose" metformin could prevent weight gain induced by pioglitazone... - Multicenter prevention trial of slowly progressive type 1 diabetes with small dose of insulin (the Tokyo study): preliminary reportTaro Maruyama
Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama, Japan
Ann N Y Acad Sci 1005:362-9. 2003..We recommend avoiding SU treatment and instead administering insulin to NIDDM patients with high GADA titer... - Thiazolidinediones may not reduce diabetes incidence in type 1 diabetesToshikatsu Shigihara
Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Ann N Y Acad Sci 1079:365-8. 2006..Therefore, further research should take place before the application of thiazolidinediones to human slowly progressive insulin-dependent diabetes mellitus (SPIDDM) patients... - Relationship between beta cell mass of NOD donors and diabetes development of NOD-scid recipients in adoptive transfer systemSatoru Yamada
Department of Internal Medicine, Kitasato Institute Hospital, Tokyo, Japan
Ann N Y Acad Sci 1005:211-4. 2003..CONCLUSIONS: According to our observations, beta cell mass seems to be preserved until just before the onset of diabetes and decreased dramatically within a few weeks... - Relation between development of nephropathy and the p22phox C242T and receptor for advanced glycation end product G1704T gene polymorphisms in type 2 diabetic patientsSeiko Matsunaga-Irie
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Diabetes Care 27:303-7. 2004..We studied the relation between the genotypes of the NADPH p22phox C242T and RAGE G1704T polymorphisms and the development of diabetic nephropathy in type 2 diabetic patients... - CXC chemokine ligand 10 neutralization suppresses the occurrence of diabetes in nonobese diabetic mice through enhanced beta cell proliferation without affecting insulitisJiro Morimoto
Division of Endocrinology, School of Medicine, Keio University, Tokyo, Japan
J Immunol 173:7017-24. 2004..Thus, CXCL10 neutralization can be a new therapeutic target for beta cell survival, not only during the early stage of type 1 diabetes, but also after islet transplantation... - Induction of anti-whole GAD65 reactivity in vivo results in disease suppression in type 1 diabetesYasuhiko Kanazawa
Department of Internal Medicine, Keio University School of Medicine, Shimanomachi Shinjuku ku, Tokyo, Japan
J Autoimmun 32:104-9. 2009..Based upon these results, we propose that anti-whole GAD65-reactive T cells have the ability to regulate the development of type 1 diabetes... - T-cell function in anti-GAD65(+)diabetes with residual beta-cell functionRyuji Suzuki
Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
J Autoimmun 20:83-90. 2003.... - Effect of combination therapy of a rapid-acting insulin secretagogue (glinide) with premixed insulin in type 2 diabetes mellitusSatoru Yamada
Department of Internal Medicine, Kitasato Institute Hospital, Tokyo
Intern Med 46:1893-7. 2007..To examine this, we added glinide once a day to twice daily injections of premixed insulin... - Two cases of "fulminant" type 1 diabetes suggesting involvement of autoimmunityYoshinori Nakagawa
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Ann N Y Acad Sci 1005:359-61. 2003..Here, we report two cases of fulminant type 1 diabetes in which these markers were detected and in which the involvement of islet-associated autoimmunity is suggested... - NKT cell frequency in Japanese type 1 diabetesYoichi Oikawa
Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
Ann N Y Acad Sci 1005:230-2. 2003..Here, we combined the data of NKT cell frequency in Ab+ and Ab- "classic" type 1 diabetic patients and then analyzed the relationship between NKT cell frequency and disease activity... - Insulin-like growth factor-1 (IGF-1)-derived peptide protects against diabetes in NOD miceKeiichi Kodama
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Autoimmunity 37:481-7. 2004..It was suggested that IGF-1 peptide 50-70 immunization can be used as a tool for prevention of type 1 diabetes... - Pioglitazone may accelerate disease course of slowly progressive type 1 diabetesAkira Shimada
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Diabetes Metab Res Rev 27:951-3. 2011..However, the rate of progression to SPIDDM with the use of insulin-sensitizing agents is unknown. The aim of this study was to determine the effect of insulin-sensitizing agents on SPIDDM patients... 
CXC chemokine ligand 10 DNA vaccination plus Complete Freund's Adjuvant reverses hyperglycemia in non-obese diabetic miceYoichi Oikawa
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Rev Diabet Stud 7:209-24. 2010..In the present study, we aimed to examine whether anti-CXCL10 plus CFA treatment can effectively reverse autoimmune diabetes development...- Hyperplastic islets observed in "reversed" NOD mice treated without hematopoietic cellsYoshiaki Okubo
Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo 160 8582, Japan
Diabetes Res Clin Pract 79:18-23. 2008.... - Significance of serum CXCL10/IP-10 level in type 1 diabetesToshikatsu Shigihara
Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Tokyo 160-8582, Japan
J Autoimmun 26:66-71. 2006..These results suggest that serum CXCL10 level may reflect accumulation of Th1 lymphocytes in pancreatic LN, and measurement of serum CXCL10 level may be useful to assess the pathophysiology of the disease course in type 1 diabetes... - Expression levels of CXC chemokine receptors 3 are associated with clinical phenotype of type 1 diabetesSatoru Yamada
Department of Internal Medicine, Kitasato Institute Hospital, 5 9 1 Shirokane, Minato ku, Tokyo 108 8642, Japan
Ann N Y Acad Sci 1079:186-9. 2006..CXCR3 expression level is associated with the onset pattern of type 1 diabetes. Further studies are needed to clarify the role of chemokines in type 1 diabetes... - Assessment of beta cell mass and oxidative peritoneal exudate cells in murine type 1 diabetes using adoptive transfer systemSatoru Yamada
Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Autoimmunity 36:63-70. 2003..These results suggest that a marked reduction of beta cell mass occurs at the very late prediabetic stage, and assessment of the proportion of oxidative PEC is useful to evaluate disease activity in type 1 diabetes... - Beta cell dysfunction and its clinical significance in gestational diabetesYoshifumi Saisho
Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
Endocr J 57:973-80. 2010..The level of beta cell dysfunction in GDM was associated with the severity of glucose intolerance and total insulin dosage required. These findings underpin clinical significance of beta cell dysfunction in GDM... - Associations of insulin resistance and glycemic control with the risk of kidney stonesYusuke Kabeya
Department of Internal Medicine, Saiseikai Central Hospital, Japan
Intern Med 51:699-705. 2012..The associations of insulin resistance and glycemic control with the risk of kidney stones were explored... - Effects of olmesartan medoxomil, an angiotensin II type 1 receptor antagonist, on plasma concentration of B-type natriuretic peptide, in hypertensive patients with type 2 diabetes mellitus: a preliminary, observational, open-label studyToshihide Kawai
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
Clin Drug Investig 31:237-45. 2011..The objective of this study was to determine the effects of olmesartan medoxomil, a novel ARB, on the plasma level of BNP in hypertensive patients with type 2 diabetes... - Proatherogenic effect of interleukin-18 is exerted with high-fat diet, but not with normal diet in spontaneously hyperlipidemic miceTakatoshi Imai
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
J Atheroscler Thromb 18:1090-101. 2011..The purpose of this study was to reveal the effect of increased serum IL-18 within its physiological fluctuations on atherosclerosis development under different conditions of dietary fat content... - Effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy in patients with type 2 diabetes, in relation to suppression of N(ɛ)-carboxymethyl lysineToshihide Kawai
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
J Diabetes Complications 24:424-32. 2010..We investigated the efficacy of epalrestat, an aldose reductase inhibitor, for diabetic peripheral neuropathy in Japanese patients with type 2 diabetes... - Determinants of an optimal response to pioglitazone in terms of HDL-cholesterolYusuke Kabeya
Department of Internal Medicine, Saiseikai Central Hospital, Japan
Intern Med 50:825-31. 2011..In the present study, the characteristics of lipid responders were investigated... - Stromal cell-derived factor-1 chemokine gene polymorphism is not associated with onset age of Japanese type 1 diabetesToshikatsu Shigihara
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Ann N Y Acad Sci 1005:328-31. 2003..The SDF-1 gene polymorphism was not associated with onset age (or onset pattern) of type 1 diabetes in Japanese. Further study is necessary to conclude whether SDF-1 gene polymorphism affects the onset age in type 1 diabetes in general... - Systemic administration of IL-18 promotes diabetes development in young nonobese diabetic miceYoichi Oikawa
Department of Internal Medicine, Keio University School of Medicine, Department of Internal Medicine, Tokyo Denryoku Hospital, Japan
J Immunol 171:5865-75. 2003.... - Effect of obesity on declining beta cell function after diagnosis of type 2 diabetes: a possible link suggested by cross-sectional analysisYoshifumi Saisho
Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
Endocr J 59:187-95. 2012..Treatment of obesity may be an important strategy to preserve beta cell function in patients with type 2 diabetes... - Effect on the atherogenic marker plasminogen activator inhibitor type-1 of addition of the ACE inhibitor imidapril to angiotensin II type 1 receptor antagonist therapy in hypertensive patients with abnormal glucose metabolism: a prospective cohort study iKen Yajima
Department of Internal Medicine, Federation of National Public Service Personnel Mutual Aid Associations, Tachikawa Hospital, 4 2 22 Nishikicho, Tachikawa, Tokyo 190 8531, Japan
Clin Drug Investig 29:811-9. 2009..The objective of this study was to determine whether the ACE inhibitor imidapril reduces PAI-1 levels in hypertensive patients already being treated with an ARB... - Vitamin D receptor gene polymorphism affects onset pattern of type 1 diabetesYoshiko Motohashi
Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
J Clin Endocrinol Metab 88:3137-40. 2003..Assessment of this VDR gene polymorphism may contribute to prediction of the onset pattern in individuals with a high risk of type 1 diabetes... - Postprandial serum C-peptide to plasma glucose ratio as a predictor of subsequent insulin treatment in patients with type 2 diabetesYoshifumi Saisho
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Endocr J 58:315-22. 2011..Our study indicates that among CPR measurements, postprandial CPR index is the best predictive marker for future insulin therapy... - High frequency of valpha24(+) vbeta11(+) T-cells observed in type 1 diabetesYoichi Oikawa
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Diabetes Care 25:1818-23. 2002..In this study, we measured the frequency of peripheral Valpha24(+) Vbeta11(+) T-cells, which include human NKT cells, in Japanese diabetic patients... - GAD65 autoantibody responses in Japanese latent autoimmune diabetes in adult patientsTaro Maruyama
Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama, Japan
Diabetes Care 31:1602-7. 2008..To determine whether development of insulin requirement in patients with latent autoimmune diabetes in adults (LADA) is accompanied with the emergence of a type 1 diabetes-like autoimmune response... - Anti-insulin-like growth factor-1 autoantibodies in type 1 diabetesTaro Maruyama
Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama, 336 0002, Japan
Ann N Y Acad Sci 958:267-70. 2002..Further study is necessary to clarify whether anti-IGF-1 autoantibodies are existent in human type 1 diabetes and to determine the significance of IGF-1 in the pathogensesis of type 1 diabetes... - Nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) P22 Phox C242T gene polymorphism in type 1 diabetesSeiko Matsunaga
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Ann N Y Acad Sci 1005:324-7. 2003..In conclusion, the p22 phox C242T gene polymorphism did not affect the susceptibility to and clinical course of Japanese type 1 diabetes... - A mimic of viral double-stranded RNA triggers fulminant type 1 diabetes-like syndrome in regulatory T cell-deficient autoimmune diabetic mouseAi Tada
Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
J Immunol 187:4947-53. 2011..We conclude that an FT1D-like phenotype can be induced in the background of autoimmune diabetes by a mimic of viral dsRNA, and this model is useful for understanding human FT1D... - Risk for future diabetes among individuals with high-normal glycemia at 40 years of ageYusuke Kabeya
Department of Internal Medicine, Saiseikai Central Hospital, Japan
Intern Med 51:2703-8. 2012..The present study investigated the risk for future diabetes among individuals with high-normal glycemia (fasting plasma glucose (FPG) of 100-109 mg/dL) in an early middle-aged population... - Eradication of Helicobactor pylori may trigger onset of type 1 diabetes: a case reportAi Tada
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Ann N Y Acad Sci 1150:208-9. 2008..Although further investigation is needed to understand the pathophysiology of T1D, we would like to emphasize that clinicians should consider the risk of its development after eradication of Helicobactor pylori... - Efficacy of pitavastatin, a new HMG-CoA reductase inhibitor, on lipid and glucose metabolism in patients with type 2 diabetesToshihide Kawai
Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Diabetes Care 28:2980-1. 2005 - Pancreatic beta-cell function and fetal growth in gestational impaired glucose toleranceKei Miyakoshi
Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
Acta Obstet Gynecol Scand 89:769-75. 2010..To investigate the metabolic phenotype and pregnancy outcomes of gestational impaired glucose tolerance (IGT) defined by isolated hyperglycemia during an oral glucose tolerance test (OGTT)... - Hypertensive disorders in Japanese women with gestational glucose intoleranceKei Miyakoshi
Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Diabetes Res Clin Pract 64:201-5. 2004..2% or 4.1%, respectively, compared to those with normal glucose tolerance). Japanese women with gestational glucose intolerance therefore have an increased risk of developing GH... - Age-associated difference in gene expression of paediatric acute myelomonocytic lineage leukaemia (FAB M4 and M5 subtypes) and its correlation with prognosisAoi Jo
Genetics Division, National Cancer Centre Research Institute, Tokyo, Japan
Br J Haematol 144:917-29. 2009.... - The Role of the CXCL10/CXCR3 System in Type 1 DiabetesAkira Shimada
Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Rev Diabet Stud 6:81-4. 2009..Thus, understanding the CXCL10/CXCR3 system may be important for finding a cure. In this short review, we discuss the role of the CXCL10/CXCR3 system in type 1 diabetes and propose relevant treatment options... - Insulin intervention to preserve beta cells in slowly progressive insulin-dependent (type 1) diabetes mellitusTetsuro Kobayashi
Department of Endocrinology and Metabolism, Toranomon Hospital, Okinaka Memorial Institute for Medical Research, Tokyo, 105 8470, Japan
Ann N Y Acad Sci 958:117-30. 2002..Insulin intervention to preserve beta cell dysfunction in SPIDDM is effective and safe in patients with preserved beta cell function and high GADAb titers at the initiation of insulin... - Improved Monitoring of the Hyperglycemic State in Type 1 Diabetes Patients by Use of the Glycoalbumin/HbA1c RatioTakatoshi Imai
Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Rev Diabet Stud 4:44-8. 2007..However, in type 1 diabetic patients, we often find an even higher GA/HbA1c ratio of nearly 3.5. Therefore, this study was performed to examine the significance of a higher GA/HbA1c ratio... - Correlation between serum resistin level and adiposity in obese individualsKoichiro Azuma
Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Obes Res 11:997-1001. 2003..The aim of our study was to examine the relationship of serum resistin level to body composition, insulin resistance, and related obesity phenotypes in humans... - Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignanciesYuyan Chen
Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Genes Chromosomes Cancer 45:583-91. 2006..Our data suggest that mutations of PTPN11 as well as RAS play a role in the pathogenesis of not only myeloid hematological malignancies but also a subset of RMS malignancies... - The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multicenter collaborative study in JapanHiroshi Ikegami
Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka 565 0871, Japan
J Clin Endocrinol Metab 91:1087-92. 2006..The low incidence of type 1 diabetes in Asian countries, however, makes it difficult to perform large-scale studies in Asia... - Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): association between a promoter polymorphism and type 1 diabetes in Asian populationsEiji Kawasaki
Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan
Am J Med Genet A 140:586-93. 2006..In conclusion, the type 1 diabetes association with PTPN22 is confirmed, but it cannot be attributed solely to the +1858C > T variant. The promoter -1123G > C SNP is a more likely causative variant in PTPN22... - Immunopathological and genetic features in slowly progressive insulin-dependent diabetes mellitus and latent autoimmune diabetes in adultsTetsuro Kobayashi
Third Department of Internal Medicine, School of Medicine, University of Yamanashi, Tamaho, Yamanashi 409 3898, Japan
Ann N Y Acad Sci 1079:60-6. 2006.... - T cell immunity to glutamic acid decarboxylase in fulminant type 1 diabetes without significant elevation of serum amylaseKanemi Aoki
Department of Internal Medicine, Division of Endocrinology and Metabolism, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba, Yokohama, Kanagawa, Japan 227-8501
Ann N Y Acad Sci 1079:181-5. 2006.... - High titer of autoantibodies to GAD identifies a specific phenotype of adult-onset autoimmune diabetes: response to Buzzetti et alTetsuro Kobayashi
Diabetes Care 30:e126; author reply e127. 2007 - Fulminant type 1 diabetes: a nationwide survey in JapanAkihisa Imagawa
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
Diabetes Care 26:2345-52. 2003..Flu-like symptoms are characteristic of disease onset. Metabolic derangement is more severe in this subtype than in autoimmune type 1 diabetes... - Insulin gene/IDDM2 locus in Japanese type 1 diabetes: contribution of class I alleles and influence of class I subdivision in susceptibility to type 1 diabetesTakuya Awata
Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
J Clin Endocrinol Metab 92:1791-5. 2007..It is suggested that insulin autoimmunity plays an important role in the development of type 1 diabetes in humans. However, the association between insulin gene (INS) region (IDDM2) and type 1 diabetes has been uncertain in Asians... - Nationwide survey to compare the prevalence of transient elevation of liver transaminase during treatment of diabetic ketosis or ketoacidosis in new-onset acute and fulminant type 1 diabetes mellitusHiroko Takaike
Diabetes Center, Tokyo Women s Medical University, Japan
Ann Med 40:395-400. 2008..The aim of the present study was to assess the cause and prevalence of the elevation of liver transaminase levels in fulminant and acute-onset type 1 diabetic patients experiencing diabetic ketosis or ketoacidosis... - Insulin intervention in slowly progressive insulin-dependent (type 1) diabetes mellitusTaro Maruyama
Third Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, Japan
J Clin Endocrinol Metab 93:2115-21. 2008.... - Seroconversion of GAD antibody in unclassified diabetes with long duration of diseaseToshikatsu Shigihara
Diabetes Care 27:1836-7. 2004 - Evaluation of the diagnostic accuracy of the stop codon (SC) assay for identifying protein-truncating mutations in the BRCA1and BRCA2genes in familial breast cancerMasato Sakayori
Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
J Hum Genet 48:130-7. 2003.... - AML1 mutation and FLT3-internal tandem duplication in leukemia transformed from myelodysplastic syndromeAkira Shimada
J Pediatr Hematol Oncol 29:666-7. 2007 - Detection of ATM gene mutation in human glioma cell line M059J by a rapid frameshift/stop codon assay in yeastRika Tsuchida
Department of Pediatrics and Developmental Biology, Postgraduate Medical School, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Radiat Res 158:195-201. 2002..Thus the radiosensitive phenotype of M059J cells appears to be due to a defect in PRKDC and a truncating ATM mutation... - A case of fulminant type 1 diabetes with strong evidence of autoimmunityAkira Shimada
Diabetes Care 25:1482-3. 2002 - [Rhabdomyolysis in the diabetic state]Satoru Yamada
Department of Internal Medicine, Kitasato Institute Hospital
Nippon Rinsho 60:443-8. 2002 - T-cell-mediated autoimmunity may be involved in fulminant type 1 diabetesAkira Shimada
Diabetes Care 25:635-6. 2002 - Incidence and underlying etiologies of bronchial secretion in terminally ill cancer patients: a multicenter, prospective, observational studyTatsuya Morita
Seirei Hospice, Seirei Mikatabara Hospital, Hamamatsu, Shizuoka, Japan
J Pain Symptom Manage 27:533-9. 2004..Etiology-based classification of bronchial secretion is useful to identify the most suitable palliative treatments and to clarify treatment efficacy in each specific pathophysiology... - KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study GroupAkira Shimada
Department of Hematology/Oncology, Gunma Children's Medical Center, 779 Shimohakoda, Kitatachibana, Gunma 377-8577, Japan
Blood 107:1806-9. 2006..0% versus 2.7%, P < .001). Furthermore, FLT3 internal tandem duplication was found in only 2 (4.3%) patients. These results suggested that KIT mutations are strongly associated with a poor prognosis in pediatric t(8;21) AML... - Artificial hydration therapy, laboratory findings, and fluid balance in terminally ill patients with abdominal malignanciesTatsuya Morita
Department of Palliative and Supportive Care, Palliative Care Team and Seirei Hospice, Seirei Mikatahara General Hospital, Hamamatsu, Japan
J Pain Symptom Manage 31:130-9. 2006..Calculated fluid balance is not an appropriate alternative to direct monitoring of patient symptoms. More studies are needed to determine the clinical efficacy of artificial hydration for terminally ill cancer patients... - Omenn syndrome--review of several phenotypes of Omenn syndrome and RAG1/RAG2 mutations in JapanMasahiko Kato
Department of Allergy and Immunology, Gunma Children s Medical Center, Hokkitsu, Gunma, Japan gcmc pref gunma jp
Allergol Int 55:115-9. 2006..In this review, we will focus on the variation of several phenotypes of OS... - [Chronic kidney diseases and other diseases: 6. Obesity]Toshihide Kawai
Nippon Naika Gakkai Zasshi 96:916-21. 2007 - GAD antibody in mitochondrial diabetes associated with tRNA(UUR) mutation at position 3271Yoshihiko Suzuki
Diabetes Care 25:1097-8. 2002