Hideyuki Saya

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. ncbi request reprint Mechanism and biological significance of CD44 cleavage
    Osamu Nagano
    Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Cancer Sci 95:930-5. 2004
  2. ncbi request reprint Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44
    Daizo Murakami
    Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, Japan
    Oncogene 22:1511-6. 2003
  3. pmc Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor
    E Sugihara
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan
    Oncogene 31:2849-61. 2012
  4. pmc Establishment of HRAS(G12V) transgenic medaka as a stable tumor model for in vivo screening of anticancer drugs
    Yuriko Matsuzaki
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan
    PLoS ONE 8:e54424. 2013
  5. pmc Mad2 inhibits the mitotic kinesin MKlp2
    Sang Hyun Lee
    Program in Cancer and Stem Cell Biology, Graduate Medical School, Duke National University of Singapore, 169857 Singapore
    J Cell Biol 191:1069-77. 2010
  6. ncbi request reprint [Role of CD44-mediated signal in cancer invasion and metastasis]
    Hideyuki Saya
    Tanpakushitsu Kakusan Koso 53:1225-30. 2008
  7. doi request reprint Functional role of CD44v-xCT system in the development of spasmolytic polypeptide-expressing metaplasia
    Takeyuki Wada
    Division of Gene Regulation, Institute for Advanced Medical Research, Tokyo, Japan Department of Surgery, School of Medicine, Keio University, Tokyo, Japan
    Cancer Sci 104:1323-9. 2013
  8. doi request reprint Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells
    Takeshi Motohara
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Carcinogenesis 32:1597-606. 2011
  9. doi request reprint Twist2 functions as a tumor suppressor in murine osteosarcoma cells
    Tomoki Ishikawa
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan
    Cancer Sci 104:880-8. 2013
  10. doi request reprint The cell cycle regulator Cdh1 controls the pool sizes of hematopoietic stem cells and mature lineage progenitors by protecting from genotoxic stress
    Jo Ishizawa
    Division of Gene Regulation, Institute for Advanced Medical Research, Department of Medicine, School of Medicine, Keio University, Tokyo, Japan
    Cancer Sci 102:967-74. 2011

Detail Information

Publications66

  1. ncbi request reprint Mechanism and biological significance of CD44 cleavage
    Osamu Nagano
    Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Cancer Sci 95:930-5. 2004
    ..An understanding of the underlying mechanism of these cleavages of CD44 could provide novel therapeutic targets for cancer cell invasion and metastasis...
  2. ncbi request reprint Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44
    Daizo Murakami
    Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, Japan
    Oncogene 22:1511-6. 2003
    ..Our present findings suggest important implications for understanding CD44-dependent signal transduction and a potential role of PS/gamma-secretase activity in the functional regulation of adhesion molecules...
  3. pmc Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor
    E Sugihara
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan
    Oncogene 31:2849-61. 2012
    ..Collectively, these findings indicate that Ink4a and Arf are critical determining factors of the cell of origin and the therapeutic sensitivity of Myc-induced lymphoid tumors...
  4. pmc Establishment of HRAS(G12V) transgenic medaka as a stable tumor model for in vivo screening of anticancer drugs
    Yuriko Matsuzaki
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan
    PLoS ONE 8:e54424. 2013
    ....
  5. pmc Mad2 inhibits the mitotic kinesin MKlp2
    Sang Hyun Lee
    Program in Cancer and Stem Cell Biology, Graduate Medical School, Duke National University of Singapore, 169857 Singapore
    J Cell Biol 191:1069-77. 2010
    ..This correlates with an increased incidence of cytokinesis failure. Together, these findings reveal that MKlp2 is a novel mitotic target of Mad2 necessary for proper mitotic progression and cytokinesis...
  6. ncbi request reprint [Role of CD44-mediated signal in cancer invasion and metastasis]
    Hideyuki Saya
    Tanpakushitsu Kakusan Koso 53:1225-30. 2008
  7. doi request reprint Functional role of CD44v-xCT system in the development of spasmolytic polypeptide-expressing metaplasia
    Takeyuki Wada
    Division of Gene Regulation, Institute for Advanced Medical Research, Tokyo, Japan Department of Surgery, School of Medicine, Keio University, Tokyo, Japan
    Cancer Sci 104:1323-9. 2013
    ..Therapy targeted to CD44v-xCT could thus prove effective for prevention or attenuation of the CD44v-dependent development of preneoplastic lesions and cancer. ..
  8. doi request reprint Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells
    Takeshi Motohara
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Carcinogenesis 32:1597-606. 2011
    ..These data reveal a role for p53 in the development and expansion of ovarian stem-like tumor cells and subsequent malignant progression...
  9. doi request reprint Twist2 functions as a tumor suppressor in murine osteosarcoma cells
    Tomoki Ishikawa
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan
    Cancer Sci 104:880-8. 2013
    ..Data from the present study suggest that Twist2 inhibits formation of a microenvironment conducive to tumor growth and thereby attenuates tumorigenesis in osteosarcoma. ..
  10. doi request reprint The cell cycle regulator Cdh1 controls the pool sizes of hematopoietic stem cells and mature lineage progenitors by protecting from genotoxic stress
    Jo Ishizawa
    Division of Gene Regulation, Institute for Advanced Medical Research, Department of Medicine, School of Medicine, Keio University, Tokyo, Japan
    Cancer Sci 102:967-74. 2011
    ..This is the first report revealing Cdh1 function in adult hematopoiesis and showing a role of Cdh1 in a G2/M checkpoint regulation in vivo...
  11. pmc Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer
    Yoshimi Arima
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo 160 8582, Japan
    J Biol Chem 287:7896-906. 2012
    ..Together, our findings suggest that RB inactivation contributes to tumor progression not only through loss of cell cycle control but also through up-regulation of ZEB expression and induction of an invasive phenotype...
  12. doi request reprint Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells
    Mayumi Tamada
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    Cancer Res 72:1438-48. 2012
    ..Taken together, our findings suggest that metabolic modulation by CD44 is a potential therapeutic target for glycolytic cancer cells that manifest drug resistance...
  13. doi request reprint The APC/C activator Cdh1 regulates the G2/M transition during differentiation of placental trophoblast stem cells
    Hideaki Naoe
    Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 430:757-62. 2013
    ..Furthermore, the Cdh1(GT/GT) TS cells and placenta showed aberrant expression of placental differentiation markers. These data highlight an important role of Cdh1 in the G2/M transition during placental differentiation...
  14. doi request reprint Loss of p16 expression is associated with the stem cell characteristics of surface markers and therapeutic resistance in estrogen receptor-negative breast cancer
    Yoshimi Arima
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Int J Cancer 130:2568-79. 2012
    ..Consistent with this conclusion, immunohistochemical analysis of the clinical samples suggests that low p16 expression in TNBC is associated with resistance to preoperative chemotherapy...
  15. doi request reprint Acquired expression of NFATc1 downregulates E-cadherin and promotes cancer cell invasion
    Tsukasa Oikawa
    Laboratory of Cell and Tissue Biology, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan
    Cancer Res 73:5100-9. 2013
    ..Induced expression of NFATc1CA also downregulated E-cadherin expression and increased invasive activity in tumor xenografts in vivo. Our results thus suggest that the acquisition of NFATc1 expression contributes to tumor progression...
  16. pmc LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression
    Tatsuyuki Chiyoda
    Division of Gene Regulation, Institute for Advanced Medical Research, Department of Obstetrics and Gynecology, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    J Cell Biol 197:625-41. 2012
    ..These results indicate that LATS1 phosphorylates a phosphatase as does the yeast Dbf2 and demonstrate a novel role of LATS1 in controlling PLK1 at the G2 DNA damage checkpoint...
  17. doi request reprint xCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma
    Momoko Yoshikawa
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, School of Medicine, Keio University, Shinjuku ku, Japan
    Cancer Res 73:1855-66. 2013
    ..Thus, xCT-targeted therapy may deplete CD44v-expressing undifferentiated HNSCC cells and concurrently sensitize the remaining differentiating cells to available treatments including EGFR-targeted therapy...
  18. doi request reprint Fibroblast growth factor-2 is an important factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma
    Takatsune Shimizu
    Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160 8582, Japan
    Mol Cancer Res 10:454-68. 2012
    ..The combined blockade of the signaling pathways of several growth factors, including Fgf2, might be useful in controlling the aggressiveness of osteosarcoma...
  19. doi request reprint CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth
    Takatsugu Ishimoto
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Cancer Cell 19:387-400. 2011
    ..It also induced activation of p38(MAPK), a downstream target of ROS, and expression of the gene for the cell cycle inhibitor p21(CIP1/WAF1). These findings establish a function for CD44v in regulation of ROS defense and tumor growth...
  20. pmc Invasion precedes tumor mass formation in a malignant brain tumor model of genetically modified neural stem cells
    Oltea Sampetrean
    Division of Gene Regulation, School of Medicine, Keio University, Tokyo, Japan
    Neoplasia 13:784-91. 2011
    ..Our results showed that perivascular and intraparenchymal tumor cell migration precede tumor mass formation in the adult brain, suggesting the need for an early and sustained anti-invasion therapy...
  21. doi request reprint Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell
    Toshifumi Yae
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nat Commun 3:883. 2012
    ..The epithelial splicing regulatory protein 1-CD44v-xCT axis is thus a potential therapeutic target for the prevention of metastasis...
  22. pmc Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction
    Eri Takahashi
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo 160 8582, Japan
    J Biol Chem 285:4060-73. 2010
    ..The production of hyaluronan and its interaction with CD44, thus, play an essential role in TNF-alpha-induced EMT and are potential therapeutic targets in fibrotic disorders...
  23. doi request reprint Energy management by enhanced glycolysis in G1-phase in human colon cancer cells in vitro and in vivo
    Yan Bao
    Department of Biochemistry, School of Medicine, Keio University, and Leader, JST ERATO Suematsu Gas Biology Project, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Mol Cancer Res 11:973-85. 2013
    ..Thus, as the cell cycle progressed from G2-M to G1 phases, the dependency of energy production on glycolysis was increased while the mitochondrial energy production was reciprocally decreased...
  24. pmc Up-regulation of Imp3 confers in vivo tumorigenicity on murine osteosarcoma cells
    Arisa Ueki
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan
    PLoS ONE 7:e50621. 2012
    ..Our results implicate Imp3 as a key regulator of stem-like tumorigenic characteristics in osteosarcoma cells and as a potential therapeutic target for this malignancy...
  25. doi request reprint Pyruvate kinase M2: multiple faces for conferring benefits on cancer cells
    Mayumi Tamada
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan
    Clin Cancer Res 18:5554-61. 2012
    ..Therefore, inhibitors and activators of PKM2 are well underway to evaluate their anticancer effects and suitability for use as novel therapeutic strategies...
  26. pmc Establishment of a choriocarcinoma model from immortalized normal extravillous trophoblast cells transduced with HRASV12
    Yusuke Kobayashi
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University and the Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Agency, Tokyo, Japan
    Am J Pathol 179:1471-82. 2011
    ..Our murine model represents a potent new tool for studying the pathogenesis and treatment of choriocarcinoma...
  27. pmc APC(CDH1) targets MgcRacGAP for destruction in the late M phase
    Koutarou Nishimura
    Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo, Japan
    PLoS ONE 8:e63001. 2013
    ..Expression of MgcRacGAP is strictly controlled in a cell cycle-dependent manner. However, the underlying mechanisms have not been elucidated...
  28. doi request reprint Characteristics of glioma stem cells
    Oltea Sampetrean
    Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    Brain Tumor Pathol 30:209-14. 2013
    ..Here, we review the characteristics necessary for a glioma cell to be considered a stem cell, and we adopt our murine glioblastoma model based on genetically modified neural stem cells to illustrate and discuss the GSC concept...
  29. pmc The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation
    Hideaki Naoe
    Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160 8582, Japan
    Mol Cell Biol 30:3994-4005. 2010
    ..Our data revealed a novel function for Cdh1 as a regulator of Rho and provided insights into the role of Cdh1 in cell cytoskeleton organization and cell motility...
  30. doi request reprint Molecular mechanisms regulating dissociation of cell-cell junction of epithelial cells by oxidative stress
    Junko Inumaru
    Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160 8582, Japan
    Genes Cells 14:703-16. 2009
    ..These findings suggest that oxidative stress is a crucial factor to induce the cell-cell dissociation, an initial step of EMT, but does not provide sufficient signals to establish and to maintain the EMT...
  31. ncbi request reprint Lysyl oxidase is induced by cell density-mediated cell cycle suppression via RB-E2F1-HIF-1α axis
    Takaaki M Goto
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Cell Struct Funct 38:9-14. 2013
    ..These findings suggest that elevated cell density enhances cell cycle arrest and matrix remodeling via RB-E2F1-HIF-1α axis...
  32. doi request reprint CD44+ slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis
    Takatsugu Ishimoto
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan
    Cancer Sci 101:673-8. 2010
    ..These observations suggest that PGE(2)-mediated inflammatory signaling and Wnt signaling cooperatively trigger the expansion of CD44(+) slow-cycling stem-like cells in SCJ, leading to development of lethal gastric tumors in mice...
  33. doi request reprint [Encounter of cancer cells with bone. The significance of cancer stem cells and epithelial-mesenchymal transition in tumor invasion and metastasis]
    Go J Yoshida
    Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine
    Clin Calcium 21:411-7. 2011
    ..However, some recent studies suggest that EMT is not essential requirement for tumor invasion and metastasis. Herein, we discuss the biological significance of CSCs and EMT in tumor invasion and metastasis...
  34. doi request reprint Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation
    Hiroyuki Nobusue
    1 Laboratory of Cell and Tissue Biology, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa 252 0880, Japan 2 Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160 8582, Japan
    Nat Commun 5:3368. 2014
    ..Our findings thus provide new mechanistic insight into the relation between the dynamics of cell shape and transcriptional regulation during cellular differentiation. ..
  35. doi request reprint Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation
    Go J Yoshida
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan Electronic address
    Biochem Biophys Res Commun 443:622-7. 2014
    ....
  36. doi request reprint Complexity of cancer stem cells
    Eiji Sugihara
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan
    Int J Cancer 132:1249-59. 2013
    ..In this review, we summarize the history of the discovery and characterization of CSCs, as well as address recent advances that have revealed the complexity of these cells and their therapeutic implications...
  37. doi request reprint Glycan profiling of gestational choriocarcinoma using a lectin microarray
    Yusuke Kobayashi
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan
    Oncol Rep 31:1121-6. 2014
    ..This is the first report of a lectin array analysis in choriocarcinoma and provides useful information for understanding of the disease. ..
  38. pmc In vivo assessment of cancerous tumors using boron doped diamond microelectrode
    Stéphane Fierro
    Department of Chemistry, Faculty of Science and Technology, Keio University, 3 14 1 Hiyoshi, Yokohama 223 8522, Japan
    Sci Rep 2:901. 2012
    ..Moreover, GSH detection measurements carried out before and after X-ray irradiation have proved that it is possible to assess in vivo the decrease in GSH concentration in the tumor after a specific treatment...
  39. doi request reprint Expression profiles of carcinosarcoma of the uterine corpus-are these similar to carcinoma or sarcoma?
    Tatsuyuki Chiyoda
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan
    Genes Chromosomes Cancer 51:229-39. 2012
    ..TGF-beta signaling is activated in CS and chromosomal gains at 19q13, which includes the TGFB1 locus, suggest that this may contribute to high expression of TGF-beta and thereby EMT phenotype of CS...
  40. ncbi request reprint [Molecular mechanism regulating effect of anti-cancer agents]
    Hideyuki Saya
    Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Japan
    Gan To Kagaku Ryoho 36:1-5. 2009
    ..Given that G1 and G2 checkpoint functions are generally impaired in cancer cells, cells with DNA damage are unable to maintain G2 arrest and eventually die as they enter mitosis. This process is known as mitotic catastrophe...
  41. pmc In vivo pH monitoring using boron doped diamond microelectrode and silver needles: application to stomach disorder diagnosis
    Stéphane Fierro
    Department of Chemistry, Faculty of Science and Technology, Keio University, 3 14 1 Hiyoshi, Yokohama 223 8522, Japan
    Sci Rep 3:3257. 2013
    ..It is proposed that the catheter-free pH monitoring system presented in this study could be potentially employed in any biological environment. ..
  42. doi request reprint Maintenance of HCT116 colon cancer cell line conforms to a stochastic model but not a cancer stem cell model
    Kazuharu Kai
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan
    Cancer Sci 100:2275-82. 2009
    ..Thus, HCT116 cells have plasticity when they are set in floating-spheres, suggesting that maintenance of the HCT116 cell line conforms to a stochastic model, not a CSC model...
  43. pmc Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells
    Masanao Tabuse
    Neuroimmunology Research Group, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Mol Cancer 10:60. 2011
    ..HOX genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development. They also behave as oncogenes in some malignancies...
  44. ncbi request reprint Decreased expression of neurofibromin contributes to epithelial-mesenchymal transition in neurofibromatosis type 1
    Yoshimi Arima
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan
    Exp Dermatol 19:e136-41. 2010
    ..Our findings suggest that the loss of neurofibromin activated the EMT-related signaling pathway and that the excessive mesenchymal reaction may play a key role in the development of NF1-associated neurofibromas...
  45. ncbi request reprint EpCAM expression in the prostate cancer makes the difference in the response to growth factors
    Go J Yoshida
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan Electronic address
    Biochem Biophys Res Commun 443:239-45. 2014
    ..However, little is known about how EpCAM is involved in the ability of cells to adapt to micro-environmental changes in available growth factors, which is one of the essential biological phenotypes of cancer stem-like cells (CSCs)...
  46. ncbi request reprint [Current clinical trials using new targeted therapies for myeloid leukemia and the research trends]
    Jo Ishizawa
    Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine
    Nihon Rinsho 67:1932-7. 2009
    ..This review summarizes the current clinical trials using new targeted therapies and research trends on myeloid leukemia...
  47. doi request reprint Breast cancer stem cells
    Kazuharu Kai
    Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Breast Cancer 17:80-5. 2010
    ..The emerging picture of the biological properties of BCSCs would contribute for devising innovative therapies for breast cancer, targeting the intrinsic and extrinsic factors that maintain the BCSCs...
  48. pmc Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell-cell fusion
    Tsukasa Oikawa
    Laboratory of Cell and Tissue Biology, Institute for Advanced Medical Research, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    J Cell Biol 197:553-68. 2012
    ..Our results thus reveal an unexpected link between circumferential podosome/invadopodium formation and cell-cell fusion in and beyond osteoclasts...
  49. doi request reprint Identification of CD44 as a cell surface marker for Müller glia precursor cells
    Toru Shinoe
    Division of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Neurochem 115:1633-42. 2010
    ..Together, CD44 was identified as an early cell surface marker of the Müller glia lineage, and Notch signalling was involved in commitment of retinal progenitor cells to CD44 positive Müller glial precursor cells...
  50. doi request reprint Three-dimensional culture of sebaceous gland cells revealing the role of prostaglandin E2-induced activation of canonical Wnt signaling
    Go J Yoshida
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 438:640-6. 2013
    ..Given that 2D culture of SZ95 cells does not recapitulate the organization of sebaceous glands in situ, we developed a 3D culture system for these cells and examined the effects of PGE2 on cell morphology and function...
  51. pmc RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathways
    Jun Muto
    Department of Physiology, Keio University School of Medicine, Shinjuku, Tokyo, Japan
    PLoS ONE 7:e33431. 2012
    ..These results suggest that MSI1 increases the growth and/or survival of certain types of glioma cells by promoting the activation of both Notch and PI(3) kinase/Akt signaling...
  52. ncbi request reprint Reversible whole-organism cell cycle arrest in a living vertebrate
    Oltea Sampetrean
    Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    Cell Cycle 8:620-7. 2009
    ..Our results suggest that this manipulation can be performed from the early stages of development, has no toxicity and does not alter the cell cycle profile of the embryo...
  53. doi request reprint Multiple café au lait spots in familial patients with MAP2K2 mutation
    Toshiki Takenouchi
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
    Am J Med Genet A 164:392-6. 2014
    ..The present observation suggests that some perturbation in the RAS/MAPK signaling cascade results in multiple café au lait spots, a key diagnostic phenotype of rasopathies, although the exact mechanism remains to be elucidated...
  54. pmc M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis
    Yoshiaki Kubota
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    J Exp Med 206:1089-102. 2009
    ..Continuous M-CSF inhibition did not affect healthy vascular and lymphatic systems outside tumors. These results suggest that M-CSF-targeted therapy is an ideal strategy for treating ocular neovascular diseases and cancer...
  55. ncbi request reprint [Molecular mechanism of cell death induced by chemotherapeutic agents]
    Hideyuki Saya
    Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Brain Nerve 61:843-7. 2009
    ..An understanding of the molecular mechanisms of chemotherapy will enable us to use conventional drugs more appropriately for cancer treatment...
  56. doi request reprint Involvement of hyaluronan and its receptor CD44 with choroidal neovascularization
    Hiroshi Mochimaru
    Department of Ophthalmology, Laboratory of Retinal Cell Biology, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:4410-5. 2009
    ..The purpose of the present study was to clarify a role of HA and CD44 in the development of choroidal neovascularization (CNV)...
  57. ncbi request reprint [Molecular mechanisms of brain tumor invasion]
    Hideyuki Saya
    Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University
    Nihon Rinsho 63:61-7. 2005
  58. pmc Proteolytic cleavage of the CD44 adhesion molecule in multiple human tumors
    Isamu Okamoto
    Department of Microbiology and Immunology, Kimmel Cancer Institute, BLSB 2002, Thomas Jefferson University, 233 S 10th St, Philadelphia, PA 19107, USA
    Am J Pathol 160:441-7. 2002
    ..Tumors expressing a CD44 splice variant showed a significantly higher incidence of enhanced CD44 cleavage. The wide prevalence of CD44 cleavage suggests that it plays an important role in the pathogenesis of human tumors...
  59. doi request reprint EGFR and ErbB2 are functionally coupled to CD44 and regulate shedding, internalization and motogenic effect of CD44
    Zsuzsanna Pályi-Krekk
    Department of Biophysics and Cell Biology, Medical and Health Science Center, University of Debrecen, 1 Egyetem Square, H 4010 Debrecen, Hungary
    Cancer Lett 263:231-42. 2008
    ..Our experiments point to an unexpected, but potentially important mechanism of action of ErbB receptor-targeted monoclonal antibodies used in the treatment of cancer...
  60. ncbi request reprint [Aurora kinases: Functions and roles in tumorigenesis]
    Hideyuki Saya
    Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Seikagaku 79:131-9. 2007
  61. ncbi request reprint Hyaluronan oligosaccharides induce CD44 cleavage and promote cell migration in CD44-expressing tumor cells
    Kazuki N Sugahara
    Laboratory of Molecular and Cellular Recognition, Osaka University Graduate School of Medicine, 2 2, Yamada oka, Suita 565 0871, Japan
    J Biol Chem 278:32259-65. 2003
    ..These results raise the possibility that small HA oligosaccharides, which are known to occur in various tumor tissues, promote tumor invasion by enhancing the tumor cell motility that may be driven by CD44 cleavage...
  62. pmc Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation
    Osamu Nagano
    Dept of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    J Cell Biol 165:893-902. 2004
    ..The spatio-temporal regulation of two independent signaling pathways for CD44 cleavage plays a crucial role in cell-matrix interaction and cell migration...
  63. ncbi request reprint Aurora-A - a guardian of poles
    Tomotoshi Marumoto
    Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Nat Rev Cancer 5:42-50. 2005
    ..What are the normal physiological roles of Aurora-A, how are these regulated and how might the enzyme function during tumorigenesis?..
  64. doi request reprint Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition
    Yoshimi Arima
    Radiobiology Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Cancer Res 68:5104-12. 2008
    ....
  65. ncbi request reprint The UHRF family: oncogenes that are drugable targets for cancer therapy in the near future?
    Christian Bronner
    CNRS UMR 7175, Département de Pharmacologie et Pharmacochimie des Interactions Moléculaires et Cellulaires, Faculte de Pharmacie, 74 route du Rhin, BP 60024, 67401, Illkirch Cedex, France
    Pharmacol Ther 115:419-34. 2007
    ..Alteration of these regulatory mechanisms, such as those occurring in cancer cells, may be involved in carcinogenesis. The reasons why the UHRF family could be an interesting target for developing anticancer drugs is also developed...
  66. ncbi request reprint ADAM-17 associated with CD44 cleavage and metastasis in oral squamous cell carcinoma
    Yasuo Takamune
    Department of Oral and Maxillofacial Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Virchows Arch 450:169-77. 2007
    ..The level of ADAM-17 expression was significantly correlated to the nodal metastasis and local recurrence in oral SCC. Our findings suggest that ADAM-17 is involved in CD44 cleavage and contributes to tumor progression in oral SCC...