Kazunobu Sawamoto

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. ncbi Isolation and transplantation of dopaminergic neurons and neural stem cells
    Hideyuki Okano
    Department of Physiology, School of Medicine, Keio University, Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Parkinsonism Relat Disord 9:23-8. 2002
  2. ncbi Vascular adventitia generates neuronal progenitors in the monkey hippocampus after ischemia
    Tetsumori Yamashima
    Department of Neurosurgery, Division of Neuroscience, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Hippocampus 14:861-75. 2004
  3. ncbi New neurons follow the flow of cerebrospinal fluid in the adult brain
    Kazunobu Sawamoto
    Department of Neurological Surgery and Developmental and Stem Cell Biology Program, University of California San Francisco, San Francisco, CA 94143, USA
    Science 311:629-32. 2006
  4. pmc Neural stem cells: involvement in adult neurogenesis and CNS repair
    Hideyuki Okano
    Department of Physiology, Keio University School of Medicine, Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Philos Trans R Soc Lond B Biol Sci 363:2111-22. 2008
  5. ncbi Regeneration of the central nervous system using endogenous repair mechanisms
    Hideyuki Okano
    Department of Physiology, Keio University School of Medicine, Shinanomachi, Shinjuku ku, Tokyo, Japan
    J Neurochem 102:1459-65. 2007
  6. pmc Galectin-1 is expressed in early-type neural progenitor cells and down-regulates neurogenesis in the adult hippocampus
    Yoichi Imaizumi
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    Mol Brain 4:7. 2011
  7. ncbi Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum
    Toru Yamashita
    Bridgestone Laboratory of Developmental and Regenerative Neurobiology, Keio University School of Medicine, Shinanomachi, Tokyo 160 8582, Japan
    J Neurosci 26:6627-36. 2006
  8. ncbi Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone
    Yuki Hirota
    Department of Developmental and Regenerative Biology, Institute of Molecular Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Neurosci 27:12829-38. 2007
  9. ncbi [Neuronal migration in the adult brain]
    Naoko Kaneko
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 27:215-8. 2007
  10. ncbi Isolation and transplantation of dopaminergic neurons generated from mouse embryonic stem cells
    Takahito Yoshizaki
    Department of Physiuology, Keio University School of Medicine, Tokyo, Japan
    Neurosci Lett 363:33-7. 2004

Collaborators

Detail Information

Publications26

  1. ncbi Isolation and transplantation of dopaminergic neurons and neural stem cells
    Hideyuki Okano
    Department of Physiology, School of Medicine, Keio University, Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Parkinsonism Relat Disord 9:23-8. 2002
    ..Transplantation of the sorted cells resulted in recovery of a rat model of the PD. This strategy should be useful for developing new therapies for PD...
  2. ncbi Vascular adventitia generates neuronal progenitors in the monkey hippocampus after ischemia
    Tetsumori Yamashima
    Department of Neurosurgery, Division of Neuroscience, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Hippocampus 14:861-75. 2004
    ..These data implicate the vascular adventitia as a novel potential source of neuronal progenitor cells in the postischemic primate SGZ...
  3. ncbi New neurons follow the flow of cerebrospinal fluid in the adult brain
    Kazunobu Sawamoto
    Department of Neurological Surgery and Developmental and Stem Cell Biology Program, University of California San Francisco, San Francisco, CA 94143, USA
    Science 311:629-32. 2006
    ..Results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons...
  4. pmc Neural stem cells: involvement in adult neurogenesis and CNS repair
    Hideyuki Okano
    Department of Physiology, Keio University School of Medicine, Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Philos Trans R Soc Lond B Biol Sci 363:2111-22. 2008
    ....
  5. ncbi Regeneration of the central nervous system using endogenous repair mechanisms
    Hideyuki Okano
    Department of Physiology, Keio University School of Medicine, Shinanomachi, Shinjuku ku, Tokyo, Japan
    J Neurochem 102:1459-65. 2007
    ..In this review, we will summarize the recent advances in regeneration-based therapeutic approaches using endogenous NSCs, including the results of our own collaborative groups...
  6. pmc Galectin-1 is expressed in early-type neural progenitor cells and down-regulates neurogenesis in the adult hippocampus
    Yoichi Imaizumi
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    Mol Brain 4:7. 2011
    ..However, little is known about its detailed expression profile in the NPCs and functions in adult neurogenesis in the DG...
  7. ncbi Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum
    Toru Yamashita
    Bridgestone Laboratory of Developmental and Regenerative Neurobiology, Keio University School of Medicine, Shinanomachi, Tokyo 160 8582, Japan
    J Neurosci 26:6627-36. 2006
    ..These results highlight the role of the SVZ in neuronal regeneration after a stroke and its potential as an important therapeutic target for various neurological disorders...
  8. ncbi Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone
    Yuki Hirota
    Department of Developmental and Regenerative Biology, Institute of Molecular Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Neurosci 27:12829-38. 2007
    ..These findings suggest that Cdk5 plays an important role in neuroblast migration in the postnatal subventricular zone...
  9. ncbi [Neuronal migration in the adult brain]
    Naoko Kaneko
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 27:215-8. 2007
    ..Although there are a lot of subjects to be elucidated, understanding the comprehensive mechanism of adult neurogenesis should be useful for developing successful regenerative therapies for neuropsychological diseases in the future...
  10. ncbi Isolation and transplantation of dopaminergic neurons generated from mouse embryonic stem cells
    Takahito Yoshizaki
    Department of Physiuology, Keio University School of Medicine, Tokyo, Japan
    Neurosci Lett 363:33-7. 2004
    ..This strategy of isolation and transplantation of ES-cell-derived DA neurons should be useful for cellular and molecular studies of DA neurons and for clinical application in the treatment of Parkinson's disease...
  11. ncbi Enhanced neurogenesis in the ischemic striatum following EGF-induced expansion of transit-amplifying cells in the subventricular zone
    Mikiko Ninomiya
    Bridgestone Laboratory of Developmental and Regenerative Neurobiology, Keio University School of Medicine, 35 Shinanomachi, Tokyo 160 8582, Japan
    Neurosci Lett 403:63-7. 2006
    ..These results suggest that the replacement of neurons in injured striatum can be enhanced by an EGF-induced expansion of transit-amplifying cells in the SVZ...
  12. ncbi Mapping spatio-temporal activation of Notch signaling during neurogenesis and gliogenesis in the developing mouse brain
    Akinori Tokunaga
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    J Neurochem 90:142-54. 2004
    ..Taken together, the present method has enabled us to determine the timing, gradients, and boundaries of the activation of Notch signaling...
  13. ncbi [Adult neurogenesis in physiological and pathological conditions]
    Naoko Kaneko
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    Brain Nerve 60:319-28. 2008
    ..For development of successful regenerative medicine for injured brain, we need to understand more precise and comprehensive mechanisms regulating adult neurogenesis...
  14. ncbi [Neuronal migration in the adult brain]
    Naoko Kaneko
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, 467 8601 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 28:63-8. 2008
    ..Understanding more precise and comprehensive mechanisms of adult neurogenesis should lead to future development of regenerative therapies for neuropsychiatric diseases...
  15. ncbi [Neurogenesis in the adult subventricular zone]
    Yuki Hirota
    Tanpakushitsu Kakusan Koso 53:863-9. 2008
  16. ncbi Enhanced proliferation of progenitor cells in the subventricular zone and limited neuronal production in the striatum and neocortex of adult macaque monkeys after global cerebral ischemia
    Anton B Tonchev
    Department of Restorative Neurosurgery, Division of Neuroscience, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan
    J Neurosci Res 81:776-88. 2005
    ..Taken together, our data suggest an enhanced neurogenic response in the adult primate telencephalon after a cerebral ischemic insult...
  17. doi Cell-cycle-specific nestin expression coordinates with morphological changes in embryonic cortical neural progenitors
    Takehiko Sunabori
    Department of Physiology, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Cell Sci 121:1204-12. 2008
    ..Collectively, these findings demonstrate precisely orchestrated gene regulation that correlates with the 3D morphological changes in neural progenitor cells in vivo...
  18. ncbi Beta-catenin signaling promotes proliferation of progenitor cells in the adult mouse subventricular zone
    Kazuhide Adachi
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    Stem Cells 25:2827-36. 2007
    ..These results suggest that beta-catenin signaling plays a role in the proliferation of progenitor cells in the SVZ of the adult mouse brain...
  19. ncbi Role of the cholinergic system in regulating survival of newborn neurons in the adult mouse dentate gyrus and olfactory bulb
    Naoko Kaneko
    Department of Physiology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Genes Cells 11:1145-59. 2006
    ..Taken together, these results suggest that activation of the cholinergic system promotes survival of newborn neurons in the adult dentate gyrus and olfactory bulb under both normal and stressed conditions...
  20. ncbi Implication of "Down syndrome cell adhesion molecule" in the hippocampal neurogenesis of ischemic monkeys
    Tetsumori Yamashima
    Department of Restorative Neurosurgery, Kanazawa University, Graduate School of Medical Science, Kanazawa, Japan
    Hippocampus 16:924-35. 2006
    ..Young astrocytes were in intimate contact with newly generated neurons in the subgranular zone. These data suggest implication of DSCAM in the adult neurogenesis of primate hippocampus upregulated after ischemia...
  21. ncbi Characterization of the isoforms of MOVO zinc finger protein, a mouse homologue of Drosophila Ovo, as transcription factors
    Sawako Unezaki
    Department of Medical Chemistry, Kansai Medical University, 10 15 Fumizono, Moriguchi, Osaka 570 8506 Japan
    Gene 336:47-58. 2004
    ..MOVO-A partially rescued oogenesis of a Drosophila ovo mutant. These results suggest that MOVO isoforms are transcription factors to regulate genes carrying the MOVO-binding motifs in the testis...
  22. pmc A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells
    Masanori Sakaguchi
    Department of Physiology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Proc Natl Acad Sci U S A 103:7112-7. 2006
    ..Based on results from intraventricular infusion experiments and phenotypic analyses of knockout mice, we demonstrate that Galectin-1 is an endogenous factor that promotes the proliferation of NSCs in the adult brain...
  23. ncbi The Sox2 regulatory region 2 functions as a neural stem cell-specific enhancer in the telencephalon
    Satoru Miyagi
    Division of Developmental Biology, Research Center for Genomic Medicine, Saitama Medical University, 1397 1 Yamane, Hidaka, Saitama 350 1241, Japan
    J Biol Chem 281:13374-81. 2006
    ..Our data also suggest that the specific recruitment of these proteins to the SRR2 in the telencephalon defines the spatiotemporal activity of the enhancer in the developing nervous system...
  24. ncbi Distinct functions of human numb isoforms revealed by misexpression in the neural stem cell lineage in the Drosophila larval brain
    Masako Toriya
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    Dev Neurosci 28:142-55. 2006
    ....
  25. ncbi Gain-of-function screen identifies a role of the Sec61alpha translocon in Drosophila postmitotic neurotoxicity
    Hirotaka Kanuka
    Department of Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Biochim Biophys Acta 1726:225-37. 2005
    ....
  26. ncbi Blockade of interleukin-6 signaling aggravates ischemic cerebral damage in mice: possible involvement of Stat3 activation in the protection of neurons
    Toru Yamashita
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    J Neurochem 94:459-68. 2005
    ..These results suggest that endogenous IL-6 plays a critical role in preventing damaged neurons from undergoing apoptosis in the acute phase of cerebral ischemia and that its role may be mediated by Stat3 activation...