Yoshifumi Saisho

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. ncbi Beta cell dysfunction and its clinical significance in gestational diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Endocr J 57:973-80. 2010
  2. ncbi Effect of obesity on declining beta cell function after diagnosis of type 2 diabetes: a possible link suggested by cross-sectional analysis
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 59:187-95. 2012
  3. ncbi Postprandial serum C-peptide to plasma glucose ratio as a predictor of subsequent insulin treatment in patients with type 2 diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Endocr J 58:315-22. 2011
  4. ncbi Association between beta cell function and future glycemic control in patients with type 2 diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 60:517-23. 2013
  5. ncbi Marked decline in beta cell function during pregnancy leads to the development of glucose intolerance in Japanese women
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 60:533-9. 2013
  6. doi Effects of olmesartan medoxomil, an angiotensin II type 1 receptor antagonist, on plasma concentration of B-type natriuretic peptide, in hypertensive patients with type 2 diabetes mellitus: a preliminary, observational, open-label study
    Toshihide Kawai
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Clin Drug Investig 31:237-45. 2011
  7. pmc C-reactive protein, high-molecular-weight adiponectin and development of metabolic syndrome in the Japanese general population: a longitudinal cohort study
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 8:e73430. 2013
  8. ncbi Effects of mitiglinide, a short-acting insulin secretagogue, on daily glycemic variability and oxidative stress markers in Japanese patients with type 2 diabetes mellitus
    Noriko Kodani
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Clin Drug Investig 33:563-70. 2013
  9. ncbi Pancreatic beta-cell function and fetal growth in gestational impaired glucose tolerance
    Kei Miyakoshi
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Acta Obstet Gynecol Scand 89:769-75. 2010
  10. ncbi Usefulness of C-reactive protein to high-molecular-weight adiponectin ratio to predict insulin resistance and metabolic syndrome in Japanese men
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 17:944-52. 2010

Collaborators

Detail Information

Publications20

  1. ncbi Beta cell dysfunction and its clinical significance in gestational diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Endocr J 57:973-80. 2010
    ..The level of beta cell dysfunction in GDM was associated with the severity of glucose intolerance and total insulin dosage required. These findings underpin clinical significance of beta cell dysfunction in GDM...
  2. ncbi Effect of obesity on declining beta cell function after diagnosis of type 2 diabetes: a possible link suggested by cross-sectional analysis
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 59:187-95. 2012
    ..Treatment of obesity may be an important strategy to preserve beta cell function in patients with type 2 diabetes...
  3. ncbi Postprandial serum C-peptide to plasma glucose ratio as a predictor of subsequent insulin treatment in patients with type 2 diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Endocr J 58:315-22. 2011
    ..Our study indicates that among CPR measurements, postprandial CPR index is the best predictive marker for future insulin therapy...
  4. ncbi Association between beta cell function and future glycemic control in patients with type 2 diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 60:517-23. 2013
    ..Multivariate analyses showed consistent results (OR 1.23, 95%CI 1.03-1.48, P = 0.021). In conclusion, preserved beta cell function at baseline was associated with better glycemic control thereafter in patients with type 2 diabetes...
  5. ncbi Marked decline in beta cell function during pregnancy leads to the development of glucose intolerance in Japanese women
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 60:533-9. 2013
    ..05). Women with late-onset GDM showed significantly lower indices compared with NGT (each p < 0.05). The failure of beta cell to compensate for decreased insulin sensitivity could contribute to the development of the late-onset GDM...
  6. doi Effects of olmesartan medoxomil, an angiotensin II type 1 receptor antagonist, on plasma concentration of B-type natriuretic peptide, in hypertensive patients with type 2 diabetes mellitus: a preliminary, observational, open-label study
    Toshihide Kawai
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Clin Drug Investig 31:237-45. 2011
    ..The objective of this study was to determine the effects of olmesartan medoxomil, a novel ARB, on the plasma level of BNP in hypertensive patients with type 2 diabetes...
  7. pmc C-reactive protein, high-molecular-weight adiponectin and development of metabolic syndrome in the Japanese general population: a longitudinal cohort study
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 8:e73430. 2013
    ..To clarify predictive values of C-reactive protein (CRP) and high-molecular-weight (HMW) adiponectin for development of metabolic syndrome...
  8. ncbi Effects of mitiglinide, a short-acting insulin secretagogue, on daily glycemic variability and oxidative stress markers in Japanese patients with type 2 diabetes mellitus
    Noriko Kodani
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Clin Drug Investig 33:563-70. 2013
    ....
  9. ncbi Pancreatic beta-cell function and fetal growth in gestational impaired glucose tolerance
    Kei Miyakoshi
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Acta Obstet Gynecol Scand 89:769-75. 2010
    ..To investigate the metabolic phenotype and pregnancy outcomes of gestational impaired glucose tolerance (IGT) defined by isolated hyperglycemia during an oral glucose tolerance test (OGTT)...
  10. ncbi Usefulness of C-reactive protein to high-molecular-weight adiponectin ratio to predict insulin resistance and metabolic syndrome in Japanese men
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 17:944-52. 2010
    ..We questioned whether the ratio of C-reactive protein to high-molecular-weight adiponectin (C/A ratio), compared to each value alone, is more useful to predict insulin resistance and/or metabolic syndrome...
  11. ncbi Clinical impact of women with gestational diabetes mellitus by the new consensus criteria: two year experience in a single institution in Japan
    Satoru Ikenoue
    Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 61:353-8. 2014
    ..Our data suggest that the IADPSG-defined GDM with 1-AV show less severe glucose intolerance, but might be at risk of insulin requirement when a first-degree family history of diabetes exists. ..
  12. ncbi Islet number rather than islet size is a major determinant of β- and α-cell mass in humans
    Kinsei Kou
    Departments of Internal Medicine K K, Y S, S S, H I and Pathology T Y, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Endocrinol Metab 99:1733-40. 2014
    ..The objective of the study was to clarify the relative contribution of islet number and islet size to β- and α-cell mass in humans. Research..
  13. pmc Relationship between Stage of Diabetic Retinopathy and Pulse Wave Velocity in Japanese Patients with Type 2 Diabetes
    Kumiko Tanaka
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Diabetes Res 2013:193514. 2013
    ..Physicians should therefore pay attention to the value of PWV and macroangiopathy regardless of the stage of diabetic retinopathy...
  14. ncbi Effects of 12-month valsartan therapy on glycation and oxidative stress markers in type 2 diabetic subjects with hypertension
    Naoko Komiya
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Int Heart J 49:681-9. 2008
    ..In conclusion, the findings suggest that treatment with valsartan, even at a low dose, may ameliorate some glycation and oxidative stress markers independently of an effect on blood pressure in hypertensive type 2 diabetic subjects...
  15. ncbi Lower beta cell function relates to sustained higher glycated albumin to glycated hemoglobin ratio in Japanese patients with type 2 diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 61:149-57. 2014
    ..In conclusion, our findings suggest that lower beta cell function is associated with sustained higher GA/HbA1c ratio in patients with type 2 diabetes. ..
  16. doi Change in β-cell mass in Japanese nondiabetic obese individuals
    Kinsei Kou
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Clin Endocrinol Metab 98:3724-30. 2013
    ..The aim of this study was to clarify the change in β-cell mass in Japanese obese individuals...
  17. ncbi Prediction of recovery time from hypoglycemia in patients with insulin overdose
    Takako Ohyama
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 58:607-11. 2011
    ..This equation may be useful to predict the duration of glucose supplementation for treatment of insulin overdose...
  18. ncbi Effects of DHMEQ, a novel nuclear factor-kappab inhibitor, on beta cell dysfunction in INS-1 cells
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Endocr J 55:433-8. 2008
    ..In this study we tested this hypothesis by investigating the effects of dehydroxymethylepoxyquinomicin (DHMEQ), a novel NF-kappaB inhibitor, on tumor necrosis factor-alpha (TNF-alpha)-induced beta cell dysfunction...
  19. ncbi Combination of C-reactive protein and high molecular weight (HMW)-adiponectin reflects further metabolic abnormalities compared with each of them alone in Japanese type 2 diabetic subjects
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Endocr J 55:331-8. 2008
    ..In the present study, we investigated whether the combination of CRP and adiponectin is associated with further metabolic abnormalities compared to each of them alone...
  20. ncbi Study on the mechanism causing elevation of serum CA19-9 levels in diabetic patients
    Jun Murai
    Department of Internal Medicine, Kinki Central Hospital, Itami 664 8533, Japan
    Endocr J 60:885-91. 2013
    ..Taken all together, prolonged half-life of serum CA19-9 may contribute to the increase in serum CA19-9 levels in diabetic patients without obvious cancer. ..