Yuichi Oike

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. ncbi Angiopoietin-related growth factor antagonizes obesity and insulin resistance
    Yuichi Oike
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nat Med 11:400-8. 2005
  2. ncbi [AGF/Angpt16]
    Mitsuhisa Tabata
    Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, School of Medicine, Keio University
    Nihon Rinsho 64:263-9. 2006
  3. ncbi Angiopoietin-related growth factor (AGF) promotes angiogenesis
    Yuichi Oike
    Department of Cell Differentiation, School of Medicine, Keio University, Tokyo, Japan
    Blood 103:3760-5. 2004
  4. ncbi Angiopoietin-like proteins: potential new targets for metabolic syndrome therapy
    Yuichi Oike
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Trends Mol Med 11:473-9. 2005
  5. ncbi Angiopoietin-related/angiopoietin-like proteins regulate angiogenesis
    Yuichi Oike
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Shinanomachi, Shinjuku ku, Tokyo, Japan
    Int J Hematol 80:21-8. 2004
  6. ncbi Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:422-9. 2007
  7. pmc (Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Inaida Endowed Department of Anti Aging Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Pathol 173:1911-8. 2008
  8. pmc Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina
    Toshihide Kurihara
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Diabetes 57:2191-8. 2008
  9. doi Inhibition of choroidal neovascularization with an anti-inflammatory carotenoid astaxanthin
    Kanako Izumi-Nagai
    Laboratory of Retinal Cell Biology, Keio University of Medicne, Tokyo, Japan
    Invest Ophthalmol Vis Sci 49:1679-85. 2008
  10. doi Prevention of ocular inflammation in endotoxin-induced uveitis with resveratrol by inhibiting oxidative damage and nuclear factor-kappaB activation
    Shunsuke Kubota
    Department ofOphthalmology, Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:3512-9. 2009

Collaborators

Detail Information

Publications58

  1. ncbi Angiopoietin-related growth factor antagonizes obesity and insulin resistance
    Yuichi Oike
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nat Med 11:400-8. 2005
    ..01) body weight loss and increases insulin sensitivity in mice fed a high-fat diet. This study establishes AGF as a new hepatocyte-derived circulating factor that counteracts obesity and related insulin resistance...
  2. ncbi [AGF/Angpt16]
    Mitsuhisa Tabata
    Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, School of Medicine, Keio University
    Nihon Rinsho 64:263-9. 2006
  3. ncbi Angiopoietin-related growth factor (AGF) promotes angiogenesis
    Yuichi Oike
    Department of Cell Differentiation, School of Medicine, Keio University, Tokyo, Japan
    Blood 103:3760-5. 2004
    ..On the basis of these observations, we propose that AGF is a novel angiogenic factor and that handling of its biologic functions could lead to novel therapeutic strategies for control of angiogenesis...
  4. ncbi Angiopoietin-like proteins: potential new targets for metabolic syndrome therapy
    Yuichi Oike
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Trends Mol Med 11:473-9. 2005
    ..As more is discovered about the functions of Angptls, so their potential as therapeutic targets for metabolic syndrome is explored...
  5. ncbi Angiopoietin-related/angiopoietin-like proteins regulate angiogenesis
    Yuichi Oike
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Shinanomachi, Shinjuku ku, Tokyo, Japan
    Int J Hematol 80:21-8. 2004
    ....
  6. ncbi Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:422-9. 2007
    ..The purpose of the present study was to investigate whether nonproteolytically activated prorenin plays a role in ischemia-induced retinal neovascularization...
  7. pmc (Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Inaida Endowed Department of Anti Aging Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Pathol 173:1911-8. 2008
    ..These results indicate the significant contribution of RAPS to CNV pathogenesis...
  8. pmc Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina
    Toshihide Kurihara
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Diabetes 57:2191-8. 2008
    ..The aim of the present study was to show the relationship of the renin-angiotensin system (RAS) with the synaptic vesicle protein synaptophysin and neuronal activity in the diabetic retina...
  9. doi Inhibition of choroidal neovascularization with an anti-inflammatory carotenoid astaxanthin
    Kanako Izumi-Nagai
    Laboratory of Retinal Cell Biology, Keio University of Medicne, Tokyo, Japan
    Invest Ophthalmol Vis Sci 49:1679-85. 2008
    ..The purpose of the present study was to investigate the effect of AST on the development of experimental choroidal neovascularization (CNV) with underlying cellular and molecular mechanisms...
  10. doi Prevention of ocular inflammation in endotoxin-induced uveitis with resveratrol by inhibiting oxidative damage and nuclear factor-kappaB activation
    Shunsuke Kubota
    Department ofOphthalmology, Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:3512-9. 2009
    ..Resveratrol is known as one of the antioxidant polyphenols contained in red wine and grape skin. The purpose of the present study was to investigate the role of resveratrol in ocular inflammation in endotoxin-induced uveitis (EIU)...
  11. ncbi Eicosapentaenoic acid is anti-inflammatory in preventing choroidal neovascularization in mice
    Takashi Koto
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:4328-34. 2007
    ..To investigate the role of eicosapentaenoic acid (EPA), the major omega-3 polyunsaturated fatty acid (PUFA), in the development of choroidal neovascularization (CNV), together with underlying molecular mechanisms...
  12. ncbi Suppression of diabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-kappaB pathway
    Norihiro Nagai
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:4342-50. 2007
    ..To investigate the involvement of the renin-angiotensin system (RAS) and the nuclear factor (NF)-kappaB pathway with diabetes-induced retinal inflammation...
  13. ncbi Suppression of ocular inflammation in endotoxin-induced uveitis by blocking the angiotensin II type 1 receptor
    Norihiro Nagai
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 46:2925-31. 2005
    ..To examine whether the angiotensin II type 1 receptor (AT1-R) signaling plays a role in ocular inflammation in endotoxin-induced uveitis (EIU)...
  14. ncbi Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4
    Yasuhiro Ito
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Cancer Res 63:6651-7. 2003
    ..These findings demonstrate that ARP4 functions as a novel antiangiogenic modulatory factor and indicate a potential therapeutic effect of ARP4 in neoplastic diseases...
  15. pmc (Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammation
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Diabetes 58:1625-33. 2009
    ..The aim of the present study was to define the association of the RAPS with diabetes-induced retinal inflammation...
  16. pmc Cooperative interaction of Angiopoietin-like proteins 1 and 2 in zebrafish vascular development
    Yoshiaki Kubota
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Proc Natl Acad Sci U S A 102:13502-7. 2005
    ..These results provide a physiological demonstration of the cooperative interaction of Angptl1 and Angptl2 in endothelial cells through phosphatidylinositol 3-kinase/Akt mediated antiapoptotic activities...
  17. ncbi Angiotensin II type 1 receptor-mediated inflammation is required for choroidal neovascularization
    Norihiro Nagai
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arterioscler Thromb Vasc Biol 26:2252-9. 2006
    ..The aim of the current study was to determine the involvement of the renin-angiotensin system (RAS) with the development of CNV, using human surgical samples and the murine model of laser-induced CNV...
  18. ncbi Macular pigment lutein is antiinflammatory in preventing choroidal neovascularization
    Kanako Izumi-Nagai
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arterioscler Thromb Vasc Biol 27:2555-62. 2007
    ..The aim of the current study was to investigate the effect of lutein supplementation on the development of the murine model of laser-induced CNV together with underlying molecular mechanisms...
  19. ncbi Suppression of choroidal neovascularization by inhibiting angiotensin-converting enzyme: minimal role of bradykinin
    Norihiro Nagai
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:2321-6. 2007
    ..The purpose of the present study was to investigate the role of bradykinin in the development of choroidal neovascularization (CNV), with or without ACE inhibition...
  20. doi Angiopoietins contribute to lung development by regulating pulmonary vascular network formation
    Tai Hato
    Department of Cell Differentiation, Keio University School of Medicine, Shinanomachi 35, Shinjuku ku, Tokyo 160 8556, Japan
    Biochem Biophys Res Commun 381:218-23. 2009
    ..Thus, the precise regulation of Tie2 signaling through an Ang1/Ang2 expression switch is important to construct a mature lung vascular network system required for normal lung development...
  21. pmc Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration
    Yuichi Oike
    Department of Cell Differentiation, The Sakaguchi Laboratory, Keio University School of Medicine, Tokyo 160 8582, Japan
    Proc Natl Acad Sci U S A 100:9494-9. 2003
    ..These findings demonstrate that biological functions of AGF in epidermal keratinocytes could lead to novel therapeutic strategies for wound care and epidermal regenerative medicine...
  22. doi Angiopoietin-related growth factor enhances blood flow via activation of the ERK1/2-eNOS-NO pathway in a mouse hind-limb ischemia model
    Takashi Urano
    Laboratory of Vascular Biology and Metabolism, Center for Integrated Medical Research, Department of Cell Differentiation, School of Medicine, Keio University, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 28:827-34. 2008
    ..Our goal was to determine whether AGF enhances blood flow in a mouse hind-limb ischemia model and to define molecular mechanisms underlying AGF signaling in endothelial cells...
  23. ncbi Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, Tokyo, and Department of Ophthalmology, Kobe City General Hospital, Japan
    Invest Ophthalmol Vis Sci 47:2686-92. 2006
    ..The purpose of the present study was to elucidate the role of the receptor-dependent nonproteolytic activation of prorenin in ocular inflammation in endotoxin-induced uveitis (EIU)...
  24. ncbi Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation
    Tohru Morisada
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan
    Blood 105:4649-56. 2005
    ..On the basis of these observations, we propose that Ang signaling regulates lymphatic vessel formation through Tie2...
  25. ncbi Isolation and expression patterns of genes for three angiopoietin-like proteins, Angptl1, 2 and 6 in zebrafish
    Yoshiaki Kubota
    The Sakaguchi Laboratory, Department of Cell Differentiation, School of Medicine, Keio University, Tokyo, Japan
    Gene Expr Patterns 5:679-85. 2005
    ..Zangptl6 is expressed in the notochord. In addition to its embryonic expression, Zangptl2 is induced in adult fish during fin regeneration...
  26. ncbi Neuroprotective effects of angiotensin II type 1 receptor (AT1R) blocker, telmisartan, via modulating AT1R and AT2R signaling in retinal inflammation
    Toshihide Kurihara
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 47:5545-52. 2006
    ..To investigate the retinal neural damage that occurs during inflammation and the therapeutic effects of the angiotensin II type 1 receptor (AT1R) blocker, telmisartan, using a model of endotoxin-induced uveitis (EIU)...
  27. pmc Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization
    Kanako Izumi-Nagai
    Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Am J Pathol 170:2149-58. 2007
    ....
  28. ncbi Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression
    Eiji Horio
    From the Department of Molecular Genetics E H, T K, K M, H H, M E, M Tabata, H T, Z T, O T, K T, Y O, Department of Cardiovascular Medicine E H, H O, K K, and Department of Cell Pathology M Takeya, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan Division of Geriatric Medicine, Department of Internal Medicine Y A, N H and Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine K H, T S, Keio University School of Medicine, Tokyo, Japan Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Y D, T N, Y K Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Kingston
    Arterioscler Thromb Vasc Biol 34:790-800. 2014
    ..Here, we ask whether angiopoietin-like protein 2 (Angptl2), a proinflammatory protein, contributes to vascular inflammation that promotes atherosclerosis progression...
  29. pmc Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression
    Hiromi Yuasa
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan
    EMBO J 24:1976-87. 2005
    ..Our results reveal that GATA-2 is presumably one of critical targets for Evi1 and that transcription factors regulate the HSC pool hierarchically...
  30. ncbi Distinct roles of ephrin-B2 forward and EphB4 reverse signaling in endothelial cells
    Koichi Hamada
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto, Japan
    Arterioscler Thromb Vasc Biol 23:190-7. 2003
    ..However, how such bidirectional signals are required for cell-cell adhesion or repulsion remains unclear...
  31. pmc Resveratrol prevents light-induced retinal degeneration via suppressing activator protein-1 activation
    Shunsuke Kubota
    Laboratories of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Am J Pathol 177:1725-31. 2010
    ..Our data suggest the potential use of resveratrol as a therapeutic agent to prevent retinal degeneration related to light damage...
  32. pmc Loss of Tie2 receptor compromises embryonic stem cell-derived endothelial but not hematopoietic cell survival
    Isao Hamaguchi
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan
    Blood 107:1207-13. 2006
    ..Interestingly, Tie2-/- ES cells did not show measurable defects in development of the hematopoietic system, suggesting that Tie2 is not essential for hematopoietic cell development...
  33. ncbi [Role of angiopoietin-like protein (Angptl)]
    Yuichi Oike
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Seikagaku 77:1412-7. 2005
  34. ncbi Ephrin-B2 induces migration of endothelial cells through the phosphatidylinositol-3 kinase pathway and promotes angiogenesis in adult vasculature
    Hiromitsu Maekawa
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, 35 Shinano machi, Shinjyuku ku, Tokyo 160 8582, Japan
    Arterioscler Thromb Vasc Biol 23:2008-14. 2003
    ..The purpose of this study was to elucidate the molecular mechanisms of ephrin-B2 signaling through the EphB receptor in endothelial cells and to determine whether ephrin-B2 contributes to in vivo angiogenesis in adult mice...
  35. ncbi Selective suppression of pathologic, but not physiologic, retinal neovascularization by blocking the angiotensin II type 1 receptor
    Norihiro Nagai
    Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Invest Ophthalmol Vis Sci 46:1078-84. 2005
    ..To investigate the anti-inflammatory and anti-angiogenic effects of telmisartan, an angiotensin II type 1 receptor (AT1-R) antagonist, on ischemia-induced retinal neovascularization...
  36. ncbi Angiopoietins and angiopoietin-like proteins in angiogenesis
    Tohru Morisada
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan
    Endothelium 13:71-9. 2006
    ..Here, the authors review current findings relating to the roles of angiopoietins and Angptls in vascular biology and discuss molecular mechanisms relevant to these factors and angiogenesis...
  37. ncbi Neuropilin-1 on hematopoietic cells as a source of vascular development
    Yoshihiro Yamada
    Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, Tokyo, Japan
    Blood 101:1801-9. 2003
    ..In NP-1-/- embryos, vascular sprouting is impaired at the central nervous system (CNS) and pericardium where VEGF is not abundant, indicating that NP-1-expressing cells are required for normal vascular development...
  38. doi The role of angiopoietin-like proteins in angiogenesis and metabolism
    Tai Hato
    Laboratory of Vascular Biology and Metabolism, Center for Integrated Medical Research, Department of General Thoracic Surgery, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    Trends Cardiovasc Med 18:6-14. 2008
    ..Recently, several lines of evidence reveal differential roles of Angptl structural domains in both angiogenesis and metabolism. Here, we briefly review what is currently known about Angptls function...
  39. ncbi Defective smooth muscle development in qkI-deficient mice
    Zhenghua Li
    Department of Developmental Genetics, Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 862 0976, Japan
    Dev Growth Differ 45:449-62. 2003
    ..These data suggest that QKI protein has a critical regulatory role in smooth muscle cell development, and that smooth muscle cells play an important role in inducing vascular remodeling...
  40. ncbi Distribution of lymphatic vessels in mouse thymus: immunofluorescence analysis
    Chikako Odaka
    Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Cell Tissue Res 325:13-22. 2006
    ..Our results suggest the presence of lymphatic capillary networks throughout the thymus...
  41. doi Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity
    Jun Kurokawa
    Laboratory of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo, 113 0033, Japan
    Cell Metab 11:479-92. 2010
    ..Interestingly, metabolic rates are comparable in AIM(-)(/-) and AIM(+/+) mice, suggesting that AIM specifically influences adipocyte status. Thus, this AIM function in adipocytes may be physiologically relevant to obesity progression...
  42. doi Angiopoietin-like protein 2 is a potent hemangiogenic and lymphangiogenic factor in corneal inflammation
    Tetsuya Toyono
    Department of Ophthalmology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Invest Ophthalmol Vis Sci 54:4278-85. 2013
    ..We determined the plausible functional role of angiopoietin-like protein 2 (Angptl2) in inflammatory corneal hemangiogenesis and lymphangiogenesis in vivo...
  43. pmc Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL
    Sahoko Matsuoka
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Genes Dev 22:986-91. 2008
    ..Thus, Fbxw7 functions as a fail-safe mechanism against both premature HSC loss and leukemogenesis...
  44. doi Hepatic AdipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice
    Kengo Tomita
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Keio University School of Medicine, Tokyo, Japan
    Hepatology 48:458-73. 2008
    ....
  45. ncbi Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells
    Yuichi Oike
    Department of Cell Differentiation, the Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    Blood 100:1326-33. 2002
    ..EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells plays an essential role in vasculogenesis, angiogenesis, and vessel maturation...
  46. pmc DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells
    Mitsuru Yagi
    Department of Cell Differentiation, The Sakaguchi Laboratory, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Exp Med 202:345-51. 2005
    ..We have thus identified an essential regulator of osteoclast and macrophage cell fusion, DC-STAMP, and an essential role of osteoclast multinucleation in bone homeostasis...
  47. ncbi Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice
    Toshimasa Yamauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Nat Genet 30:221-6. 2002
    ..This study demonstrates that CBP may function as a 'master-switch' between energy storage and expenditure...
  48. ncbi Angiopoietin-1 promotes lymphatic sprouting and hyperplasia
    Tuomas Tammela
    Molecular Cancer Biology Laboratory, Ludwig Institute for Cancer Research, Biomedicum Helsinki, Finland
    Blood 105:4642-8. 2005
    ..Furthermore, a soluble form of VEGFR-3 inhibited the observed lymphatic sprouting. Our results reinforce the concept that Ang1 therapy may be useful in settings of tissue edema...
  49. ncbi Angiopoietin-related growth factor suppresses gluconeogenesis through the Akt/forkhead box class O1-dependent pathway in hepatocytes
    Masashi Kitazawa
    Molecular Medicine Research Laboratories, Drug Discovery Research, Astellas Pharma, Inc, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    J Pharmacol Exp Ther 323:787-93. 2007
    ..These results suggest that in hepatocytes, AGF suppresses gluconeogenesis via reduced transcriptional activity of FoxO1 resulting from the activation of PI3K/Akt signaling cascades...
  50. ncbi Analysis of human TIE2 function on hematopoietic stem cells in umbilical cord blood
    Hiromi Yuasa
    Department of Hamatopoiesis, Institute of Molecular Genetics and Embryology, Kumamoto University, Japan
    Biochem Biophys Res Commun 298:731-7. 2002
    ..A ligand for TIE2, Ang-1 promoted the adhesion of sorted primary Lin(-/low)CD34(+)TIE2(+) cells to fibronectin (FN), and this adhesion may play a critical role in keeping HSCs in an immature status under the stromal cells...
  51. ncbi Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo
    Mitsuhiro Uchiba
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto, 860 0811, Japan
    Circ Res 95:34-41. 2004
    ..These in vitro events induced by APC might at least partly explain the angiogenic activity in vivo. This angiogenic activity of APC might contribute to maintain proper microcirculation in addition to its antithrombotic activity...
  52. ncbi Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the alpha/beta hydrolase domain containing 2 gene
    Keishi Miyata
    Department of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, 4 24 1 Kuhonji, Kumamoto 862 0976, Japan
    Biochem Biophys Res Commun 329:296-304. 2005
    ..Our results show that Abhd2 is involved in SMC migration and neointimal thickening on vascular SMCs...
  53. ncbi Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette
    Takuya Taniwaki
    Institute of Molecular Embryology and Genetics, Kumamoto University, Kuhonji 4 24 1, Kumamoto 862 0976, Japan
    Dev Growth Differ 47:163-72. 2005
    ....
  54. ncbi Dll4-selective Notch signaling induces ephrinB2 gene expression in endothelial cells
    Tatsuya Iso
    Department of Medicine and Biological Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Biochem Biophys Res Commun 341:708-14. 2006
    ..Our data provide new insight into the molecular mechanism of ligand-selective Notch activation during differentiation of arterial EC...
  55. ncbi Intestinal and peri-tumoral lymphatic endothelial cells are resistant to radiation-induced apoptosis
    Hoon Ki Sung
    Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology KAIST, Daejeon 305 701, Republic of Korea
    Biochem Biophys Res Commun 345:545-51. 2006
    ..Our results suggest the need for alternative therapeutic modalities that can block lymphatic endothelial cell survival, and thus disrupt the integrity of lymphatic vessels in peri-tumor areas...
  56. ncbi Angiogenic role of LYVE-1-positive macrophages in adipose tissue
    Chung Hyun Cho
    National Research Laboratory of Vascular Biology and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
    Circ Res 100:e47-57. 2007
    ....
  57. pmc Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades
    Koichi Mishima
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Mol Biol Cell 18:1421-9. 2007
    ....
  58. ncbi Effect of direct angiogenesis inhibition in rheumatoid arthritis using a soluble vascular endothelial growth factor receptor 1 chimeric protein
    Tomohisa Sekimoto
    Department of Orthopedic Surgery, Miyazaki Medical College, Kiyotake, Japan
    J Rheumatol 29:240-5. 2002
    ..We evaluated the effect of direct angiogenesis inhibition in synovium of patients with rheumatoid arthritis (RA), using a soluble vascular endothelial growth factor receptor 1 (VEGFR1) chimeric protein...